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Q8CFE6

- S38A2_MOUSE

UniProt

Q8CFE6 - S38A2_MOUSE

Protein

Sodium-coupled neutral amino acid transporter 2

Gene

Slc38a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.1 Publication

    Enzyme regulationi

    Inhibited by N-methyl-D-glucamine and choline.By similarity

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: MGI
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. amino acid transmembrane transport Source: GOC
    2. amino acid transport Source: MGI
    3. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 2
    Alternative name(s):
    Amino acid transporter A2
    Solute carrier family 38 member 2
    System A amino acid transporter 2
    System A transporter 1
    System N amino acid transporter 2
    Gene namesi
    Name:Slc38a2
    Synonyms:Ata2, Kiaa1382, Sat2, Snat2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1915010. Slc38a2.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
    Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Sodium-coupled neutral amino acid transporter 2PRO_0000311370Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121PhosphoserineBy similarity
    Modified residuei22 – 221PhosphoserineBy similarity
    Modified residuei55 – 551Phosphoserine1 Publication
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ8CFE6.
    PRIDEiQ8CFE6.

    PTM databases

    PhosphoSiteiQ8CFE6.

    Expressioni

    Tissue specificityi

    Expressed in cerebral and cerebellar astrocytes and neurons.1 Publication

    Inductioni

    Up-regulated upon amino acid deprivation.1 Publication

    Gene expression databases

    BgeeiQ8CFE6.
    CleanExiMM_SAT2.
    MM_SLC38A2.
    GenevestigatoriQ8CFE6.

    Interactioni

    Protein-protein interaction databases

    BioGridi212424. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CFE6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7676CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 1025ExtracellularSequence Analysis
    Topological domaini124 – 15835CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 1889ExtracellularSequence Analysis
    Topological domaini210 – 2178CytoplasmicSequence Analysis
    Topological domaini239 – 28951ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini311 – 32616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini348 – 36821ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini390 – 41021CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini432 – 4332ExtracellularSequence Analysis
    Topological domaini455 – 47117CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini493 – 50412ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei369 – 38921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei411 – 43121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei434 – 45421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei472 – 49221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9696Regulates protein turnover upon amino acid deprivationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG236441.
    GeneTreeiENSGT00650000093166.
    HOVERGENiHBG059571.
    InParanoidiQ8CFE6.
    KOiK14207.
    OMAiMFLMYLF.
    OrthoDBiEOG7WHH9J.
    PhylomeDBiQ8CFE6.
    TreeFamiTF328787.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CFE6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKTEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN    50
    FLLESNLGKK KYETDFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG 100
    IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGHK AYGLAGKLAA 150
    SGSITMQNIG AMSSYLFIVK YELPLVIKAL MNIEDTNGLW YLNGDYLVLL 200
    VSLVLILPLS LLRNLGYLGY TSGLSLLCMI FFLIVVICKK FQIPCPVEAA 250
    LVANETVNGT FTQAALALAF NSTADDACRP RYFIFNSQTV YAVPILTFSF 300
    VCHPAVLPIY EELKSRSRRR MMNVSKISFF AMFLMYLLAA LFGYLTFYGH 350
    VESELLHTYS EIVGTDILLL VVRLAVLVAV TLTVPVVIFP IRSSVTHLLC 400
    PTKEFSWLRH SIITVTILSF TNLLVIFVPT IRDIFGFIGA SAAAMLIFIL 450
    PSAFYIKLVK KEPMRSVQKI GALCFLLSGI VVMIGSMGLI VLDWVHDASA 500
    AGGH 504
    Length:504
    Mass (Da):55,503
    Last modified:March 1, 2003 - v1
    Checksum:iE69A497E350B5AEF
    GO

    Sequence cautioni

    The sequence BAC98152.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti245 – 2451C → R in BAC27479. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129342 mRNA. Translation: BAC98152.1. Different initiation.
    AK031615 mRNA. Translation: BAC27479.1.
    AK033812 mRNA. Translation: BAC28483.1.
    AK169378 mRNA. Translation: BAE41125.1.
    BC041108 mRNA. Translation: AAH41108.1.
    BC048178 mRNA. Translation: AAH48178.1.
    BC049271 mRNA. Translation: AAH49271.1.
    BC057454 mRNA. Translation: AAH57454.1.
    CCDSiCCDS27778.1.
    RefSeqiNP_780330.2. NM_175121.3.
    UniGeneiMm.46754.

