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Unreviewed, UniProtKB/TrEMBL Q8CFK4 (Q8CFK4_MOUSE)

Last modified February 9, 2010. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Putative uncharacterized protein EMBL BAE41897.1
Submitted name:
    Tec protein EMBL AAH37071.1
Gene names
Name: Tec EMBL AAH37071.1 MGI 98662
OrganismMus musculus (Mouse) EMBL AAH37071.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Spearmint SPM020635

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 PH domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Contains 1 protein kinase domain.

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Sequences

Sequence LengthMass (Da)Tools
Q8CFK4-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 5C2256F9FBBF95CD

FASTA60870,990
        10         20         30         40         50         60 
MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSVLSY YEGRAEKKYR KGVIDISKIK 

        70         80         90        100        110        120 
CVEIVKNDDG VIPCQNKFPF QVVHDANTLY IFAPSPQSRD RWVKKLKEEI KNNNNIMIKY 

       130        140        150        160        170        180 
HPKFWADGSY QCCRQTEKLA PGCEKYNLFE SSIRKTLPPA PEIKKRRPPP PIPPEEENTE 

       190        200        210        220        230        240 
EIVVAMYDFQ ATEAHDLRLE RGQEYIILEK NDLHWWRARD KYGWYCRNTN RSKAEQLLRT 

       250        260        270        280        290        300 
EDKEGGFMVR DSSQPGLYTV SLYTKFGGEG SSGFRHYHIK ETATSPKKYY LAEKHAFGSI 

       310        320        330        340        350        360 
PEIIEYHKHN AAGLVTRLRY PVSTKGKNAP TTAGFSYDKW EINPSELTFM RELGSGLFGV 

       370        380        390        400        410        420 
VRLGKWRAQY KVAIKAIREG AMCEEDFIEE AKVMMKLTHP KLVQLYGVCT QQKPIYIVTE 

       430        440        450        460        470        480 
FMERGCLLNF LRQRQGHFSR DMLLSMCQDV CEGMEYLERN SFIHRDLAAR NCLVNEAGVV 

       490        500        510        520        530        540 
KVSDFGMARY VLDDQYTSSS GAKFPVKWCP PEVFNYSRFS SKSDVWSFGV LMWEIFTEGR 

       550        560        570        580        590        600 
MPFEKNTNYE VVTMVTRGHR LHRPKLASKY LYEVMLRCWQ ERPEGRPSFE DLLRTIDELV 


ECEETFGR

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Mix FVB/N EMBL AAH37071.1.
Tissue: Mammary tumor. WAP-TGF alpha model. 7 months old EMBL AAH37071.1.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD EMBL BAE41897.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC037071 mRNA. Translation: AAH37071.1.
AK170588 mRNA. Translation: BAE41897.1.
IPIIPI00420822.
RefSeqNP_001106932.1.
UniGeneMm.319581

3D structure databases

HSSPHSSP built from PDB template 1GL5 based on UniProtKB P24604.
SMRQ8CFK4. Positions 5-145, 154-220, 180-605.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8CFK4.

Genome annotation databases

EnsemblENSMUST00000073843; ENSMUSP00000073509; ENSMUSG00000029217; Mus musculus. [Genome view]
GeneID21682.
UCSCuc008xsf.1. mouse.

Organism-specific databases

CTD21682.
MGIMGI:98662. Tec.

Phylogenomic databases

HOVERGENQ8CFK4.
OrthoDBEOG97WR7S.

Gene expression databases

ArrayExpressQ8CFK4.
BgeeQ8CFK4.
GenevestigatorQ8CFK4.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR011993. PH_type.
IPR001849. Pleckstrin_homology.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR020755. Tyr_kinase_non-rcpt_Txk/Tec.
IPR020635. Tyr_Pkinase_cat_dom.
IPR020685. Tyr_prot_kinase.
IPR008266. Tyr_prot_kinase_AS.
IPR001562. Znf_Btk_motif.
[Graphical view]
Gene3DG3DSA:2.30.29.30. PH_type. 1 hit.
G3DSA:3.30.505.10. SH2. 1 hit.
PANTHERPTHR23256:SF263. Tyr_kinase_non-rcpt_Txk/Tec. 1 hit.
PTHR23256. Tyr_prot_kinase. 1 hit.
PfamPF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00402. TECBTKDOMAIN.
SMARTSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio300992.
SOURCESearch...

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Entry information

Entry nameQ8CFK4_MOUSE
AccessionPrimary (citable) accession number: Q8CFK4
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 9, 2010
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information