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Protein

Doublesex- and mab-3-related transcription factor A1

Gene

Dmrta1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi86 – 13348DMPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein homodimerization activity Source: MGI
  • sequence-specific DNA binding Source: MGI
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • male mating behavior Source: MGI
  • ovarian follicle development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Doublesex- and mab-3-related transcription factor A1
Alternative name(s):
Doublesex- and mab-3-related transcription factor 4
Gene namesi
Name:Dmrta1
Synonyms:Dmrt4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2653627. Dmrta1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutant animals are viable and fertile, with no obvious anatomical defects. Ovaries from mutant females may have an elevated number of polyovular follicles. 25% of mutant males consistently exhibit copulatory behavior toward other males.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Doublesex- and mab-3-related transcription factor A1PRO_0000242701Add
BLAST

Proteomic databases

MaxQBiQ8CFG4.
PaxDbiQ8CFG4.
PRIDEiQ8CFG4.

PTM databases

PhosphoSiteiQ8CFG4.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in ovary, testis, epididymis, preputial gland, vomeronasal organ, liver, salivary glands and heart. Also expressed throughout the brain with highest levels in the olfactory bulbs and medulla. Detected at similar levels in gonads of both sexes.2 Publications

Developmental stagei

Expressed in gonads from 11.5 dpc onward. Expressed in the genital ridge at 11.5 dpc and in the seminiferous tubules at 12.5 dpc.1 Publication

Gene expression databases

BgeeiQ8CFG4.
GenevisibleiQ8CFG4. MM.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057488.

Structurei

3D structure databases

ProteinModelPortaliQ8CFG4.
SMRiQ8CFG4. Positions 81-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DMRT family.Curated
Contains 1 DM DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3815. Eukaryota.
ENOG410XSK9. LUCA.
GeneTreeiENSGT00550000074486.
HOGENOMiHOG000231615.
HOVERGENiHBG058695.
InParanoidiQ8CFG4.
KOiK19491.
OMAiGRLYFRP.
OrthoDBiEOG7TXKGH.
PhylomeDBiQ8CFG4.
TreeFamiTF317837.

Family and domain databases

Gene3Di4.10.1040.10. 1 hit.
InterProiIPR001275. DM_DNA-bd.
IPR005173. DMA.
IPR026607. DMRT/dsx/mab-3.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR12322. PTHR12322. 1 hit.
PfamiPF00751. DM. 1 hit.
PF03474. DMA. 1 hit.
[Graphical view]
SMARTiSM00301. DM. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF82927. SSF82927. 1 hit.
PROSITEiPS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CFG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLPHGRRD RSGGCRPHLA PGRAAAPASA ARSVSSGIPV SATFLRPPGL
60 70 80 90 100
FLRSTASSGR AGCAPGPGLD RALGAVGCGY PRTPKCARCR NHGVVSALKG
110 120 130 140 150
HKRFCRWRDC ACAKCTLIAE RQRVMAAQVA LRRQQAQEES EARGLHRLLY
160 170 180 190 200
QGSSGSGAQA SGGSGRTESP QVLNNPMAVA VLGAGASRHP GSRSVPTFEV
210 220 230 240 250
FQQDYADRKQ EPKQRNCESC QSRQEEPVSN THHHSLGSSK GNVTVEKQGF
260 270 280 290 300
MSSIPEHPDK STIILSPCPT DQSGGEDSPR SFSSSDLESG NESEWARDYI
310 320 330 340 350
ATRASLSTVT SRPRDPLGIL TRIFPGYKHS RLEGILQFCK GDVVQAIEQI
360 370 380 390 400
LNGREHKPDC RDLARADLEN AAFQRASDFS LAGIGFGTLS NKSALSPLEA
410 420 430 440 450
ASAAYGGDST LYSFNPRLAF SPLRLAYSSP GRALSGFVSP YLTPGLVPAL
460 470 480 490
PFRPTLDYAF PGMIREPSHL PSKHLVAGGR LYFRPNQEHL
Length:490
Mass (Da):52,653
Last modified:March 1, 2003 - v1
Checksum:iEF52FF88E2D39D0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542047 mRNA. Translation: AAN77234.1.
AL772403 Genomic DNA. Translation: CAM24936.1.
CCDSiCCDS18352.1.
RefSeqiNP_783578.1. NM_175647.3.
UniGeneiMm.130167.

Genome annotation databases

EnsembliENSMUST00000052478; ENSMUSP00000057488; ENSMUSG00000043753.
GeneIDi242523.
KEGGimmu:242523.
UCSCiuc008tol.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542047 mRNA. Translation: AAN77234.1.
AL772403 Genomic DNA. Translation: CAM24936.1.
CCDSiCCDS18352.1.
RefSeqiNP_783578.1. NM_175647.3.
UniGeneiMm.130167.

3D structure databases

ProteinModelPortaliQ8CFG4.
SMRiQ8CFG4. Positions 81-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057488.

PTM databases

PhosphoSiteiQ8CFG4.

Proteomic databases

MaxQBiQ8CFG4.
PaxDbiQ8CFG4.
PRIDEiQ8CFG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052478; ENSMUSP00000057488; ENSMUSG00000043753.
GeneIDi242523.
KEGGimmu:242523.
UCSCiuc008tol.1. mouse.

Organism-specific databases

CTDi63951.
MGIiMGI:2653627. Dmrta1.

Phylogenomic databases

eggNOGiKOG3815. Eukaryota.
ENOG410XSK9. LUCA.
GeneTreeiENSGT00550000074486.
HOGENOMiHOG000231615.
HOVERGENiHBG058695.
InParanoidiQ8CFG4.
KOiK19491.
OMAiGRLYFRP.
OrthoDBiEOG7TXKGH.
PhylomeDBiQ8CFG4.
TreeFamiTF317837.

Miscellaneous databases

NextBioi385396.
PROiQ8CFG4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CFG4.
GenevisibleiQ8CFG4. MM.

Family and domain databases

Gene3Di4.10.1040.10. 1 hit.
InterProiIPR001275. DM_DNA-bd.
IPR005173. DMA.
IPR026607. DMRT/dsx/mab-3.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR12322. PTHR12322. 1 hit.
PfamiPF00751. DM. 1 hit.
PF03474. DMA. 1 hit.
[Graphical view]
SMARTiSM00301. DM. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF82927. SSF82927. 1 hit.
PROSITEiPS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad."
    Kim S., Kettlewell J.R., Anderson R.C., Bardwell V.J., Zarkower D.
    Gene Expr. Patterns 3:77-82(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Spinal ganglion.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Mice mutant in the DM domain gene Dmrt4 are viable and fertile but have polyovular follicles."
    Balciuniene J., Bardwell V.J., Zarkower D.
    Mol. Cell. Biol. 26:8984-8991(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiDMRTA_MOUSE
AccessioniPrimary (citable) accession number: Q8CFG4
Secondary accession number(s): A2AL09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.