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Protein

Potassium voltage-gated channel subfamily V member 2

Gene

Kcnv2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 2
Alternative name(s):
Voltage-gated potassium channel subunit Kv8.2
Gene namesi
Name:Kcnv2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2670981. Kcnv2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 163163CytoplasmicSequence analysisAdd
BLAST
Transmembranei164 – 18421Helical; Name=Segment S1Sequence analysisAdd
BLAST
Topological domaini185 – 26985ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=Segment S2Sequence analysisAdd
BLAST
Topological domaini291 – 34454CytoplasmicSequence analysisAdd
BLAST
Transmembranei345 – 36521Helical; Name=Segment S3Sequence analysisAdd
BLAST
Topological domaini366 – 39126ExtracellularSequence analysisAdd
BLAST
Transmembranei392 – 41221Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd
BLAST
Topological domaini413 – 42715CytoplasmicSequence analysisAdd
BLAST
Transmembranei428 – 44821Helical; Name=Segment S5Sequence analysisAdd
BLAST
Topological domaini449 – 46113ExtracellularSequence analysisAdd
BLAST
Intramembranei462 – 48221Pore-forming; Name=Segment H5Sequence analysisAdd
BLAST
Topological domaini483 – 4886ExtracellularSequence analysis
Transmembranei489 – 50921Helical; Name=Segment S6Sequence analysisAdd
BLAST
Topological domaini510 – 56253CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Potassium voltage-gated channel subfamily V member 2PRO_0000320144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CFS6.
PRIDEiQ8CFS6.

PTM databases

PhosphoSiteiQ8CFS6.

Expressioni

Gene expression databases

BgeeiQ8CFS6.
CleanExiMM_KCNV2.
GenevisibleiQ8CFS6. MM.

Interactioni

Subunit structurei

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055091.

Structurei

3D structure databases

ProteinModelPortaliQ8CFS6.
SMRiQ8CFS6. Positions 109-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi474 – 4796Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG095321.
InParanoidiQ8CFS6.
KOiK04935.
OMAiFQLIYNF.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ8CFS6.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 2 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CFS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKQSNERRW SLSYKPWSTP ETEDVPNTGS NQHRRSICSL GARTGSQASI
60 70 80 90 100
APQWTEGNYN YYIEEDEDCG EEGEDWKDDL AEENQKAECL TSLLDGHNDT
110 120 130 140 150
PAQMSTLKVN VGGHSYLLEC CELANYPKTR LGRLATSTTR RGQLGLCDDY
160 170 180 190 200
EAQTDEYFFD RDPAVFQLIY NFYTSGVLLV RDELCPRSFL EELGYWGVRL
210 220 230 240 250
KYTPRCCRIC FEERRDELSE QLKIQRELRA QAQAEEAEEL FRDMRFYGPQ
260 270 280 290 300
RQRLWNLMEK PFSSVAAKAM GVATNLFVLI SVVALALNTV EEMQHQAEQG
310 320 330 340 350
TGGGDPRPIL EHVEMLCVAF FTLEFLLRLA STPNLQRFAR SALNLVDLVA
360 370 380 390 400
ILPFYLQLLL ECFTSEDQRH NKDSPREHDL ETVGRVGKVG QVLRIMRLMR
410 420 430 440 450
IFRILKLARH STGLRAFGFT LRQCYQQVGC LMLFITMGIF SFSAAVYSVE
460 470 480 490 500
HDVPGTNFTS ILHAWWWAAV SISTVGYGDM YPETHLGRLF AFLCIAFGII
510 520 530 540 550
LNGMPISILY NKFSDYYSKL KAYEYTAIRR ERGKVNFMQR ATKKMAECLS
560
ESHAQSTTRQ EN
Length:562
Mass (Da):64,461
Last modified:March 1, 2003 - v1
Checksum:i4D06B01C93BF8C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238939 mRNA. Translation: AAP70480.1.
BC039042 mRNA. Translation: AAH39042.1.
CCDSiCCDS29722.1.
RefSeqiNP_899002.1. NM_183179.1.
UniGeneiMm.269759.

Genome annotation databases

EnsembliENSMUST00000056708; ENSMUSP00000055091; ENSMUSG00000047298.
GeneIDi240595.
KEGGimmu:240595.
UCSCiuc008hbw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238939 mRNA. Translation: AAP70480.1.
BC039042 mRNA. Translation: AAH39042.1.
CCDSiCCDS29722.1.
RefSeqiNP_899002.1. NM_183179.1.
UniGeneiMm.269759.

3D structure databases

ProteinModelPortaliQ8CFS6.
SMRiQ8CFS6. Positions 109-557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055091.

PTM databases

PhosphoSiteiQ8CFS6.

Proteomic databases

PaxDbiQ8CFS6.
PRIDEiQ8CFS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056708; ENSMUSP00000055091; ENSMUSG00000047298.
GeneIDi240595.
KEGGimmu:240595.
UCSCiuc008hbw.1. mouse.

Organism-specific databases

CTDi169522.
MGIiMGI:2670981. Kcnv2.

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG095321.
InParanoidiQ8CFS6.
KOiK04935.
OMAiFQLIYNF.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ8CFS6.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Miscellaneous databases

PROiQ8CFS6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CFS6.
CleanExiMM_KCNV2.
GenevisibleiQ8CFS6. MM.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 2 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the heteromeric potassium channel formed by Kv2.1 and the retinal subunit Kv8.2 in Xenopus oocytes."
    Czirjak G., Toth Z.E., Enyedi P.
    J. Neurophysiol. 98:1213-1222(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NMRI.
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiKCNV2_MOUSE
AccessioniPrimary (citable) accession number: Q8CFS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.