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Q8CFC2

- MYT1_MOUSE

UniProt

Q8CFC2 - MYT1_MOUSE

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Protein
Myelin transcription factor 1
Gene
Myt1, Kiaa0835, Nzf2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription By similarity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri28 – 5427C2HC-type 1
Add
BLAST
Zinc fingeri442 – 46827C2HC-type 2
Add
BLAST
Zinc fingeri486 – 51227C2HC-type 3
Add
BLAST
Zinc fingeri800 – 82627C2HC-type 4
Add
BLAST
Zinc fingeri844 – 87027C2HC-type 5
Add
BLAST
Zinc fingeri893 – 91927C2HC-type 6
Add
BLAST
Zinc fingeri946 – 97227C2HC-type 7
Add
BLAST

GO - Molecular functioni

  1. enhancer sequence-specific DNA binding Source: MGI
  2. protein binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin transcription factor 1
Short name:
MyT1
Alternative name(s):
Neural zinc finger factor 2
Short name:
NZF-2
Gene namesi
Name:Myt1
Synonyms:Kiaa0835, Nzf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1100535. Myt1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11271127Myelin transcription factor 1
PRO_0000096677Add
BLAST

Proteomic databases

PRIDEiQ8CFC2.

PTM databases

PhosphoSiteiQ8CFC2.

Expressioni

Tissue specificityi

Isoform 1 is more predominant than isoform 2 at all stages of development and adulthood. Expressed in differentiated neurons especially at higher levels in newly generated ones.1 Publication

Developmental stagei

Isoform 1 is detected in the earliest born neurons. At 9.5 dpc it is detected in the ventrolateral part of the spinal cord, which later become motor neurons and is also detected in the dispersed cells of the alar plate interneurons. During spinal cord development, the expression is highest in the latest born neurons (the subventricular zone). Detected in the early differentiated neurons within the neuroepithelium and the neural crest cells at 9.5 dpc. At 12.5 dpc, detected in the differentiated neurons within the forebrain, midbrain, and hindbrain. In these neurons, the expression level is highest in the latest born neurons and is also detected in the differentiated neurons of the sensory organs and the peripheral ganglia.1 Publication

Gene expression databases

BgeeiQ8CFC2.
CleanExiMM_MYT1.
GenevestigatoriQ8CFC2.

Interactioni

Subunit structurei

Interacts with STEAP3 By similarity.

Protein-protein interaction databases

BioGridi201678. 1 interaction.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi801 – 8033
Beta strandi813 – 8164
Beta strandi821 – 8244
Beta strandi853 – 8553
Beta strandi857 – 8604
Beta strandi865 – 8695
Turni871 – 8744

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JX1NMR-A843-873[»]
2JYDNMR-A837-878[»]
2MF8NMR-A792-878[»]
ProteinModelPortaliQ8CFC2.
SMRiQ8CFC2. Positions 28-59, 440-515, 799-985.

Miscellaneous databases

EvolutionaryTraceiQ8CFC2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi210 – 30798Glu-rich
Add
BLAST
Compositional biasi687 – 72539Ser-rich
Add
BLAST

Domaini

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG329034.
GeneTreeiENSGT00440000038465.
HOGENOMiHOG000234099.
HOVERGENiHBG006433.
InParanoidiB0R0C3.

Family and domain databases

InterProiIPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF08474. MYT1. 2 hits.
PF01530. zf-C2HC. 7 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CFC2-1) [UniParc]FASTAAdd to Basket

