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Q8CFC2

- MYT1_MOUSE

UniProt

Q8CFC2 - MYT1_MOUSE

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Protein

Myelin transcription factor 1

Gene

Myt1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri28 – 5427C2HC-type 1Add
BLAST
Zinc fingeri442 – 46827C2HC-type 2Add
BLAST
Zinc fingeri486 – 51227C2HC-type 3Add
BLAST
Zinc fingeri800 – 82627C2HC-type 4Add
BLAST
Zinc fingeri844 – 87027C2HC-type 5Add
BLAST
Zinc fingeri893 – 91927C2HC-type 6Add
BLAST
Zinc fingeri946 – 97227C2HC-type 7Add
BLAST

GO - Molecular functioni

  1. enhancer sequence-specific DNA binding Source: MGI
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin transcription factor 1
Short name:
MyT1
Alternative name(s):
Neural zinc finger factor 2
Short name:
NZF-2
Gene namesi
Name:Myt1
Synonyms:Kiaa0835, Nzf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1100535. Myt1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11271127Myelin transcription factor 1PRO_0000096677Add
BLAST

Proteomic databases

MaxQBiQ8CFC2.
PRIDEiQ8CFC2.

PTM databases

PhosphoSiteiQ8CFC2.

Expressioni

Tissue specificityi

Isoform 1 is more predominant than isoform 2 at all stages of development and adulthood. Expressed in differentiated neurons especially at higher levels in newly generated ones.1 Publication

Developmental stagei

Isoform 1 is detected in the earliest born neurons. At 9.5 dpc it is detected in the ventrolateral part of the spinal cord, which later become motor neurons and is also detected in the dispersed cells of the alar plate interneurons. During spinal cord development, the expression is highest in the latest born neurons (the subventricular zone). Detected in the early differentiated neurons within the neuroepithelium and the neural crest cells at 9.5 dpc. At 12.5 dpc, detected in the differentiated neurons within the forebrain, midbrain, and hindbrain. In these neurons, the expression level is highest in the latest born neurons and is also detected in the differentiated neurons of the sensory organs and the peripheral ganglia.1 Publication

Gene expression databases

BgeeiQ8CFC2.
CleanExiMM_MYT1.
ExpressionAtlasiQ8CFC2. baseline and differential.
GenevestigatoriQ8CFC2.

Interactioni

Subunit structurei

Interacts with STEAP3.By similarity

Protein-protein interaction databases

BioGridi201678. 1 interaction.

Structurei

Secondary structure

1
1127
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi801 – 8033Combined sources
Beta strandi813 – 8164Combined sources
Beta strandi821 – 8244Combined sources
Beta strandi853 – 8553Combined sources
Beta strandi857 – 8604Combined sources
Beta strandi865 – 8695Combined sources
Turni871 – 8744Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JX1NMR-A843-873[»]
2JYDNMR-A837-878[»]
2MF8NMR-A792-878[»]
ProteinModelPortaliQ8CFC2.
SMRiQ8CFC2. Positions 28-59, 440-515, 799-985.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8CFC2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi210 – 30798Glu-richAdd
BLAST
Compositional biasi687 – 72539Ser-richAdd
BLAST

Domaini

Sequence similaritiesi

Contains 7 C2HC-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri28 – 5427C2HC-type 1Add
BLAST
Zinc fingeri442 – 46827C2HC-type 2Add
BLAST
Zinc fingeri486 – 51227C2HC-type 3Add
BLAST
Zinc fingeri800 – 82627C2HC-type 4Add
BLAST
Zinc fingeri844 – 87027C2HC-type 5Add
BLAST
Zinc fingeri893 – 91927C2HC-type 6Add
BLAST
Zinc fingeri946 – 97227C2HC-type 7Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG329034.
GeneTreeiENSGT00440000038465.
HOGENOMiHOG000234099.
HOVERGENiHBG006433.
InParanoidiQ8CFC2.

Family and domain databases

InterProiIPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF08474. MYT1. 2 hits.
PF01530. zf-C2HC. 7 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CFC2-1) [UniParc]FASTAAdd to Basket

