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Protein

CLK4-associating serine/arginine rich protein

Gene

Clasrp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
CLK4-associating serine/arginine rich protein
Alternative name(s):
Clk4-associating SR-related protein
Serine/arginine-rich splicing factor 16
Splicing factor, arginine/serine-rich 16
Suppressor of white-apricot homolog 2
Gene namesi
Name:Clasrp
Synonyms:Clasp, Sfrs16, Srsf16, Swap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1855695. Clasrp.

Subcellular locationi

  • Nucleus

  • Note: Located in nuclear dots.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819461 – 668CLK4-associating serine/arginine rich proteinAdd BLAST668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101PhosphoserineBy similarity1
Modified residuei285PhosphoserineCombined sources1
Modified residuei294PhosphoserineBy similarity1
Modified residuei327PhosphothreonineBy similarity1
Modified residuei331PhosphoserineBy similarity1
Modified residuei335PhosphoserineCombined sources1
Modified residuei541PhosphoserineCombined sources1
Modified residuei567PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated in vitro by CLK4.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CFC7.
PaxDbiQ8CFC7.
PeptideAtlasiQ8CFC7.
PRIDEiQ8CFC7.

PTM databases

iPTMnetiQ8CFC7.
PhosphoSitePlusiQ8CFC7.

Expressioni

Tissue specificityi

Highly expressed in brain. Expressed at intermediate level in lung and liver. In brain, it is expressed in the hippocampus, cerebellum and olfactory bulb.

Gene expression databases

BgeeiENSMUSG00000061028.
ExpressionAtlasiQ8CFC7. baseline and differential.
GenevisibleiQ8CFC7. MM.

Interactioni

Subunit structurei

Probably interacts with CLK4.

Protein-protein interaction databases

BioGridi207329. 1 interactor.
STRINGi10090.ENSMUSP00000083205.

Structurei

3D structure databases

ProteinModelPortaliQ8CFC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili579 – 641Sequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi369 – 667Arg-richAdd BLAST299
Compositional biasi377 – 529Ser-richAdd BLAST153

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2548. Eukaryota.
COG0303. LUCA.
GeneTreeiENSGT00730000111260.
HOVERGENiHBG065901.
InParanoidiQ8CFC7.
KOiK13168.
OMAiERYRQQH.
OrthoDBiEOG091G0J7A.
PhylomeDBiQ8CFC7.
TreeFamiTF351621.

Family and domain databases

InterProiIPR019147. SWAP_N_domain.
[Graphical view]
PfamiPF09750. DRY_EERY. 1 hit.
[Graphical view]
SMARTiSM01141. DRY_EERY. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CFC7-1) [UniParc]FASTAAdd to basket
Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWHEARKHER KLRGMMVDYK KRAERRREYY EKIKKDPAQF LQVHGRACKV
60 70 80 90 100
HLDSAVALAA ESPVNMMPWQ GDTNNMIDRF DVRAHLDHIP DYTPPLLTTI
110 120 130 140 150
SPEQESDERK CNYERYRGLV QNDFAGISEE QCLYQIYIDE LYGGLQRPSE
160 170 180 190 200
DEKKKLAEKK ASIGYTYEDS TVAEVEKVAE KPEEEESPAE EESNSDEDEV
210 220 230 240 250
IPDIDVEVDV DELNQEQVAD LNKQATTYGM ADGDFVRMLR KDKEEAEAIK
260 270 280 290 300
HAKALEEEKA MYSGRRSRRQ RREFREKRLR GRKISPPSYA RRDSPTYDPY
310 320 330 340 350
KRSPSESSSE SRSRSRSPSP GREEKITFIT SFGGSDEEAA AAAAAAAASG
360 370 380 390 400
AAPGKPPAPP QTGGPAPGRN ASTRRRSSSS SASRTSSSRS SSRSSSRSRR
410 420 430 440 450
GYYRSGRHAR SRSRSWSRSR SRSRRYSRSR SRGRRHSDGG SRDGHRYSRS
460 470 480 490 500
PARRGGYVPR RRSRSRSRSG DRYKRGARGP RHHSSSHSRS SWSLSPSRSR
510 520 530 540 550
SVTRSGSRSQ SRSRSRSQSH SQSQSHSPSP PREKLTRPAA SPAVGEKLKK
560 570 580 590 600
TEPAAGKETG AAKPKLTPQE RLKLRMQKAL NRQFKADKKA AQEKMIQQEH
610 620 630 640 650
ERQEREDELR AMARKIRMKE RERREKEREE WERQYSRQSR SPSPRYSREY
660
SSSRRRSRSR SRSPHYRH
Length:668
Mass (Da):76,825
Last modified:April 14, 2009 - v3
Checksum:i1A0322702F7A9C40
GO
Isoform 2 (identifier: Q8CFC7-2) [UniParc]FASTAAdd to basket
Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
     564-588: PKLTPQERLKLRMQKALNRQFKADK → VTQADPTGEAEASDAEGSEPPVQGG
     589-668: Missing.