Also known as: NZF-2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSESDDKRA RTRSKTLRGP PETTGADLSC PTPGCTGSGH VRGKYSRHRS     50
LQSCPLAKKR KLEDAETEHL VSKRKSHPLR LALDEGYRMD SDGSEDAEVK 100
DVSVSDESEG PLEEAEAEMS GQEEIHHPQT AEGKSLIKPH FDSNPTSSPS 150
GFSKSSYSSY QGIIATSLLN LGQIAEEALV KEDSVSVAKL SPTVVHQLQD 200
EAAMGVNSDE GEKDLFIQPE DVEEVIEVTS ERSQEPCPQS LKDMVSEESS 250
KQKGVLGHEE EGEEEEEDEE EEDEEEEEEG EEGEEEEEEE EEEEEEEDEE 300
EEEEEEEAAP NVIFGEDTSH TSVQKASPEF RGPELSSPKP EYSVIVEVRS 350
DDDKDEDSRS QKSAVTDESE MYDMMTRGNL GLLEQAIALK AEQVRAVCES 400
GCPPAEQGHL GPGEPGKMAK PLDVVRKSCY SKDPSRVEKR EIKCPTPGCD 450
GTGHVTGLYP HHRSLSGCPH KDRIPPEILA MHENVLKCPT PGCTGQGHVN 500
SNRNTHRSLS GCPIAAAEKL AKSHEKQQLQ TGDPPKNNSN SDRILRPMCF 550
VKQLEVPPYG SYRPNVAPAT PRANLAKELE KFSKVTFDYA SFDAQVFGKR 600
MLAPKIQTSE TSPKAFQCFD YSHDAEAAHM AATAILNLST RCWEMPENLS 650
TKPQDLPSKA VDIEVDENGT LDLSMHKHRK RENTFPSSSS CSSSPGVKSP 700
DVSQRQSSTS APSSSMTSPQ SSQASRQDEW DRPLDYTKPS RLREEEPEES 750
EPAAHSFASS EADDQEVSEE NFEERKYPGE VTLTNFKLKF LSKDIKKELL 800
TCPTPGCDGS GHITGNYASH RSLSGCPLAD KSLRNLMAAH SADLKCPTPG 850
CDGSGHITGN YASHRSLSGC PRAKKSGLKV APTKDDKEDP ELMKCPVPGC 900
VGLGHISGKY ASHRSASGCP LAARRQKEGA LNGSSFSWKS LKNEGPTCPT 950
PGCDGSGHAN GSFLTHRSLS GCPRATFAGK KGKLSGDEIL SPKFKTSDVL 1000
ENDEEIKQLN QEIRDLNESN SEMEAAMVQL QSQISSMEKN LKNIEEENKL 1050
IEEQNEALFL ELSGLSQALI QSLANIRLPH MEPICEQNFD AYVNTLTDMY 1100
SNQDCYQNPE NKGLLETIKQ AVRGIQV 1127
Length:1,127
Mass (Da):123,576
Last modified:March 1, 2003 - v1
Checksum:iCB46958837E50008
GO
Isoform 2 (identifier: Q8CFC2-2) [UniParc]FASTAAdd to Basket

Also known as: NZF-2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: MSSESDDKRA...SNPTSSPSGF → MMDGIGIRTE...LQPHKQPFWL

Show »
Length:1,078
Mass (Da):118,701
Checksum:i6D414F1AE89BE01A
GO
Isoform 3 (identifier: Q8CFC2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     508-545: Missing.

Note: No experimental confirmation available.

Show »
Length:1,089
Mass (Da):119,547
Checksum:i13E8D20C1F5FFACA
GO

Sequence cautioni

The sequence BAC41451.2 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 152152MSSES…SPSGF → MMDGIGIRTEKYQSNLAKID SFLVFESRQKADRMAYSSFP YFLSYSAESGQVGIGGELAT VGSRDLETFPHALFKAPLFL VLCRKKPHQAPFLLQPHKQP FWL in isoform 2.
VSP_015720Add
BLAST
Alternative sequencei508 – 54538Missing in isoform 3.
VSP_015721Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381P → R in AAC53456. 1 Publication
Sequence conflicti446 – 4461T → A in AAC53456. 1 Publication
Sequence conflicti502 – 5021N → Y in AAC53456. 1 Publication
Sequence conflicti701 – 7011D → G in AAC53456. 1 Publication
Sequence conflicti879 – 8791K → R in AAC53456. 1 Publication
Sequence conflicti1022 – 10221E → G in AAC53456. 1 Publication
Sequence conflicti1039 – 10391K → R in AAC53456. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF004294 mRNA. Translation: AAC53456.1.
AB082378 mRNA. Translation: BAC16512.1.
AB093267 mRNA. Translation: BAC41451.2. Different initiation.
AL845173 Genomic DNA. Translation: CAM20798.1.
AL845173 Genomic DNA. Translation: CAM20799.1.
BC063252 mRNA. Translation: AAH63252.1.
CCDSiCCDS17223.1. [Q8CFC2-1]
CCDS50857.1. [Q8CFC2-3]
PIRiT42712.
RefSeqiNP_001165086.1. NM_001171615.1.
NP_001165087.1. NM_001171616.1. [Q8CFC2-3]
NP_032691.2. NM_008665.4. [Q8CFC2-1]
UniGeneiMm.458718.

