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Q8CFZ5

- S22AC_MOUSE

UniProt

Q8CFZ5 - S22AC_MOUSE

Protein

Solute carrier family 22 member 12

Gene

Slc22a12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions or chloride ions.1 Publication

    GO - Molecular functioni

    1. PDZ domain binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. urate transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. organic acid transport Source: GOC
    2. response to drug Source: UniProtKB
    3. urate metabolic process Source: Ensembl
    4. urate transport Source: UniProtKB

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198604. Organic anion transport.

    Protein family/group databases

    TCDBi2.A.1.19.14. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 12
    Alternative name(s):
    Renal-specific transporter
    Short name:
    RST
    Urate anion exchanger 1
    Gene namesi
    Name:Slc22a12
    Synonyms:Urat1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1195269. Slc22a12.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Detected in the luminal membrane of the epithelium of renal proximal tubules.

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. brush border membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Solute carrier family 22 member 12PRO_0000307945Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8CFZ5.
    PaxDbiQ8CFZ5.
    PRIDEiQ8CFZ5.

    PTM databases

    PhosphoSiteiQ8CFZ5.

    Expressioni

    Tissue specificityi

    Detected in kidney (at protein level). Detected in kidney cortex, in proximal tubules.2 Publications

    Gene expression databases

    BgeeiQ8CFZ5.
    GenevestigatoriQ8CFZ5.

    Interactioni

    Subunit structurei

    Interacts with PDZK1.By similarity

    Protein-protein interaction databases

    IntActiQ8CFZ5. 2 interactions.
    MINTiMINT-4104972.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CFZ5.
    SMRiQ8CFZ5. Positions 153-536.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei412 – 43221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei435 – 45521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei466 – 48621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei495 – 51521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00750000117657.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ8CFZ5.
    KOiK08208.
    OrthoDBiEOG7NW68T.
    PhylomeDBiQ8CFZ5.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CFZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFPELLDRV GGLGRFQLFQ TVALVTPILW VTTQNMLENF SAAVPHHRCW    50
    VPLLDNSTSQ ASIPGDLGPD VLLAVSIPPG PDQQPHQCLR FRQPQWQLTE 100
    SNATATNWSD AATEPCEDGW VYDHSTFRST IVTTWDLVCN SQALRPMAQS 150
    IFLAGILVGA AVCGHASDRF GRRRVLTWSY LLVSVSGTAA AFMPTFPLYC 200
    LFRFLLASAV AGVMMNTASL LMEWTSAQGS PLVMTLNALG FSFGQVLTGS 250
    VAYGVRSWRM LQLAVSAPFF LFFVYSWWLP ESARWLITVG KLDQGLQELQ 300
    RVAAVNRRKA EGDTLTMEVL RSAMEEEPSR DKAGASLGTL LHTPGLRHRT 350
    IISMLCWFAF GFTFYGLALD LQALGSNIFL LQALIGIVDF PVKTGSLLLI 400
    SRLGRRFCQV SFLVLPGLCI LSNILVPHGM GVLRSALAVL GLGCLGGAFT 450
    CITIFSSELF PTVIRMTAVG LCQVAARGGA MLGPLVRLLG VYGSWMPLLV 500
    YGVVPVLSGL AALLLPETKN LPLPDTIQDI QKQSVKKVTH DTPDGSILMS 550
    TRL 553
    Length:553
    Mass (Da):60,194
    Last modified:March 1, 2003 - v1
    Checksum:iD331583A8D54DBBF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti407 – 4071F → L in BAA23875. (PubMed:9409754)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005451 mRNA. Translation: BAA23875.1.
    BC035927 mRNA. Translation: AAH35927.1.
    CCDSiCCDS29505.1.
    RefSeqiNP_033229.3. NM_009203.3.
    UniGeneiMm.391146.

    Genome annotation databases

    EnsembliENSMUST00000113451; ENSMUSP00000109078; ENSMUSG00000061742.
    GeneIDi20521.
    KEGGimmu:20521.
    UCSCiuc012bho.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005451 mRNA. Translation: BAA23875.1 .
    BC035927 mRNA. Translation: AAH35927.1 .
    CCDSi CCDS29505.1.
    RefSeqi NP_033229.3. NM_009203.3.
    UniGenei Mm.391146.

    3D structure databases

    ProteinModelPortali Q8CFZ5.
    SMRi Q8CFZ5. Positions 153-536.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CFZ5. 2 interactions.
    MINTi MINT-4104972.

    Protein family/group databases

    TCDBi 2.A.1.19.14. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q8CFZ5.

    Proteomic databases

    MaxQBi Q8CFZ5.
    PaxDbi Q8CFZ5.
    PRIDEi Q8CFZ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000113451 ; ENSMUSP00000109078 ; ENSMUSG00000061742 .
    GeneIDi 20521.
    KEGGi mmu:20521.
    UCSCi uc012bho.1. mouse.

    Organism-specific databases

    CTDi 116085.
    MGIi MGI:1195269. Slc22a12.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00750000117657.
    HOGENOMi HOG000234569.
    HOVERGENi HBG108433.
    InParanoidi Q8CFZ5.
    KOi K08208.
    OrthoDBi EOG7NW68T.
    PhylomeDBi Q8CFZ5.
    TreeFami TF315847.

    Enzyme and pathway databases

    Reactomei REACT_198604. Organic anion transport.

    Miscellaneous databases

    NextBioi 298747.
    PROi Q8CFZ5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CFZ5.
    Genevestigatori Q8CFZ5.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Kidney-specific expression of a novel mouse organic cation transporter-like protein."
      Mori K., Ogawa Y., Ebihara K., Aoki T., Tamura N., Sugawara A., Kuwahara T., Ozaki S., Mukoyama M., Tashiro K., Tanaka I., Nakao K.
      FEBS Lett. 417:371-374(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.
    3. "Function and localization of urate transporter 1 in mouse kidney."
      Hosoyamada M., Ichida K., Enomoto A., Hosoya T., Endou H.
      J. Am. Soc. Nephrol. 15:261-268(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, GLYCOSYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiS22AC_MOUSE
    AccessioniPrimary (citable) accession number: Q8CFZ5
    Secondary accession number(s): O54778
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3