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Protein
Submitted name:

Signal transducer and activator of transcription 1

Gene

Stat1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-1059683 Interleukin-6 signaling
R-MMU-1169408 ISG15 antiviral mechanism
R-MMU-1433557 Signaling by SCF-KIT
R-MMU-186763 Downstream signal transduction
R-MMU-6785807 Interleukin-4 and 13 signaling
R-MMU-877300 Interferon gamma signaling
R-MMU-877312 Regulation of IFNG signaling
R-MMU-8854691 Interleukin-20 family signaling
R-MMU-8984722 Interleukin-35 Signalling
R-MMU-9020956 Interleukin-27 signaling
R-MMU-9020958 Interleukin-21 signaling
R-MMU-909733 Interferon alpha/beta signaling
R-MMU-912694 Regulation of IFNA signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Signal transducer and activator of transcription 1Imported
Submitted name:
Stat1 proteinImported
Gene namesi
Name:Stat1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:103063 Stat1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000026104

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 164SH2InterPro annotationAdd BLAST98

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
HOVERGENiHBG071022
KOiK11220

Family and domain databases

CDDicd10372 SH2_STAT1, 1 hit
Gene3Di1.10.8.1200, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR038295 STAT1_C_sf
IPR035859 STAT1_SH2
IPR022752 STAT1_TAZ2-bd_C
IPR013801 STAT_TF_DNA-bd
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12162 STAT1_TAZ2bind, 1 hit
PF02864 STAT_bind, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q8CFQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NQTNRQQHGG AHLSSQAGGV GGPNAGPDGL IPWTRFCKEN INDKNFSFWP
60 70 80 90 100
WIDTILELIK KHLLCLWNDG CIMGFISKER ERALLKDQQP GTFLLRFSES
110 120 130 140 150
SREGAITFTW VERSQNGGEP DFHAVEPYTK KELSAVTFPD IIRNYKVMAA
160 170 180 190 200
ENIPENPLKY LYPNIDKDHA FGKYYSRPKE APEPMELDDP KRTGYIKTEL
210 220 230 240
ISVSEVHPSR LQTTDNLLPM SPEEFDEMSR IVGPEFDSMM STV
Length:243
Mass (Da):27,667
Last modified:March 1, 2003 - v1
Checksum:i7D3487545E72C4AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123752 Genomic DNA No translation available.
BC042551 mRNA Translation: AAH42551.1
RefSeqiNP_001192242.1, NM_001205313.1
NP_001192243.1, NM_001205314.1
NP_033309.3, NM_009283.4
UniGeneiMm.277406
Mm.487336

Genome annotation databases

EnsembliENSMUST00000189244; ENSMUSP00000140482; ENSMUSG00000026104
GeneIDi20846
KEGGimmu:20846

Similar proteinsi

Entry informationi

Entry nameiQ8CFQ1_MOUSE
AccessioniPrimary (citable) accession number: Q8CFQ1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health