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Protein

RNA-binding protein 45

Gene

Rbm45

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.1 PublicationBy similarity

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • nervous system development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 45
Alternative name(s):
Developmentally-regulated RNA-binding protein 1
RNA-binding motif protein 45
Gene namesi
Name:Rbm45
Synonyms:Drb1Imported, Drbp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628862. Rbm45.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815741 – 476RNA-binding protein 45Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei199PhosphoserineCombined sources1
Modified residuei464PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CFD1.
PRIDEiQ8CFD1.

PTM databases

iPTMnetiQ8CFD1.
PhosphoSitePlusiQ8CFD1.

Expressioni

Tissue specificityi

Expressed predominantly in fetal brain, in neurons but not glial cells. Mostly expressed in neuronal progenitor cells with reduced expression in differentiated cells. Less abundant in adult brain where expression is limited to cerebellum, olfactory bulb and hippocampus. Also found at lower levels in fetal and adult kidney, heart, lung and spleen.1 Publication

Developmental stagei

Expression is highest in fetal brain at E16 with decreased levels as development progresses. By postnatal day 3 detected in hippocampal pyrimidal neurons and cortical neurons.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051270.

Structurei

3D structure databases

ProteinModelPortaliQ8CFD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 106RRM 1PROSITE-ProRule annotationAdd BLAST81
Domaini121 – 192RRM 2PROSITE-ProRule annotationAdd BLAST72
Domaini392 – 464RRM 3PROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKU. Eukaryota.
ENOG410XP9Z. LUCA.
HOGENOMiHOG000231828.
HOVERGENiHBG051404.
InParanoidiQ8CFD1.
PhylomeDBiQ8CFD1.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CFD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDAGSSGGS GGFRPGVDSL DEPPNSRIFL VISKYTSESV LREHFSPFGD
60 70 80 90 100
IQDIWVVRDK HTKESKGIAF VKFARSSQAC RAMEEMHGQC LGPNDTKPIK
110 120 130 140 150
VFIAQSRSSG SHRDVEDEEL TRIFVMIPKS YTEEDLREKF KVYGDIEYCS
160 170 180 190 200
VIKNKVTGES KGLGYVRYLK PSQAAQAIEN CDRSFRALLA EPKNKVLESP
210 220 230 240 250
EQDYYSSVRQ ETLGHEPRGN LFPFVGEQQS EFSTFDKNDS RGQEAISKRL
260 270 280 290 300
SVASRVPFTE EQLFSIFDIV PGLEYCEVHR DPYLNYGHGV VQYFNVASAV
310 320 330 340 350
YAQYKLHGFQ YPPGNRIAVS FLDDGSNSAD LIRKMATQMV AAQLASTVWS
360 370 380 390 400
NPSHQQFLQF GGSAGSQVPQ IQTDVVLPSC RKKAPPETPV KERLFIVFNP
410 420 430 440 450
HPLPLDVLED IFCRFGNLIE VYLVSGKNVG YVKYADRMSA NDAITTLHGK
460 470
ILNGVRLKVM LADSPREVSK KRQRTY
Length:476
Mass (Da):53,431
Last modified:March 1, 2003 - v1
Checksum:iE9DCFBE089070EDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036990 mRNA. Translation: BAC16206.1.
RefSeqiNP_695218.1. NM_153306.1.
UniGeneiRn.204106.

Genome annotation databases

GeneIDi266631.
KEGGirno:266631.
UCSCiRGD:628862. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036990 mRNA. Translation: BAC16206.1.
RefSeqiNP_695218.1. NM_153306.1.
UniGeneiRn.204106.

3D structure databases

ProteinModelPortaliQ8CFD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051270.

PTM databases

iPTMnetiQ8CFD1.
PhosphoSitePlusiQ8CFD1.

Proteomic databases

PaxDbiQ8CFD1.
PRIDEiQ8CFD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266631.
KEGGirno:266631.
UCSCiRGD:628862. rat.

Organism-specific databases

CTDi129831.
RGDi628862. Rbm45.

Phylogenomic databases

eggNOGiENOG410IEKU. Eukaryota.
ENOG410XP9Z. LUCA.
HOGENOMiHOG000231828.
HOVERGENiHBG051404.
InParanoidiQ8CFD1.
PhylomeDBiQ8CFD1.

Miscellaneous databases

PROiQ8CFD1.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM45_RAT
AccessioniPrimary (citable) accession number: Q8CFD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.