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Protein

RNA-binding protein 45

Gene

Rbm45

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.1 PublicationBy similarity

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • nervous system development Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 45
Alternative name(s):
Developmentally-regulated RNA-binding protein 1
RNA-binding motif protein 45
Gene namesi
Name:Rbm45
Synonyms:Drb1Imported, Drbp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628862. Rbm45.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815741 – 476RNA-binding protein 45Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei199PhosphoserineCombined sources1
Modified residuei464PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8CFD1.
PRIDEiQ8CFD1.

PTM databases

iPTMnetiQ8CFD1.
PhosphoSitePlusiQ8CFD1.

Expressioni

Tissue specificityi

Expressed predominantly in fetal brain, in neurons but not glial cells. Mostly expressed in neuronal progenitor cells with reduced expression in differentiated cells. Less abundant in adult brain where expression is limited to cerebellum, olfactory bulb and hippocampus. Also found at lower levels in fetal and adult kidney, heart, lung and spleen.1 Publication

Developmental stagei

Expression is highest in fetal brain at E16 with decreased levels as development progresses. By postnatal day 3 detected in hippocampal pyrimidal neurons and cortical neurons.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051270.

Structurei

3D structure databases

ProteinModelPortaliQ8CFD1.
SMRiQ8CFD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 106RRM 1PROSITE-ProRule annotationAdd BLAST81
Domaini121 – 192RRM 2PROSITE-ProRule annotationAdd BLAST72
Domaini392 – 464RRM 3PROSITE-ProRule annotationAdd BLAST73

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKU. Eukaryota.
ENOG410XP9Z. LUCA.
HOGENOMiHOG000231828.
HOVERGENiHBG051404.
InParanoidiQ8CFD1.
PhylomeDBiQ8CFD1.

Family and domain databases

CDDicd12366. RRM1_RBM45. 1 hit.
cd12367. RRM2_RBM45. 1 hit.
cd12368. RRM3_RBM45. 1 hit.
cd12369. RRM4_RBM45. 1 hit.
InterProiView protein in InterPro
IPR034203. RBM45_RRM1.
IPR034206. RBM45_RRM2.
IPR034207. RBM45_RRM3.
IPR034208. RBM45_RRM4.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 3 hits.
SMARTiView protein in SMART
SM00360. RRM. 4 hits.
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiView protein in PROSITE
PS50102. RRM. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8CFD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDAGSSGGS GGFRPGVDSL DEPPNSRIFL VISKYTSESV LREHFSPFGD
60 70 80 90 100
IQDIWVVRDK HTKESKGIAF VKFARSSQAC RAMEEMHGQC LGPNDTKPIK
110 120 130 140 150
VFIAQSRSSG SHRDVEDEEL TRIFVMIPKS YTEEDLREKF KVYGDIEYCS
160 170 180 190 200
VIKNKVTGES KGLGYVRYLK PSQAAQAIEN CDRSFRALLA EPKNKVLESP
210 220 230 240 250
EQDYYSSVRQ ETLGHEPRGN LFPFVGEQQS EFSTFDKNDS RGQEAISKRL
260 270 280 290 300
SVASRVPFTE EQLFSIFDIV PGLEYCEVHR DPYLNYGHGV VQYFNVASAV
310 320 330 340 350
YAQYKLHGFQ YPPGNRIAVS FLDDGSNSAD LIRKMATQMV AAQLASTVWS
360 370 380 390 400
NPSHQQFLQF GGSAGSQVPQ IQTDVVLPSC RKKAPPETPV KERLFIVFNP
410 420 430 440 450
HPLPLDVLED IFCRFGNLIE VYLVSGKNVG YVKYADRMSA NDAITTLHGK
460 470
ILNGVRLKVM LADSPREVSK KRQRTY
Length:476
Mass (Da):53,431
Last modified:March 1, 2003 - v1
Checksum:iE9DCFBE089070EDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036990 mRNA. Translation: BAC16206.1.
RefSeqiNP_695218.1. NM_153306.1.
UniGeneiRn.204106.

Genome annotation databases

GeneIDi266631.
KEGGirno:266631.
UCSCiRGD:628862. rat.

Similar proteinsi

Entry informationi

Entry nameiRBM45_RAT
AccessioniPrimary (citable) accession number: Q8CFD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome