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Protein
Submitted name:

Nerve growth factor receptor (TNFR superfamily, member 16)

Gene

Ngfr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Enzyme and pathway databases

ReactomeiR-MMU-193634 Axonal growth inhibition (RHOA activation)
R-MMU-193692 Regulated proteolysis of p75NTR
R-MMU-205017 NFG and proNGF binds to p75NTR
R-MMU-205025 NADE modulates death signalling
R-MMU-205043 NRIF signals cell death from the nucleus
R-MMU-209543 p75NTR recruits signalling complexes
R-MMU-209560 NF-kB is activated and signals survival
R-MMU-209563 Axonal growth stimulation

Names & Taxonomyi

Protein namesi
Submitted name:
Nerve growth factor receptor (TNFR superfamily, member 16)Imported
Submitted name:
Tumor necrosis factor receptor superfamily member 16Imported
Gene namesi
Name:NgfrImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97323 Ngfr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_501458890432 – 427Sequence analysisAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 60PROSITE-ProRule annotation
Disulfide bondi89 ↔ 102PROSITE-ProRule annotation
Disulfide bondi92 ↔ 110PROSITE-ProRule annotation
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation
Disulfide bondi131 ↔ 149PROSITE-ProRule annotation
Disulfide bondi152 ↔ 167PROSITE-ProRule annotation
Disulfide bondi170 ↔ 183PROSITE-ProRule annotation
Disulfide bondi173 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000000120

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 67TNFR-CysInterPro annotationAdd BLAST34
Repeati34 – 67TNFR-CysPROSITE-ProRule annotationAdd BLAST34
Domaini69 – 110TNFR-CysInterPro annotationAdd BLAST42
Repeati69 – 110TNFR-CysPROSITE-ProRule annotationAdd BLAST42
Domaini111 – 149TNFR-CysInterPro annotationAdd BLAST39
Repeati111 – 149TNFR-CysPROSITE-ProRule annotationAdd BLAST39
Domaini151 – 191TNFR-CysInterPro annotationAdd BLAST41
Repeati151 – 191TNFR-CysPROSITE-ProRule annotationAdd BLAST41
Domaini356 – 421DeathInterPro annotationAdd BLAST66

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQFC Eukaryota
ENOG4111F3C LUCA
GeneTreeiENSGT00730000110974
HOGENOMiHOG000059587
HOVERGENiHBG060431
KOiK02583
OMAiAQPCGAN
OrthoDBiEOG091G0M0X
TreeFamiTF106466

Family and domain databases

CDDicd13416 TNFRSF16, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022325 TNFR_16
IPR034046 TNFRSF16_N
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PRINTSiPR01966 TNFACTORR16
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q8CFT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAGAACSA MDRLRLLLLL LLLLGVSFGG AKETCSTGMY THSGECCKAC
60 70 80 90 100
NLGEGVAQPC GANQTVCEPC LDSVTFSDVV SATEPCKPCT ECLGLQSMSA
110 120 130 140 150
PCVEADDAVC RCSYGYYQDE ETGRCEACSV CGVGSGLVFS CQDKQNTVCE
160 170 180 190 200
ECPEGTYSDE ANHVDPCLPC TVCEDTERQL RECTPWADAE CEEIPGRWIT
210 220 230 240 250
RSTPPEGSDV TTPSTQEPEA PPERDLIAST VADTVTTVMG SSQPVVTRGT
260 270 280 290 300
ADNLIPVYCS ILAAVVVGLV AYIAFKRWNS CKQNKQGANS RPVNQTPPPE
310 320 330 340 350
GEKLHSDSGI SVDSQSLHDQ QTHTQTASGQ ALKGDGNLYS SLPLTKREEV
360 370 380 390 400
EKLLNGDTWR HLAGELGYQP EHIDSFTHEA CPVRALLASW GAQDSATLDA
410 420
LLAALRRIQR ADIVESLCSE STATSPV
Length:427
Mass (Da):45,647
Last modified:March 1, 2003 - v1
Checksum:i7AC73263F7B31436
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662875 Genomic DNA No translation available.
BC038365 mRNA Translation: AAH38365.1
RefSeqiNP_150086.2, NM_033217.3
UniGeneiMm.283893

Genome annotation databases

EnsembliENSMUST00000000122; ENSMUSP00000000122; ENSMUSG00000000120
GeneIDi18053
KEGGimmu:18053
UCSCiuc007lam.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ8CFT3_MOUSE
AccessioniPrimary (citable) accession number: Q8CFT3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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