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Protein

Glypican-3

Gene

Gpc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • anterior/posterior axis specification Source: MGI
  • body morphogenesis Source: MGI
  • bone mineralization Source: MGI
  • branching involved in ureteric bud morphogenesis Source: MGI
  • cell proliferation involved in kidney development Source: MGI
  • cell proliferation involved in metanephros development Source: MGI
  • coronary vasculature development Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • glycosaminoglycan biosynthetic process Source: Reactome
  • kidney development Source: MGI
  • lung development Source: MGI
  • mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
  • mesonephric duct morphogenesis Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of growth Source: MGI
  • negative regulation of smoothened signaling pathway Source: MGI
  • osteoclast differentiation Source: MGI
  • positive regulation of BMP signaling pathway Source: MGI
  • positive regulation of endocytosis Source: MGI
  • positive regulation of glucose import Source: MGI
  • positive regulation of protein catabolic process Source: MGI
  • positive regulation of smoothened signaling pathway Source: MGI
  • positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: MGI
  • regulation of growth Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022928. HS-GAG biosynthesis.
R-MMU-2024096. HS-GAG degradation.
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-3
Cleaved into the following chain:
Gene namesi
Name:Gpc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:104903. Gpc3.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • extracellular space Source: UniProtKB-SubCell
  • Golgi lumen Source: Reactome
  • integral component of plasma membrane Source: MGI
  • lysosome Source: MGI
  • plasma membrane Source: MGI
  • proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000012312? – 579Removed in mature formSequence analysis
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001231125 – ?Glypican-3
ChainiPRO_000033384525 – ?Secreted glypican-3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1
Glycosylationi240N-linked (GlcNAc...)Sequence analysis1
Modified residuei351PhosphoserineBy similarity1
Glycosylationi417N-linked (GlcNAc...)Sequence analysis1
Glycosylationi494O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Glycosylationi508O-linked (Xyl...) (heparan sulfate)Sequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiQ8CFZ4.
PaxDbiQ8CFZ4.
PRIDEiQ8CFZ4.

PTM databases

PhosphoSitePlusiQ8CFZ4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055653.
CleanExiMM_GPC3.
ExpressionAtlasiQ8CFZ4. baseline and differential.
GenevisibleiQ8CFZ4. MM.

Interactioni

Subunit structurei

Interacts with DPP4.By similarity

Protein-protein interaction databases

IntActiQ8CFZ4. 3 interactors.
STRINGi10090.ENSMUSP00000064131.

Structurei

3D structure databases

ProteinModelPortaliQ8CFZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000049177.
HOVERGENiHBG005896.
InParanoidiQ8CFZ4.
KOiK08109.
OMAiMNPGLPE.
OrthoDBiEOG091G06T6.
PhylomeDBiQ8CFZ4.
TreeFamiTF105317.

Family and domain databases

InterProiIPR001863. Glypican.
IPR015501. Glypican-3.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF4. PTHR10822:SF4. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CFZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGTVRTACL LVAMLLGLGC LGQAQPPPPP DATCHQVRSF FQRLQPGLKW
60 70 80 90 100
VPETPVPGSD LQVCLPKGPT CCSRKMEEKY QLTARLNMEQ LLQSASMELK
110 120 130 140 150
FLIIQNAAVF QEAFEIVVRH AKNYTNAMFK NNYPSLTPQA FEFVGEFFTD
160 170 180 190 200
VSLYILGSDI NVDDMVNELF DSLFPVIYTQ MMNPGLPESV LDINECLRGA
210 220 230 240 250
RRDLKVFGSF PKLIMTQVSK SLQVTRIFLQ ALNLGIEVIN TTDHLKFSKD
260 270 280 290 300
CGRMLTRMWY CSYCQGLMMV KPCGGYCNVV MQGCMAGVVE IDKYWREYIL
310 320 330 340 350
SLEELVNGMY RIYDMENVLL GLFSTIHDSI QYVQKNGGKL TTTIGKLCAH
360 370 380 390 400
SQQRQYRSAY YPEDLFIDKK ILKVAHVEHE ETLSSRRREL IQKLKSFINF
410 420 430 440 450
YSALPGYICS HSPVAENDTL CWNGQELVER YSQKAARNGM KNQFNLHELK
460 470 480 490 500
MKGPEPVVSQ IIDKLKHINQ LLRTMSVPKG KVLDKSLDEE GLESGDCGDD
510 520 530 540 550
EDECIGSSGD GMVKVKNQLR FLAELAYDLD VDDAPGNKQH GNQKDNEITT
560 570
SHSVGNMPSP LKILISVAIY VACFFFLVH
Length:579
Mass (Da):65,332
Last modified:March 1, 2003 - v1
Checksum:i066C23B3493A9346
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036126 mRNA. Translation: AAH36126.1.
CCDSiCCDS30125.1.
RefSeqiNP_057906.2. NM_016697.3.
UniGeneiMm.22515.

Genome annotation databases

EnsembliENSMUST00000069360; ENSMUSP00000064131; ENSMUSG00000055653.
GeneIDi14734.
KEGGimmu:14734.
UCSCiuc009teg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036126 mRNA. Translation: AAH36126.1.
CCDSiCCDS30125.1.
RefSeqiNP_057906.2. NM_016697.3.
UniGeneiMm.22515.

3D structure databases

ProteinModelPortaliQ8CFZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CFZ4. 3 interactors.
STRINGi10090.ENSMUSP00000064131.

PTM databases

PhosphoSitePlusiQ8CFZ4.

Proteomic databases

MaxQBiQ8CFZ4.
PaxDbiQ8CFZ4.
PRIDEiQ8CFZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069360; ENSMUSP00000064131; ENSMUSG00000055653.
GeneIDi14734.
KEGGimmu:14734.
UCSCiuc009teg.2. mouse.

Organism-specific databases

CTDi2719.
MGIiMGI:104903. Gpc3.

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000049177.
HOVERGENiHBG005896.
InParanoidiQ8CFZ4.
KOiK08109.
OMAiMNPGLPE.
OrthoDBiEOG091G06T6.
PhylomeDBiQ8CFZ4.
TreeFamiTF105317.

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022928. HS-GAG biosynthesis.
R-MMU-2024096. HS-GAG degradation.
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

ChiTaRSiGpc3. mouse.
PROiQ8CFZ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055653.
CleanExiMM_GPC3.
ExpressionAtlasiQ8CFZ4. baseline and differential.
GenevisibleiQ8CFZ4. MM.

Family and domain databases

InterProiIPR001863. Glypican.
IPR015501. Glypican-3.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF4. PTHR10822:SF4. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPC3_MOUSE
AccessioniPrimary (citable) accession number: Q8CFZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.