Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor IIIB 90 kDa subunit

Gene

Brf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6ZincBy similarity1
Metal bindingi9ZincBy similarity1
Metal bindingi25ZincBy similarity1
Metal bindingi28ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 33TFIIB-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor IIIB 90 kDa subunit
Short name:
TFIIIB90
Short name:
mTFIIIB90
Alternative name(s):
B-related factor 1
Short name:
BRF-1
Gene namesi
Name:Brf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919558 Brf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001193481 – 676Transcription factor IIIB 90 kDa subunitAdd BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei365PhosphothreonineCombined sources1
Modified residuei449PhosphoserineCombined sources1
Modified residuei552PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CFK2
MaxQBiQ8CFK2
PaxDbiQ8CFK2
PRIDEiQ8CFK2

PTM databases

iPTMnetiQ8CFK2
PhosphoSitePlusiQ8CFK2

Interactioni

Subunit structurei

TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts with BDP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011302

Structurei

3D structure databases

ProteinModelPortaliQ8CFK2
SMRiQ8CFK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati91 – 1721Add BLAST82
Repeati185 – 2692Add BLAST85

Sequence similaritiesi

Belongs to the TFIIB family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 33TFIIB-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1598 Eukaryota
COG1405 LUCA
HOGENOMiHOG000198688
HOVERGENiHBG023540
InParanoidiQ8CFK2
PhylomeDBiQ8CFK2

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR029529 Brf1
IPR011665 BRF1_TBP-bd_dom
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR000812 TFIIB
IPR013150 TFIIB_cyclin
IPR013137 Znf_TFIIB
PANTHERiPTHR11618 PTHR11618, 1 hit
PTHR11618:SF4 PTHR11618:SF4, 1 hit
PfamiView protein in Pfam
PF07741 BRF1, 1 hit
PF08271 TF_Zn_Ribbon, 1 hit
PF00382 TFIIB, 2 hits
PRINTSiPR00685 TIFACTORIIB
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS51134 ZF_TFIIB, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CFK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGRVCRGCG GTDIELDAAR GDAVCTGCGS VLEDNIIVSE VQFVENSGGG
60 70 80 90 100
SSAVGQFVSL DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGSQL
110 120 130 140 150
QLNQHCLDTA FNFFKMAVSK HLTRGRKMAH VIAACLYLVC RTEGTPHMLL
160 170 180 190 200
DLSDLLQVNV YVLGKTFLLL ARELCINAPA IDPCLYIPRF AHLLEFGEKN
210 220 230 240 250
HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH DFRRTVKEVI
260 270 280 290 300
SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK
310 320 330 340 350
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GALANLSKDG
360 370 380 390 400
SGEDATSSPR CEEDTEDEEL EAAASHMNKD FYRELLGDDD GSEAAGDPDG
410 420 430 440 450
GSRPLALESL LGPLPTAASL GISDSIRECI SSPSGDPKDS SGDGELDLSG
460 470 480 490 500
IDDLEIDRYI LNESEARVKA ELWMRENAEY LREQKEKEAR IAKEKELGIY
510 520 530 540 550
KEHKPKKSCK RREPILASTA GEAIEKMLEQ KKISSKINYS VLRDLNSKGG
560 570 580 590 600
GSPPRDDSQP PERASTKKLS RRKRATTRNS ADPGTSTGKR LRPLLSAQPA
610 620 630 640 650
KKAAVGEALL LSSPALGAEP VKPSAVLVES GPVPYHPEED ADEEDAEDED
660 670
GEPCVSALQM MGGNDYGCDG DEDDGY
Length:676
Mass (Da):73,799
Last modified:March 1, 2003 - v1
Checksum:i35110297F64E7E7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037224 mRNA Translation: AAH37224.1
CCDSiCCDS49195.1
UniGeneiMm.196721

Similar proteinsi

Entry informationi

Entry nameiTF3B_MOUSE
AccessioniPrimary (citable) accession number: Q8CFK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health