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Q8CFE3

- RCOR1_MOUSE

UniProt

Q8CFE3 - RCOR1_MOUSE

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Protein
REST corepressor 1
Gene
Rcor1, D12Wsu95e, Kiaa0071
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.3 Publications

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  2. chromatin binding Source: InterPro
  3. protein binding Source: UniProtKB
  4. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. erythrocyte differentiation Source: UniProtKB
  2. histone H4 deacetylation Source: Ensembl
  3. positive regulation of megakaryocyte differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
REST corepressor 1
Alternative name(s):
Protein CoREST
Gene namesi
Name:Rcor1
Synonyms:D12Wsu95e, Kiaa0071
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:106340. Rcor1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcriptional repressor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477REST corepressor 1
PRO_0000226774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181Phosphoserine By similarity
Modified residuei251 – 2511Phosphoserine2 Publications
Modified residuei451 – 4511Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8CFE3.
PaxDbiQ8CFE3.
PRIDEiQ8CFE3.

PTM databases

PhosphoSiteiQ8CFE3.

Expressioni

Tissue specificityi

Expressed in the external germinal layer (EGL) and internal granular layer (IGL) of the cerebellum and in Purkinje cells (at protein level).1 Publication

Developmental stagei

At embryonic day 8.5, it is highly expressed in the head mesenchyme, but neither in the somites nor in the presomitic mesoderm. By day 11.5 it is expressed fairly ubiquitously throughout the embryo.1 Publication

Inductioni

Down-regulated by the transcriptional repressor ZEB1 during NEUROD2-induced neurogenesis.1 Publication

Gene expression databases

ArrayExpressiQ8CFE3.
BgeeiQ8CFE3.
CleanExiMM_RCOR1.
GenevestigatoriQ8CFE3.

Interactioni

Subunit structurei

Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with REST. Interacts with the SMARCE1/BAF57, suggesting that the BHC complex may recruit the ATP-dependent chromatin-remodeling SWI-SNF complex By similarity. Interacts directly with GFI1 AND GFI1B in a RCOR/GFI/KDM1A/HDAC complex. Interacts with INMS1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nr4a2Q062195EBI-2337309,EBI-2337255

Protein-protein interaction databases

BioGridi229971. 1 interaction.
DIPiDIP-48899N.
IntActiQ8CFE3. 5 interactions.
STRINGi10090.ENSMUSP00000112089.

Structurei

3D structure databases

ProteinModelPortaliQ8CFE3.
SMRiQ8CFE3. Positions 94-230, 302-434.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 18087ELM2
Add
BLAST
Domaini181 – 23252SANT 1
Add
BLAST
Domaini372 – 42352SANT 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 248180Interaction with HDAC1 By similarity
Add
BLAST
Regioni287 – 37589Interaction with KDM1A By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili235 – 26228 Reviewed prediction
Add
BLAST
Coiled coili325 – 36036 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 6851Ala-rich
Add
BLAST

Domaini

The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A By similarity.

Sequence similaritiesi

Belongs to the CoREST family.
Contains 1 ELM2 domain.
Contains 2 SANT domains.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG326181.
GeneTreeiENSGT00730000110737.
HOGENOMiHOG000065784.
HOVERGENiHBG079800.
InParanoidiQ8CFE3.
KOiK11829.
PhylomeDBiQ8CFE3.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CFE3-1 [UniParc]FASTAAdd to Basket

« Hide

MVEKGPEVSG KRRGRNTAAS AASAAASAAS AAASAAASAG TXSASAAAAA    50
SAAAXPNNGQ NKSLAAAAPN GNSGSNSWEE GSSGSSSDEE HGGGGMRVGP 100
QYQAAVPDFD PAKLARRSQE RDNLGMLVWS PNQSLSEAKL DEYIAIAKEK 150
HGYNMEQALG MLFWHKHNIE KSLADLPNFT PFPDEWTVED KVLFEQAFSF 200
HGKTFHRIQQ MLPDKSIASL VKFYYSWKKT RTKTSVMDRH ARKQKREREE 250
SEDELEETNG SNPVDIEIDP NKESKKEVPP TETVPQVKKE KHSTQAKNRA 300
KRKPPKGMFL SQEDVEAVSA NATAATTVLR QLDMELVSIK RQIQNIKQTN 350
SALKEKLDGG IEPYRLPEVI QKCNARWTTE EQLLAVQAIR KYGRDFQAIS 400
DVIGNKSVVQ VKNFFVNYRR RFNIDEVLQE WEAEHGKDET NGPANQKPVK 450
SPESSIKIPE EEDEAASVLD VRYASAS 477
Length:477
Mass (Da):52,496
Last modified:March 7, 2006 - v2
Checksum:i80FBBF1FBE50D25B
GO

