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Protein

ATPase WRNIP1

Gene

Wrnip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi20ZincBy similarity1
Metal bindingi23ZincBy similarity1
Metal bindingi31Zinc; via tele nitrogenBy similarity1
Metal bindingi35Zinc; via tele nitrogenBy similarity1
Metal bindingi39ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 40UBZ-typeSequence analysisAdd BLAST24
Nucleotide bindingi265 – 271ATPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA replication
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase WRNIP1 (EC:3.6.1.3By similarity)
Alternative name(s):
Werner helicase-interacting protein 1
Gene namesi
Name:Wrnip1By similarity
Synonyms:WrnipImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628836. Wrnip1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Colocalizes with WRN in granular structures in the nucleus.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847871 – 660ATPase WRNIP1Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65PhosphoserineBy similarity1
Modified residuei75PhosphoserineCombined sources1
Cross-linki81Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei85PhosphothreonineBy similarity1
Modified residuei91PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei116PhosphothreonineBy similarity1
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei153PhosphoserineCombined sources1
Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki296Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki311Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki477Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei529PhosphotyrosineBy similarity1
Modified residuei557PhosphotyrosineBy similarity1
Cross-linki622Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei628N6-acetyllysine; alternateBy similarity1
Cross-linki628Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki631Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Sumoylated with SUMO1 and SUMO2/3.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8CG07.
PRIDEiQ8CG07.

PTM databases

iPTMnetiQ8CG07.
PhosphoSitePlusiQ8CG07.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017040.

Interactioni

Subunit structurei

May form homooligomers, possibly octamers. Directly interacts with POLD1, POLD2 and POLD4 (By similarity). Interacts with the N-terminal domain of WRN (By similarity). Interacts (via UBZ-type zinc finger) with polyubiquitin (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023332.

Structurei

3D structure databases

ProteinModelPortaliQ8CG07.
SMRiQ8CG07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The UBZ-type zinc finger binds ubiquitin.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 40UBZ-typeSequence analysisAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2028. Eukaryota.
COG2256. LUCA.
HOGENOMiHOG000017623.
HOVERGENiHBG062192.
InParanoidiQ8CG07.
KOiK07478.
PhylomeDBiQ8CG07.
TreeFamiTF324547.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR032423. AAA_assoc_2.
IPR003959. ATPase_AAA_core.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR021886. MgsA_C.
IPR027417. P-loop_NTPase.
IPR006642. Znf_Rad18_put.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF16193. AAA_assoc_2. 1 hit.
PF12002. MgsA_C. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00734. ZnF_Rad18. 1 hit.
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CG07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSGPEDDP FLSQLHQVQC PVCQQMMPAA HINSHLDRCL LLHPAGHAEP
60 70 80 90 100
AAGPHRAGER AKGPSPPGAK RRRLSESSAL KQPATPTAAE SSEGEGEEGD
110 120 130 140 150
DGGETESRES YDAPPTPSGA RLIPDFPVAR SSSPARKGLG KRPAAAAAAG
160 170 180 190 200
SASPRSWDET EAQEEEEAGV DGDGDADVDG EDDPGHWDAD AADASFGVSA
210 220 230 240 250
GRAHPRALPA EEIRQMLEGK PLADKMRPDT LQDYIGQSRA VGQETLLRSL
260 270 280 290 300
LETNEIPSLI LWGPPGCGKT TLAHIIANNS KKHSIRFVTL SATNAKTNDV
310 320 330 340 350
RDVIKQAQNE KSFFKRKTIL FIDEIHRFNK SQQDTFLPHV ECGTITLIGA
360 370 380 390 400
TTENPSFQVN TALLSRCRVI VLEKLPVEAM VTILMRAINS LGIHVLDSSR
410 420 430 440 450
PTDPLSHSSN CSSEPSVFIE DKAVDTLAYL SDGDARTGLN GLQLAVLARL
460 470 480 490 500
SSRKMFCKKS GQTYSPSRVL ITENDVKEGL QRSHILYDRA GEEHYNCISA
510 520 530 540 550
LHKAMRGSDQ NASLYWLARM LEGGEDPLYV ARRLVRFASE DIGLADPSAL
560 570 580 590 600
AQAVAAYQGC HFIGMPECEV LLAQCVVYFA RAPKSIEVYS AYNNVKACLR
610 620 630 640 650
SHQGPLPPVP LHLRNAPTRL MKDLGYGKGY KYNPMYSEPV DQDYLPEELR
660
GVDFFKQRRC
Length:660
Mass (Da):71,934
Last modified:March 1, 2003 - v1
Checksum:i5FE09B9C225840F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY136827 mRNA. Translation: AAN15750.1.
BC098652 mRNA. Translation: AAH98652.1.
RefSeqiNP_758835.1. NM_172332.2.
UniGeneiRn.8783.

Genome annotation databases

GeneIDi282835.
KEGGirno:282835.
UCSCiRGD:628836. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiWRIP1_RAT
AccessioniPrimary (citable) accession number: Q8CG07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: May 10, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families