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Q8CFX1

- G6PE_MOUSE

UniProt

Q8CFX1 - G6PE_MOUSE

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Protein

GDH/6PGL endoplasmic bifunctional protein

Gene
H6pd
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates By similarity.

Catalytic activityi

Beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.
D-glucose 6-phosphate + NAD(P)+ = D-glucono-1,5-lactone 6-phosphate + NAD(P)H.
6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311NADP By similarity
Binding sitei63 – 631NADP By similarity
Binding sitei201 – 2011Substrate By similarity
Binding sitei205 – 2051Substrate By similarity
Active sitei264 – 2641Proton acceptor By similarity

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: MGI
  2. glucose 1-dehydrogenase [NAD(P)] activity Source: UniProtKB-EC
  3. glucose-6-phosphate dehydrogenase activity Source: MGI
  4. NADP binding Source: InterPro

GO - Biological processi

  1. pentose-phosphate shunt Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

SABIO-RKQ8CFX1.

Names & Taxonomyi

Protein namesi
Recommended name:
GDH/6PGL endoplasmic bifunctional protein
Including the following 2 domains:
Glucose 1-dehydrogenase (EC:1.1.1.47)
Alternative name(s):
Hexose-6-phosphate dehydrogenase
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:H6pd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2140356. H6pd.

Subcellular locationi

Endoplasmic reticulum lumen By similarity
Note: Microsomes, endoplasmic reticulum lumen By similarity.

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed predictionAdd
BLAST
Chaini17 – 789773GDH/6PGL endoplasmic bifunctional proteinPRO_0000236794Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171Pyrrolidone carboxylic acid By similarity
Glycosylationi154 – 1541N-linked (GlcNAc...) Reviewed prediction
Modified residuei205 – 2051N6-succinyllysine1 Publication
Glycosylationi279 – 2791N-linked (GlcNAc...) Reviewed prediction
Modified residuei424 – 4241N6-succinyllysine1 Publication
Glycosylationi681 – 6811N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiQ8CFX1.
PaxDbiQ8CFX1.
PRIDEiQ8CFX1.

PTM databases

PhosphoSiteiQ8CFX1.

Expressioni

Gene expression databases

ArrayExpressiQ8CFX1.
BgeeiQ8CFX1.
GenevestigatoriQ8CFX1.

Interactioni

Protein-protein interaction databases

IntActiQ8CFX1. 3 interactions.
MINTiMINT-1837869.

Structurei

3D structure databases

ProteinModelPortaliQ8CFX1.
SMRiQ8CFX1. Positions 25-500, 554-786.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 524508Glucose 1-dehydrogenaseAdd
BLAST
Regioni525 – 53814LinkerAdd
BLAST
Regioni539 – 7892516-phosphogluconolactonaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00530000063435.
HOGENOMiHOG000231077.
HOVERGENiHBG005780.
InParanoidiB2KGW7.
KOiK13937.
OrthoDBiEOG7BW0HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR006148. Glc/Gal-6P_isomerase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PF01182. Glucosamine_iso. 1 hit.
[Graphical view]
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR01198. pgl. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CFX1-1 [UniParc]FASTAAdd to Basket

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MLLAAMCLAL LGCLQAQELK GHVSIILLGA TGDLAKKYLW QGLFQLYLDE    50
AGKGHSFSFH GAALTAPQQG QKLMDKVLES LSCPKDLVPS RCDELKGQFL 100
QLSQYRQLKT VEDYQTLNKD IETQVQQDGL WEAGRIFYFS VPPFAYADIA 150
RNINSSCRPH PGAWLRVVFE KPFGHDHLSA QQLASELGSF FQEEEMYRVD 200
HYLGKQAVAQ ILPFRDQNRK ALDGLWNRHH VERVEIILKE TIDAEGRASF 250
YEEYGVIRDT LQNHLTEILT LVAMELPLNI SSSAAVLQHK LWAFQALRGL 300
QKSSAILGQY QAYSGQVRRE LQKPDGFQSL TPTFAGVLVH IDNLRWEGVP 350
FILMSGKALD ERVGYVRIVF KNRAYCTQSE RHWVPEQSRC LPQQIIFYIG 400
HGELGHPAIL VSRNLFKPSL PTQKWKEVQD QPGLRLFGRP LSDYYAYRPV 450
REQDAYSTLL SHIFHCRKES FITTENLLAS WVFWTPLLDS LAFEVPRPYP 500
GGAENGQLLD FEFSGGQLTF SQQQLEVLIP DLGSVPKPSD FQVLGARYRQ 550
SPLITAWPEE LISKLASDIE AAAVQAVRHF GKFHLALSGG SSPIALFQQL 600
ATGHYSFPWA HTHLWLVDER CVPLSDPDSN FQGLQAHLLQ HVRVPYYNIH 650
PMPVHLHQRL CAEEDQGAQT YASEISALVA NSSFDLVLLG MGTDGHTASL 700
FPQSPTGLDG DQLVVLTESP FRPHQRMSLS LPLINRAKKV AVLVMGRTKR 750
EITTLVSRVG HEPKKWPISG VVPLSGQLVW YMDYEAFLG 789
Length:789
Mass (Da):88,928
Last modified:July 27, 2011 - v2
Checksum:iE970CE8B35D3E1E5
GO