Also known as: NZF-2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSESDDKRA RTRSKTLRGP PETTGADLSC PTPGCTGSGH VRGKYSRHRS
60 70 80 90 100
LQSCPLAKKR KLEDAETEHL VSKRKSHPLR LALDEGYRMD SDGSEDAEVK
110 120 130 140 150
DVSVSDESEG PLEEAEAEMS GQEEIHHPQT AEGKSLIKPH FDSNPTSSPS
160 170 180 190 200
GFSKSSYSSY QGIIATSLLN LGQIAEEALV KEDSVSVAKL SPTVVHQLQD
210 220 230 240 250
EAAMGVNSDE GEKDLFIQPE DVEEVIEVTS ERSQEPCPQS LKDMVSEESS
260 270 280 290 300
KQKGVLGHEE EGEEEEEDEE EEDEEEEEEG EEGEEEEEEE EEEEEEEDEE
310 320 330 340 350
EEEEEEEAAP NVIFGEDTSH TSVQKASPEF RGPELSSPKP EYSVIVEVRS
360 370 380 390 400
DDDKDEDSRS QKSAVTDESE MYDMMTRGNL GLLEQAIALK AEQVRAVCES
410 420 430 440 450
GCPPAEQGHL GPGEPGKMAK PLDVVRKSCY SKDPSRVEKR EIKCPTPGCD
460 470 480 490 500
GTGHVTGLYP HHRSLSGCPH KDRIPPEILA MHENVLKCPT PGCTGQGHVN
510 520 530 540 550
SNRNTHRSLS GCPIAAAEKL AKSHEKQQLQ TGDPPKNNSN SDRILRPMCF
560 570 580 590 600
VKQLEVPPYG SYRPNVAPAT PRANLAKELE KFSKVTFDYA SFDAQVFGKR
610 620 630 640 650
MLAPKIQTSE TSPKAFQCFD YSHDAEAAHM AATAILNLST RCWEMPENLS
660 670 680 690 700
TKPQDLPSKA VDIEVDENGT LDLSMHKHRK RENTFPSSSS CSSSPGVKSP
710 720 730 740 750
DVSQRQSSTS APSSSMTSPQ SSQASRQDEW DRPLDYTKPS RLREEEPEES
760 770 780 790 800
EPAAHSFASS EADDQEVSEE NFEERKYPGE VTLTNFKLKF LSKDIKKELL
810 820 830 840 850
TCPTPGCDGS GHITGNYASH RSLSGCPLAD KSLRNLMAAH SADLKCPTPG
860 870 880 890 900
CDGSGHITGN YASHRSLSGC PRAKKSGLKV APTKDDKEDP ELMKCPVPGC
910 920 930 940 950
VGLGHISGKY ASHRSASGCP LAARRQKEGA LNGSSFSWKS LKNEGPTCPT
960 970 980 990 1000
PGCDGSGHAN GSFLTHRSLS GCPRATFAGK KGKLSGDEIL SPKFKTSDVL
1010 1020 1030 1040 1050
ENDEEIKQLN QEIRDLNESN SEMEAAMVQL QSQISSMEKN LKNIEEENKL
1060 1070 1080 1090 1100
IEEQNEALFL ELSGLSQALI QSLANIRLPH MEPICEQNFD AYVNTLTDMY
1110 1120
SNQDCYQNPE NKGLLETIKQ AVRGIQV
Length:1,127
Mass (Da):123,576
Last modified:March 1, 2003 - v1
Checksum:iCB46958837E50008
GO
Isoform 2 (identifier: Q8CFC2-2) [UniParc]FASTAAdd to Basket

Also known as: NZF-2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: MSSESDDKRA...SNPTSSPSGF → MMDGIGIRTE...LQPHKQPFWL

Show »
Length:1,078
Mass (Da):118,701
Checksum:i6D414F1AE89BE01A
GO
Isoform 3 (identifier: Q8CFC2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     508-545: Missing.

Note: No experimental confirmation available.

Show »
Length:1,089
Mass (Da):119,547
Checksum:i13E8D20C1F5FFACA
GO

Sequence cautioni

The sequence BAC41451.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381P → R in AAC53456. (PubMed:9373037)Curated
Sequence conflicti446 – 4461T → A in AAC53456. (PubMed:9373037)Curated
Sequence conflicti502 – 5021N → Y in AAC53456. (PubMed:9373037)Curated
Sequence conflicti701 – 7011D → G in AAC53456. (PubMed:9373037)Curated
Sequence conflicti879 – 8791K → R in AAC53456. (PubMed:9373037)Curated
Sequence conflicti1022 – 10221E → G in AAC53456. (PubMed:9373037)Curated
Sequence conflicti1039 – 10391K → R in AAC53456. (PubMed:9373037)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 152152MSSES…SPSGF → MMDGIGIRTEKYQSNLAKID SFLVFESRQKADRMAYSSFP YFLSYSAESGQVGIGGELAT VGSRDLETFPHALFKAPLFL VLCRKKPHQAPFLLQPHKQP FWL in isoform 2. 1 PublicationVSP_015720Add
BLAST
Alternative sequencei508 – 54538Missing in isoform 3. 1 PublicationVSP_015721Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004294 mRNA. Translation: AAC53456.1.
AB082378 mRNA. Translation: BAC16512.1.
AB093267 mRNA. Translation: BAC41451.2. Different initiation.
AL845173 Genomic DNA. Translation: CAM20798.1.
AL845173 Genomic DNA. Translation: CAM20799.1.
BC063252 mRNA. Translation: AAH63252.1.
CCDSiCCDS17223.1. [Q8CFC2-1]
CCDS50857.1. [Q8CFC2-3]
PIRiT42712.
RefSeqiNP_001165086.1. NM_001171615.1.
NP_001165087.1. NM_001171616.1. [Q8CFC2-3]
NP_032691.2. NM_008665.4. [Q8CFC2-1]
UniGeneiMm.458718.

