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Q8CFF0 (PAR11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly [ADP-ribose] polymerase 11
Short name=PARP-11
EC=2.4.2.30
Gene names
Name:Parp11
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Sequence similarities

Contains 1 PARP catalytic domain.

Contains 1 WWE domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   LigandNAD
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionNAD+ ADP-ribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8CFF0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8CFF0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8CFF0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     177-331: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Poly [ADP-ribose] polymerase 11
PRO_0000273420

Regions

Domain15 – 9985WWE
Domain116 – 331216PARP catalytic

Natural variations

Alternative sequence1 – 8383Missing in isoform 2.
VSP_022557
Alternative sequence177 – 331155Missing in isoform 3.
VSP_022558

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 70CF1926D8363C8F

FASTA33138,737
        10         20         30         40         50         60 
MFHKTEEFFP KKTDSDVDDM DTSDTQWGWF YLAECGKWHM FQPDTNIQCS VSSEDIEKSF 

        70         80         90        100        110        120 
KTNPCGSISF TTSKFSYKID FAEMKQMNLV TGKQRLIKRA PFSISAFSYI CENEAIPMPT 

       130        140        150        160        170        180 
HWENVNPDVP YQLVSLQNQT HEYNEVASLF GKTMDRNRIK RIQRIQNLDL WEFFCRKKAQ 

       190        200        210        220        230        240 
LKKKRGVPQI NEQMLFHGTS SEFVEAICIH NFDWRINGVH GAVFGKGTYF ARDAAYSSRF 

       250        260        270        280        290        300 
CKDDIKHGNT FQIHGVSLQQ RHLFRTYKSM FLARVLIGDY INGDSKYMRP PSKDGSYVNL 

       310        320        330 
YDSCVDDTWN PKIFVVFDAN QIYPEYLIDF H

« Hide

Isoform 2 [UniParc].

Checksum: 533F35E23F303A69
Show »

FASTA24829,053
Isoform 3 [UniParc].

Checksum: 0B286F82B97AA7B3
Show »

FASTA17620,772

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Strain: C57BL/6J.
Tissue: Bone marrow and Pituitary.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK133697 mRNA. Translation: BAE21788.1.
AK151393 mRNA. Translation: BAE30362.1.
BC040269 mRNA. Translation: AAH40269.1.
IPIIPI00229292.
IPI00828890.
IPI00828944.
RefSeqNP_852067.1. NM_181402.3.
UniGeneMm.110818.

3D structure databases

ProteinModelPortalQ8CFF0.
SMRQ8CFF0. Positions 13-103, 130-330.
ModBaseSearch...

Proteomic databases

PRIDEQ8CFF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000039680; ENSMUSP00000036127; ENSMUSG00000037997.
ENSMUST00000112191; ENSMUSP00000107810; ENSMUSG00000037997.
ENSMUST00000112193; ENSMUSP00000107812; ENSMUSG00000037997.
ENSMUST00000112195; ENSMUSP00000107814; ENSMUSG00000037997.
GeneID101187.
KEGGmmu:101187.
UCSCuc009dvw.1. mouse.
uc009dvx.1. mouse.
uc009dvy.1. mouse.

Organism-specific databases

CTD57097.
MGIMGI:2141505. Parp11.

Phylogenomic databases

eggNOGroNOG14478.
GeneTreeENSGT00600000084343.
HOGENOMHBG446356.
HOVERGENHBG056772.
InParanoidQ8CFF0.
OMAFCRKKAQ.
OrthoDBEOG46DM35.
PhylomeDBQ8CFF0.

Gene expression databases

ArrayExpressQ8CFF0.
BgeeQ8CFF0.
CleanExMM_PARP11.
GenevestigatorQ8CFF0.

Family and domain databases

InterProIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
[Graphical view]
KOK15259.
PfamPF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
[Graphical view]
PROSITEPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio354804.
SOURCESearch...

Entry information

Entry namePAR11_MOUSE
AccessionPrimary (citable) accession number: Q8CFF0
Secondary accession number(s): Q3UAF2, Q3UZR7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: November 16, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents