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Q8CFZ4

- GPC3_MOUSE

UniProt

Q8CFZ4 - GPC3_MOUSE

Protein

Glypican-3

Gene

Gpc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition By similarity.By similarity

    GO - Molecular functioni

    1. peptidyl-dipeptidase inhibitor activity Source: UniProtKB
    2. protein binding Source: MGI

    GO - Biological processi

    1. anterior/posterior axis specification Source: MGI
    2. body morphogenesis Source: MGI
    3. bone mineralization Source: MGI
    4. branching involved in ureteric bud morphogenesis Source: MGI
    5. cell proliferation involved in kidney development Source: MGI
    6. cell proliferation involved in metanephros development Source: MGI
    7. coronary vasculature development Source: MGI
    8. embryonic hindlimb morphogenesis Source: MGI
    9. kidney development Source: MGI
    10. lung development Source: MGI
    11. mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
    12. mesonephric duct morphogenesis Source: MGI
    13. negative regulation of canonical Wnt signaling pathway Source: MGI
    14. negative regulation of cell proliferation Source: MGI
    15. negative regulation of epithelial cell proliferation Source: MGI
    16. negative regulation of growth Source: MGI
    17. negative regulation of smoothened signaling pathway Source: MGI
    18. organ morphogenesis Source: MGI
    19. osteoclast differentiation Source: MGI
    20. positive regulation of BMP signaling pathway Source: MGI
    21. positive regulation of endocytosis Source: MGI
    22. positive regulation of glucose import Source: MGI
    23. positive regulation of protein catabolic process Source: MGI
    24. positive regulation of smoothened signaling pathway Source: MGI
    25. positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: MGI
    26. regulation of growth Source: MGI

    Keywords - Molecular functioni

    Protease inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_198569. Retinoid metabolism and transport.
    REACT_198654. HS-GAG biosynthesis.
    REACT_198967. HS-GAG degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glypican-3
    Cleaved into the following chain:
    Gene namesi
    Name:Gpc3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:104903. Gpc3.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity; Extracellular side By similarity

    GO - Cellular componenti

    1. anchored component of plasma membrane Source: MGI
    2. extracellular space Source: UniProtKB-SubCell
    3. Golgi lumen Source: Reactome
    4. integral component of plasma membrane Source: MGI
    5. lysosome Source: MGI
    6. plasma membrane Source: MGI
    7. proteinaceous extracellular matrix Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei? – 579Removed in mature formSequence AnalysisPRO_0000012312
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – ?Glypican-3PRO_0000012311
    Chaini25 – ?Secreted glypican-3PRO_0000333845

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi494 – 4941O-linked (Xyl...) (heparan sulfate)Sequence Analysis
    Glycosylationi508 – 5081O-linked (Xyl...) (heparan sulfate)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

    Proteomic databases

    PRIDEiQ8CFZ4.

    PTM databases

    PhosphoSiteiQ8CFZ4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8CFZ4.
    BgeeiQ8CFZ4.
    CleanExiMM_GPC3.
    GenevestigatoriQ8CFZ4.

    Interactioni

    Subunit structurei

    Interacts with DPP4.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CFZ4.
    SMRiQ8CFZ4. Positions 33-474.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glypican family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG281821.
    GeneTreeiENSGT00550000074430.
    HOGENOMiHOG000049177.
    HOVERGENiHBG005896.
    InParanoidiQ8CFZ4.
    KOiK08109.
    OMAiCWNGQEL.
    OrthoDBiEOG761BTG.
    PhylomeDBiQ8CFZ4.
    TreeFamiTF105317.