Genome annotation databases

EnsembliENSMUST00000108756; ENSMUSP00000104387; ENSMUSG00000010505. [Q8CFC2-1]
ENSMUST00000108757; ENSMUSP00000104388; ENSMUSG00000010505. [Q8CFC2-3]
GeneIDi17932.
KEGGimmu:17932.
UCSCiuc008ons.2. mouse. [Q8CFC2-1]
uc012cmw.1. mouse. [Q8CFC2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004294 mRNA. Translation: AAC53456.1 .
AB082378 mRNA. Translation: BAC16512.1 .
AB093267 mRNA. Translation: BAC41451.2 . Different initiation.
AL845173 Genomic DNA. Translation: CAM20798.1 .
AL845173 Genomic DNA. Translation: CAM20799.1 .
BC063252 mRNA. Translation: AAH63252.1 .
CCDSi CCDS17223.1. [Q8CFC2-1 ]
CCDS50857.1. [Q8CFC2-3 ]
PIRi T42712.
RefSeqi NP_001165086.1. NM_001171615.1.
NP_001165087.1. NM_001171616.1. [Q8CFC2-3 ]
NP_032691.2. NM_008665.4. [Q8CFC2-1 ]
UniGenei Mm.458718.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JX1 NMR - A 843-873 [» ]
2JYD NMR - A 837-878 [» ]
2MF8 NMR - A 792-878 [» ]
ProteinModelPortali Q8CFC2.
SMRi Q8CFC2. Positions 28-59, 440-515, 799-985.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201678. 1 interaction.

PTM databases

PhosphoSitei Q8CFC2.

Proteomic databases

MaxQBi Q8CFC2.
PRIDEi Q8CFC2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108756 ; ENSMUSP00000104387 ; ENSMUSG00000010505 . [Q8CFC2-1 ]
ENSMUST00000108757 ; ENSMUSP00000104388 ; ENSMUSG00000010505 . [Q8CFC2-3 ]
GeneIDi 17932.
KEGGi mmu:17932.
UCSCi uc008ons.2. mouse. [Q8CFC2-1 ]
uc012cmw.1. mouse. [Q8CFC2-3 ]

Organism-specific databases

CTDi 4661.
MGIi MGI:1100535. Myt1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG329034.
GeneTreei ENSGT00440000038465.
HOGENOMi HOG000234099.
HOVERGENi HBG006433.
InParanoidi Q8CFC2.

Miscellaneous databases

EvolutionaryTracei Q8CFC2.
NextBioi 292819.
PROi Q8CFC2.
SOURCEi Search...

Gene expression databases

Bgeei Q8CFC2.
CleanExi MM_MYT1.
ExpressionAtlasi Q8CFC2. baseline and differential.
Genevestigatori Q8CFC2.

Family and domain databases

InterProi IPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view ]
Pfami PF08474. MYT1. 2 hits.
PF01530. zf-C2HC. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system."
    Kim J.G., Armstrong R.C., Agoston D.V., Robinsky A., Wiese C., Nagle J., Hudson L.D.
    J. Neurosci. Res. 50:272-290(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
  2. "NZF-2b is a novel predominant form of mouse NZF-2/MyT1, expressed in differentiated neurons especially at higher levels in newly generated ones."
    Matsushita F., Kameyama T., Marunouchi T.
    Mech. Dev. 118:209-213(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: ICR.
    Tissue: Brain.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Fetal brain.
  4. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  7. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 537-543, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  8. "Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1."
    Gamsjaeger R., Swanton M.K., Kobus F.J., Lehtomaki E., Lowry J.A., Kwan A.H., Matthews J.M., Mackay J.P.
    J. Biol. Chem. 283:5158-5167(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 837-878, DNA-BINDING.

Entry informationi

Entry nameiMYT1_MOUSE
AccessioniPrimary (citable) accession number: Q8CFC2
Secondary accession number(s): B0R0C3
, B0R0C4, O08995, Q8CFH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3