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Protein

Solute carrier family 25 member 45

Gene

Slc25a45

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 45
Gene namesi
Name:Slc25a45
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147731. Slc25a45.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei266 – 28621Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Solute carrier family 25 member 45PRO_0000291827Add
BLAST

Proteomic databases

EPDiQ8CFJ7.
MaxQBiQ8CFJ7.
PaxDbiQ8CFJ7.
PRIDEiQ8CFJ7.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in testis, liver and kidney and low levels in brain, including cortex, cerebellum, hippocampus and hypothalamus, and heart.1 Publication

Gene expression databases

BgeeiQ8CFJ7.
CleanExiMM_SLC25A45.
ExpressionAtlasiQ8CFJ7. baseline and differential.
GenevisibleiQ8CFJ7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025732.

Structurei

3D structure databases

ProteinModelPortaliQ8CFJ7.
SMRiQ8CFJ7. Positions 5-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 8383Solcar 1Add
BLAST
Repeati97 – 19195Solcar 2Add
BLAST
Repeati199 – 28688Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ8CFJ7.
KOiK15123.
OMAiKSRMQMA.
PhylomeDBiQ8CFJ7.
TreeFamiTF351739.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CFJ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVEEFVAGW ISGAVGLVLG HPFDTVKVRL QTQSTYQGIV DCVVKTYRHE
60 70 80 90 100
SVLGFFKGMS FPIASVALVN SVLFGVYSNT LLALTATSHQ ERRAQPPSYT
110 120 130 140 150
NIFIAGCTGG LLQAYCLAPF DLIKVRLQNQ TEPRMQISSS MPRYRGPVHC
160 170 180 190 200
AASILREEGP QGLFRGSWAL VLRDTPTLGM YFVTYEGLCR QYTPEGQNPS
210 220 230 240 250
SATVLVAGGF AGIASWITAT PFDVIKSRMQ MDGLKGRKYG GMLDCMASSF
260 270 280
RQEGIGVFFK GMTLNSARAF PVNAATFLSY EYLLRLWR
Length:288
Mass (Da):31,690
Last modified:March 1, 2003 - v1
Checksum:iD86B0DE50886A11A
GO
Isoform 2 (identifier: Q8CFJ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-212: SATVLVAGGFAG → KWGEVGWGGGTA
     213-288: Missing.

Note: No experimental confirmation available.
Show »
Length:212
Mass (Da):23,243
Checksum:i4C0B08FB5EA2EF54
GO

Sequence cautioni

The sequence AAH22156.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE42082.1 differs from that shown. Reason: Frameshift at position 259. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei201 – 21212SATVL…GGFAG → KWGEVGWGGGTA in isoform 2. 1 PublicationVSP_026250Add
BLAST
Alternative sequencei213 – 28876Missing in isoform 2. 1 PublicationVSP_026251Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133879 mRNA. Translation: BAE21908.1.
AK155754 mRNA. Translation: BAE33419.1.
AK169876 mRNA. Translation: BAE41428.1.
AK170869 mRNA. Translation: BAE42082.1. Frameshift.
BC022156 mRNA. Translation: AAH22156.1. Different initiation.
BC037680 mRNA. Translation: AAH37680.1.
CCDSiCCDS29482.1. [Q8CFJ7-1]
RefSeqiNP_598915.1. NM_134154.3. [Q8CFJ7-1]
XP_006531684.1. XM_006531621.2. [Q8CFJ7-1]
UniGeneiMm.5323.

Genome annotation databases

EnsembliENSMUST00000025732; ENSMUSP00000025732; ENSMUSG00000024818. [Q8CFJ7-1]
ENSMUST00000125114; ENSMUSP00000122076; ENSMUSG00000024818. [Q8CFJ7-2]
ENSMUST00000155697; ENSMUSP00000121596; ENSMUSG00000024818. [Q8CFJ7-1]
GeneIDi107375.
KEGGimmu:107375.
UCSCiuc008gfq.1. mouse. [Q8CFJ7-1]
uc008gfr.1. mouse. [Q8CFJ7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133879 mRNA. Translation: BAE21908.1.
AK155754 mRNA. Translation: BAE33419.1.
AK169876 mRNA. Translation: BAE41428.1.
AK170869 mRNA. Translation: BAE42082.1. Frameshift.
BC022156 mRNA. Translation: AAH22156.1. Different initiation.
BC037680 mRNA. Translation: AAH37680.1.
CCDSiCCDS29482.1. [Q8CFJ7-1]
RefSeqiNP_598915.1. NM_134154.3. [Q8CFJ7-1]
XP_006531684.1. XM_006531621.2. [Q8CFJ7-1]
UniGeneiMm.5323.

3D structure databases

ProteinModelPortaliQ8CFJ7.
SMRiQ8CFJ7. Positions 5-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025732.

Proteomic databases

EPDiQ8CFJ7.
MaxQBiQ8CFJ7.
PaxDbiQ8CFJ7.
PRIDEiQ8CFJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025732; ENSMUSP00000025732; ENSMUSG00000024818. [Q8CFJ7-1]
ENSMUST00000125114; ENSMUSP00000122076; ENSMUSG00000024818. [Q8CFJ7-2]
ENSMUST00000155697; ENSMUSP00000121596; ENSMUSG00000024818. [Q8CFJ7-1]
GeneIDi107375.
KEGGimmu:107375.
UCSCiuc008gfq.1. mouse. [Q8CFJ7-1]
uc008gfr.1. mouse. [Q8CFJ7-2]

Organism-specific databases

CTDi283130.
MGIiMGI:2147731. Slc25a45.

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ8CFJ7.
KOiK15123.
OMAiKSRMQMA.
PhylomeDBiQ8CFJ7.
TreeFamiTF351739.

Miscellaneous databases

PROiQ8CFJ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CFJ7.
CleanExiMM_SLC25A45.
ExpressionAtlasiQ8CFJ7. baseline and differential.
GenevisibleiQ8CFJ7. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Liver and Mammary tumor.
  3. "The human and mouse SLC25A29 mitochondrial transporters rescue the deficient ornithine metabolism in fibroblasts of patients with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome."
    Camacho J.A., Rioseco-Camacho N.
    Pediatr. Res. 66:35-41(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Liver, Pancreas and Testis.

Entry informationi

Entry nameiS2545_MOUSE
AccessioniPrimary (citable) accession number: Q8CFJ7
Secondary accession number(s): Q3TC75, Q3UZE9, Q8VBZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.