Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8CFG6

- CA2D2_RAT

UniProt

Q8CFG6 - CA2D2_RAT

Protein

Voltage-dependent calcium channel subunit alpha-2/delta-2

Gene

Cacna2d2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi300 – 3001Divalent metal cationBy similarity
    Metal bindingi302 – 3021Divalent metal cationBy similarity
    Metal bindingi304 – 3041Divalent metal cationBy similarity

    GO - Molecular functioni

    1. calcium channel regulator activity Source: RGD
    2. metal ion binding Source: UniProtKB-KW
    3. voltage-gated calcium channel activity Source: RGD

    GO - Biological processi

    1. calcium ion transport Source: RGD

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel subunit alpha-2/delta-2
    Alternative name(s):
    Voltage-gated calcium channel subunit alpha-2/delta-2
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Cacna2d2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi631360. Cacna2d2.

    Subcellular locationi

    Membrane Curated; Single-pass type I membrane protein Curated
    Note: Colocalizes with CACNA1A in lipid raft fractions.By similarity

    GO - Cellular componenti

    1. voltage-gated calcium channel complex Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 11571139Voltage-dependent calcium channel subunit alpha-2/delta-2PRO_0000304643Add
    BLAST
    Chaini19 – 1004986Voltage-dependent calcium channel subunit alpha-2-2Sequence AnalysisPRO_0000304644Add
    BLAST
    Chaini1005 – 1157153Voltage-dependent calcium channel subunit delta-2Sequence AnalysisPRO_0000304645Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi446 ↔ 1104Interchain (between alpha-2-2 and delta-2 chains)By similarity
    Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi543 – 5431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi864 – 8641N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity
    May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8CFG6.
    PRIDEiQ8CFG6.

    Expressioni

    Tissue specificityi

    In heart, it is highly expressed in atrium and at lower level in ventricle.2 Publications

    Gene expression databases

    GenevestigatoriQ8CFG6.

    Interactioni

    Subunit structurei

    Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ8CFG6. 4 interactions.
    STRINGi10116.ENSRNOP00000021216.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CFG6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 11191101ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1141 – 115717CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1120 – 114021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini294 – 472179VWFAPROSITE-ProRule annotationAdd
    BLAST
    Domaini488 – 57790CacheAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi300 – 3045MIDAS-like motif

    Domaini

    The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.By similarity

    Sequence similaritiesi

    Contains 1 cache domain.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG307080.
    HOGENOMiHOG000004860.
    HOVERGENiHBG057779.
    InParanoidiQ8CFG6.
    KOiK04859.
    PhylomeDBiQ8CFG6.

    Family and domain databases

    Gene3Di3.40.50.410. 1 hit.
    InterProiIPR004010. Cache_domain.
    IPR013680. VDCC_a2/dsu.
    IPR013608. VWA_N.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF02743. Cache_1. 1 hit.
    PF08473. VGCC_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    PF08399. VWA_N. 1 hit.
    [Graphical view]
    SMARTiSM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    PROSITEiPS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CFG6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVPARTCGA SWPGPVRTAR PWPGRGPRPC PDPRGPASGP ARPLLLLLPP     50
    LLLLPLLTAP GASAYSFPQQ HTMQHWARRL EQEIDGVMRI FGGVQQLREI 100
    YKDNRNLFDV QENEPQKLVE KVAGDIESLL DRKVQALKRL ADAAENFQKA 150
    HRWQDNIKEE DIMYYDAKAD AELDDPESED MERGSKTSAL RLDFIEEPNF 200
    KNKVNYSYTA VQIPTDIYKG STVILNELNW TEALENVFIE NRRQDPTLLW 250
    QVFGSATGVT RYYPATPWRA PKKIDLYDVR RRPWYIQGAS SPKDMVIIVD 300
    VSGSVSGLTL KLMKTSVCEM LDTLSDDDYV NVASFNEKAQ PVSCFTHLVQ 350
    ANVRNKKVFK EAVQGMVAKG TTGYKAGFEY AFDQLQNSNI TRANCNKMIM 400
    MFTDGGEDRV QDVFEKYNWP NRTVRVFTFS VGQHNYDVTP LQWMACTNKG 450
    YYFEIPSIGA IRINTQEYLD VLGRPMVLAG KDAKQVQWTN VYEDALGLGL 500
    VVTGTLPVFN LTQDGPGDKK NQLILGVMGI DVALNDIKRL TPNYTLGANG 550
    YVFAIDLNGY VLLHPNLKPQ ITNFREPVTL DFLDAELEDE NKEEIRRSMI 600
    DGDKGHKQIR TLVKSLDERY IDEVIRNYTW VPIRSTNYSL GLVLPPYSTY 650
    YLQANLSDQI LQVKLPISKL KDFEFLLPSS FESEGHVFIA PREYCKDLNA 700
    SDNNTEFLKN FIELMEKVTP DSKQCNNFLL HNLILDTGIT QQLVERVWRD 750
    QDLNTYSLLA VFAATDGGIT RVFPNKAAED WTENPEPFNA SFYRRSLDNR 800
    GYIFKPPHQD SLLRPLELEN DTVGVLVSTA VELSLGRRTL RPAVVGVKLD 850
    LEAWAEKFKV LASNRTHQDQ PQKQCGPSSH CEMDCEVNNE DLLCVLIDDG 900
    GFLVLSNQNH QWDQVGRFFS EVDANLMLAL YNNSFYTRKE SYDYQAACAP 950
    QPPGNLGAAP RGVFVPTIAD FLNLAWWTSA AAWSLFQQLL YGLIYHSWFQ 1000
    ADPAEAEGSP ETRESSCVMK QTQYYFGSVN ASYNAIIDCG NCSRLFHAQR 1050
    LTNTNLLFVV AEKPLCSQCE VGRLLQKETH CPADGPEQCE LVQRPRYRTG 1100
    PHICFDYNAT EDTSDCGRGA SFPPSLGVLV SLQLLLLLGL PPRPQPQIHS 1150
    FTPSRRL 1157
    Length:1,157
    Mass (Da):130,776
    Last modified:March 1, 2003 - v1
    Checksum:i5E81446A1E1EBAF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF486277 mRNA. Translation: AAO14653.1.
    RefSeqiNP_783182.1. NM_175592.2.
    UniGeneiRn.91563.

    Genome annotation databases

    GeneIDi300992.
    KEGGirno:300992.
    UCSCiRGD:631360. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF486277 mRNA. Translation: AAO14653.1 .
    RefSeqi NP_783182.1. NM_175592.2.
    UniGenei Rn.91563.

    3D structure databases

    ProteinModelPortali Q8CFG6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CFG6. 4 interactions.
    STRINGi 10116.ENSRNOP00000021216.

    Chemistry

    BindingDBi Q8CFG6.

    Proteomic databases

    PaxDbi Q8CFG6.
    PRIDEi Q8CFG6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 300992.
    KEGGi rno:300992.
    UCSCi RGD:631360. rat.

    Organism-specific databases

    CTDi 9254.
    RGDi 631360. Cacna2d2.

    Phylogenomic databases

    eggNOGi NOG307080.
    HOGENOMi HOG000004860.
    HOVERGENi HBG057779.
    InParanoidi Q8CFG6.
    KOi K04859.
    PhylomeDBi Q8CFG6.

    Miscellaneous databases

    NextBioi 647862.
    PROi Q8CFG6.

    Gene expression databases

    Genevestigatori Q8CFG6.

    Family and domain databases

    Gene3Di 3.40.50.410. 1 hit.
    InterProi IPR004010. Cache_domain.
    IPR013680. VDCC_a2/dsu.
    IPR013608. VWA_N.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF02743. Cache_1. 1 hit.
    PF08473. VGCC_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    PF08399. VWA_N. 1 hit.
    [Graphical view ]
    SMARTi SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    PROSITEi PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of calcium channel alpha(2)delta-subunits from rat atria and the differential regulation of their expression by IGF-1."
      Chu P.-J., Best P.M.
      J. Mol. Cell. Cardiol. 35:207-215(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Heart atrium.
    2. "Molecular and electrophysiological differences in the L-type Ca2+ channel of the atrium and ventricle of rat hearts."
      Hatano S., Yamashita T., Sekiguchi A., Iwasaki Y., Nakazawa K., Sagara K., Iinuma H., Aizawa T., Fu L.-T.
      Jpn. Circ. J. 70:610-614(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCA2D2_RAT
    AccessioniPrimary (citable) accession number: Q8CFG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Binds gabapentin, an antiepileptic drug.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3