Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA

Gene

Mina

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.By similarity1 Publication

Catalytic activityi

L-histidine-[60S ribosomal protein L27a] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L27a] + succinate + CO2.

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi179 – 1791Iron; catalyticPROSITE-ProRule annotation
Metal bindingi181 – 1811Iron; catalyticPROSITE-ProRule annotation
Metal bindingi240 – 2401Iron; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Ribosome biogenesis, Transcription, Transcription regulation

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA (EC:1.14.11.-)
Alternative name(s):
Histone lysine demethylase MINA
MYC-induced nuclear antigen
Gene namesi
Name:MinaImported
Synonyms:Mina53Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708521. Mina.

Subcellular locationi

  • Nucleus By similarity
  • Nucleusnucleolus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINAPRO_0000308380Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8CFC1.

PTM databases

iPTMnetiQ8CFC1.
PhosphoSiteiQ8CFC1.

Structurei

3D structure databases

ProteinModelPortaliQ8CFC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini139 – 271133JmjCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ROX family. MINA53 subfamily.Curated
Contains 1 JmjC domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000007965.
HOVERGENiHBG055265.
InParanoidiQ8CFC1.
PhylomeDBiQ8CFC1.
TreeFamiTF318659.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PfamiPF08007. Cupin_4. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CFC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKVKPTGD ENEEESVPCK QVKEELPNTL SVLNFDSPSS FFESLISPIK
60 70 80 90 100
VETFFKEFWE QKPLLIQRDD PSLAAYYQSL FSLSDLRSLC SQGLYYGRDV
110 120 130 140 150
NVCRCIGGKK KVLNKDGKAQ FLQLRKDFDQ KRATIQFHQP QRFKDELWRI
160 170 180 190 200
QEKLECYFGS LVGSNVYMTP AGSQGLPPHY DDVEVFILQL EGRKRWRLYS
210 220 230 240 250
PTVPLAREYS VEPEDRIGTP THDFLLKPGD LLYFPRGTIH QAETPSGLAH
260 270 280 290 300
SIHLTISTYQ NNSWGDYLLD SISGLVFDIA KEDVALRTGM PRRMLMNVET
310 320 330 340 350
PADVTRKLSG FLRTLADQLE GRKELLSSDM KKDFVMHRLP PFCVGNGTES
360 370 380 390 400
MNPGGKLPRL NSIVRLQFKD HIVLTVGPDQ NQSDEAQQKV VYIYHSLKNE
410 420 430 440 450
RQTHMMGKEV ETEIYGLRFP LSYVDALKQI WCGSPVRVKD LKLGTDEEKE
460
NLAVSLWTEC LVHVL
Length:465
Mass (Da):53,216
Last modified:March 1, 2003 - v1
Checksum:i4CDC8038AA81B5AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083195 mRNA. Translation: BAC16362.1.
BC087650 mRNA. Translation: AAH87650.1.
RefSeqiNP_695221.1. NM_153309.2.
UniGeneiRn.77753.

Genome annotation databases

GeneIDi266670.
KEGGirno:266670.
UCSCiRGD:708521. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083195 mRNA. Translation: BAC16362.1.
BC087650 mRNA. Translation: AAH87650.1.
RefSeqiNP_695221.1. NM_153309.2.
UniGeneiRn.77753.

3D structure databases

ProteinModelPortaliQ8CFC1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8CFC1.
PhosphoSiteiQ8CFC1.

Proteomic databases

PRIDEiQ8CFC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266670.
KEGGirno:266670.
UCSCiRGD:708521. rat.

Organism-specific databases

CTDi84864.
RGDi708521. Mina.

Phylogenomic databases

HOGENOMiHOG000007965.
HOVERGENiHBG055265.
InParanoidiQ8CFC1.
PhylomeDBiQ8CFC1.
TreeFamiTF318659.

Miscellaneous databases

PROiQ8CFC1.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PfamiPF08007. Cupin_4. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMINA_RAT
AccessioniPrimary (citable) accession number: Q8CFC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.