Genome annotation databases

EnsembliENSMUST00000108756; ENSMUSP00000104387; ENSMUSG00000010505. [Q8CFC2-1]
ENSMUST00000108757; ENSMUSP00000104388; ENSMUSG00000010505. [Q8CFC2-3]
GeneIDi17932.
KEGGimmu:17932.
UCSCiuc008ons.2. mouse. [Q8CFC2-1]
uc012cmw.1. mouse. [Q8CFC2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF004294 mRNA. Translation: AAC53456.1 .
AB082378 mRNA. Translation: BAC16512.1 .
AB093267 mRNA. Translation: BAC41451.2 . Different initiation.
AL845173 Genomic DNA. Translation: CAM20798.1 .
AL845173 Genomic DNA. Translation: CAM20799.1 .
BC063252 mRNA. Translation: AAH63252.1 .
CCDSi CCDS17223.1. [Q8CFC2-1 ]
CCDS50857.1. [Q8CFC2-3 ]
PIRi T42712.
RefSeqi NP_001165086.1. NM_001171615.1.
NP_001165087.1. NM_001171616.1. [Q8CFC2-3 ]
NP_032691.2. NM_008665.4. [Q8CFC2-1 ]
UniGenei Mm.458718.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JX1 NMR - A 843-873 [» ]
2JYD NMR - A 837-878 [» ]
2MF8 NMR - A 792-878 [» ]
ProteinModelPortali Q8CFC2.
SMRi Q8CFC2. Positions 28-59, 440-515, 799-985.
ModBasei Search...

Protein-protein interaction databases

BioGridi 201678. 1 interaction.

PTM databases

PhosphoSitei Q8CFC2.

Proteomic databases

PRIDEi Q8CFC2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108756 ; ENSMUSP00000104387 ; ENSMUSG00000010505 . [Q8CFC2-1 ]
ENSMUST00000108757 ; ENSMUSP00000104388 ; ENSMUSG00000010505 . [Q8CFC2-3 ]
GeneIDi 17932.
KEGGi mmu:17932.
UCSCi uc008ons.2. mouse. [Q8CFC2-1 ]
uc012cmw.1. mouse. [Q8CFC2-3 ]

Organism-specific databases

CTDi 4661.
MGIi MGI:1100535. Myt1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG329034.
GeneTreei ENSGT00440000038465.
HOGENOMi HOG000234099.
HOVERGENi HBG006433.
InParanoidi B0R0C3.

Miscellaneous databases

EvolutionaryTracei Q8CFC2.
NextBioi 292819.
PROi Q8CFC2.
SOURCEi Search...

Gene expression databases

Bgeei Q8CFC2.
CleanExi MM_MYT1.
Genevestigatori Q8CFC2.

Family and domain databases

InterProi IPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view ]
Pfami PF08474. MYT1. 2 hits.
PF01530. zf-C2HC. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system."
    Kim J.G., Armstrong R.C., Agoston D.V., Robinsky A., Wiese C., Nagle J., Hudson L.D.
    J. Neurosci. Res. 50:272-290(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
  2. "NZF-2b is a novel predominant form of mouse NZF-2/MyT1, expressed in differentiated neurons especially at higher levels in newly generated ones."
    Matsushita F., Kameyama T., Marunouchi T.
    Mech. Dev. 118:209-213(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: ICR.
    Tissue: Brain.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Fetal brain.
  4. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  7. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 537-543, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  8. "Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1."
    Gamsjaeger R., Swanton M.K., Kobus F.J., Lehtomaki E., Lowry J.A., Kwan A.H., Matthews J.M., Mackay J.P.
    J. Biol. Chem. 283:5158-5167(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 837-878, DNA-BINDING.

Entry informationi

Entry nameiMYT1_MOUSE
AccessioniPrimary (citable) accession number: Q8CFC2
Secondary accession number(s): B0R0C3
, B0R0C4, O08995, Q8CFH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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