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Q8CFG6

- CA2D2_RAT

UniProt

Q8CFG6 - CA2D2_RAT

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Protein
Voltage-dependent calcium channel subunit alpha-2/delta-2
Gene
Cacna2d2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi300 – 3001Divalent metal cation By similarity
Metal bindingi302 – 3021Divalent metal cation By similarity
Metal bindingi304 – 3041Divalent metal cation By similarity

GO - Molecular functioni

  1. calcium channel regulator activity Source: RGD
  2. metal ion binding Source: UniProtKB-KW
  3. voltage-gated calcium channel activity Source: RGD

GO - Biological processi

  1. calcium ion transport Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel subunit alpha-2/delta-2
Alternative name(s):
Voltage-gated calcium channel subunit alpha-2/delta-2
Cleaved into the following 2 chains:
Gene namesi
Name:Cacna2d2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi631360. Cacna2d2.

Subcellular locationi

Membrane; Single-pass type I membrane protein Reviewed prediction
Note: Colocalizes with CACNA1A in lipid raft fractions By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 11191101Extracellular Reviewed prediction
Add
BLAST
Transmembranei1120 – 114021Helical; Reviewed prediction
Add
BLAST
Topological domaini1141 – 115717Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. voltage-gated calcium channel complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 11571139Voltage-dependent calcium channel subunit alpha-2/delta-2
PRO_0000304643Add
BLAST
Chaini19 – 1004986Voltage-dependent calcium channel subunit alpha-2-2 Reviewed prediction
PRO_0000304644Add
BLAST
Chaini1005 – 1157153Voltage-dependent calcium channel subunit delta-2 Reviewed prediction
PRO_0000304645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi205 – 2051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi389 – 3891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi421 – 4211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi446 ↔ 1104Interchain (between alpha-2-2 and delta-2 chains) By similarity
Glycosylationi510 – 5101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi543 – 5431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi627 – 6271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi864 – 8641N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.
May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8CFG6.
PRIDEiQ8CFG6.

Expressioni

Tissue specificityi

In heart, it is highly expressed in atrium and at lower level in ventricle.2 Publications

Gene expression databases

GenevestigatoriQ8CFG6.

Interactioni

Subunit structurei

Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio By similarity.

Protein-protein interaction databases

IntActiQ8CFG6. 4 interactions.
STRINGi10116.ENSRNOP00000021216.

Structurei

3D structure databases

ProteinModelPortaliQ8CFG6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini294 – 472179VWFA
Add
BLAST
Domaini488 – 57790Cache
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi300 – 3045MIDAS-like motif

Domaini

The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch By similarity.

Sequence similaritiesi

Contains 1 cache domain.
Contains 1 VWFA domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307080.
HOGENOMiHOG000004860.
HOVERGENiHBG057779.
InParanoidiQ8CFG6.
KOiK04859.
PhylomeDBiQ8CFG6.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR004010. Cache_domain.
IPR013680. VDCC_a2/dsu.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view]
PfamiPF02743. Cache_1. 1 hit.
PF08473. VGCC_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CFG6-1 [UniParc]FASTAAdd to Basket

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MAVPARTCGA SWPGPVRTAR PWPGRGPRPC PDPRGPASGP ARPLLLLLPP     50
LLLLPLLTAP GASAYSFPQQ HTMQHWARRL EQEIDGVMRI FGGVQQLREI 100
YKDNRNLFDV QENEPQKLVE KVAGDIESLL DRKVQALKRL ADAAENFQKA 150
HRWQDNIKEE DIMYYDAKAD AELDDPESED MERGSKTSAL RLDFIEEPNF 200
KNKVNYSYTA VQIPTDIYKG STVILNELNW TEALENVFIE NRRQDPTLLW 250
QVFGSATGVT RYYPATPWRA PKKIDLYDVR RRPWYIQGAS SPKDMVIIVD 300
VSGSVSGLTL KLMKTSVCEM LDTLSDDDYV NVASFNEKAQ PVSCFTHLVQ 350
ANVRNKKVFK EAVQGMVAKG TTGYKAGFEY AFDQLQNSNI TRANCNKMIM 400
MFTDGGEDRV QDVFEKYNWP NRTVRVFTFS VGQHNYDVTP LQWMACTNKG 450
YYFEIPSIGA IRINTQEYLD VLGRPMVLAG KDAKQVQWTN VYEDALGLGL 500
VVTGTLPVFN LTQDGPGDKK NQLILGVMGI DVALNDIKRL TPNYTLGANG 550
YVFAIDLNGY VLLHPNLKPQ ITNFREPVTL DFLDAELEDE NKEEIRRSMI 600
DGDKGHKQIR TLVKSLDERY IDEVIRNYTW VPIRSTNYSL GLVLPPYSTY 650
YLQANLSDQI LQVKLPISKL KDFEFLLPSS FESEGHVFIA PREYCKDLNA 700
SDNNTEFLKN FIELMEKVTP DSKQCNNFLL HNLILDTGIT QQLVERVWRD 750
QDLNTYSLLA VFAATDGGIT RVFPNKAAED WTENPEPFNA SFYRRSLDNR 800
GYIFKPPHQD SLLRPLELEN DTVGVLVSTA VELSLGRRTL RPAVVGVKLD 850
LEAWAEKFKV LASNRTHQDQ PQKQCGPSSH CEMDCEVNNE DLLCVLIDDG 900
GFLVLSNQNH QWDQVGRFFS EVDANLMLAL YNNSFYTRKE SYDYQAACAP 950
QPPGNLGAAP RGVFVPTIAD FLNLAWWTSA AAWSLFQQLL YGLIYHSWFQ 1000
ADPAEAEGSP ETRESSCVMK QTQYYFGSVN ASYNAIIDCG NCSRLFHAQR 1050
LTNTNLLFVV AEKPLCSQCE VGRLLQKETH CPADGPEQCE LVQRPRYRTG 1100
PHICFDYNAT EDTSDCGRGA SFPPSLGVLV SLQLLLLLGL PPRPQPQIHS 1150
FTPSRRL 1157
Length:1,157
Mass (Da):130,776
Last modified:March 1, 2003 - v1
Checksum:i5E81446A1E1EBAF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF486277 mRNA. Translation: AAO14653.1.
RefSeqiNP_783182.1. NM_175592.2.
UniGeneiRn.91563.

Genome annotation databases

GeneIDi300992.
KEGGirno:300992.
UCSCiRGD:631360. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF486277 mRNA. Translation: AAO14653.1 .
RefSeqi NP_783182.1. NM_175592.2.
UniGenei Rn.91563.

3D structure databases

ProteinModelPortali Q8CFG6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CFG6. 4 interactions.
STRINGi 10116.ENSRNOP00000021216.

Chemistry

BindingDBi Q8CFG6.

Proteomic databases

PaxDbi Q8CFG6.
PRIDEi Q8CFG6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 300992.
KEGGi rno:300992.
UCSCi RGD:631360. rat.

Organism-specific databases

CTDi 9254.
RGDi 631360. Cacna2d2.

Phylogenomic databases

eggNOGi NOG307080.
HOGENOMi HOG000004860.
HOVERGENi HBG057779.
InParanoidi Q8CFG6.
KOi K04859.
PhylomeDBi Q8CFG6.

Miscellaneous databases

NextBioi 647862.
PROi Q8CFG6.

Gene expression databases

Genevestigatori Q8CFG6.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR004010. Cache_domain.
IPR013680. VDCC_a2/dsu.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF02743. Cache_1. 1 hit.
PF08473. VGCC_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view ]
SMARTi SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of calcium channel alpha(2)delta-subunits from rat atria and the differential regulation of their expression by IGF-1."
    Chu P.-J., Best P.M.
    J. Mol. Cell. Cardiol. 35:207-215(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Heart atrium.
  2. "Molecular and electrophysiological differences in the L-type Ca2+ channel of the atrium and ventricle of rat hearts."
    Hatano S., Yamashita T., Sekiguchi A., Iwasaki Y., Nakazawa K., Sagara K., Iinuma H., Aizawa T., Fu L.-T.
    Jpn. Circ. J. 70:610-614(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCA2D2_RAT
AccessioniPrimary (citable) accession number: Q8CFG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds gabapentin, an antiepileptic drug By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi