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Q8CFZ4 (GPC3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glypican-3

Cleaved into the following chain:

  1. Secreted glypican-3
Gene names
Name:Gpc3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length579 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition By similarity.

Subunit structure

Interacts with DPP4 By similarity.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor; Extracellular side By similarity.

Secreted glypican-3: Secretedextracellular space By similarity.

Sequence similarities

Belongs to the glypican family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
Secreted
   DomainSignal
   Molecular functionProtease inhibitor
   PTMGlycoprotein
GPI-anchor
Heparan sulfate
Lipoprotein
Proteoglycan
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior axis specification

Inferred from genetic interaction PubMed 10964473. Source: MGI

body morphogenesis

Inferred from mutant phenotype PubMed 18477453. Source: MGI

bone mineralization

Inferred from mutant phenotype PubMed 15936336. Source: MGI

branching involved in ureteric bud morphogenesis

Inferred from genetic interaction PubMed 15925496. Source: MGI

cell proliferation involved in kidney development

Inferred from mutant phenotype PubMed 11180950. Source: MGI

cell proliferation involved in metanephros development

Inferred from mutant phenotype PubMed 10402475. Source: MGI

coronary vasculature development

Inferred from mutant phenotype PubMed 19733558. Source: MGI

embryonic hindlimb morphogenesis

Inferred from genetic interaction PubMed 10964473. Source: MGI

kidney development

Inferred from mutant phenotype PubMed 10402475. Source: MGI

lung development

Inferred from mutant phenotype PubMed 10402475. Source: MGI

mesenchymal cell proliferation involved in ureteric bud development

Inferred from mutant phenotype PubMed 15925496. Source: UniProtKB

mesonephric duct morphogenesis

Inferred from mutant phenotype PubMed 11180950. Source: MGI

negative regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 15537637. Source: MGI

negative regulation of cell proliferation

Inferred from genetic interaction PubMed 15925496. Source: MGI

negative regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 10402475. Source: MGI

negative regulation of growth

Inferred from mutant phenotype PubMed 11846487PubMed 15537637. Source: MGI

negative regulation of smoothened signaling pathway

Inferred from mutant phenotype PubMed 18477453. Source: MGI

organ morphogenesis

Inferred from mutant phenotype PubMed 9853964. Source: MGI

osteoclast differentiation

Inferred from mutant phenotype PubMed 15936336. Source: MGI

positive regulation of BMP signaling pathway

Inferred from mutant phenotype PubMed 15925496. Source: MGI

positive regulation of Wnt signaling pathway, planar cell polarity pathway

Inferred from mutant phenotype PubMed 15537637. Source: MGI

positive regulation of endocytosis

Inferred from direct assay PubMed 18477453. Source: MGI

positive regulation of glucose import

Inferred from direct assay PubMed 18343214. Source: MGI

positive regulation of protein catabolic process

Inferred from direct assay PubMed 18477453. Source: MGI

positive regulation of smoothened signaling pathway

Inferred from mutant phenotype PubMed 19733558. Source: MGI

regulation of growth

Inferred from mutant phenotype PubMed 10402475. Source: MGI

   Cellular_componentGolgi lumen

Traceable author statement. Source: Reactome

anchored component of plasma membrane

Inferred from mutant phenotype PubMed 18477453. Source: MGI

extracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of plasma membrane

Inferred from sequence or structural similarity PubMed 7657705. Source: MGI

lysosome

Inferred from direct assay PubMed 18477453. Source: MGI

plasma membrane

Inferred from direct assay PubMed 18343214. Source: MGI

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: InterPro

   Molecular_functionpeptidyl-dipeptidase inhibitor activity

Inferred from sequence or structural similarity. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 18343214PubMed 18477453. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – ?Glypican-3PRO_0000012311
Chain25 – ?Secreted glypican-3PRO_0000333845
Propeptide? – 579Removed in mature form PotentialPRO_0000012312

