Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 25 member 45

Gene

Slc25a45

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 45
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147731 Slc25a45

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei266 – 286Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918271 – 288Solute carrier family 25 member 45Add BLAST288

Proteomic databases

PaxDbiQ8CFJ7
PeptideAtlasiQ8CFJ7
PRIDEiQ8CFJ7

PTM databases

SwissPalmiQ8CFJ7

Expressioni

Tissue specificityi

Widely expressed, with highest levels in testis, liver and kidney and low levels in brain, including cortex, cerebellum, hippocampus and hypothalamus, and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000024818
CleanExiMM_SLC25A45
ExpressionAtlasiQ8CFJ7 baseline and differential
GenevisibleiQ8CFJ7 MM

Interactioni

Protein-protein interaction databases

BioGridi223254, 1 interactor
STRINGi10090.ENSMUSP00000025732

Structurei

3D structure databases

ProteinModelPortaliQ8CFJ7
SMRiQ8CFJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 83Solcar 1Add BLAST83
Repeati97 – 191Solcar 2Add BLAST95
Repeati199 – 286Solcar 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758 Eukaryota
ENOG410XS86 LUCA
GeneTreeiENSGT00700000104295
HOGENOMiHOG000168307
HOVERGENiHBG003500
InParanoidiQ8CFJ7
KOiK15123
OMAiDENHKFR
OrthoDBiEOG091G0HVE
PhylomeDBiQ8CFJ7
TreeFamiTF351739

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CFJ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVEEFVAGW ISGAVGLVLG HPFDTVKVRL QTQSTYQGIV DCVVKTYRHE
60 70 80 90 100
SVLGFFKGMS FPIASVALVN SVLFGVYSNT LLALTATSHQ ERRAQPPSYT
110 120 130 140 150
NIFIAGCTGG LLQAYCLAPF DLIKVRLQNQ TEPRMQISSS MPRYRGPVHC
160 170 180 190 200
AASILREEGP QGLFRGSWAL VLRDTPTLGM YFVTYEGLCR QYTPEGQNPS
210 220 230 240 250
SATVLVAGGF AGIASWITAT PFDVIKSRMQ MDGLKGRKYG GMLDCMASSF
260 270 280
RQEGIGVFFK GMTLNSARAF PVNAATFLSY EYLLRLWR
Length:288
Mass (Da):31,690
Last modified:March 1, 2003 - v1
Checksum:iD86B0DE50886A11A
GO
Isoform 2 (identifier: Q8CFJ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-212: SATVLVAGGFAG → KWGEVGWGGGTA
     213-288: Missing.

Note: No experimental confirmation available.
Show »
Length:212
Mass (Da):23,243
Checksum:i4C0B08FB5EA2EF54
GO

Sequence cautioni

The sequence AAH22156 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE42082 differs from that shown. Reason: Frameshift at position 259.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026250201 – 212SATVL…GGFAG → KWGEVGWGGGTA in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_026251213 – 288Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133879 mRNA Translation: BAE21908.1
AK155754 mRNA Translation: BAE33419.1
AK169876 mRNA Translation: BAE41428.1
AK170869 mRNA Translation: BAE42082.1 Frameshift.
BC022156 mRNA Translation: AAH22156.1 Different initiation.
BC037680 mRNA Translation: AAH37680.1
CCDSiCCDS29482.1 [Q8CFJ7-1]
RefSeqiNP_598915.1, NM_134154.3 [Q8CFJ7-1]
XP_006531684.1, XM_006531621.3 [Q8CFJ7-1]
UniGeneiMm.5323

Genome annotation databases

EnsembliENSMUST00000025732; ENSMUSP00000025732; ENSMUSG00000024818 [Q8CFJ7-1]
ENSMUST00000125114; ENSMUSP00000122076; ENSMUSG00000024818 [Q8CFJ7-2]
ENSMUST00000155697; ENSMUSP00000121596; ENSMUSG00000024818 [Q8CFJ7-1]
GeneIDi107375
KEGGimmu:107375
UCSCiuc008gfq.1 mouse [Q8CFJ7-1]
uc008gfr.1 mouse [Q8CFJ7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS2545_MOUSE
AccessioniPrimary (citable) accession number: Q8CFJ7
Secondary accession number(s): Q3TC75, Q3UZE9, Q8VBZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health