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Protein

Potassium voltage-gated channel subfamily V member 2

Gene

Kcnv2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 2
Alternative name(s):
Voltage-gated potassium channel subunit Kv8.2
Gene namesi
Name:Kcnv2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2670981. Kcnv2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 163CytoplasmicSequence analysisAdd BLAST163
Transmembranei164 – 184Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini185 – 269ExtracellularSequence analysisAdd BLAST85
Transmembranei270 – 290Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini291 – 344CytoplasmicSequence analysisAdd BLAST54
Transmembranei345 – 365Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini366 – 391ExtracellularSequence analysisAdd BLAST26
Transmembranei392 – 412Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini413 – 427CytoplasmicSequence analysisAdd BLAST15
Transmembranei428 – 448Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini449 – 461ExtracellularSequence analysisAdd BLAST13
Intramembranei462 – 482Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini483 – 488ExtracellularSequence analysis6
Transmembranei489 – 509Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini510 – 562CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003201441 – 562Potassium voltage-gated channel subfamily V member 2Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CFS6.
PRIDEiQ8CFS6.

PTM databases

PhosphoSitePlusiQ8CFS6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047298.
CleanExiMM_KCNV2.
GenevisibleiQ8CFS6. MM.

Interactioni

Subunit structurei

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055091.

Structurei

3D structure databases

ProteinModelPortaliQ8CFS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi474 – 479Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG095321.
InParanoidiQ8CFS6.
KOiK04935.
OMAiFQLIYNF.
OrthoDBiEOG091G0FP3.
PhylomeDBiQ8CFS6.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 2 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CFS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKQSNERRW SLSYKPWSTP ETEDVPNTGS NQHRRSICSL GARTGSQASI
60 70 80 90 100
APQWTEGNYN YYIEEDEDCG EEGEDWKDDL AEENQKAECL TSLLDGHNDT
110 120 130 140 150
PAQMSTLKVN VGGHSYLLEC CELANYPKTR LGRLATSTTR RGQLGLCDDY
160 170 180 190 200
EAQTDEYFFD RDPAVFQLIY NFYTSGVLLV RDELCPRSFL EELGYWGVRL
210 220 230 240 250
KYTPRCCRIC FEERRDELSE QLKIQRELRA QAQAEEAEEL FRDMRFYGPQ
260 270 280 290 300
RQRLWNLMEK PFSSVAAKAM GVATNLFVLI SVVALALNTV EEMQHQAEQG
310 320 330 340 350
TGGGDPRPIL EHVEMLCVAF FTLEFLLRLA STPNLQRFAR SALNLVDLVA
360 370 380 390 400
ILPFYLQLLL ECFTSEDQRH NKDSPREHDL ETVGRVGKVG QVLRIMRLMR
410 420 430 440 450
IFRILKLARH STGLRAFGFT LRQCYQQVGC LMLFITMGIF SFSAAVYSVE
460 470 480 490 500
HDVPGTNFTS ILHAWWWAAV SISTVGYGDM YPETHLGRLF AFLCIAFGII
510 520 530 540 550
LNGMPISILY NKFSDYYSKL KAYEYTAIRR ERGKVNFMQR ATKKMAECLS
560
ESHAQSTTRQ EN
Length:562
Mass (Da):64,461
Last modified:March 1, 2003 - v1
Checksum:i4D06B01C93BF8C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238939 mRNA. Translation: AAP70480.1.
BC039042 mRNA. Translation: AAH39042.1.
CCDSiCCDS29722.1.
RefSeqiNP_899002.1. NM_183179.1.
UniGeneiMm.269759.

Genome annotation databases

EnsembliENSMUST00000056708; ENSMUSP00000055091; ENSMUSG00000047298.
GeneIDi240595.
KEGGimmu:240595.
UCSCiuc008hbw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238939 mRNA. Translation: AAP70480.1.
BC039042 mRNA. Translation: AAH39042.1.
CCDSiCCDS29722.1.
RefSeqiNP_899002.1. NM_183179.1.
UniGeneiMm.269759.

3D structure databases

ProteinModelPortaliQ8CFS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055091.

PTM databases

PhosphoSitePlusiQ8CFS6.

Proteomic databases

PaxDbiQ8CFS6.
PRIDEiQ8CFS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056708; ENSMUSP00000055091; ENSMUSG00000047298.
GeneIDi240595.
KEGGimmu:240595.
UCSCiuc008hbw.1. mouse.

Organism-specific databases

CTDi169522.
MGIiMGI:2670981. Kcnv2.

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG095321.
InParanoidiQ8CFS6.
KOiK04935.
OMAiFQLIYNF.
OrthoDBiEOG091G0FP3.
PhylomeDBiQ8CFS6.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Miscellaneous databases

PROiQ8CFS6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047298.
CleanExiMM_KCNV2.
GenevisibleiQ8CFS6. MM.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 2 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNV2_MOUSE
AccessioniPrimary (citable) accession number: Q8CFS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.