Amino acid modifications

Glycosylation1231N-linked (GlcNAc...) Potential
Glycosylation2401N-linked (GlcNAc...) Potential
Glycosylation4171N-linked (GlcNAc...) Potential
Glycosylation4941O-linked (Xyl...) (heparan sulfate) Potential
Glycosylation5081O-linked (Xyl...) (heparan sulfate) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8CFZ4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 066C23B3493A9346

FASTA57965,332
        10         20         30         40         50         60 
MAGTVRTACL LVAMLLGLGC LGQAQPPPPP DATCHQVRSF FQRLQPGLKW VPETPVPGSD 

        70         80         90        100        110        120 
LQVCLPKGPT CCSRKMEEKY QLTARLNMEQ LLQSASMELK FLIIQNAAVF QEAFEIVVRH 

       130        140        150        160        170        180 
AKNYTNAMFK NNYPSLTPQA FEFVGEFFTD VSLYILGSDI NVDDMVNELF DSLFPVIYTQ 

       190        200        210        220        230        240 
MMNPGLPESV LDINECLRGA RRDLKVFGSF PKLIMTQVSK SLQVTRIFLQ ALNLGIEVIN 

       250        260        270        280        290        300 
TTDHLKFSKD CGRMLTRMWY CSYCQGLMMV KPCGGYCNVV MQGCMAGVVE IDKYWREYIL 

       310        320        330        340        350        360 
SLEELVNGMY RIYDMENVLL GLFSTIHDSI QYVQKNGGKL TTTIGKLCAH SQQRQYRSAY 

       370        380        390        400        410        420 
YPEDLFIDKK ILKVAHVEHE ETLSSRRREL IQKLKSFINF YSALPGYICS HSPVAENDTL 

       430        440        450        460        470        480 
CWNGQELVER YSQKAARNGM KNQFNLHELK MKGPEPVVSQ IIDKLKHINQ LLRTMSVPKG 

       490        500        510        520        530        540 
KVLDKSLDEE GLESGDCGDD EDECIGSSGD GMVKVKNQLR FLAELAYDLD VDDAPGNKQH 

       550        560        570 
GNQKDNEITT SHSVGNMPSP LKILISVAIY VACFFFLVH 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC036126 mRNA. Translation: AAH36126.1.
CCDSCCDS30125.1.
RefSeqNP_057906.2. NM_016697.3.
UniGeneMm.22515.

3D structure databases

ProteinModelPortalQ8CFZ4.
SMRQ8CFZ4. Positions 33-474.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8CFZ4.

Proteomic databases

PRIDEQ8CFZ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000069360; ENSMUSP00000064131; ENSMUSG00000055653.
GeneID14734.
KEGGmmu:14734.
UCSCuc009teg.2. mouse.

Organism-specific databases

CTD2719.
MGIMGI:104903. Gpc3.

Phylogenomic databases

eggNOGNOG281821.
GeneTreeENSGT00550000074430.
HOGENOMHOG000049177.
HOVERGENHBG005896.
InParanoidQ8CFZ4.
KOK08109.
OMACWNGQEL.
OrthoDBEOG761BTG.
PhylomeDBQ8CFZ4.
TreeFamTF105317.

Enzyme and pathway databases

ReactomeREACT_188937. Metabolism.
REACT_189085. Disease.

Gene expression databases

ArrayExpressQ8CFZ4.
BgeeQ8CFZ4.
CleanExMM_GPC3.
GenevestigatorQ8CFZ4.

Family and domain databases

InterProIPR001863. Glypican.
IPR015501. Glypican-3.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF4. PTHR10822:SF4. 1 hit.
PfamPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEPS01207. GLYPICAN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGPC3. mouse.
NextBio286781.
PROQ8CFZ4.
SOURCESearch...

Entry information

Entry nameGPC3_MOUSE
AccessionPrimary (citable) accession number: Q8CFZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot