Reviewed, UniProtKB/Swiss-Prot Q8CG19 (LTBP1_MOUSE)

Names and origin

Protein names

Recommended name:
    Latent-transforming growth factor beta-binding protein 1
      Short name=LTBP-1
Alternative name(s):
    Transforming growth factor beta-1-binding protein 1
      Short name=TGF-beta1-BP-1

Gene names

Name:

Ltbp1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	1712 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).
Subunit structure	The large latent complex of TGFB1 from platelets is composed of the TGFB1 molecule non-covalently associated with a disulfide-bonded complex of a dimer of the N-terminal propeptide of the TGFB1 precursor and LTBP1. LTBP1 does not bind directly to active TGFB1. Binds to FBN1 and FBN2. Interacts with ADAMTSL2 By similarity.
Subcellular location	Secreted By similarity. UniProtKB Q14766
Domain	Associates covalently with small latent TGF-beta complex via domain TB 3 By similarity.
Post-translational modification	Contains hydroxylated asparagine residues By similarity. UniProtKB P22064 The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.
Sequence similarities	Belongs to the LTBP family. Contains 18 EGF-like domains. Contains 4 TB (TGF-beta binding) domains.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	EGF-like domain Repeat Signal
Ligand	Growth factor binding
PTM	Disulfide bond Glycoprotein Hydroxylation Phosphoprotein
Gene Ontology (GO)
Biological process	transforming growth factor beta receptor signaling pathway Traceable author statement. Source: MGI
Cellular component	proteinaceous extracellular matrix Inferred from direct assay. Source: MGI
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro growth factor binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: Q8CG19-1)

Also known as: LTBP-1L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Short (identifier: Q8CG19-2)

Also known as: LTBP-1S;

The sequence of this isoform differs from the canonical sequence as follows:
     1-318: Missing.
     319-336: EGSFSLRYGQEQGTAPFQ → MDTKLMCLLFFLCLPLLL

