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Q8CFZ5

- S22AC_MOUSE

UniProt

Q8CFZ5 - S22AC_MOUSE

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Protein

Solute carrier family 22 member 12

Gene
Slc22a12, Urat1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions or chloride ions.1 Publication

GO - Molecular functioni

  1. PDZ domain binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. urate transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. organic acid transport Source: GOC
  2. response to drug Source: UniProtKB
  3. urate metabolic process Source: Ensembl
  4. urate transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198604. Organic anion transport.

Protein family/group databases

TCDBi2.A.1.19.14. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 12
Alternative name(s):
Renal-specific transporter
Short name:
RST
Urate anion exchanger 1
Gene namesi
Name:Slc22a12
Synonyms:Urat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1195269. Slc22a12.

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Detected in the luminal membrane of the epithelium of renal proximal tubules.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021Helical; Reviewed predictionAdd
BLAST
Transmembranei146 – 16621Helical; Reviewed predictionAdd
BLAST
Transmembranei182 – 20221Helical; Reviewed predictionAdd
BLAST
Transmembranei204 – 22421Helical; Reviewed predictionAdd
BLAST
Transmembranei232 – 25221Helical; Reviewed predictionAdd
BLAST
Transmembranei260 – 28021Helical; Reviewed predictionAdd
BLAST
Transmembranei351 – 37121Helical; Reviewed predictionAdd
BLAST
Transmembranei378 – 39821Helical; Reviewed predictionAdd
BLAST
Transmembranei412 – 43221Helical; Reviewed predictionAdd
BLAST
Transmembranei435 – 45521Helical; Reviewed predictionAdd
BLAST
Transmembranei466 – 48621Helical; Reviewed predictionAdd
BLAST
Transmembranei495 – 51521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. brush border membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Solute carrier family 22 member 12PRO_0000307945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8CFZ5.
PaxDbiQ8CFZ5.
PRIDEiQ8CFZ5.

PTM databases

PhosphoSiteiQ8CFZ5.

Expressioni

Tissue specificityi

Detected in kidney (at protein level). Detected in kidney cortex, in proximal tubules.2 Publications

Gene expression databases

BgeeiQ8CFZ5.
GenevestigatoriQ8CFZ5.

Interactioni

Subunit structurei

Interacts with PDZK1 By similarity.

Protein-protein interaction databases

IntActiQ8CFZ5. 2 interactions.
MINTiMINT-4104972.

Structurei

3D structure databases

ProteinModelPortaliQ8CFZ5.
SMRiQ8CFZ5. Positions 153-536.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00750000117657.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ8CFZ5.
KOiK08208.
OrthoDBiEOG7NW68T.
PhylomeDBiQ8CFZ5.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CFZ5-1 [UniParc]FASTAAdd to Basket

« Hide

MAFPELLDRV GGLGRFQLFQ TVALVTPILW VTTQNMLENF SAAVPHHRCW    50
VPLLDNSTSQ ASIPGDLGPD VLLAVSIPPG PDQQPHQCLR FRQPQWQLTE 100
SNATATNWSD AATEPCEDGW VYDHSTFRST IVTTWDLVCN SQALRPMAQS 150
IFLAGILVGA AVCGHASDRF GRRRVLTWSY LLVSVSGTAA AFMPTFPLYC 200
LFRFLLASAV AGVMMNTASL LMEWTSAQGS PLVMTLNALG FSFGQVLTGS 250
VAYGVRSWRM LQLAVSAPFF LFFVYSWWLP ESARWLITVG KLDQGLQELQ 300
RVAAVNRRKA EGDTLTMEVL RSAMEEEPSR DKAGASLGTL LHTPGLRHRT 350
IISMLCWFAF GFTFYGLALD LQALGSNIFL LQALIGIVDF PVKTGSLLLI 400
SRLGRRFCQV SFLVLPGLCI LSNILVPHGM GVLRSALAVL GLGCLGGAFT 450
CITIFSSELF PTVIRMTAVG LCQVAARGGA MLGPLVRLLG VYGSWMPLLV 500
YGVVPVLSGL AALLLPETKN LPLPDTIQDI QKQSVKKVTH DTPDGSILMS 550
TRL 553
Length:553
Mass (Da):60,194
Last modified:March 1, 2003 - v1
Checksum:iD331583A8D54DBBF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti407 – 4071F → L in BAA23875. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB005451 mRNA. Translation: BAA23875.1.
BC035927 mRNA. Translation: AAH35927.1.
CCDSiCCDS29505.1.
RefSeqiNP_033229.3. NM_009203.3.
UniGeneiMm.391146.

Genome annotation databases

EnsembliENSMUST00000113451; ENSMUSP00000109078; ENSMUSG00000061742.
GeneIDi20521.
KEGGimmu:20521.
UCSCiuc012bho.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB005451 mRNA. Translation: BAA23875.1 .
BC035927 mRNA. Translation: AAH35927.1 .
CCDSi CCDS29505.1.
RefSeqi NP_033229.3. NM_009203.3.
UniGenei Mm.391146.

3D structure databases

ProteinModelPortali Q8CFZ5.
SMRi Q8CFZ5. Positions 153-536.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CFZ5. 2 interactions.
MINTi MINT-4104972.

Protein family/group databases

TCDBi 2.A.1.19.14. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q8CFZ5.

Proteomic databases

MaxQBi Q8CFZ5.
PaxDbi Q8CFZ5.
PRIDEi Q8CFZ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113451 ; ENSMUSP00000109078 ; ENSMUSG00000061742 .
GeneIDi 20521.
KEGGi mmu:20521.
UCSCi uc012bho.1. mouse.

Organism-specific databases

CTDi 116085.
MGIi MGI:1195269. Slc22a12.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00750000117657.
HOGENOMi HOG000234569.
HOVERGENi HBG108433.
InParanoidi Q8CFZ5.
KOi K08208.
OrthoDBi EOG7NW68T.
PhylomeDBi Q8CFZ5.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_198604. Organic anion transport.

Miscellaneous databases

NextBioi 298747.
PROi Q8CFZ5.
SOURCEi Search...

Gene expression databases

Bgeei Q8CFZ5.
Genevestigatori Q8CFZ5.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Kidney-specific expression of a novel mouse organic cation transporter-like protein."
    Mori K., Ogawa Y., Ebihara K., Aoki T., Tamura N., Sugawara A., Kuwahara T., Ozaki S., Mukoyama M., Tashiro K., Tanaka I., Nakao K.
    FEBS Lett. 417:371-374(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  3. "Function and localization of urate transporter 1 in mouse kidney."
    Hosoyamada M., Ichida K., Enomoto A., Hosoya T., Endou H.
    J. Am. Soc. Nephrol. 15:261-268(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GLYCOSYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiS22AC_MOUSE
AccessioniPrimary (citable) accession number: Q8CFZ5
Secondary accession number(s): O54778
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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