Sequence cautioni

The sequence AAH42731.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti441 – 4411N → Y in BAC36804. 1 Publication
Sequence conflicti441 – 4411N → Y in BAE21612. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK077445 mRNA. Translation: BAC36804.1.
AK133352 mRNA. Translation: BAE21612.1.
BY729958 mRNA. No translation available.
BC042731 mRNA. Translation: AAH42731.1. Different initiation.
AB093210 mRNA. Translation: BAC41394.1.
RefSeqiNP_932140.1. NM_198023.2.
UniGeneiMm.23808.

Genome annotation databases

EnsembliENSMUST00000116388; ENSMUSP00000112089; ENSMUSG00000037896.
GeneIDi217864.
KEGGimmu:217864.
UCSCiuc007pck.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK077445 mRNA. Translation: BAC36804.1 .
AK133352 mRNA. Translation: BAE21612.1 .
BY729958 mRNA. No translation available.
BC042731 mRNA. Translation: AAH42731.1 . Different initiation.
AB093210 mRNA. Translation: BAC41394.1 .
RefSeqi NP_932140.1. NM_198023.2.
UniGenei Mm.23808.

3D structure databases

ProteinModelPortali Q8CFE3.
SMRi Q8CFE3. Positions 94-230, 302-434.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229971. 1 interaction.
DIPi DIP-48899N.
IntActi Q8CFE3. 5 interactions.
STRINGi 10090.ENSMUSP00000112089.

PTM databases

PhosphoSitei Q8CFE3.

Proteomic databases

MaxQBi Q8CFE3.
PaxDbi Q8CFE3.
PRIDEi Q8CFE3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000116388 ; ENSMUSP00000112089 ; ENSMUSG00000037896 .
GeneIDi 217864.
KEGGi mmu:217864.
UCSCi uc007pck.1. mouse.

Organism-specific databases

CTDi 23186.
MGIi MGI:106340. Rcor1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG326181.
GeneTreei ENSGT00730000110737.
HOGENOMi HOG000065784.
HOVERGENi HBG079800.
InParanoidi Q8CFE3.
KOi K11829.
PhylomeDBi Q8CFE3.

Enzyme and pathway databases

Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSi RCOR1. mouse.
NextBioi 376067.
PROi Q8CFE3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8CFE3.
Bgeei Q8CFE3.
CleanExi MM_RCOR1.
Genevestigatori Q8CFE3.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view ]
Pfami PF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view ]
SMARTi SM00717. SANT. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS51156. ELM2. 1 hit.
PS51293. SANT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-111 AND 249-477.
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-477.
    Strain: NMRI.
    Tissue: Mammary tumor.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-477.
    Tissue: Brain.
  4. "The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex."
    Grimes J.A., Nielsen S.J., Battaglioli E., Miska E.A., Speh J.C., Berry D.L., Atouf F., Holdener B.C., Mandel G., Kouzarides T.
    J. Biol. Chem. 275:9461-9467(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  5. "REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis."
    Ballas N., Grunseich C., Lu D.D., Speh J.C., Mandel G.
    Cell 121:645-657(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1."
    Saleque S., Kim J., Rooke H.M., Orkin S.H.
    Mol. Cell 27:562-572(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY AS A COMPONENT OF A GFI-RCOR-KDM1A-HDAC COMPLEX, INTERACTION WITH GFI1 AND GFI1B, FUNCTION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation."
    Ravanpay A.C., Hansen S.J., Olson J.M.
    Mol. Cell. Neurosci. 44:178-189(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
  10. "Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors."
    Welcker J.E., Hernandez-Miranda L.R., Paul F.E., Jia S., Ivanov A., Selbach M., Birchmeier C.
    Development 140:4947-4958(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INMS1.

Entry informationi

Entry nameiRCOR1_MOUSE
AccessioniPrimary (citable) accession number: Q8CFE3
Secondary accession number(s): Q3V092, Q8BK28, Q8CHI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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