Isoform 3 (identifier: Q8CG19-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-318: Missing.
     319-336: EGSFSLRYGQEQGTAPFQ → MDTKLMCLLFFLCLPLLL
     716-768: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 1712	1689	Latent-transforming growth factor beta-binding protein 1		PRO_0000007637
Regions
	Domain	181 – 213	33	EGF-like 1
	Domain	391 – 423	33	EGF-like 2
	Domain	549 – 601	53	TB 1
	Domain	618 – 658	41	EGF-like 3; calcium-binding Potential
	Domain	669 – 721	53	TB 2
	Domain	865 – 906	42	EGF-like 4; calcium-binding Potential
	Domain	907 – 948	42	EGF-like 5; calcium-binding Potential
	Domain	949 – 989	41	EGF-like 6; calcium-binding Potential
	Domain	990 – 1029	40	EGF-like 7; calcium-binding Potential
	Domain	1030 – 1070	41	EGF-like 8; calcium-binding Potential
	Domain	1071 – 1111	41	EGF-like 9; calcium-binding Potential
	Domain	1112 – 1152	41	EGF-like 10; calcium-binding Potential
	Domain	1153 – 1193	41	EGF-like 11; calcium-binding Potential
	Domain	1194 – 1235	42	EGF-like 12; calcium-binding Potential
	Domain	1236 – 1277	42	EGF-like 13; calcium-binding Potential
	Domain	1278 – 1320	43	EGF-like 14; calcium-binding Potential
	Domain	1338 – 1392	55	TB 3
	Domain	1415 – 1457	43	EGF-like 15; calcium-binding Potential
	Domain	1458 – 1498	41	EGF-like 16; calcium-binding Potential
	Domain	1515 – 1568	54	TB 4
	Domain	1612 – 1652	41	EGF-like 17
	Domain	1653 – 1697	45	EGF-like 18; calcium-binding Potential
	Compositional bias	96 – 124	29	Pro-rich
Amino acid modifications
	Modified residue	966	1	(3R)-3-hydroxyasparagine By similarity
	Modified residue	1129	1	(3R)-3-hydroxyasparagine By similarity
	Modified residue	1588	1	Phosphoserine By similarity
	Modified residue	1591	1	Phosphotyrosine By similarity
	Glycosylation	339	1	N-linked (GlcNAc...) Potential
	Glycosylation	370	1	N-linked (GlcNAc...) Potential
	Glycosylation	416	1	N-linked (GlcNAc...) Potential
	Glycosylation	612	1	N-linked (GlcNAc...) Potential
	Glycosylation	1042	1	N-linked (GlcNAc...) Potential
	Glycosylation	1242	1	N-linked (GlcNAc...) Potential
	Glycosylation	1357	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	185 ↔ 195		By similarity
	Disulfide bond	189 ↔ 201		By similarity
	Disulfide bond	203 ↔ 212		By similarity
	Disulfide bond	395 ↔ 405		By similarity
	Disulfide bond	399 ↔ 411		By similarity
	Disulfide bond	413 ↔ 422		By similarity
	Disulfide bond	622 ↔ 633		By similarity
	Disulfide bond	628 ↔ 642		By similarity
	Disulfide bond	644 ↔ 657		By similarity
	Disulfide bond	869 ↔ 881		By similarity
