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Q8CFA7

- KLF17_MOUSE

UniProt

Q8CFA7 - KLF17_MOUSE

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Protein
Krueppel-like factor 17
Gene
Klf17, Gzf, Zfp393, Znf393
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri256 – 28025C2H2-type 1
Add
BLAST
Zinc fingeri286 – 31025C2H2-type 2
Add
BLAST
Zinc fingeri316 – 33823C2H2-type 3
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  3. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. gamete generation Source: MGI
  2. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 17
Alternative name(s):
Germ cell-specific zinc finger protein
Zinc finger protein 393
Gene namesi
Name:Klf17
Synonyms:Gzf, Zfp393, Znf393
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2181068. Klf17.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Krueppel-like factor 17
PRO_0000047556Add
BLAST

Proteomic databases

PRIDEiQ8CFA7.

Expressioni

Tissue specificityi

Exclusively expressed in testis and ovary. Localized to step 3-8 spermatids in testis and growing oocytes in ovary.1 Publication

Gene expression databases

BgeeiQ8CFA7.
CleanExiMM_KLF17.
GenevestigatoriQ8CFA7.

Structurei

3D structure databases

ProteinModelPortaliQ8CFA7.
SMRiQ8CFA7. Positions 227-339.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117314.
HOGENOMiHOG000049152.
HOVERGENiHBG080136.
InParanoidiB1ASI5.
KOiK09211.
OMAiWSFFRSD.
OrthoDBiEOG7FJH1D.
PhylomeDBiQ8CFA7.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CFA7-1 [UniParc]FASTAAdd to Basket

« Hide

MEQDNKEQAM HQPPMDNKML VPVSNVPVSS GNSGFHQPPA TQYLPEMMRS    50
YMASAEELRC NEREWESQLI RSLPEHGVRC PSQLAPIPFQ NYCQRSIGRG 100
SHVMPVGSSG TLGVTISFSE NLMPQGGLPS SRGVSVMAHS SAPAMPYPMP 150
PTVPATTGSL KHGILLVPGM ASAGTHAVAP FMDQMLHSIN PCNPEMLPAR 200
FQQLLPLDSQ DSLVTESNTQ EEPFVREPPT PAPEGAESPS TSRGATRRQS 250
PVSRPYVCTY NSCGKSYTKR SHLVSHQRKH TGVKPFACDW NGCTWKFFRS 300
DELGRHKRIH TRYRPHKCDE CDREFMRSDH LRQHKRTHLP K 341
Length:341
Mass (Da):38,076
Last modified:November 8, 2005 - v2
Checksum:i03F400D4485DDE3A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411S → G in AAH64748. 1 Publication
Sequence conflicti165 – 1651L → M in BAB31177. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF508984 mRNA. Translation: AAN31656.1.
AK018361 mRNA. Translation: BAB31177.1.
AK139827 mRNA. Translation: BAE24150.1.
AL627128, AL671520 Genomic DNA. Translation: CAM14707.1.
AL671520, AL627128 Genomic DNA. Translation: CAM27525.1.
CH466552 Genomic DNA. Translation: EDL30543.1.
BC064748 mRNA. Translation: AAH64748.1.
CCDSiCCDS18537.1.
RefSeqiNP_083692.2. NM_029416.2.
XP_006543943.1. XM_006543880.1.
UniGeneiMm.3848.

Genome annotation databases

EnsembliENSMUST00000062747; ENSMUSP00000052316; ENSMUSG00000048626.
GeneIDi75753.
KEGGimmu:75753.
UCSCiuc008uix.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF508984 mRNA. Translation: AAN31656.1 .
AK018361 mRNA. Translation: BAB31177.1 .
AK139827 mRNA. Translation: BAE24150.1 .
AL627128 , AL671520 Genomic DNA. Translation: CAM14707.1 .
AL671520 , AL627128 Genomic DNA. Translation: CAM27525.1 .
CH466552 Genomic DNA. Translation: EDL30543.1 .
BC064748 mRNA. Translation: AAH64748.1 .
CCDSi CCDS18537.1.
RefSeqi NP_083692.2. NM_029416.2.
XP_006543943.1. XM_006543880.1.
UniGenei Mm.3848.

3D structure databases

ProteinModelPortali Q8CFA7.
SMRi Q8CFA7. Positions 227-339.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8CFA7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062747 ; ENSMUSP00000052316 ; ENSMUSG00000048626 .
GeneIDi 75753.
KEGGi mmu:75753.
UCSCi uc008uix.1. mouse.

Organism-specific databases

CTDi 128209.
MGIi MGI:2181068. Klf17.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00750000117314.
HOGENOMi HOG000049152.
HOVERGENi HBG080136.
InParanoidi B1ASI5.
KOi K09211.
OMAi WSFFRSD.
OrthoDBi EOG7FJH1D.
PhylomeDBi Q8CFA7.
TreeFami TF350556.

Miscellaneous databases

ChiTaRSi KLF17. mouse.
NextBioi 343862.
PROi Q8CFA7.
SOURCEi Search...

Gene expression databases

Bgeei Q8CFA7.
CleanExi MM_KLF17.
Genevestigatori Q8CFA7.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein."
    Yan W., Burns K.H., Ma L., Matzuk M.M.
    Mech. Dev. 118:233-239(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: 129/Sv X C57BL.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg.
  6. "KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer."
    Gumireddy K., Li A., Gimotty P.A., Klein-Szanto A.J., Showe L.C., Katsaros D., Coukos G., Zhang L., Huang Q.
    Nat. Cell Biol. 11:1297-1304(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.

Entry informationi

Entry nameiKLF17_MOUSE
AccessioniPrimary (citable) accession number: Q8CFA7
Secondary accession number(s): B1ASI5
, Q3UT30, Q6P233, Q9D351
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi