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Protein

Collagen triple helix repeat-containing protein 1

Gene

Cthrc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Its overexpression in smooth muscle cell lines increases their migratory ability and inhibits collagen type I expression. May act as a negative regulator of collagen matrix deposition.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen triple helix repeat-containing protein 1
Gene namesi
Name:Cthrc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi628801 Cthrc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000002104033 – 245Collagen triple helix repeat-containing protein 1Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CG08
PRIDEiQ8CG08

Expressioni

Tissue specificityi

Expressed after injury in the carotid arteries (at protein level). Expressed in brain, lung, and after injury in fibroblasts of the adventitia and the neointima of the arteries.1 Publication

Inductioni

Strongly induced in carotid arteries after injury (balloon catheter injury model). By various growth factor (BMP4, TGFB1) in NIH 3T3 cell line.1 Publication

Gene expression databases

BgeeiENSRNOG00000004578
GenevisibleiQ8CG08 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006142

Structurei

3D structure databases

SMRiQ8CG08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 92Collagen-likeAdd BLAST34

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IHSA Eukaryota
ENOG4111TT8 LUCA
GeneTreeiENSGT00390000018094
HOGENOMiHOG000237344
HOVERGENiHBG051218
InParanoidiQ8CG08
OMAiSACCQRW
OrthoDBiEOG091G0HRY
PhylomeDBiQ8CG08
TreeFamiTF328705

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CG08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPQGRAASP QLLLGLFLVL LLLLQLSAPS SASENPKVKQ KALIRQREVV
60 70 80 90 100
DLYNGMCLQG PAGVPGRDGS PGANGIPGTP GIPGRDGFKG EKGECLRESF
110 120 130 140 150
EESWTPNYKQ CSWSSLNYGI DLGKIAECTF TKMRSNSALR VLFSGSLRLK
160 170 180 190 200
CRNACCQRWY FTFNGAECSG PLPIEAIIYL DQGSPELNST INIHRTSSVE
210 220 230 240
GLCEGIGAGL VDVAIWVGTC SDYPKGDAST GWNSVSRIII EELPK
Length:245
Mass (Da):26,424
Last modified:March 1, 2003 - v1
Checksum:i2296FD6DCDBA21F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY136824 mRNA Translation: AAN15748.1
RefSeqiNP_758836.1, NM_172333.2
UniGeneiRn.9468

Genome annotation databases

EnsembliENSRNOT00000006142; ENSRNOP00000006142; ENSRNOG00000004578
GeneIDi282836
KEGGirno:282836
UCSCiRGD:628801 rat

Similar proteinsi

Entry informationi

Entry nameiCTHR1_RAT
AccessioniPrimary (citable) accession number: Q8CG08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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