Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8CFA7

- KLF17_MOUSE

UniProt

Q8CFA7 - KLF17_MOUSE

Protein

Krueppel-like factor 17

Gene

Klf17

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (08 Nov 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri256 – 28025C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri286 – 31025C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri316 – 33823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    3. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. gamete generation Source: MGI
    2. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 17
    Alternative name(s):
    Germ cell-specific zinc finger protein
    Zinc finger protein 393
    Gene namesi
    Name:Klf17
    Synonyms:Gzf, Zfp393, Znf393
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2181068. Klf17.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Krueppel-like factor 17PRO_0000047556Add
    BLAST

    Proteomic databases

    PRIDEiQ8CFA7.

    Expressioni

    Tissue specificityi

    Exclusively expressed in testis and ovary. Localized to step 3-8 spermatids in testis and growing oocytes in ovary.1 Publication

    Gene expression databases

    BgeeiQ8CFA7.
    CleanExiMM_KLF17.
    GenevestigatoriQ8CFA7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CFA7.
    SMRiQ8CFA7. Positions 227-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri256 – 28025C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri286 – 31025C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri316 – 33823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117314.
    HOGENOMiHOG000049152.
    HOVERGENiHBG080136.
    InParanoidiB1ASI5.
    KOiK09211.
    OMAiWSFFRSD.
    OrthoDBiEOG7FJH1D.
    PhylomeDBiQ8CFA7.
    TreeFamiTF350556.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CFA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQDNKEQAM HQPPMDNKML VPVSNVPVSS GNSGFHQPPA TQYLPEMMRS    50
    YMASAEELRC NEREWESQLI RSLPEHGVRC PSQLAPIPFQ NYCQRSIGRG 100
    SHVMPVGSSG TLGVTISFSE NLMPQGGLPS SRGVSVMAHS SAPAMPYPMP 150
    PTVPATTGSL KHGILLVPGM ASAGTHAVAP FMDQMLHSIN PCNPEMLPAR 200
    FQQLLPLDSQ DSLVTESNTQ EEPFVREPPT PAPEGAESPS TSRGATRRQS 250
    PVSRPYVCTY NSCGKSYTKR SHLVSHQRKH TGVKPFACDW NGCTWKFFRS 300
    DELGRHKRIH TRYRPHKCDE CDREFMRSDH LRQHKRTHLP K 341
    Length:341
    Mass (Da):38,076
    Last modified:November 8, 2005 - v2
    Checksum:i03F400D4485DDE3A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti141 – 1411S → G in AAH64748. (PubMed:15489334)Curated
    Sequence conflicti165 – 1651L → M in BAB31177. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF508984 mRNA. Translation: AAN31656.1.
    AK018361 mRNA. Translation: BAB31177.1.
    AK139827 mRNA. Translation: BAE24150.1.
    AL627128, AL671520 Genomic DNA. Translation: CAM14707.1.
    AL671520, AL627128 Genomic DNA. Translation: CAM27525.1.
    CH466552 Genomic DNA. Translation: EDL30543.1.
    BC064748 mRNA. Translation: AAH64748.1.
    CCDSiCCDS18537.1.
    RefSeqiNP_083692.2. NM_029416.2.
    XP_006543943.1. XM_006543880.1.
    UniGeneiMm.3848.

    Genome annotation databases

    EnsembliENSMUST00000062747; ENSMUSP00000052316; ENSMUSG00000048626.
    GeneIDi75753.
    KEGGimmu:75753.
    UCSCiuc008uix.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF508984 mRNA. Translation: AAN31656.1 .
    AK018361 mRNA. Translation: BAB31177.1 .
    AK139827 mRNA. Translation: BAE24150.1 .
    AL627128 , AL671520 Genomic DNA. Translation: CAM14707.1 .
    AL671520 , AL627128 Genomic DNA. Translation: CAM27525.1 .
    CH466552 Genomic DNA. Translation: EDL30543.1 .
    BC064748 mRNA. Translation: AAH64748.1 .
    CCDSi CCDS18537.1.
    RefSeqi NP_083692.2. NM_029416.2.
    XP_006543943.1. XM_006543880.1.
    UniGenei Mm.3848.

    3D structure databases

    ProteinModelPortali Q8CFA7.
    SMRi Q8CFA7. Positions 227-339.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8CFA7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062747 ; ENSMUSP00000052316 ; ENSMUSG00000048626 .
    GeneIDi 75753.
    KEGGi mmu:75753.
    UCSCi uc008uix.1. mouse.

    Organism-specific databases

    CTDi 128209.
    MGIi MGI:2181068. Klf17.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117314.
    HOGENOMi HOG000049152.
    HOVERGENi HBG080136.
    InParanoidi B1ASI5.
    KOi K09211.
    OMAi WSFFRSD.
    OrthoDBi EOG7FJH1D.
    PhylomeDBi Q8CFA7.
    TreeFami TF350556.

    Miscellaneous databases

    ChiTaRSi KLF17. mouse.
    NextBioi 343862.
    PROi Q8CFA7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CFA7.
    CleanExi MM_KLF17.
    Genevestigatori Q8CFA7.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein."
      Yan W., Burns K.H., Ma L., Matzuk M.M.
      Mech. Dev. 118:233-239(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: 129/Sv X C57BL.
      Tissue: Testis.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Egg.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Egg.
    6. "KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer."
      Gumireddy K., Li A., Gimotty P.A., Klein-Szanto A.J., Showe L.C., Katsaros D., Coukos G., Zhang L., Huang Q.
      Nat. Cell Biol. 11:1297-1304(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING.

    Entry informationi

    Entry nameiKLF17_MOUSE
    AccessioniPrimary (citable) accession number: Q8CFA7
    Secondary accession number(s): B1ASI5
    , Q3UT30, Q6P233, Q9D351
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3