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Protein

Protoheme IX farnesyltransferase, mitochondrial

Gene

Cox10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Converts protoheme IX and farnesyl diphosphate to heme O.By similarity

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: MGI
  • cellular respiration Source: MGI
  • cytochrome complex assembly Source: MGI
  • heme a biosynthetic process Source: MGI
  • heme O biosynthetic process Source: InterPro
  • hydrogen ion transmembrane transport Source: MGI
  • mitochondrial fission Source: MGI
  • mitochondrion organization Source: MGI
  • protein farnesylation Source: MGI
  • respiratory chain complex IV assembly Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Heme biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-189451. Heme biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoheme IX farnesyltransferase, mitochondrial (EC:2.5.1.-)
Alternative name(s):
Heme O synthase
Gene namesi
Name:Cox10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917633. Cox10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence analysisAdd
BLAST
Transmembranei308 – 32821HelicalSequence analysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence analysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 443Protoheme IX farnesyltransferase, mitochondrialPRO_0000035924
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ8CFY5.
MaxQBiQ8CFY5.
PaxDbiQ8CFY5.
PRIDEiQ8CFY5.

PTM databases

PhosphoSiteiQ8CFY5.

Expressioni

Gene expression databases

BgeeiQ8CFY5.
ExpressionAtlasiQ8CFY5. baseline and differential.
GenevisibleiQ8CFY5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040138.

Structurei

3D structure databases

ProteinModelPortaliQ8CFY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1380. Eukaryota.
COG0109. LUCA.
GeneTreeiENSGT00390000008408.
HOGENOMiHOG000189335.
HOVERGENiHBG051084.
InParanoidiQ8CFY5.
KOiK02257.
OMAiMGWAGCA.
OrthoDBiEOG7SFHX1.
PhylomeDBiQ8CFY5.
TreeFamiTF105071.

Family and domain databases

HAMAPiMF_00154. CyoE_CtaB.
InterProiIPR006369. Protohaem_IX_farnesylTrfase.
IPR016315. Protohaem_IX_farnesylTrfase_mt.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
PIRSFiPIRSF001773. COX10. 1 hit.
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CFY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASPHTISS RLLTGSVGGC IWYLERRAIQ GLPHRVTRLF RNVSNQWVTL
60 70 80 90 100
QHLSFLKRMY VTQLHRGLSQ RVKPKPEPPA SPFLEHTSSG QARADEDELP
110 120 130 140 150
SFPAPSRPLS RKPNEELVEL EATSIVDHSL DTAKEKKEER QWKEMKLHTD
160 170 180 190 200
DLPGILARLS KIKLTALVVS TTSAGFALAP GPFDWSCFLL TSLGTGLASC
210 220 230 240 250
AANSINQFFE VPFDSNMNRT KNRPLVRGQI SPLLAVSFAT CCAVPGVALL
260 270 280 290 300
TWGVNPLTGA LGVFNIFLYT CCYTPLKRVS ITNTWVGAVV GAIPPVMGWT
310 320 330 340 350
AATGSLDAGA LLLGGILYSW QFPHFNALSW GLREDYSRGG YCMMSVTHPA
360 370 380 390 400
LCRRVALRHC LALIALSTAA PVLDITTWVF PVISLPINLY ISYLGFRFYV
410 420 430 440
DADRRSSRKL FFCSLWHLPL LLLLMLTCKQ RPGQEGDKGE APS
Length:443
Mass (Da):48,884
Last modified:March 1, 2003 - v1
Checksum:i11DDF4F70FD31F61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL603889, AL663033 Genomic DNA. Translation: CAI25610.1.
AL663033, AL603889 Genomic DNA. Translation: CAI26029.1.
BC038046 mRNA. Translation: AAH38046.1.
CCDSiCCDS24839.1.
RefSeqiNP_848466.1. NM_178379.3.
UniGeneiMm.340211.

Genome annotation databases

EnsembliENSMUST00000049091; ENSMUSP00000040138; ENSMUSG00000042148.
GeneIDi70383.
KEGGimmu:70383.
UCSCiuc007jko.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL603889, AL663033 Genomic DNA. Translation: CAI25610.1.
AL663033, AL603889 Genomic DNA. Translation: CAI26029.1.
BC038046 mRNA. Translation: AAH38046.1.
CCDSiCCDS24839.1.
RefSeqiNP_848466.1. NM_178379.3.
UniGeneiMm.340211.

3D structure databases

ProteinModelPortaliQ8CFY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040138.

PTM databases

PhosphoSiteiQ8CFY5.

Proteomic databases

EPDiQ8CFY5.
MaxQBiQ8CFY5.
PaxDbiQ8CFY5.
PRIDEiQ8CFY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049091; ENSMUSP00000040138; ENSMUSG00000042148.
GeneIDi70383.
KEGGimmu:70383.
UCSCiuc007jko.2. mouse.

Organism-specific databases

CTDi1352.
MGIiMGI:1917633. Cox10.

Phylogenomic databases

eggNOGiKOG1380. Eukaryota.
COG0109. LUCA.
GeneTreeiENSGT00390000008408.
HOGENOMiHOG000189335.
HOVERGENiHBG051084.
InParanoidiQ8CFY5.
KOiK02257.
OMAiMGWAGCA.
OrthoDBiEOG7SFHX1.
PhylomeDBiQ8CFY5.
TreeFamiTF105071.

Enzyme and pathway databases

ReactomeiR-MMU-189451. Heme biosynthesis.

Miscellaneous databases

ChiTaRSiCox10. mouse.
PROiQ8CFY5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CFY5.
ExpressionAtlasiQ8CFY5. baseline and differential.
GenevisibleiQ8CFY5. MM.

Family and domain databases

HAMAPiMF_00154. CyoE_CtaB.
InterProiIPR006369. Protohaem_IX_farnesylTrfase.
IPR016315. Protohaem_IX_farnesylTrfase_mt.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
PIRSFiPIRSF001773. COX10. 1 hit.
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiCOX10_MOUSE
AccessioniPrimary (citable) accession number: Q8CFY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.