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Protein

Leucine zipper putative tumor suppressor 1

Gene

Lzts1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity).By similarity

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • negative regulation of macroautophagy Source: Ensembl
  • regulation of dendrite morphogenesis Source: RGD
  • regulation of synaptic plasticity Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 1
Alternative name(s):
PSD-Zip70
Gene namesi
Name:Lzts1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi708565. Lzts1.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • cell body Source: RGD
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB-SubCell
  • dendritic shaft Source: RGD
  • dendritic spine Source: RGD
  • neuron projection Source: RGD
  • postsynaptic density Source: RGD
  • postsynaptic membrane Source: RGD
  • synapse Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 601600Leucine zipper putative tumor suppressor 1PRO_0000182973Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication

Post-translational modificationi

Phorphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ8CFC9.
PRIDEiQ8CFC9.

PTM databases

iPTMnetiQ8CFC9.
PhosphoSiteiQ8CFC9.

Expressioni

Tissue specificityi

Highly expressed in brain, in particular in cortex, the CA2 region of the hippocampus, olfactory bulb, striatum and pons. Not detectable in the other tissues tested.1 Publication

Developmental stagei

Highly expressed in cerebellum in 1 to 3 week old rats. Expression levels before and after are much lower. Expression in total brain increases slightly during development and remains at a constant high level after birth.

Gene expression databases

GenevisibleiQ8CFC9. RN.

Interactioni

Subunit structurei

Binds EEF1G, TLK2 and CDK1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015800.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili255 – 573319Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the LZTS family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJE. Eukaryota.
ENOG4111JZA. LUCA.
GeneTreeiENSGT00510000046769.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiQ8CFC9.
OMAiGMELKTQ.
OrthoDBiEOG7F7W8K.
PhylomeDBiQ8CFC9.
TreeFamiTF331420.

Family and domain databases

InterProiIPR033293. LZTS1.
[Graphical view]
PANTHERiPTHR19354:SF5. PTHR19354:SF5. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CFC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVSSLISG HSLHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS
60 70 80 90 100
GRGKSSSKMG KSEDFFYIKV SQKARGSHRP DYTALSSGDM GGQTGVDFDP
110 120 130 140 150
ATPPKLMPFS SQLEMSSDKA AVRPTAFKPV LPRSGAILHS SPESTNHQLH
160 170 180 190 200
PMPPDKPKEQ ELKPGLCSGA LSDSGRNSMS SLPTHSTTSS YQLDPLVTPV
210 220 230 240 250
GPTSRFGGSA HNITQGIILQ DSNMMSLKAL SFSDGGSKLA HPGKVEKGSS
260 270 280 290 300
CVRSPLSTDE CTIQELEQKL LQRETALQKL QRSFDEKEFA SGQTFEERPR
310 320 330 340 350
RTRDELECLE PKSKLKPASQ KSQRTQQVLQ LQVLQLQQEK RQLRQELESL
360 370 380 390 400
MKEQDLLETK LRSYEREKTN FAPALEETQW EVCQKSGEIS LLKQQLKESQ
410 420 430 440 450
MEVNAKASEI LSLKAQLKDT RGKLEGMELK TQDLESALRT KGLELEVCEN
460 470 480 490 500
ELQRKKNEAE LLREKVNLLE QELLELRAQA ALHRDAAPLG PPGIGLTFSE
510 520 530 540 550
DIPALQRELD RLRAELKEER QGHDQMSSGF QHERLVWKEE KEKVIQYQKQ
560 570 580 590 600
LQQSYLAMYQ RNQRLEKALQ QLARGDIAGE PFEIDLEGAD IPYEDIIATE

I
Length:601
Mass (Da):67,565
Last modified:January 23, 2007 - v3
Checksum:iA7FC7DF8541714CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075607 mRNA. Translation: BAC16535.1.
RefSeqiNP_703200.1. NM_153470.1.
UniGeneiRn.3213.

Genome annotation databases

EnsembliENSRNOT00000015799; ENSRNOP00000015800; ENSRNOG00000011826.
GeneIDi266711.
KEGGirno:266711.
UCSCiRGD:708565. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075607 mRNA. Translation: BAC16535.1.
RefSeqiNP_703200.1. NM_153470.1.
UniGeneiRn.3213.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015800.

PTM databases

iPTMnetiQ8CFC9.
PhosphoSiteiQ8CFC9.

Proteomic databases

PaxDbiQ8CFC9.
PRIDEiQ8CFC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015799; ENSRNOP00000015800; ENSRNOG00000011826.
GeneIDi266711.
KEGGirno:266711.
UCSCiRGD:708565. rat.

Organism-specific databases

CTDi11178.
RGDi708565. Lzts1.

Phylogenomic databases

eggNOGiENOG410IGJE. Eukaryota.
ENOG4111JZA. LUCA.
GeneTreeiENSGT00510000046769.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiQ8CFC9.
OMAiGMELKTQ.
OrthoDBiEOG7F7W8K.
PhylomeDBiQ8CFC9.
TreeFamiTF331420.

Miscellaneous databases

PROiQ8CFC9.

Gene expression databases

GenevisibleiQ8CFC9. RN.

Family and domain databases

InterProiIPR033293. LZTS1.
[Graphical view]
PANTHERiPTHR19354:SF5. PTHR19354:SF5. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The postsynaptic density and dendritic raft localization of PSD-Zip70, which contains an N-myristoylation sequence and leucine-zipper motifs."
    Konno D., Ko J.-A., Usui S., Hori K., Maruoka H., Inui M., Fujikado T., Tano Y., Suzuki T., Tohyama K., Sobue K.
    J. Cell Sci. 115:4695-4706(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MYRISTOYLATION AT GLY-2, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiLZTS1_RAT
AccessioniPrimary (citable) accession number: Q8CFC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.