Show »
Length:588
Mass (Da):65,969
Checksum:i6085DFC8C8F7FFEE
GO
Isoform 3 (identifier: Q8CFC7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-627: PKLTPQERLK...MKERERREKE → VSKNLELARL...TPAGPQVPDS
     628-668: Missing.

Show »
Length:627
Mass (Da):70,289
Checksum:i2656F106CBD80607
GO

Sequence cautioni

The sequence AAC82338 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB26225 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008213564 – 627PKLTP…RREKE → VSKNLELARLTPVSSSVQSW ARWACRGPRGRGEPAQRLGK GYPGKLSPIPASHGTPAGPQ VPDS in isoform 3. 2 PublicationsAdd BLAST64
Alternative sequenceiVSP_008211564 – 588PKLTP…FKADK → VTQADPTGEAEASDAEGSEP PVQGG in isoform 2. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_008212589 – 668Missing in isoform 2. 2 PublicationsAdd BLAST80
Alternative sequenceiVSP_008214628 – 668Missing in isoform 3. 2 PublicationsAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042799 mRNA. Translation: AAC82338.1. Different initiation.
AK009334 mRNA. Translation: BAB26225.1. Different initiation.
BC051916 mRNA. Translation: AAH51916.2.
AB080582 mRNA. Translation: BAC15600.1.
AB080583 mRNA. Translation: BAC15601.1.
CCDSiCCDS52061.1. [Q8CFC7-1]
RefSeqiNP_057889.3. NM_016680.5. [Q8CFC7-1]
UniGeneiMm.20913.

Genome annotation databases

EnsembliENSMUST00000086041; ENSMUSP00000083205; ENSMUSG00000061028. [Q8CFC7-1]
ENSMUST00000207907; ENSMUSP00000146982; ENSMUSG00000061028. [Q8CFC7-3]
ENSMUST00000208068; ENSMUSP00000147103; ENSMUSG00000061028. [Q8CFC7-2]
GeneIDi53609.
KEGGimmu:53609.
UCSCiuc009fml.2. mouse. [Q8CFC7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042799 mRNA. Translation: AAC82338.1. Different initiation.
AK009334 mRNA. Translation: BAB26225.1. Different initiation.
BC051916 mRNA. Translation: AAH51916.2.
AB080582 mRNA. Translation: BAC15600.1.
AB080583 mRNA. Translation: BAC15601.1.
CCDSiCCDS52061.1. [Q8CFC7-1]
RefSeqiNP_057889.3. NM_016680.5. [Q8CFC7-1]
UniGeneiMm.20913.

3D structure databases

ProteinModelPortaliQ8CFC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207329. 1 interactor.
STRINGi10090.ENSMUSP00000083205.

PTM databases

iPTMnetiQ8CFC7.
PhosphoSitePlusiQ8CFC7.

Proteomic databases

EPDiQ8CFC7.
PaxDbiQ8CFC7.
PeptideAtlasiQ8CFC7.
PRIDEiQ8CFC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086041; ENSMUSP00000083205; ENSMUSG00000061028. [Q8CFC7-1]
ENSMUST00000207907; ENSMUSP00000146982; ENSMUSG00000061028. [Q8CFC7-3]
ENSMUST00000208068; ENSMUSP00000147103; ENSMUSG00000061028. [Q8CFC7-2]
GeneIDi53609.
KEGGimmu:53609.
UCSCiuc009fml.2. mouse. [Q8CFC7-1]

Organism-specific databases

CTDi11129.
MGIiMGI:1855695. Clasrp.

Phylogenomic databases

eggNOGiKOG2548. Eukaryota.
COG0303. LUCA.
GeneTreeiENSGT00730000111260.
HOVERGENiHBG065901.
InParanoidiQ8CFC7.
KOiK13168.
OMAiERYRQQH.
OrthoDBiEOG091G0J7A.
PhylomeDBiQ8CFC7.
TreeFamiTF351621.

Miscellaneous databases

ChiTaRSiClasrp. mouse.
PROiQ8CFC7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061028.
ExpressionAtlasiQ8CFC7. baseline and differential.
GenevisibleiQ8CFC7. MM.

Family and domain databases

InterProiIPR019147. SWAP_N_domain.
[Graphical view]
PfamiPF09750. DRY_EERY. 1 hit.
[Graphical view]
SMARTiSM01141. DRY_EERY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLASR_MOUSE
AccessioniPrimary (citable) accession number: Q8CFC7
Secondary accession number(s): Q5RKW4, Q8CFC8, Q9Z2N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: April 14, 2009
Last modified: November 30, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.