Sequence cautioni

The sequence BAC32260.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771V → A in BAE35029. 1 Publication
Sequence conflicti77 – 771V → A in CAQ51682. 1 Publication
Sequence conflicti77 – 771V → A in AAH42677. 1 Publication
Sequence conflicti106 – 1061R → H in BAE35029. 1 Publication
Sequence conflicti106 – 1061R → H in CAQ51682. 1 Publication
Sequence conflicti106 – 1061R → H in AAH42677. 1 Publication
Sequence conflicti285 – 2851A → T in BAE35029. 1 Publication
Sequence conflicti285 – 2851A → T in CAQ51682. 1 Publication
Sequence conflicti285 – 2851A → T in AAH42677. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK045199 mRNA. Translation: BAC32260.1. Different initiation.
AK159373 mRNA. Translation: BAE35029.1.
AL606914 Genomic DNA. Translation: CAM16119.1.
CU463327 Genomic DNA. Translation: CAQ51682.1.
BC042677 mRNA. Translation: AAH42677.1.
CCDSiCCDS71524.1.
RefSeqiNP_001277933.1. NM_001291004.1.
NP_775547.2. NM_173371.4.
XP_006537124.1. XM_006537061.1.
XP_006538524.1. XM_006538461.1.
UniGeneiMm.22183.

Genome annotation databases

EnsembliENSMUST00000084117; ENSMUSP00000081134; ENSMUSG00000028980.
GeneIDi100198.
KEGGimmu:100198.
UCSCiuc008vxh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK045199 mRNA. Translation: BAC32260.1 . Different initiation.
AK159373 mRNA. Translation: BAE35029.1 .
AL606914 Genomic DNA. Translation: CAM16119.1 .
CU463327 Genomic DNA. Translation: CAQ51682.1 .
BC042677 mRNA. Translation: AAH42677.1 .
CCDSi CCDS71524.1.
RefSeqi NP_001277933.1. NM_001291004.1.
NP_775547.2. NM_173371.4.
XP_006537124.1. XM_006537061.1.
XP_006538524.1. XM_006538461.1.
UniGenei Mm.22183.

3D structure databases

ProteinModelPortali Q8CFX1.
SMRi Q8CFX1. Positions 25-500, 554-786.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CFX1. 3 interactions.
MINTi MINT-1837869.

PTM databases

PhosphoSitei Q8CFX1.

Proteomic databases

MaxQBi Q8CFX1.
PaxDbi Q8CFX1.
PRIDEi Q8CFX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084117 ; ENSMUSP00000081134 ; ENSMUSG00000028980 .
GeneIDi 100198.
KEGGi mmu:100198.
UCSCi uc008vxh.1. mouse.

Organism-specific databases

CTDi 9563.
MGIi MGI:2140356. H6pd.

Phylogenomic databases

eggNOGi COG0363.
GeneTreei ENSGT00530000063435.
HOGENOMi HOG000231077.
HOVERGENi HBG005780.
InParanoidi B2KGW7.
KOi K13937.
OrthoDBi EOG7BW0HS.

Enzyme and pathway databases

SABIO-RK Q8CFX1.

Miscellaneous databases

NextBioi 354313.
PROi Q8CFX1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8CFX1.
Bgeei Q8CFX1.
Genevestigatori Q8CFX1.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR005900. 6-phosphogluconolactonase_DevB.
IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR006148. Glc/Gal-6P_isomerase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PF01182. Glucosamine_iso. 1 hit.
[Graphical view ]
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR01198. pgl. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-205 AND LYS-424, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiG6PE_MOUSE
AccessioniPrimary (citable) accession number: Q8CFX1
Secondary accession number(s): A2A7A9, B2KGW7, Q8BLH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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