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Protein

Neuritin

Gene

Nrn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

  • axonogenesis Source: MGI
  • neuron projection extension Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neuritin
Alternative name(s):
Candidate plasticity gene 15 protein
Gene namesi
Name:Nrn1
Synonyms:Cpg15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1915654. Nrn1.

Subcellular locationi

GO - Cellular componenti

  • AMPA glutamate receptor complex Source: MGI
  • anchored component of plasma membrane Source: MGI
  • cell junction Source: UniProtKB-KW
  • extracellular space Source: MGI
  • synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 11689NeuritinPRO_0000262514Add
BLAST
Propeptidei117 – 14226Removed in mature formSequence analysisPRO_0000262515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi116 – 1161GPI-anchor amidated glycineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ8CFV4.
PaxDbiQ8CFV4.
PRIDEiQ8CFV4.

PTM databases

iPTMnetiQ8CFV4.
PhosphoSiteiQ8CFV4.

Expressioni

Tissue specificityi

Expressed in the brain (at protein level).1 Publication

Inductioni

By synaptic activity through NMDA receptors and L-type voltage-sensitive calcium channels. By cAMP in active neurons.1 Publication

Gene expression databases

BgeeiENSMUSG00000039114.
CleanExiMM_NRN1.
ExpressionAtlasiQ8CFV4. baseline and differential.
GenevisibleiQ8CFV4. MM.

Interactioni

Subunit structurei

Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

IntActiQ8CFV4. 1 interaction.
STRINGi10090.ENSMUSP00000040900.

Family & Domainsi

Sequence similaritiesi

Belongs to the neuritin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXWR. Eukaryota.
ENOG410YHS3. LUCA.
GeneTreeiENSGT00530000063853.
HOGENOMiHOG000059601.
HOVERGENiHBG052772.
InParanoidiQ8CFV4.
OMAiFHSCATT.
PhylomeDBiQ8CFV4.
TreeFamiTF332589.

Family and domain databases

InterProiIPR026144. Neuritin_fam.
[Graphical view]
PANTHERiPTHR15902. PTHR15902. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CFV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKLNGRYI SLILAVQIAY LVQAVRAAGK CDAVFKGFSD CLLKLGDSMA
60 70 80 90 100
NYPQGLDDKT NIKTVCTYWE DFHSCTVTAL TDCQEGAKDM WDKLRKESKN
110 120 130 140
LNIQGSLFEL CGSSNGAAGS LLPALSVLLV SLSAALATWF SF
Length:142
Mass (Da):15,353
Last modified:March 1, 2003 - v1
Checksum:i6E5CCE2C9822C6E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK161859 mRNA. Translation: BAE36610.1.
BC035531 mRNA. Translation: AAH35531.1.
AY150584 Genomic DNA. Translation: AAN84528.1.
CCDSiCCDS26455.1.
RefSeqiNP_705757.1. NM_153529.2.
UniGeneiMm.232930.

Genome annotation databases

EnsembliENSMUST00000037623; ENSMUSP00000040900; ENSMUSG00000039114.
GeneIDi68404.
KEGGimmu:68404.
UCSCiuc007qcm.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK161859 mRNA. Translation: BAE36610.1.
BC035531 mRNA. Translation: AAH35531.1.
AY150584 Genomic DNA. Translation: AAN84528.1.
CCDSiCCDS26455.1.
RefSeqiNP_705757.1. NM_153529.2.
UniGeneiMm.232930.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CFV4. 1 interaction.
STRINGi10090.ENSMUSP00000040900.

PTM databases

iPTMnetiQ8CFV4.
PhosphoSiteiQ8CFV4.

Proteomic databases

MaxQBiQ8CFV4.
PaxDbiQ8CFV4.
PRIDEiQ8CFV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037623; ENSMUSP00000040900; ENSMUSG00000039114.
GeneIDi68404.
KEGGimmu:68404.
UCSCiuc007qcm.3. mouse.

Organism-specific databases

CTDi51299.
MGIiMGI:1915654. Nrn1.

Phylogenomic databases

eggNOGiENOG410IXWR. Eukaryota.
ENOG410YHS3. LUCA.
GeneTreeiENSGT00530000063853.
HOGENOMiHOG000059601.
HOVERGENiHBG052772.
InParanoidiQ8CFV4.
OMAiFHSCATT.
PhylomeDBiQ8CFV4.
TreeFamiTF332589.

Miscellaneous databases

PROiQ8CFV4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039114.
CleanExiMM_NRN1.
ExpressionAtlasiQ8CFV4. baseline and differential.
GenevisibleiQ8CFV4. MM.

Family and domain databases

InterProiIPR026144. Neuritin_fam.
[Graphical view]
PANTHERiPTHR15902. PTHR15902. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNRN1_MOUSE
AccessioniPrimary (citable) accession number: Q8CFV4
Secondary accession number(s): Q7TSR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.