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Q8CFA7 (KLF17_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Krueppel-like factor 17
Alternative name(s):
Germ cell-specific zinc finger protein
Zinc finger protein 393
Gene names
Name:Klf17
Synonyms:Gzf, Zfp393, Znf393
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development. Ref.6

Subcellular location

Nucleus Potential.

Tissue specificity

Exclusively expressed in testis and ovary. Localized to step 3-8 spermatids in testis and growing oocytes in ovary. Ref.1

Sequence similarities

Belongs to the Sp1 C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Krueppel-like factor 17
PRO_0000047556

Regions

Zinc finger256 – 28025C2H2-type 1
Zinc finger286 – 31025C2H2-type 2
Zinc finger316 – 33823C2H2-type 3

Experimental info

Sequence conflict1411S → G in AAH64748. Ref.5
Sequence conflict1651L → M in BAB31177. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8CFA7 [UniParc].

Last modified November 8, 2005. Version 2.
Checksum: 03F400D4485DDE3A

FASTA34138,076
        10         20         30         40         50         60 
MEQDNKEQAM HQPPMDNKML VPVSNVPVSS GNSGFHQPPA TQYLPEMMRS YMASAEELRC 

        70         80         90        100        110        120 
NEREWESQLI RSLPEHGVRC PSQLAPIPFQ NYCQRSIGRG SHVMPVGSSG TLGVTISFSE 

       130        140        150        160        170        180 
NLMPQGGLPS SRGVSVMAHS SAPAMPYPMP PTVPATTGSL KHGILLVPGM ASAGTHAVAP 

       190        200        210        220        230        240 
FMDQMLHSIN PCNPEMLPAR FQQLLPLDSQ DSLVTESNTQ EEPFVREPPT PAPEGAESPS 

       250        260        270        280        290        300 
TSRGATRRQS PVSRPYVCTY NSCGKSYTKR SHLVSHQRKH TGVKPFACDW NGCTWKFFRS 

       310        320        330        340 
DELGRHKRIH TRYRPHKCDE CDREFMRSDH LRQHKRTHLP K

« Hide

References

« Hide 'large scale' references
[1]"Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein."
Yan W., Burns K.H., Ma L., Matzuk M.M.
Mech. Dev. 118:233-239(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: 129/Sv X C57BL.
Tissue: Testis.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Egg.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Egg.
[6]"KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer."
Gumireddy K., Li A., Gimotty P.A., Klein-Szanto A.J., Showe L.C., Katsaros D., Coukos G., Zhang L., Huang Q.
Nat. Cell Biol. 11:1297-1304(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF508984 mRNA. Translation: AAN31656.1.
AK018361 mRNA. Translation: BAB31177.1.
AK139827 mRNA. Translation: BAE24150.1.
AL627128, AL671520 Genomic DNA. Translation: CAM14707.1.
AL671520, AL627128 Genomic DNA. Translation: CAM27525.1.
CH466552 Genomic DNA. Translation: EDL30543.1.
BC064748 mRNA. Translation: AAH64748.1.
IPIIPI00319065.
RefSeqNP_083692.2. NM_029416.2.
XP_003946193.1. XM_003946144.1.
UniGeneMm.3848.

3D structure databases

ProteinModelPortalQ8CFA7.
SMRQ8CFA7. Positions 227-338.
ModBaseSearch...

Proteomic databases

PRIDEQ8CFA7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000062747; ENSMUSP00000052316; ENSMUSG00000048626.
GeneID75753.
KEGGmmu:75753.
UCSCuc008uix.1. mouse.

Organism-specific databases

CTD128209.
MGIMGI:2181068. Klf17.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00680000099668.
HOGENOMHOG000049152.
HOVERGENHBG080136.
InParanoidB1ASI5.
KOK09211.
OMAWSFFRSD.
OrthoDBEOG4PG610.

Gene expression databases

BgeeQ8CFA7.
CleanExMM_KLF17.
GenevestigatorQ8CFA7.
GermOnlineENSMUSG00000048626. Mus musculus.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKLF17. mouse.
NextBio343862.
SOURCESearch...

Entry information

Entry nameKLF17_MOUSE
AccessionPrimary (citable) accession number: Q8CFA7
Secondary accession number(s): B1ASI5 expand/collapse secondary AC list , Q3UT30, Q6P233, Q9D351
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents