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Protein
Submitted name:

Nerve growth factor receptor (TNFR superfamily, member 16)

Gene

Ngfr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Enzyme and pathway databases

ReactomeiR-MMU-193634. Axonal growth inhibition (RHOA activation).
R-MMU-193692. Regulated proteolysis of p75NTR.
R-MMU-205017. NFG and proNGF binds to p75NTR.
R-MMU-205025. NADE modulates death signalling.
R-MMU-205043. NRIF signals cell death from the nucleus.
R-MMU-209543. p75NTR recruits signalling complexes.
R-MMU-209560. NF-kB is activated and signals survival.
R-MMU-209563. Axonal growth stimulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Nerve growth factor receptor (TNFR superfamily, member 16)Imported
Submitted name:
Tumor necrosis factor receptor superfamily member 16Imported
Gene namesi
Name:NgfrImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97323. Ngfr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_500934693032 – 427Sequence analysisAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 60PROSITE-ProRule annotation
Disulfide bondi89 ↔ 102PROSITE-ProRule annotation
Disulfide bondi92 ↔ 110PROSITE-ProRule annotation
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation
Disulfide bondi131 ↔ 149PROSITE-ProRule annotation
Disulfide bondi152 ↔ 167PROSITE-ProRule annotation
Disulfide bondi170 ↔ 183PROSITE-ProRule annotation
Disulfide bondi173 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000000120.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000122.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 67TNFR-CysInterPro annotationAdd BLAST34
Repeati34 – 67TNFR-CysPROSITE-ProRule annotationAdd BLAST34
Domaini69 – 110TNFR-CysInterPro annotationAdd BLAST42
Repeati69 – 110TNFR-CysPROSITE-ProRule annotationAdd BLAST42
Domaini111 – 149TNFR-CysInterPro annotationAdd BLAST39
Repeati111 – 149TNFR-CysPROSITE-ProRule annotationAdd BLAST39
Domaini151 – 191TNFR-CysInterPro annotationAdd BLAST41
Repeati151 – 191TNFR-CysPROSITE-ProRule annotationAdd BLAST41
Domaini356 – 421DeathInterPro annotationAdd BLAST66

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQFC. Eukaryota.
ENOG4111F3C. LUCA.
GeneTreeiENSGT00730000110974.
HOGENOMiHOG000059587.
HOVERGENiHBG060431.
KOiK02583.
OMAiAQPCGAN.
OrthoDBiEOG091G0M0X.
TreeFamiTF106466.

Family and domain databases

CDDicd13416. TNFRSF16. 1 hit.
Gene3Di1.10.533.10. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
IPR034046. TNFRSF16_N.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
PRINTSiPR01966. TNFACTORR16.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q8CFT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAGAACSA MDRLRLLLLL LLLLGVSFGG AKETCSTGMY THSGECCKAC
60 70 80 90 100
NLGEGVAQPC GANQTVCEPC LDSVTFSDVV SATEPCKPCT ECLGLQSMSA
110 120 130 140 150
PCVEADDAVC RCSYGYYQDE ETGRCEACSV CGVGSGLVFS CQDKQNTVCE
160 170 180 190 200
ECPEGTYSDE ANHVDPCLPC TVCEDTERQL RECTPWADAE CEEIPGRWIT
210 220 230 240 250
RSTPPEGSDV TTPSTQEPEA PPERDLIAST VADTVTTVMG SSQPVVTRGT
260 270 280 290 300
ADNLIPVYCS ILAAVVVGLV AYIAFKRWNS CKQNKQGANS RPVNQTPPPE
310 320 330 340 350
GEKLHSDSGI SVDSQSLHDQ QTHTQTASGQ ALKGDGNLYS SLPLTKREEV
360 370 380 390 400
EKLLNGDTWR HLAGELGYQP EHIDSFTHEA CPVRALLASW GAQDSATLDA
410 420
LLAALRRIQR ADIVESLCSE STATSPV
Length:427
Mass (Da):45,647
Last modified:March 1, 2003 - v1
Checksum:i7AC73263F7B31436
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662875 Genomic DNA. No translation available.
BC038365 mRNA. Translation: AAH38365.1.
RefSeqiNP_150086.2. NM_033217.3.
UniGeneiMm.283893.

Genome annotation databases

EnsembliENSMUST00000000122; ENSMUSP00000000122; ENSMUSG00000000120.
GeneIDi18053.
KEGGimmu:18053.
UCSCiuc007lam.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662875 Genomic DNA. No translation available.
BC038365 mRNA. Translation: AAH38365.1.
RefSeqiNP_150086.2. NM_033217.3.
UniGeneiMm.283893.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000122.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000122; ENSMUSP00000000122; ENSMUSG00000000120.
GeneIDi18053.
KEGGimmu:18053.
UCSCiuc007lam.2. mouse.

Organism-specific databases

CTDi4804.
MGIiMGI:97323. Ngfr.

Phylogenomic databases

eggNOGiENOG410IQFC. Eukaryota.
ENOG4111F3C. LUCA.
GeneTreeiENSGT00730000110974.
HOGENOMiHOG000059587.
HOVERGENiHBG060431.
KOiK02583.
OMAiAQPCGAN.
OrthoDBiEOG091G0M0X.
TreeFamiTF106466.

Enzyme and pathway databases

ReactomeiR-MMU-193634. Axonal growth inhibition (RHOA activation).
R-MMU-193692. Regulated proteolysis of p75NTR.
R-MMU-205017. NFG and proNGF binds to p75NTR.
R-MMU-205025. NADE modulates death signalling.
R-MMU-205043. NRIF signals cell death from the nucleus.
R-MMU-209543. p75NTR recruits signalling complexes.
R-MMU-209560. NF-kB is activated and signals survival.
R-MMU-209563. Axonal growth stimulation.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000120.

Family and domain databases

CDDicd13416. TNFRSF16. 1 hit.
Gene3Di1.10.533.10. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
IPR034046. TNFRSF16_N.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
PRINTSiPR01966. TNFACTORR16.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8CFT3_MOUSE
AccessioniPrimary (citable) accession number: Q8CFT3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 15, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.