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Reviewed, UniProtKB/Swiss-Prot Q8CFX1 (G6PE_MOUSE)

Last modified June 16, 2009. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    GDH/6PGL endoplasmic bifunctional protein
Including the following 2 domains:
    1- Recommended name:
            Glucose 1-dehydrogenase
              EC=1.1.1.47
        Alternative name(s):
            Hexose-6-phosphate dehydrogenase
    2- Recommended name:
            6-phosphogluconolactonase
                Short name=6PGL
              EC=3.1.1.31
Gene names
Name: H6pd
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length789 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates By similarity.

Catalytic activity

Beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.

D-glucose 6-phosphate + NAD(P)+ = D-glucono-1,5-lactone 6-phosphate + NAD(P)H.

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Subcellular location

Endoplasmic reticulum lumen By similarity. Note: Microsomes, endoplasmic reticulum lumen By similarity.

Sequence similarities

In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.

In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 789773GDH/6PGL endoplasmic bifunctional protein
PRO_0000236794

Regions

Region17 – 524508Glucose 1-dehydrogenase
Region525 – 53814Linker
Region539 – 7892516-phosphogluconolactonase

Sites

Active site2641Proton acceptor By similarity
Binding site311NADP By similarity
Binding site631NADP By similarity
Binding site2011Substrate By similarity
Binding site2051Substrate By similarity

Amino acid modifications

Modified residue171Pyrrolidone carboxylic acid By similarity
Modified residue3131Phosphotyrosine By similarity
Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation2791N-linked (GlcNAc...) Potential
Glycosylation6811N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict771A → V in BAC32260. Ref.1
Sequence conflict1061H → R in BAC32260. Ref.1
Sequence conflict2851T → A in BAC32260. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q8CFX1-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 78C820EF38D81D2B

FASTA78988,911
        10         20         30         40         50         60 
MLLAAMCLAL LGCLQAQELK GHVSIILLGA TGDLAKKYLW QGLFQLYLDE AGKGHSFSFH 

        70         80         90        100        110        120 
GAALTAPQQG QKLMDKALES LSCPKDLVPS RCDELKGQFL QLSQYHQLKT VEDYQTLNKD 

       130        140        150        160        170        180 
IETQVQQDGL WEAGRIFYFS VPPFAYADIA RNINSSCRPH PGAWLRVVFE KPFGHDHLSA 

       190        200        210        220        230        240 
QQLASELGSF FQEEEMYRVD HYLGKQAVAQ ILPFRDQNRK ALDGLWNRHH VERVEIILKE 

       250        260        270        280        290        300 
TIDAEGRASF YEEYGVIRDT LQNHLTEILT LVAMELPLNI SSSATVLQHK LWAFQALRGL 

       310        320        330        340        350        360 
QKSSAILGQY QAYSGQVRRE LQKPDGFQSL TPTFAGVLVH IDNLRWEGVP FILMSGKALD 

       370        380        390        400        410        420 
ERVGYVRIVF KNRAYCTQSE RHWVPEQSRC LPQQIIFYIG HGELGHPAIL VSRNLFKPSL 

       430        440        450        460        470        480 
PTQKWKEVQD QPGLRLFGRP LSDYYAYRPV REQDAYSTLL SHIFHCRKES FITTENLLAS 

       490        500        510        520        530        540 
WVFWTPLLDS LAFEVPRPYP GGAENGQLLD FEFSGGQLTF SQQQLEVLIP DLGSVPKPSD 

       550        560        570        580        590        600 
FQVLGARYRQ SPLITAWPEE LISKLASDIE AAAVQAVRHF GKFHLALSGG SSPIALFQQL 

       610        620        630        640        650        660 
ATGHYSFPWA HTHLWLVDER CVPLSDPDSN FQGLQAHLLQ HVRVPYYNIH PMPVHLHQRL 

       670        680        690        700        710        720 
CAEEDQGAQT YASEISALVA NSSFDLVLLG MGTDGHTASL FPQSPTGLDG DQLVVLTESP 

       730        740        750        760        770        780 
FRPHQRMSLS LPLINRAKKV AVLVMGRTKR EITTLVSRVG HEPKKWPISG VVPLSGQLVW 


YMDYEAFLG

« Hide

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References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AK045199 mRNA. Translation: BAC32260.1. Different initiation.
AK159373 mRNA. Translation: BAE35029.1.
BC042677 mRNA. Translation: AAH42677.1.
IPIIPI00894776.
RefSeqNP_775547.2.
UniGeneMm.22183

3D structure databases

HSSPHSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBaseSearch...

PTM databases

PhosphoSiteQ8CFX1.

Genome annotation databases

EnsemblENSMUSG00000028980. Mus musculus. [Contig view]
GeneID100198.
KEGGmmu:100198.

Organism-specific databases

MGIMGI:2140356. H6pd.

Phylogenomic databases

HOVERGENQ8CFX1.

Enzyme and pathway databases

BRENDA1.1.1.47. 244.
3.1.1.31. 244.

Gene expression databases

ArrayExpressQ8CFX1.
BgeeQ8CFX1.
GermOnlineENSMUSG00000028980. Mus musculus.

Family and domain databases

InterProIPR005900. 6-phosphogluconolactonase.
IPR001282. Glc-6-P_DH.
IPR019796. Glc-6-P_DH_AS.
IPR006148. Glc/Gal-6P_isomerase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR23429. G6PDH. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 2 hits.
PF01182. Glucosamine_iso. 1 hit.
[Graphical view]
PRINTSPR00079. G6PDHDRGNASE.
ProDomPD001129. G6PD. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01198. pgl. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio354313.
SOURCESearch...

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Entry information

Entry nameG6PE_MOUSE
AccessionPrimary (citable) accession number: Q8CFX1
Secondary accession number(s): Q8BLH1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents