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Protein

Sorting nexin-8

Gene

Snx8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041Phosphatidylinositol 3-phosphateBy similarity
Binding sitei130 – 1301Phosphatidylinositol 3-phosphateBy similarity
Binding sitei143 – 1431Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-8
Gene namesi
Name:Snx8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2443816. Snx8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Sorting nexin-8PRO_0000236199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei446 – 4461PhosphothreonineBy similarity
Modified residuei450 – 4501PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8CFD4.
PaxDbiQ8CFD4.
PRIDEiQ8CFD4.

PTM databases

iPTMnetiQ8CFD4.
PhosphoSiteiQ8CFD4.

Expressioni

Gene expression databases

BgeeiQ8CFD4.
CleanExiMM_SNX8.
ExpressionAtlasiQ8CFD4. baseline and differential.
GenevisibleiQ8CFD4. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231175. 1 interaction.
IntActiQ8CFD4. 1 interaction.
STRINGi10090.ENSMUSP00000031539.

Structurei

3D structure databases

ProteinModelPortaliQ8CFD4.
SMRiQ8CFD4. Positions 87-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 176109PXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00460000041594.
HOGENOMiHOG000252992.
HOVERGENiHBG017827.
InParanoidiQ8CFD4.
KOiK17922.
OMAiMMSATVQ.
OrthoDBiEOG77128D.
PhylomeDBiQ8CFD4.
TreeFamiTF314082.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CFD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGRAMDPLP SPAVAAAAEA EADEEADPPA TGPRTSQVTE WRALDPGRMQ
60 70 80 90 100
MPQGNPLLLS YTLQELLAKD TVQVELIPEK KGLFLKHVEY EVSSQRFKSS
110 120 130 140 150
VYRRYNDFVV FHEVLLHKFP YRMVPALPPK RVLGADREFI EGRRRALKRF
160 170 180 190 200
INLVARHPPF SEDVLLKLFL SFSGSDVQHK LKEAAQCVGD EFMNCKLAAR
210 220 230 240 250
AKDFLPADIQ TQFAMSRELI RNVYNSFYKL RDRAERIASR AIDNAADLLI
260 270 280 290 300
FGKELSALGS DTTPLPSWAA LHLSTWGSLK QALKGLSVEF ALLADRAAQQ
310 320 330 340 350
GKKEENDVVE KLNLFLDLLQ SYKDLCERHE KGVLHKHQRA LHKYGLMKRQ
360 370 380 390 400
MMSAAHGREP ESVEQLESRI VEQENVIQTM ELRNYFSLYC LHQETQLVHV
410 420 430 440 450
YLPLTSHILG AFVNSQIQGH KEMSKVWNDL KPKLSCLFAG PHSVLTPPRS

PQEDGVCPH
Length:459
Mass (Da):52,059
Last modified:March 1, 2003 - v1
Checksum:i5E0BE9C1AB054454
GO

Sequence cautioni

The sequence BAC32202.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE28549.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti222 – 2221N → Y in BAC38662 (PubMed:16141072).Curated
Sequence conflicti366 – 3661L → V in BAC38662 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037599 mRNA. Translation: AAH37599.1.
AK045061 mRNA. Translation: BAC32202.1. Different initiation.
AK082871 mRNA. Translation: BAC38662.1.
AK148429 mRNA. Translation: BAE28549.1. Different initiation.
CCDSiCCDS39356.1.
RefSeqiNP_758481.1. NM_172277.2.
UniGeneiMm.27098.

Genome annotation databases

EnsembliENSMUST00000031539; ENSMUSP00000031539; ENSMUSG00000029560.
GeneIDi231834.
KEGGimmu:231834.
UCSCiuc009ahp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037599 mRNA. Translation: AAH37599.1.
AK045061 mRNA. Translation: BAC32202.1. Different initiation.
AK082871 mRNA. Translation: BAC38662.1.
AK148429 mRNA. Translation: BAE28549.1. Different initiation.
CCDSiCCDS39356.1.
RefSeqiNP_758481.1. NM_172277.2.
UniGeneiMm.27098.

3D structure databases

ProteinModelPortaliQ8CFD4.
SMRiQ8CFD4. Positions 87-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231175. 1 interaction.
IntActiQ8CFD4. 1 interaction.
STRINGi10090.ENSMUSP00000031539.

PTM databases

iPTMnetiQ8CFD4.
PhosphoSiteiQ8CFD4.

Proteomic databases

MaxQBiQ8CFD4.
PaxDbiQ8CFD4.
PRIDEiQ8CFD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031539; ENSMUSP00000031539; ENSMUSG00000029560.
GeneIDi231834.
KEGGimmu:231834.
UCSCiuc009ahp.1. mouse.

Organism-specific databases

CTDi29886.
MGIiMGI:2443816. Snx8.

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00460000041594.
HOGENOMiHOG000252992.
HOVERGENiHBG017827.
InParanoidiQ8CFD4.
KOiK17922.
OMAiMMSATVQ.
OrthoDBiEOG77128D.
PhylomeDBiQ8CFD4.
TreeFamiTF314082.

Miscellaneous databases

ChiTaRSiSnx8. mouse.
NextBioi380783.
PROiQ8CFD4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CFD4.
CleanExiMM_SNX8.
ExpressionAtlasiQ8CFD4. baseline and differential.
GenevisibleiQ8CFD4. MM.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-459.
    Strain: C57BL/6J.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-450, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney and Spleen.

Entry informationi

Entry nameiSNX8_MOUSE
AccessioniPrimary (citable) accession number: Q8CFD4
Secondary accession number(s): Q8BLI6, Q8BUQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.