    Genome annotation databases

    EnsembliENSMUST00000023099; ENSMUSP00000023099; ENSMUSG00000022462.
    GeneIDi67760.
    KEGGimmu:67760.
    UCSCiuc007xkm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129342 mRNA. Translation: BAC98152.1 . Different initiation.
    AK031615 mRNA. Translation: BAC27479.1 .
    AK033812 mRNA. Translation: BAC28483.1 .
    AK169378 mRNA. Translation: BAE41125.1 .
    BC041108 mRNA. Translation: AAH41108.1 .
    BC048178 mRNA. Translation: AAH48178.1 .
    BC049271 mRNA. Translation: AAH49271.1 .
    BC057454 mRNA. Translation: AAH57454.1 .
    CCDSi CCDS27778.1.
    RefSeqi NP_780330.2. NM_175121.3.
    UniGenei Mm.46754.

    3D structure databases

    ProteinModelPortali Q8CFE6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212424. 1 interaction.

    PTM databases

    PhosphoSitei Q8CFE6.

    Proteomic databases

    PaxDbi Q8CFE6.
    PRIDEi Q8CFE6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023099 ; ENSMUSP00000023099 ; ENSMUSG00000022462 .
    GeneIDi 67760.
    KEGGi mmu:67760.
    UCSCi uc007xkm.1. mouse.

    Organism-specific databases

    CTDi 54407.
    MGIi MGI:1915010. Slc38a2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG236441.
    GeneTreei ENSGT00650000093166.
    HOVERGENi HBG059571.
    InParanoidi Q8CFE6.
    KOi K14207.
    OMAi MFLMYLF.
    OrthoDBi EOG7WHH9J.
    PhylomeDBi Q8CFE6.
    TreeFami TF328787.

    Miscellaneous databases

    NextBioi 325493.
    PROi Q8CFE6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CFE6.
    CleanExi MM_SAT2.
    MM_SLC38A2.
    Genevestigatori Q8CFE6.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryonic tail.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Epididymis, Kidney and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and Czech II.
      Tissue: Brain and Mammary tumor.
    4. "Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element."
      Palii S.S., Chen H., Kilberg M.S.
      J. Biol. Chem. 279:3463-3471(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. "Glutamine uptake and expression of mRNA's of glutamine transporting proteins in mouse cerebellar and cerebral cortical astrocytes and neurons."
      Dolinska M., Zablocka B., Sonnewald U., Albrecht J.
      Neurochem. Int. 44:75-81(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems."
      Constancia M., Angiolini E., Sandovici I., Smith P., Smith R., Kelsey G., Dean W., Ferguson-Smith A., Sibley C.P., Reik W., Fowden A.
      Proc. Natl. Acad. Sci. U.S.A. 102:19219-19224(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2."
      Hatanaka T., Hatanaka Y., Setou M.
      J. Biol. Chem. 281:35922-35930(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, UBIQUITINATION BY NEDD4L.
    8. "Amino acid transporter ATA2 is stored at the trans-Golgi network and released by insulin stimulus in adipocytes."
      Hatanaka T., Hatanaka Y., Tsuchida J., Ganapathy V., Setou M.
      J. Biol. Chem. 281:39273-39284(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    9. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    10. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiS38A2_MOUSE
    AccessioniPrimary (citable) accession number: Q8CFE6
    Secondary accession number(s): Q3TEX3
    , Q6PFR1, Q6ZPS7, Q810U9, Q8CC66, Q8CD21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3