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Protein

Collagen triple helix repeat-containing protein 1

Gene

Cthrc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Its overexpression in smooth muscle cell lines increases their migratory ability and inhibits collagen type I expression. May act as a negative regulator of collagen matrix deposition.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen triple helix repeat-containing protein 1
Gene namesi
Name:Cthrc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi628801. Cthrc1.

Subcellular locationi

GO - Cellular componenti

  • collagen trimer Source: UniProtKB-KW
  • cytoplasm Source: Ensembl
  • extracellular space Source: Ensembl
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 245213Collagen triple helix repeat-containing protein 1PRO_0000021040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CG08.
PRIDEiQ8CG08.

Expressioni

Tissue specificityi

Expressed after injury in the carotid arteries (at protein level). Expressed in brain, lung, and after injury in fibroblasts of the adventitia and the neointima of the arteries.1 Publication

Inductioni

Strongly induced in carotid arteries after injury (balloon catheter injury model). By various growth factor (BMP4, TGFB1) in NIH 3T3 cell line.1 Publication

Gene expression databases

GenevisibleiQ8CG08. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006142.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 9234Collagen-likeAdd
BLAST

Sequence similaritiesi

Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IHSA. Eukaryota.
ENOG4111TT8. LUCA.
GeneTreeiENSGT00390000018094.
HOGENOMiHOG000237344.
HOVERGENiHBG051218.
InParanoidiQ8CG08.
OMAiVDIAIWV.
OrthoDBiEOG79CZ0C.
PhylomeDBiQ8CG08.
TreeFamiTF328705.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CG08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPQGRAASP QLLLGLFLVL LLLLQLSAPS SASENPKVKQ KALIRQREVV
60 70 80 90 100
DLYNGMCLQG PAGVPGRDGS PGANGIPGTP GIPGRDGFKG EKGECLRESF
110 120 130 140 150
EESWTPNYKQ CSWSSLNYGI DLGKIAECTF TKMRSNSALR VLFSGSLRLK
160 170 180 190 200
CRNACCQRWY FTFNGAECSG PLPIEAIIYL DQGSPELNST INIHRTSSVE
210 220 230 240
GLCEGIGAGL VDVAIWVGTC SDYPKGDAST GWNSVSRIII EELPK
Length:245
Mass (Da):26,424
Last modified:March 1, 2003 - v1
Checksum:i2296FD6DCDBA21F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY136824 mRNA. Translation: AAN15748.1.
RefSeqiNP_758836.1. NM_172333.2.
UniGeneiRn.9468.

Genome annotation databases

EnsembliENSRNOT00000006142; ENSRNOP00000006142; ENSRNOG00000004578.
GeneIDi282836.
KEGGirno:282836.
UCSCiRGD:628801. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY136824 mRNA. Translation: AAN15748.1.
RefSeqiNP_758836.1. NM_172333.2.
UniGeneiRn.9468.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006142.

Proteomic databases

PaxDbiQ8CG08.
PRIDEiQ8CG08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006142; ENSRNOP00000006142; ENSRNOG00000004578.
GeneIDi282836.
KEGGirno:282836.
UCSCiRGD:628801. rat.

Organism-specific databases

CTDi115908.
RGDi628801. Cthrc1.

Phylogenomic databases

eggNOGiENOG410IHSA. Eukaryota.
ENOG4111TT8. LUCA.
GeneTreeiENSGT00390000018094.
HOGENOMiHOG000237344.
HOVERGENiHBG051218.
InParanoidiQ8CG08.
OMAiVDIAIWV.
OrthoDBiEOG79CZ0C.
PhylomeDBiQ8CG08.
TreeFamiTF328705.

Miscellaneous databases

PROiQ8CG08.

Gene expression databases

GenevisibleiQ8CG08. RN.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration."
    Pyagay P., Heroult M., Wang Q., Lehnert W., Belden J., Liaw L., Friesel R.E., Lindner V.
    Circ. Res. 96:261-268(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, GLYCOSYLATION, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Carotid artery.

Entry informationi

Entry nameiCTHR1_RAT
AccessioniPrimary (citable) accession number: Q8CG08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.