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Protein

REST corepressor 1

Gene

Rcor1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
REST corepressor 1
Alternative name(s):
Protein CoREST
Gene namesi
Name:Rcor1
Synonyms:D12Wsu95e, Kiaa0071
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106340. Rcor1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002267741 – 477REST corepressor 1Add BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei118PhosphoserineBy similarity1
Modified residuei251PhosphoserineCombined sources1
Modified residuei451PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CFE3.
MaxQBiQ8CFE3.
PaxDbiQ8CFE3.
PRIDEiQ8CFE3.

PTM databases

iPTMnetiQ8CFE3.
PhosphoSitePlusiQ8CFE3.

Expressioni

Tissue specificityi

Expressed in the external germinal layer (EGL) and internal granular layer (IGL) of the cerebellum and in Purkinje cells (at protein level).1 Publication

Developmental stagei

At embryonic day 8.5, it is highly expressed in the head mesenchyme, but neither in the somites nor in the presomitic mesoderm. By day 11.5 it is expressed fairly ubiquitously throughout the embryo.1 Publication

Inductioni

Down-regulated by the transcriptional repressor ZEB1 during NEUROD2-induced neurogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000037896.
CleanExiMM_RCOR1.

Interactioni

Subunit structurei

Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with REST. Interacts with the SMARCE1/BAF57, suggesting that the BHC complex may recruit the ATP-dependent chromatin-remodeling SWI-SNF complex (By similarity). Interacts directly with GFI1 AND GFI1B in a RCOR/GFI/KDM1A/HDAC complex. Interacts with INMS1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nr4a2Q062195EBI-2337309,EBI-2337255

GO - Molecular functioni

  • enzyme binding Source: MGI
  • transcription factor binding Source: GO_Central

Protein-protein interaction databases

BioGridi229971. 1 interactor.
DIPiDIP-48899N.
IntActiQ8CFE3. 5 interactors.
STRINGi10090.ENSMUSP00000112089.

Structurei

3D structure databases

ProteinModelPortaliQ8CFE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 180ELM2PROSITE-ProRule annotationAdd BLAST87
Domaini181 – 232SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini372 – 423SANT 2PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni69 – 248Interaction with HDAC1By similarityAdd BLAST180
Regioni287 – 375Interaction with KDM1ABy similarityAdd BLAST89

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili235 – 262Sequence analysisAdd BLAST28
Coiled coili325 – 360Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 68Ala-richAdd BLAST51

Domaini

The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A.By similarity

Sequence similaritiesi

Belongs to the CoREST family.Curated
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 2 SANT domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1194. Eukaryota.
ENOG410XSIS. LUCA.
HOGENOMiHOG000065784.
HOVERGENiHBG079800.
InParanoidiQ8CFE3.
KOiK11829.
PhylomeDBiQ8CFE3.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CFE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEKGPEVSG KRRGRNTAAS AASAAASAAS AAASAAASAG TXSASAAAAA
60 70 80 90 100
SAAAXPNNGQ NKSLAAAAPN GNSGSNSWEE GSSGSSSDEE HGGGGMRVGP
110 120 130 140 150
QYQAAVPDFD PAKLARRSQE RDNLGMLVWS PNQSLSEAKL DEYIAIAKEK
160 170 180 190 200
HGYNMEQALG MLFWHKHNIE KSLADLPNFT PFPDEWTVED KVLFEQAFSF
210 220 230 240 250
HGKTFHRIQQ MLPDKSIASL VKFYYSWKKT RTKTSVMDRH ARKQKREREE
260 270 280 290 300
SEDELEETNG SNPVDIEIDP NKESKKEVPP TETVPQVKKE KHSTQAKNRA
310 320 330 340 350
KRKPPKGMFL SQEDVEAVSA NATAATTVLR QLDMELVSIK RQIQNIKQTN
360 370 380 390 400
SALKEKLDGG IEPYRLPEVI QKCNARWTTE EQLLAVQAIR KYGRDFQAIS
410 420 430 440 450
DVIGNKSVVQ VKNFFVNYRR RFNIDEVLQE WEAEHGKDET NGPANQKPVK
460 470
SPESSIKIPE EEDEAASVLD VRYASAS
Length:477
Mass (Da):52,496
Last modified:March 7, 2006 - v2
Checksum:i80FBBF1FBE50D25B
GO

Sequence cautioni

The sequence AAH42731 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti441N → Y in BAC36804 (PubMed:16141072).Curated1
Sequence conflicti441N → Y in BAE21612 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077445 mRNA. Translation: BAC36804.1.
AK133352 mRNA. Translation: BAE21612.1.
BY729958 mRNA. No translation available.
BC042731 mRNA. Translation: AAH42731.1. Different initiation.
AB093210 mRNA. Translation: BAC41394.1.
RefSeqiNP_932140.1. NM_198023.2.
UniGeneiMm.23808.

Genome annotation databases

GeneIDi217864.
KEGGimmu:217864.
UCSCiuc007pck.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077445 mRNA. Translation: BAC36804.1.
AK133352 mRNA. Translation: BAE21612.1.
BY729958 mRNA. No translation available.
BC042731 mRNA. Translation: AAH42731.1. Different initiation.
AB093210 mRNA. Translation: BAC41394.1.
RefSeqiNP_932140.1. NM_198023.2.
UniGeneiMm.23808.

3D structure databases

ProteinModelPortaliQ8CFE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229971. 1 interactor.
DIPiDIP-48899N.
IntActiQ8CFE3. 5 interactors.
STRINGi10090.ENSMUSP00000112089.

PTM databases

iPTMnetiQ8CFE3.
PhosphoSitePlusiQ8CFE3.

Proteomic databases

EPDiQ8CFE3.
MaxQBiQ8CFE3.
PaxDbiQ8CFE3.
PRIDEiQ8CFE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi217864.
KEGGimmu:217864.
UCSCiuc007pck.1. mouse.

Organism-specific databases

CTDi23186.
MGIiMGI:106340. Rcor1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1194. Eukaryota.
ENOG410XSIS. LUCA.
HOGENOMiHOG000065784.
HOVERGENiHBG079800.
InParanoidiQ8CFE3.
KOiK11829.
PhylomeDBiQ8CFE3.

Miscellaneous databases

ChiTaRSiRcor1. mouse.
PROiQ8CFE3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037896.
CleanExiMM_RCOR1.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCOR1_MOUSE
AccessioniPrimary (citable) accession number: Q8CFE3
Secondary accession number(s): Q3V092, Q8BK28, Q8CHI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.