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Protein

Sodium-coupled neutral amino acid transporter 2

Gene

Slc38a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.1 Publication

Enzyme regulationi

Inhibited by N-methyl-D-glucamine and choline.By similarity

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: MGI
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-210500. Glutamate Neurotransmitter Release Cycle.
R-MMU-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 2
Alternative name(s):
Amino acid transporter A2
Solute carrier family 38 member 2
System A amino acid transporter 2
System A transporter 1
System N amino acid transporter 2
Gene namesi
Name:Slc38a2
Synonyms:Ata2, Kiaa1382, Sat2, Snat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915010. Slc38a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 102ExtracellularSequence analysis5
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 158CytoplasmicSequence analysisAdd BLAST35
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 188ExtracellularSequence analysis9
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 217CytoplasmicSequence analysis8
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 289ExtracellularSequence analysisAdd BLAST51
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 326CytoplasmicSequence analysisAdd BLAST16
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 368ExtracellularSequence analysisAdd BLAST21
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 410CytoplasmicSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 433ExtracellularSequence analysis2
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Topological domaini455 – 471CytoplasmicSequence analysisAdd BLAST17
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 504ExtracellularSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113701 – 504Sodium-coupled neutral amino acid transporter 2Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei21PhosphoserineCombined sources1
Modified residuei22PhosphoserineBy similarity1
Modified residuei55PhosphoserineCombined sources1
Glycosylationi254N-linked (GlcNAc...)Sequence analysis1
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8CFE6.
MaxQBiQ8CFE6.
PaxDbiQ8CFE6.
PeptideAtlasiQ8CFE6.
PRIDEiQ8CFE6.

PTM databases

iPTMnetiQ8CFE6.
PhosphoSitePlusiQ8CFE6.
SwissPalmiQ8CFE6.

Expressioni

Tissue specificityi

Expressed in cerebral and cerebellar astrocytes and neurons.1 Publication

Inductioni

Up-regulated upon amino acid deprivation.1 Publication

Gene expression databases

BgeeiENSMUSG00000022462.
CleanExiMM_SAT2.
MM_SLC38A2.
GenevisibleiQ8CFE6. MM.

Interactioni

Protein-protein interaction databases

BioGridi212424. 2 interactors.
STRINGi10090.ENSMUSP00000023099.

Structurei

3D structure databases

ProteinModelPortaliQ8CFE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 96Regulates protein turnover upon amino acid deprivationBy similarityAdd BLAST96

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOVERGENiHBG059571.
InParanoidiQ8CFE6.
KOiK14207.
OMAiKSHYADM.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ8CFE6.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CFE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN
60 70 80 90 100
FLLESNLGKK KYETDFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG
110 120 130 140 150
IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGHK AYGLAGKLAA
160 170 180 190 200
SGSITMQNIG AMSSYLFIVK YELPLVIKAL MNIEDTNGLW YLNGDYLVLL
210 220 230 240 250
VSLVLILPLS LLRNLGYLGY TSGLSLLCMI FFLIVVICKK FQIPCPVEAA
260 270 280 290 300
LVANETVNGT FTQAALALAF NSTADDACRP RYFIFNSQTV YAVPILTFSF
310 320 330 340 350
VCHPAVLPIY EELKSRSRRR MMNVSKISFF AMFLMYLLAA LFGYLTFYGH
360 370 380 390 400
VESELLHTYS EIVGTDILLL VVRLAVLVAV TLTVPVVIFP IRSSVTHLLC
410 420 430 440 450
PTKEFSWLRH SIITVTILSF TNLLVIFVPT IRDIFGFIGA SAAAMLIFIL
460 470 480 490 500
PSAFYIKLVK KEPMRSVQKI GALCFLLSGI VVMIGSMGLI VLDWVHDASA

AGGH
Length:504
Mass (Da):55,503
Last modified:March 1, 2003 - v1
Checksum:iE69A497E350B5AEF
GO

Sequence cautioni

The sequence BAC98152 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti245C → R in BAC27479 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129342 mRNA. Translation: BAC98152.1. Different initiation.
AK031615 mRNA. Translation: BAC27479.1.
AK033812 mRNA. Translation: BAC28483.1.
AK169378 mRNA. Translation: BAE41125.1.
BC041108 mRNA. Translation: AAH41108.1.
BC048178 mRNA. Translation: AAH48178.1.
BC049271 mRNA. Translation: AAH49271.1.
BC057454 mRNA. Translation: AAH57454.1.
CCDSiCCDS27778.1.
RefSeqiNP_780330.2. NM_175121.3.
UniGeneiMm.46754.

Genome annotation databases

EnsembliENSMUST00000023099; ENSMUSP00000023099; ENSMUSG00000022462.
GeneIDi67760.
KEGGimmu:67760.
UCSCiuc007xkm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129342 mRNA. Translation: BAC98152.1. Different initiation.
AK031615 mRNA. Translation: BAC27479.1.
AK033812 mRNA. Translation: BAC28483.1.
AK169378 mRNA. Translation: BAE41125.1.
BC041108 mRNA. Translation: AAH41108.1.
BC048178 mRNA. Translation: AAH48178.1.
BC049271 mRNA. Translation: AAH49271.1.
BC057454 mRNA. Translation: AAH57454.1.
CCDSiCCDS27778.1.
RefSeqiNP_780330.2. NM_175121.3.
UniGeneiMm.46754.

3D structure databases

ProteinModelPortaliQ8CFE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212424. 2 interactors.
STRINGi10090.ENSMUSP00000023099.

PTM databases

iPTMnetiQ8CFE6.
PhosphoSitePlusiQ8CFE6.
SwissPalmiQ8CFE6.

Proteomic databases

EPDiQ8CFE6.
MaxQBiQ8CFE6.
PaxDbiQ8CFE6.
PeptideAtlasiQ8CFE6.
PRIDEiQ8CFE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023099; ENSMUSP00000023099; ENSMUSG00000022462.
GeneIDi67760.
KEGGimmu:67760.
UCSCiuc007xkm.1. mouse.

Organism-specific databases

CTDi54407.
MGIiMGI:1915010. Slc38a2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOVERGENiHBG059571.
InParanoidiQ8CFE6.
KOiK14207.
OMAiKSHYADM.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ8CFE6.
TreeFamiTF328787.

Enzyme and pathway databases

ReactomeiR-MMU-210500. Glutamate Neurotransmitter Release Cycle.
R-MMU-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiQ8CFE6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022462.
CleanExiMM_SAT2.
MM_SLC38A2.
GenevisibleiQ8CFE6. MM.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS38A2_MOUSE
AccessioniPrimary (citable) accession number: Q8CFE6
Secondary accession number(s): Q3TEX3
, Q6PFR1, Q6ZPS7, Q810U9, Q8CC66, Q8CD21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.