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Protein
Submitted name:

Signal transducer and activator of transcription 1

Gene

Stat1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-1169408. ISG15 antiviral mechanism.
R-MMU-1433557. Signaling by SCF-KIT.
R-MMU-186763. Downstream signal transduction.
R-MMU-447115. Interleukin-12 family signaling.
R-MMU-6783589. Interleukin-6 family signaling.
R-MMU-6785807. Interleukin-4 and 13 signaling.
R-MMU-877300. Interferon gamma signaling.
R-MMU-877312. Regulation of IFNG signaling.
R-MMU-8984722. Interleukin-35 Signalling.
R-MMU-909733. Interferon alpha/beta signaling.
R-MMU-912694. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Signal transducer and activator of transcription 1Imported
Submitted name:
Stat1 proteinImported
Gene namesi
Name:Stat1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:103063. Stat1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000026104.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 164SH2InterPro annotationAdd BLAST98

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
GeneTreeiENSGT00760000119236.
HOVERGENiHBG071022.
KOiK11220.

Family and domain databases

CDDicd10372. SH2_STAT1. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR001217. STAT.
IPR035859. STAT1_SH2.
IPR022752. STAT1_TAZ2-bd_C.
IPR013801. STAT_TF_DNA-bd.
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF12162. STAT1_TAZ2bind. 1 hit.
PF02864. STAT_bind. 1 hit.
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8CFQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NQTNRQQHGG AHLSSQAGGV GGPNAGPDGL IPWTRFCKEN INDKNFSFWP
60 70 80 90 100
WIDTILELIK KHLLCLWNDG CIMGFISKER ERALLKDQQP GTFLLRFSES
110 120 130 140 150
SREGAITFTW VERSQNGGEP DFHAVEPYTK KELSAVTFPD IIRNYKVMAA
160 170 180 190 200
ENIPENPLKY LYPNIDKDHA FGKYYSRPKE APEPMELDDP KRTGYIKTEL
210 220 230 240
ISVSEVHPSR LQTTDNLLPM SPEEFDEMSR IVGPEFDSMM STV
Length:243
Mass (Da):27,667
Last modified:March 1, 2003 - v1
Checksum:i7D3487545E72C4AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123752 Genomic DNA. No translation available.
BC042551 mRNA. Translation: AAH42551.1.
RefSeqiNP_001192242.1. NM_001205313.1.
NP_001192243.1. NM_001205314.1.
NP_033309.3. NM_009283.4.
UniGeneiMm.277406.
Mm.487336.

Genome annotation databases

EnsembliENSMUST00000189244; ENSMUSP00000140482; ENSMUSG00000026104.
GeneIDi20846.
KEGGimmu:20846.

Similar proteinsi

Entry informationi

Entry nameiQ8CFQ1_MOUSE
AccessioniPrimary (citable) accession number: Q8CFQ1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported