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Protein

ATPase WRNIP1

Gene

Wrnip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 4024UBZ-typeAdd
BLAST
Nucleotide bindingi263 – 2708ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

DNA damage, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase WRNIP1 (EC:3.6.1.3)
Alternative name(s):
Werner helicase-interacting protein 1
Gene namesi
Name:Wrnip1By similarity
Synonyms:WrnipImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628836. Wrnip1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Colocalizes with WRN in granular structures in the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660ATPase WRNIP1PRO_0000084787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651PhosphoserineBy similarity
Modified residuei75 – 751PhosphoserineCombined sources
Cross-linki81 – 81Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei85 – 851PhosphothreonineBy similarity
Modified residuei91 – 911PhosphoserineCombined sources
Modified residuei92 – 921PhosphoserineCombined sources
Modified residuei116 – 1161PhosphothreonineBy similarity
Cross-linki141 – 141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei153 – 1531PhosphoserineCombined sources
Cross-linki220 – 220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki296 – 296Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki305 – 305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki311 – 311Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki317 – 317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki330 – 330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki477 – 477Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei529 – 5291PhosphotyrosineBy similarity
Modified residuei557 – 5571PhosphotyrosineBy similarity
Cross-linki622 – 622Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei628 – 6281N6-acetyllysine; alternateBy similarity
Cross-linki628 – 628Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki631 – 631Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Sumoylated with SUMO1 and SUMO2/3.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8CG07.
PRIDEiQ8CG07.

PTM databases

iPTMnetiQ8CG07.
PhosphoSiteiQ8CG07.

Interactioni

Subunit structurei

Homooligomer; most likely an octamer. Interacts with POLD1, POLD2 and POLD4. Interacts with the N-terminal domain of WRN. Interacts (via UBZ-type zinc finger) with polyubiquitin (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023332.

Structurei

3D structure databases

ProteinModelPortaliQ8CG07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 UBZ-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 4024UBZ-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2028. Eukaryota.
COG2256. LUCA.
HOGENOMiHOG000017623.
HOVERGENiHBG062192.
InParanoidiQ8CG07.
KOiK07478.
OrthoDBiEOG744T8W.
PhylomeDBiQ8CG07.
TreeFamiTF324547.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR032423. AAA_assoc_2.
IPR003959. ATPase_AAA_core.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR021886. MgsA_C.
IPR027417. P-loop_NTPase.
IPR006642. Znf_Rad18_put.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF16193. AAA_assoc_2. 1 hit.
PF12002. MgsA_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00734. ZnF_Rad18. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CG07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSGPEDDP FLSQLHQVQC PVCQQMMPAA HINSHLDRCL LLHPAGHAEP
60 70 80 90 100
AAGPHRAGER AKGPSPPGAK RRRLSESSAL KQPATPTAAE SSEGEGEEGD
110 120 130 140 150
DGGETESRES YDAPPTPSGA RLIPDFPVAR SSSPARKGLG KRPAAAAAAG
160 170 180 190 200
SASPRSWDET EAQEEEEAGV DGDGDADVDG EDDPGHWDAD AADASFGVSA
210 220 230 240 250
GRAHPRALPA EEIRQMLEGK PLADKMRPDT LQDYIGQSRA VGQETLLRSL
260 270 280 290 300
LETNEIPSLI LWGPPGCGKT TLAHIIANNS KKHSIRFVTL SATNAKTNDV
310 320 330 340 350
RDVIKQAQNE KSFFKRKTIL FIDEIHRFNK SQQDTFLPHV ECGTITLIGA
360 370 380 390 400
TTENPSFQVN TALLSRCRVI VLEKLPVEAM VTILMRAINS LGIHVLDSSR
410 420 430 440 450
PTDPLSHSSN CSSEPSVFIE DKAVDTLAYL SDGDARTGLN GLQLAVLARL
460 470 480 490 500
SSRKMFCKKS GQTYSPSRVL ITENDVKEGL QRSHILYDRA GEEHYNCISA
510 520 530 540 550
LHKAMRGSDQ NASLYWLARM LEGGEDPLYV ARRLVRFASE DIGLADPSAL
560 570 580 590 600
AQAVAAYQGC HFIGMPECEV LLAQCVVYFA RAPKSIEVYS AYNNVKACLR
610 620 630 640 650
SHQGPLPPVP LHLRNAPTRL MKDLGYGKGY KYNPMYSEPV DQDYLPEELR
660
GVDFFKQRRC
Length:660
Mass (Da):71,934
Last modified:March 1, 2003 - v1
Checksum:i5FE09B9C225840F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY136827 mRNA. Translation: AAN15750.1.
BC098652 mRNA. Translation: AAH98652.1.
RefSeqiNP_758835.1. NM_172332.2.
UniGeneiRn.8783.

Genome annotation databases

GeneIDi282835.
KEGGirno:282835.
UCSCiRGD:628836. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY136827 mRNA. Translation: AAN15750.1.
BC098652 mRNA. Translation: AAH98652.1.
RefSeqiNP_758835.1. NM_172332.2.
UniGeneiRn.8783.

3D structure databases

ProteinModelPortaliQ8CG07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023332.

PTM databases

iPTMnetiQ8CG07.
PhosphoSiteiQ8CG07.

Proteomic databases

PaxDbiQ8CG07.
PRIDEiQ8CG07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282835.
KEGGirno:282835.
UCSCiRGD:628836. rat.

Organism-specific databases

CTDi56897.
RGDi628836. Wrnip1.

Phylogenomic databases

eggNOGiKOG2028. Eukaryota.
COG2256. LUCA.
HOGENOMiHOG000017623.
HOVERGENiHBG062192.
InParanoidiQ8CG07.
KOiK07478.
OrthoDBiEOG744T8W.
PhylomeDBiQ8CG07.
TreeFamiTF324547.

Miscellaneous databases

PROiQ8CG07.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR032423. AAA_assoc_2.
IPR003959. ATPase_AAA_core.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR021886. MgsA_C.
IPR027417. P-loop_NTPase.
IPR006642. Znf_Rad18_put.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF16193. AAA_assoc_2. 1 hit.
PF12002. MgsA_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00734. ZnF_Rad18. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of sequences in balloon-injured rat arteries."
    Liaw L., Lindner V.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-DawleyImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-91; SER-92 AND SER-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWRIP1_RAT
AccessioniPrimary (citable) accession number: Q8CG07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.