ID   KLF17_MOUSE             Reviewed;         341 AA.
AC   Q8CFA7; B1ASI5; Q3UT30; Q6P233; Q9D351;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 2.
DT   27-MAR-2024, entry version 151.
DE   RecName: Full=Krueppel-like factor 17;
DE   AltName: Full=Germ cell-specific zinc finger protein;
DE   AltName: Full=Zinc finger protein 393;
GN   Name=Klf17; Synonyms=Gzf, Zfp393, Znf393;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=129/Sv X C57BL; TISSUE=Testis;
RX   PubMed=12351194; DOI=10.1016/s0925-4773(02)00258-7;
RA   Yan W., Burns K.H., Ma L., Matzuk M.M.;
RT   "Identification of Zfp393, a germ cell-specific gene encoding a novel zinc
RT   finger protein.";
RL   Mech. Dev. 118:233-239(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Egg;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Egg;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   FUNCTION, AND DNA-BINDING.
RX   PubMed=19801974; DOI=10.1038/ncb1974;
RA   Gumireddy K., Li A., Gimotty P.A., Klein-Szanto A.J., Showe L.C.,
RA   Katsaros D., Coukos G., Zhang L., Huang Q.;
RT   "KLF17 is a negative regulator of epithelial-mesenchymal transition and
RT   metastasis in breast cancer.";
RL   Nat. Cell Biol. 11:1297-1304(2009).
CC   -!- FUNCTION: Transcription repressor that binds to the promoter of target
CC       genes and prevents their expression. Acts as a negative regulator of
CC       epithelial-mesenchymal transition and metastasis in breast cancer.
CC       Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a
CC       key metastasis regulator in breast cancer, and repress its expression.
CC       May be a germ cell-specific transcription factor that plays important
CC       roles in spermatid differentiation and oocyte development.
CC       {ECO:0000269|PubMed:19801974}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Exclusively expressed in testis and ovary.
CC       Localized to step 3-8 spermatids in testis and growing oocytes in
CC       ovary. {ECO:0000269|PubMed:12351194}.
CC   -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF508984; AAN31656.1; -; mRNA.
DR   EMBL; AK018361; BAB31177.1; -; mRNA.
DR   EMBL; AK139827; BAE24150.1; -; mRNA.
DR   EMBL; AL627128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL671520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466552; EDL30543.1; -; Genomic_DNA.
DR   EMBL; BC064748; AAH64748.1; -; mRNA.
DR   CCDS; CCDS18537.1; -.
DR   RefSeq; NP_083692.2; NM_029416.2.
DR   AlphaFoldDB; Q8CFA7; -.
DR   SMR; Q8CFA7; -.
DR   STRING; 10090.ENSMUSP00000052316; -.
DR   PhosphoSitePlus; Q8CFA7; -.
DR   PaxDb; 10090-ENSMUSP00000052316; -.
DR   Antibodypedia; 18431; 228 antibodies from 30 providers.
DR   DNASU; 75753; -.
DR   Ensembl; ENSMUST00000062747.6; ENSMUSP00000052316.6; ENSMUSG00000048626.6.
DR   GeneID; 75753; -.
DR   KEGG; mmu:75753; -.
DR   UCSC; uc008uix.1; mouse.
DR   AGR; MGI:2181068; -.
DR   CTD; 128209; -.
DR   MGI; MGI:2181068; Klf17.
DR   VEuPathDB; HostDB:ENSMUSG00000048626; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000162020; -.
DR   HOGENOM; CLU_827795_0_0_1; -.
DR   InParanoid; Q8CFA7; -.
DR   OMA; MMPLGEP; -.
DR   OrthoDB; 4892855at2759; -.
DR   PhylomeDB; Q8CFA7; -.
DR   TreeFam; TF350556; -.
DR   BioGRID-ORCS; 75753; 0 hits in 76 CRISPR screens.
DR   PRO; PR:Q8CFA7; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q8CFA7; Protein.
DR   Bgee; ENSMUSG00000048626; Expressed in animal zygote and 48 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:UniProtKB.
DR   GO; GO:0007276; P:gamete generation; IDA:MGI.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23235:SF154; KRUEPPEL-LIKE FACTOR 17; 1.
DR   PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
DR   Genevisible; Q8CFA7; MM.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..341
FT                   /note="Krueppel-like factor 17"
FT                   /id="PRO_0000047556"
FT   ZN_FING         256..280
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         286..310
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         316..338
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          214..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        141
FT                   /note="S -> G (in Ref. 5; AAH64748)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        165
FT                   /note="L -> M (in Ref. 2; BAB31177)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   341 AA;  38076 MW;  03F400D4485DDE3A CRC64;
     MEQDNKEQAM HQPPMDNKML VPVSNVPVSS GNSGFHQPPA TQYLPEMMRS YMASAEELRC
     NEREWESQLI RSLPEHGVRC PSQLAPIPFQ NYCQRSIGRG SHVMPVGSSG TLGVTISFSE
     NLMPQGGLPS SRGVSVMAHS SAPAMPYPMP PTVPATTGSL KHGILLVPGM ASAGTHAVAP
     FMDQMLHSIN PCNPEMLPAR FQQLLPLDSQ DSLVTESNTQ EEPFVREPPT PAPEGAESPS
     TSRGATRRQS PVSRPYVCTY NSCGKSYTKR SHLVSHQRKH TGVKPFACDW NGCTWKFFRS
     DELGRHKRIH TRYRPHKCDE CDREFMRSDH LRQHKRTHLP K
//