    Family and domain databases

    InterProiIPR001863. Glypican.
    IPR015501. Glypican-3.
    IPR019803. Glypican_CS.
    [Graphical view]
    PANTHERiPTHR10822. PTHR10822. 1 hit.
    PTHR10822:SF4. PTHR10822:SF4. 1 hit.
    PfamiPF01153. Glypican. 1 hit.
    [Graphical view]
    PROSITEiPS01207. GLYPICAN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CFZ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGTVRTACL LVAMLLGLGC LGQAQPPPPP DATCHQVRSF FQRLQPGLKW    50
    VPETPVPGSD LQVCLPKGPT CCSRKMEEKY QLTARLNMEQ LLQSASMELK 100
    FLIIQNAAVF QEAFEIVVRH AKNYTNAMFK NNYPSLTPQA FEFVGEFFTD 150
    VSLYILGSDI NVDDMVNELF DSLFPVIYTQ MMNPGLPESV LDINECLRGA 200
    RRDLKVFGSF PKLIMTQVSK SLQVTRIFLQ ALNLGIEVIN TTDHLKFSKD 250
    CGRMLTRMWY CSYCQGLMMV KPCGGYCNVV MQGCMAGVVE IDKYWREYIL 300
    SLEELVNGMY RIYDMENVLL GLFSTIHDSI QYVQKNGGKL TTTIGKLCAH 350
    SQQRQYRSAY YPEDLFIDKK ILKVAHVEHE ETLSSRRREL IQKLKSFINF 400
    YSALPGYICS HSPVAENDTL CWNGQELVER YSQKAARNGM KNQFNLHELK 450
    MKGPEPVVSQ IIDKLKHINQ LLRTMSVPKG KVLDKSLDEE GLESGDCGDD 500
    EDECIGSSGD GMVKVKNQLR FLAELAYDLD VDDAPGNKQH GNQKDNEITT 550
    SHSVGNMPSP LKILISVAIY VACFFFLVH 579
    Length:579
    Mass (Da):65,332
    Last modified:March 1, 2003 - v1
    Checksum:i066C23B3493A9346
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC036126 mRNA. Translation: AAH36126.1.
    CCDSiCCDS30125.1.
    RefSeqiNP_057906.2. NM_016697.3.
    UniGeneiMm.22515.

    Genome annotation databases

    EnsembliENSMUST00000069360; ENSMUSP00000064131; ENSMUSG00000055653.
    GeneIDi14734.
    KEGGimmu:14734.
    UCSCiuc009teg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC036126 mRNA. Translation: AAH36126.1 .
    CCDSi CCDS30125.1.
    RefSeqi NP_057906.2. NM_016697.3.
    UniGenei Mm.22515.

    3D structure databases

    ProteinModelPortali Q8CFZ4.
    SMRi Q8CFZ4. Positions 33-474.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8CFZ4.

    Proteomic databases

    PRIDEi Q8CFZ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069360 ; ENSMUSP00000064131 ; ENSMUSG00000055653 .
    GeneIDi 14734.
    KEGGi mmu:14734.
    UCSCi uc009teg.2. mouse.

    Organism-specific databases

    CTDi 2719.
    MGIi MGI:104903. Gpc3.

    Phylogenomic databases

    eggNOGi NOG281821.
    GeneTreei ENSGT00550000074430.
    HOGENOMi HOG000049177.
    HOVERGENi HBG005896.
    InParanoidi Q8CFZ4.
    KOi K08109.
    OMAi CWNGQEL.
    OrthoDBi EOG761BTG.
    PhylomeDBi Q8CFZ4.
    TreeFami TF105317.

    Enzyme and pathway databases

    Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_198569. Retinoid metabolism and transport.
    REACT_198654. HS-GAG biosynthesis.
    REACT_198967. HS-GAG degradation.

    Miscellaneous databases

    ChiTaRSi GPC3. mouse.
    NextBioi 286781.
    PROi Q8CFZ4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CFZ4.
    Bgeei Q8CFZ4.
    CleanExi MM_GPC3.
    Genevestigatori Q8CFZ4.

    Family and domain databases

    InterProi IPR001863. Glypican.
    IPR015501. Glypican-3.
    IPR019803. Glypican_CS.
    [Graphical view ]
    PANTHERi PTHR10822. PTHR10822. 1 hit.
    PTHR10822:SF4. PTHR10822:SF4. 1 hit.
    Pfami PF01153. Glypican. 1 hit.
    [Graphical view ]
    PROSITEi PS01207. GLYPICAN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiGPC3_MOUSE
    AccessioniPrimary (citable) accession number: Q8CFZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3