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Q8CFZ4

- GPC3_MOUSE

UniProt

Q8CFZ4 - GPC3_MOUSE

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Protein

Glypican-3

Gene

Gpc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition (By similarity).By similarity

GO - Molecular functioni

  1. peptidyl-dipeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  1. anterior/posterior axis specification Source: MGI
  2. body morphogenesis Source: MGI
  3. bone mineralization Source: MGI
  4. branching involved in ureteric bud morphogenesis Source: MGI
  5. cell proliferation involved in kidney development Source: MGI
  6. cell proliferation involved in metanephros development Source: MGI
  7. coronary vasculature development Source: MGI
  8. embryonic hindlimb morphogenesis Source: MGI
  9. kidney development Source: MGI
  10. lung development Source: MGI
  11. mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
  12. mesonephric duct morphogenesis Source: MGI
  13. negative regulation of canonical Wnt signaling pathway Source: MGI
  14. negative regulation of cell proliferation Source: MGI
  15. negative regulation of epithelial cell proliferation Source: MGI
  16. negative regulation of growth Source: MGI
  17. negative regulation of smoothened signaling pathway Source: MGI
  18. organ morphogenesis Source: MGI
  19. osteoclast differentiation Source: MGI
  20. positive regulation of BMP signaling pathway Source: MGI
  21. positive regulation of endocytosis Source: MGI
  22. positive regulation of glucose import Source: MGI
  23. positive regulation of protein catabolic process Source: MGI
  24. positive regulation of smoothened signaling pathway Source: MGI
  25. positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: MGI
  26. regulation of growth Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_198569. Retinoid metabolism and transport.
REACT_198654. HS-GAG biosynthesis.
REACT_198967. HS-GAG degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-3
Cleaved into the following chain:
Gene namesi
Name:Gpc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:104903. Gpc3.

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity; Extracellular side By similarity

GO - Cellular componenti

  1. anchored component of plasma membrane Source: MGI
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi lumen Source: Reactome
  4. integral component of plasma membrane Source: MGI
  5. lysosome Source: MGI
  6. plasma membrane Source: MGI
  7. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 579Removed in mature formSequence AnalysisPRO_0000012312
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – ?Glypican-3PRO_0000012311
Chaini25 – ?Secreted glypican-3PRO_0000333845

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi494 – 4941O-linked (Xyl...) (heparan sulfate)Sequence Analysis
Glycosylationi508 – 5081O-linked (Xyl...) (heparan sulfate)Sequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

Proteomic databases

MaxQBiQ8CFZ4.
PRIDEiQ8CFZ4.

PTM databases

PhosphoSiteiQ8CFZ4.

Expressioni

Gene expression databases

BgeeiQ8CFZ4.
CleanExiMM_GPC3.
ExpressionAtlasiQ8CFZ4. baseline and differential.
GenevestigatoriQ8CFZ4.

Interactioni

Subunit structurei

Interacts with DPP4.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8CFZ4.
SMRiQ8CFZ4. Positions 33-474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG281821.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000049177.
HOVERGENiHBG005896.
InParanoidiQ8CFZ4.
KOiK08109.
OMAiCWNGQEL.
OrthoDBiEOG761BTG.
PhylomeDBiQ8CFZ4.
TreeFamiTF105317.

Family and domain databases

InterProiIPR001863. Glypican.
IPR015501. Glypican-3.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF4. PTHR10822:SF4. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CFZ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGTVRTACL LVAMLLGLGC LGQAQPPPPP DATCHQVRSF FQRLQPGLKW
60 70 80 90 100
VPETPVPGSD LQVCLPKGPT CCSRKMEEKY QLTARLNMEQ LLQSASMELK
110 120 130 140 150
FLIIQNAAVF QEAFEIVVRH AKNYTNAMFK NNYPSLTPQA FEFVGEFFTD
160 170 180 190 200
VSLYILGSDI NVDDMVNELF DSLFPVIYTQ MMNPGLPESV LDINECLRGA
210 220 230 240 250
RRDLKVFGSF PKLIMTQVSK SLQVTRIFLQ ALNLGIEVIN TTDHLKFSKD
260 270 280 290 300
CGRMLTRMWY CSYCQGLMMV KPCGGYCNVV MQGCMAGVVE IDKYWREYIL
310 320 330 340 350
SLEELVNGMY RIYDMENVLL GLFSTIHDSI QYVQKNGGKL TTTIGKLCAH
360 370 380 390 400
SQQRQYRSAY YPEDLFIDKK ILKVAHVEHE ETLSSRRREL IQKLKSFINF
410 420 430 440 450
YSALPGYICS HSPVAENDTL CWNGQELVER YSQKAARNGM KNQFNLHELK
460 470 480 490 500
MKGPEPVVSQ IIDKLKHINQ LLRTMSVPKG KVLDKSLDEE GLESGDCGDD
510 520 530 540 550
EDECIGSSGD GMVKVKNQLR FLAELAYDLD VDDAPGNKQH GNQKDNEITT
560 570
SHSVGNMPSP LKILISVAIY VACFFFLVH
Length:579
Mass (Da):65,332
Last modified:March 1, 2003 - v1
Checksum:i066C23B3493A9346
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC036126 mRNA. Translation: AAH36126.1.
CCDSiCCDS30125.1.
RefSeqiNP_057906.2. NM_016697.3.
UniGeneiMm.22515.

Genome annotation databases

EnsembliENSMUST00000069360; ENSMUSP00000064131; ENSMUSG00000055653.
GeneIDi14734.
KEGGimmu:14734.
UCSCiuc009teg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC036126 mRNA. Translation: AAH36126.1 .
CCDSi CCDS30125.1.
RefSeqi NP_057906.2. NM_016697.3.
UniGenei Mm.22515.

3D structure databases

ProteinModelPortali Q8CFZ4.
SMRi Q8CFZ4. Positions 33-474.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8CFZ4.

Proteomic databases

MaxQBi Q8CFZ4.
PRIDEi Q8CFZ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069360 ; ENSMUSP00000064131 ; ENSMUSG00000055653 .
GeneIDi 14734.
KEGGi mmu:14734.
UCSCi uc009teg.2. mouse.

Organism-specific databases

CTDi 2719.
MGIi MGI:104903. Gpc3.

Phylogenomic databases

eggNOGi NOG281821.
GeneTreei ENSGT00550000074430.
HOGENOMi HOG000049177.
HOVERGENi HBG005896.
InParanoidi Q8CFZ4.
KOi K08109.
OMAi CWNGQEL.
OrthoDBi EOG761BTG.
PhylomeDBi Q8CFZ4.
TreeFami TF105317.

Enzyme and pathway databases

Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_198569. Retinoid metabolism and transport.
REACT_198654. HS-GAG biosynthesis.
REACT_198967. HS-GAG degradation.

Miscellaneous databases

ChiTaRSi GPC3. mouse.
NextBioi 286781.
PROi Q8CFZ4.
SOURCEi Search...

Gene expression databases

Bgeei Q8CFZ4.
CleanExi MM_GPC3.
ExpressionAtlasi Q8CFZ4. baseline and differential.
Genevestigatori Q8CFZ4.

Family and domain databases

InterProi IPR001863. Glypican.
IPR015501. Glypican-3.
IPR019803. Glypican_CS.
[Graphical view ]
PANTHERi PTHR10822. PTHR10822. 1 hit.
PTHR10822:SF4. PTHR10822:SF4. 1 hit.
Pfami PF01153. Glypican. 1 hit.
[Graphical view ]
PROSITEi PS01207. GLYPICAN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiGPC3_MOUSE
AccessioniPrimary (citable) accession number: Q8CFZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3