	Disulfide bond	876 ↔ 890		By similarity
	Disulfide bond	892 ↔ 905		By similarity
	Disulfide bond	911 ↔ 923		By similarity
	Disulfide bond	918 ↔ 932		By similarity
	Disulfide bond	934 ↔ 947		By similarity
	Disulfide bond	953 ↔ 964		By similarity
	Disulfide bond	959 ↔ 973		By similarity
	Disulfide bond	976 ↔ 988		By similarity
	Disulfide bond	994 ↔ 1005		By similarity
	Disulfide bond	1000 ↔ 1014		By similarity
	Disulfide bond	1017 ↔ 1028		By similarity
	Disulfide bond	1034 ↔ 1045		By similarity
	Disulfide bond	1040 ↔ 1054		By similarity
	Disulfide bond	1056 ↔ 1069		By similarity
	Disulfide bond	1075 ↔ 1086		By similarity
	Disulfide bond	1081 ↔ 1095		By similarity
	Disulfide bond	1097 ↔ 1110		By similarity
	Disulfide bond	1116 ↔ 1127		By similarity
	Disulfide bond	1122 ↔ 1136		By similarity
	Disulfide bond	1138 ↔ 1151		By similarity
	Disulfide bond	1157 ↔ 1169		By similarity
	Disulfide bond	1164 ↔ 1178		By similarity
	Disulfide bond	1180 ↔ 1192		By similarity
	Disulfide bond	1198 ↔ 1210		By similarity
	Disulfide bond	1204 ↔ 1219		By similarity
	Disulfide bond	1221 ↔ 1234		By similarity
	Disulfide bond	1240 ↔ 1252		By similarity
	Disulfide bond	1246 ↔ 1261		By similarity
	Disulfide bond	1263 ↔ 1276		By similarity
	Disulfide bond	1282 ↔ 1294		By similarity
	Disulfide bond	1289 ↔ 1303		By similarity
	Disulfide bond	1305 ↔ 1319		By similarity
	Disulfide bond	1340 ↔ 1363		By similarity
	Disulfide bond	1350 ↔ 1375		By similarity
	Disulfide bond	1364 ↔ 1380		By similarity
	Disulfide bond	1365 ↔ 1392		By similarity
	Disulfide bond	1419 ↔ 1432		By similarity
	Disulfide bond	1427 ↔ 1441		By similarity
	Disulfide bond	1443 ↔ 1456		By similarity
	Disulfide bond	1462 ↔ 1473		By similarity
	Disulfide bond	1468 ↔ 1482		By similarity
	Disulfide bond	1484 ↔ 1497		By similarity
	Disulfide bond	1616 ↔ 1627		By similarity
	Disulfide bond	1622 ↔ 1636		By similarity
	Disulfide bond	1638 ↔ 1651		By similarity
	Disulfide bond	1657 ↔ 1672		By similarity
	Disulfide bond	1667 ↔ 1681		By similarity
	Disulfide bond	1683 ↔ 1696		By similarity
Natural variations
	Alternative sequence	1 – 318	318	Missing in isoform Short and isoform 3.		VSP_036968
	Alternative sequence	319 – 336	18	EGSFS…TAPFQ → MDTKLMCLLFFLCLPLLL in isoform Short and isoform 3.		VSP_036969
	Alternative sequence	716 – 768	53	Missing in isoform 3.		VSP_036970
Experimental info
	Sequence conflict	313	1	S → F in AAN77250. Ref.1
	Sequence conflict	506	1	A → T in AAN77250. Ref.1
	Sequence conflict	506	1	A → T in AAN77251. Ref.1
	Sequence conflict	506	1	A → T in AAC33307. Ref.3
	Sequence conflict	559	1	Q → QQ in AAN77250. Ref.1
	Sequence conflict	559	1	Q → QQ in AAC33307. Ref.3
	Sequence conflict	1033	1	E → K in AAC33307. Ref.3
	Sequence conflict	1111	1	E → G in BAC34222. Ref.6
	Sequence conflict	1216	1	S → F in BAC34222. Ref.6
	Sequence conflict	1631	1	Q → H in AAN77250. Ref.1
	Sequence conflict	1631	1	Q → H in AAN77251. Ref.1
	Sequence conflict	1659	1	E → G in BAC34222. Ref.6
	Sequence conflict	1712	1	E → N in AAC33307. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform Long (LTBP-1L) [UniParc]. Last modified May 5, 2009. Version 2. Checksum: DB0564112F1F7843	FASTA	1,712	186,717
	10 20 30 40 50 60 MAGAWLRWGL LLWAGLLAWS AHGRVRRITY VVRPGPGLPA GALPLAGPPR TFNVALDARY 70 80 90 100 110 120 SRSSTAASSR ALAGPPAERT RRTSQPGGAA LPGLRSPLPP EPARPGGPSR QLHSKAGAQT 130 140 150 160 170 180 AVTRFAKHGR QVVRSQVQQD AQSAGGSRLQ VQQKQQLQGI NVCGGQCCHG WSKPPGSQRC 190 200 210 220 230 240 TKPSCVPPCQ NGGMCLRPQL CVCKPGSKGK ACEITAAQDT MPPAFGGQNP GSSWAPLEQA 250 260 270 280 290 300 AKHTSTKKAD TLPRVSPVAQ MTLTLKPKPS MGLSQQIHPQ VAPLSSQNVM IRHGQTQEYL 310 320 330 340 350 360 LKPKYFPAPK VVSAEQSTEG SFSLRYGQEQ GTAPFQVSNH TGRIKVVFTP SICKVTCTKG 370 380 390 400 410 420 NCQNSCQKGN TTTLISENGH AADTLTATNF RVVICHLPCM NGGQCSSRDK CQCPPNFTGK 430 440 450 460 470 480 LCQIPVLGAS MPKLYQHAQQ QGKALGSHVI HSTHTLPLTM TSQQGVKVKF PPNIVNIHVK 490 500 510 520 530 540 HPPEASVQIH QVSRIDSPGG QKVKEAQPGQ SQVSYQGLPV QKTQTVHSTY SHQQLIPHVY 550 560 570 580 590 600 PVAAKTQLGR CFQETIGSQC GKALPGLSKQ EDCCGTVGTS WGFNKCQKCP KKQSYHGYTQ 610 620 630 640 650 660 MMECLQGYKR VNNTFCQDIN ECQLQGVCPN GECLNTMGSY RCSCKMGFGP DPTFSSCVPD 670 680 690 700 710 720 PPVISEEKGP CYRLVSPGRH CMHPLSVHLT KQICCCSVGK AWGPHCEKCP LPGTAAFKEI 730 740 750 760 770 780 CPGGMGYTVS GVHRRRPIHQ HIGKEAVYVK PKNTQPVAKS THPPPLPAKE EPVEALTSSW 790 800 810 820 830 840 EHGPRGAEPE VVTAPPEKEI PSLDQEKTRL EPGQPQLSPG VSTIHLHPQF PVVVEKTSPP 850 860 870 880 890 900 VPVEVAPEAS TSSASQVIAP TQVTEINECT VNPDICGAGH CINLPVRYTC ICYEGYKFSE 910 920 930 940 950 960 QLRKCVDIDE CAQVRHLCSQ GRCENTEGSF LCVCPAGFMA SEEGTNCIDV DECLRPDMCR 970 980 990 1000 1010 1020 DGRCINTAGA FRCEYCDSGY RMSRRGYCED IDECLKPSTC PEEQCVNTPG SYQCVPCTEG 1030 1040 1050 1060 1070 1080 FRGWNGQCLD VDECLQPKVC TNGSCTNLEG SYMCSCHRGY SPTPDHRHCQ DIDECQQGNL 1090 1100 1110 1120 1130 1140 CMNGQCRNTD GSFRCTCGQG YQLSAAKDQC EDIDECEHHH LCSHGQCRNT EGSFQCVCNQ 1150 1160 1170 1180 1190 1200 GYRASVLGDH CEDINECLED SSVCQGGDCI NTAGSYDCTC PDGFQLNDNK GCQDINECAQ 1210 1220 1230 1240 1250 1260 PGLCGSHGEC LNTQGSFHCV CEQGFSISAD GRTCEDIDEC VNNTVCDSHG FCDNTAGSFR 1270 1280 1290 1300 1310 1320 CLCYQGFQAP QDGQGCVDVN ECELLSGVCG EAFCENVEGS FLCVCADENQ EYSPMTGQCR 1330 1340 1350 1360 1370 1380 SRVTEDSGVD RQPREEKKEC YYNLNDASLC DNVLAPNVTK QECCCTSGAG WGDNCEIFPC 1390 1400 1410 1420 1430 1440 PVQGTAEFTE MCPRGKGLVP AGESSYDTGG ENYKDADECL LFGEEICKNG YCLNTQPGYE 1450 1460 1470 1480 1490 1500 CYCKQGTYYD PVKLQCFDMD ECQDPNSCID GQCVNTEGSY NCFCTHPMVL DASEKRCVQP 1510 1520 1530 1540 1550 1560 TESNEQIEET DVYQDLCWEH LSEEYVCSRP LVGKQTTYTE CCCLYGEAWG MQCALCPMKD 1570 1580 1590 1600 1610 1620 SDDYAQLCNI PVTGRRRPYG RDALVDFSEQ YGPETDPYFI QDRFLNSFEE LQAEECGILN 1630 1640 1650 1660 1670 1680 GCENGRCVRV QEGYTCDCFD GYHLDMAKMT CVDVNECSEL NNRMSLCKNA KCINTEGSYK 1690 1700 1710 CLCLPGYIPS DKPNYCTPLN SALNLDKESD LE
	Isoform Short (LTBP-1S) [UniParc] [UniParc]. Checksum: 0D10BF1FB3B4A85A	FASTA	1,394	153,185
	10 20 30 40 50 60 MDTKLMCLLF FLCLPLLLVS NHTGRIKVVF TPSICKVTCT KGNCQNSCQK GNTTTLISEN 70 80 90 100 110 120 GHAADTLTAT NFRVVICHLP CMNGGQCSSR DKCQCPPNFT GKLCQIPVLG ASMPKLYQHA 130 140 150 160 170 180 QQQGKALGSH VIHSTHTLPL TMTSQQGVKV KFPPNIVNIH VKHPPEASVQ IHQVSRIDSP 190 200 210 220 230 240 GGQKVKEAQP GQSQVSYQGL PVQKTQTVHS TYSHQQLIPH VYPVAAKTQL GRCFQETIGS 250 260 270 280 290 300 QCGKALPGLS KQEDCCGTVG TSWGFNKCQK CPKKQSYHGY TQMMECLQGY KRVNNTFCQD 310 320 330 340 350 360 INECQLQGVC PNGECLNTMG SYRCSCKMGF GPDPTFSSCV PDPPVISEEK GPCYRLVSPG 370 380 390 400 410 420 RHCMHPLSVH LTKQICCCSV GKAWGPHCEK CPLPGTAAFK EICPGGMGYT VSGVHRRRPI 430 440 450 460 470 480 HQHIGKEAVY VKPKNTQPVA KSTHPPPLPA KEEPVEALTS SWEHGPRGAE PEVVTAPPEK 490 500 510 520 530 540 EIPSLDQEKT RLEPGQPQLS PGVSTIHLHP QFPVVVEKTS PPVPVEVAPE ASTSSASQVI 550 560 570 580 590 600 APTQVTEINE CTVNPDICGA GHCINLPVRY TCICYEGYKF SEQLRKCVDI DECAQVRHLC 610 620 630 640 650 660 SQGRCENTEG SFLCVCPAGF MASEEGTNCI DVDECLRPDM CRDGRCINTA GAFRCEYCDS 670 680 690 700 710 720 GYRMSRRGYC EDIDECLKPS TCPEEQCVNT PGSYQCVPCT EGFRGWNGQC LDVDECLQPK 730 740 750 760 770 780 VCTNGSCTNL EGSYMCSCHR GYSPTPDHRH CQDIDECQQG NLCMNGQCRN TDGSFRCTCG 790 800 810 820 830 840 QGYQLSAAKD QCEDIDECEH HHLCSHGQCR NTEGSFQCVC NQGYRASVLG DHCEDINECL 850 860 870 880 890 900 EDSSVCQGGD CINTAGSYDC TCPDGFQLND NKGCQDINEC AQPGLCGSHG ECLNTQGSFH 910 920 930 940 950 960 CVCEQGFSIS ADGRTCEDID ECVNNTVCDS HGFCDNTAGS FRCLCYQGFQ APQDGQGCVD 970 980 990 1000 1010 1020 VNECELLSGV CGEAFCENVE GSFLCVCADE NQEYSPMTGQ CRSRVTEDSG VDRQPREEKK 1030 1040 1050 1060 1070 1080 ECYYNLNDAS LCDNVLAPNV TKQECCCTSG AGWGDNCEIF PCPVQGTAEF TEMCPRGKGL 1090 1100 1110 1120 1130 1140 VPAGESSYDT GGENYKDADE CLLFGEEICK NGYCLNTQPG YECYCKQGTY YDPVKLQCFD 1150 1160 1170 1180 1190 1200 MDECQDPNSC IDGQCVNTEG SYNCFCTHPM VLDASEKRCV QPTESNEQIE ETDVYQDLCW 1210 1220 1230 1240 1250 1260 EHLSEEYVCS RPLVGKQTTY TECCCLYGEA WGMQCALCPM KDSDDYAQLC NIPVTGRRRP 1270 1280 1290 1300 1310 1320 YGRDALVDFS EQYGPETDPY FIQDRFLNSF EELQAEECGI LNGCENGRCV RVQEGYTCDC 1330 1340 1350 1360 1370 1380 FDGYHLDMAK MTCVDVNECS ELNNRMSLCK NAKCINTEGS YKCLCLPGYI PSDKPNYCTP 1390 LNSALNLDKE SDLE
	Isoform 3. Checksum: FB1930C28738FDE5	FASTA	1,341	147,418
	10 20 30 40 50 60 MDTKLMCLLF FLCLPLLLVS NHTGRIKVVF TPSICKVTCT KGNCQNSCQK GNTTTLISEN 70 80 90 100 110 120 GHAADTLTAT NFRVVICHLP CMNGGQCSSR DKCQCPPNFT GKLCQIPVLG ASMPKLYQHA 130 140 150 160 170 180 QQQGKALGSH VIHSTHTLPL TMTSQQGVKV KFPPNIVNIH VKHPPEASVQ IHQVSRIDSP 190 200 210 220 230 240 GGQKVKEAQP GQSQVSYQGL PVQKTQTVHS TYSHQQLIPH VYPVAAKTQL GRCFQETIGS 250 260 270 280 290 300 QCGKALPGLS KQEDCCGTVG TSWGFNKCQK CPKKQSYHGY TQMMECLQGY KRVNNTFCQD 310 320 330 340 350 360 INECQLQGVC PNGECLNTMG SYRCSCKMGF GPDPTFSSCV PDPPVISEEK GPCYRLVSPG 370 380 390 400 410 420 RHCMHPLSVH LTKQICCCSV GKAWGPHCEK CPLPGTAKEE PVEALTSSWE HGPRGAEPEV 430 440 450 460 470 480 VTAPPEKEIP SLDQEKTRLE PGQPQLSPGV STIHLHPQFP VVVEKTSPPV PVEVAPEAST 490 500 510 520 530 540 SSASQVIAPT QVTEINECTV NPDICGAGHC INLPVRYTCI CYEGYKFSEQ LRKCVDIDEC 550 560 570 580 590 600 AQVRHLCSQG RCENTEGSFL CVCPAGFMAS EEGTNCIDVD ECLRPDMCRD GRCINTAGAF 610 620 630 640 650 660 RCEYCDSGYR MSRRGYCEDI DECLKPSTCP EEQCVNTPGS YQCVPCTEGF RGWNGQCLDV 670 680 690 700 710 720 DECLQPKVCT NGSCTNLEGS YMCSCHRGYS PTPDHRHCQD IDECQQGNLC MNGQCRNTDG 730 740 750 760 770 780 SFRCTCGQGY QLSAAKDQCE DIDECEHHHL CSHGQCRNTE GSFQCVCNQG YRASVLGDHC 790 800 810 820 830 840 EDINECLEDS SVCQGGDCIN TAGSYDCTCP DGFQLNDNKG CQDINECAQP GLCGSHGECL 850 860 870 880 890 900 NTQGSFHCVC EQGFSISADG RTCEDIDECV NNTVCDSHGF CDNTAGSFRC LCYQGFQAPQ 910 920 930 940 950 960 DGQGCVDVNE CELLSGVCGE AFCENVEGSF LCVCADENQE YSPMTGQCRS RVTEDSGVDR 970 980 990 1000 1010 1020 QPREEKKECY YNLNDASLCD NVLAPNVTKQ ECCCTSGAGW GDNCEIFPCP VQGTAEFTEM 1030 1040 1050 1060 1070 1080 CPRGKGLVPA GESSYDTGGE NYKDADECLL FGEEICKNGY CLNTQPGYEC YCKQGTYYDP 1090 1100 1110 1120 1130 1140 VKLQCFDMDE CQDPNSCIDG QCVNTEGSYN CFCTHPMVLD ASEKRCVQPT ESNEQIEETD 1150 1160 1170 1180 1190 1200 VYQDLCWEHL SEEYVCSRPL VGKQTTYTEC CCLYGEAWGM QCALCPMKDS DDYAQLCNIP 1210 1220 1230 1240 1250 1260 VTGRRRPYGR DALVDFSEQY GPETDPYFIQ DRFLNSFEEL QAEECGILNG CENGRCVRVQ 1270 1280 1290 1300 1310 1320 EGYTCDCFDG YHLDMAKMTC VDVNECSELN NRMSLCKNAK CINTEGSYKC LCLPGYIPSD 1330 1340 KPNYCTPLNS ALNLDKESDL E

References

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[1]	"Molecular cloning of the mouse Ltbp-1 gene reveals tissue specific expression of alternatively spliced forms." Noguera I., Obata H., Gualandris A., Cowin P., Rifkin D.B. Gene 308:31-41(2003) [PubMed: 12711388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS LONG AND SHORT).
[2]	"The murine latent transforming growth factor-beta binding protein (Ltbp-1) is alternatively spliced, and maps to a region syntenic to human chromosome 2p21-22." Weiskirchen R., Moser M., Guenther K., Weiskirchen S., Gressner A.M. Gene 308:43-52(2003) [PubMed: 12711389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING. Strain: 129/SvJ.
[3]	Noguera I., Cowin P., Rifkin D.B. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG). Strain: BALB/c. Tissue: Heart.
[4]	The mouse genome sequencing consortium Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT). Strain: C57BL/6. Tissue: Brain.
[6]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1111-1712. Strain: C57BL/6J. Tissue: Aorta, Liver and Vein.
[7]	"Latent transforming growth factor-beta binding proteins (LTBPs) --structural extracellular matrix proteins for targeting TGF-beta action." Saharinen J., Hyytiainen M., Taipale J., Keski-Oja J. Cytokine Growth Factor Rev. 10:99-117(1999) [PubMed: 10743502] [Abstract] Cited for: REVIEW.
[8]	"The latent transforming growth factor beta binding protein (LTBP) family." Oklu R., Hesketh R. Biochem. J. 352:601-610(2000) [PubMed: 11104663] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF346465 , AF346434, AF346435, AF346436, AF346437, AF346438, AF346439, AF346440, AF346441, AF346442, AF346443, AF346444, AF346445, AF346446, AF346447, AF346448, AF346449, AF346450, AF346451, AF346452, AF346453, AF346454, AF346455, AF346456, AF346457, AF346458, AF346459, AF346460, AF346461, AF346462, AF346463, AF346464 Genomic DNA. Translation: AAN77250.1. AF346465 , AF346438, AF346439, AF346440, AF346441, AF346442, AF346443, AF346444, AF346445, AF346446, AF346447, AF346448, AF346449, AF346450, AF346451, AF346452, AF346453, AF346454, AF346455, AF346456, AF346457, AF346458, AF346459, AF346460, AF346461, AF346462, AF346463, AF346464 Genomic DNA. Translation: AAN77251.1. AY143161 Genomic DNA. Translation: AAN38831.1. AF022889 mRNA. Translation: AAC33307.1. CT033758 , AC118018, AC126550, AC154178, AC154491 Genomic DNA. Translation: CAM24102.1. CT033758, AC118018, AC154491 Genomic DNA. Translation: CAM24104.1. CT033758, AC118018, AC154491 Genomic DNA. Translation: CAM24103.1. BC094612 mRNA. Translation: AAH94612.1. AK050380 mRNA. Translation: BAC34222.1. AK080024 mRNA. Translation: BAC37808.1.
IPI	IPI00352982. IPI00828560. IPI00830551.
RefSeq	NP_064303.2. NP_996841.1.
UniGene	Mm.269747
3D structure databases
HSSP	HSSP built from PDB template 1BF9 based on UniProtKB P08709.
SMR	Q8CG19. Positions 1333-1404.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8CG19. 1 interaction.
PTM databases
PhosphoSite	Q8CG19.
Proteomic databases
PRIDE	Q8CG19.
Genome annotation databases
Ensembl	ENSMUSG00000001870. Mus musculus. [Contig view]
GeneID	268977.
Organism-specific databases
MGI	MGI:109151. Ltbp1.
Phylogenomic databases
HOGENOM	Q8CG19.
HOVERGEN	Q8CG19.
Gene expression databases
ArrayExpress	Q8CG19.
Bgee	Q8CG19.
GermOnline	ENSMUSG00000001870. Mus musculus.
Family and domain databases
InterPro	IPR006209. EGF. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_CS. IPR000742. EGF_3. IPR001881. EGF_Ca_bd. IPR013091. EGF_Ca_bd_2. IPR018097. EGF_Ca_bd_CS. IPR013111. EGF_extracell. IPR002212. Fibril-assoc. IPR017878. TFG_b-bd. [Graphical view]
Gene3D	G3DSA:3.90.290.10. Fibril-assoc. 3 hits.
Pfam	PF00008. EGF. 4 hits. PF07974. EGF_2. 1 hit. PF07645. EGF_CA. 11 hits. PF00683. TB. 4 hits. [Graphical view]
SMART	SM00181. EGF. 5 hits. SM00179. EGF_CA. 13 hits. [Graphical view]
PROSITE	PS00010. ASX_HYDROXYL. 13 hits. PS00022. EGF_1. 2 hits. PS01186. EGF_2. 11 hits. PS50026. EGF_3. 14 hits. PS01187. EGF_CA. 15 hits. PS51364. TB. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

LTBP1_MOUSE

Accession

Primary (citable) accession number: Q8CG19
Secondary accession number(s): B1B1D9 , B1B1E1, O88349, Q505C9, Q8BNW7, Q8C7F5, Q8CG18, Q8CIR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2003
Last sequence update:	May 5, 2009
Last modified:	July 7, 2009
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)