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Protein

Aminomethyltransferase, mitochondrial

Gene

Amt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine.By similarity

Catalytic activityi

[Protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei232SubstrateBy similarity1
Binding sitei261SubstrateBy similarity1
Binding sitei399SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-6783984 Glycine degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Aminomethyltransferase, mitochondrialCurated (EC:2.1.2.10By similarity)
Alternative name(s):
Glycine cleavage system T proteinBy similarity
Short name:
GCVT
Gene namesi
Name:AmtImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3646700 Amt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionBy similarityAdd BLAST28
ChainiPRO_000001075629 – 403Aminomethyltransferase, mitochondrialAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei368N6-succinyllysineCombined sources1

Proteomic databases

MaxQBiQ8CFA2
PaxDbiQ8CFA2
PRIDEiQ8CFA2

PTM databases

iPTMnetiQ8CFA2
PhosphoSitePlusiQ8CFA2
SwissPalmiQ8CFA2

Expressioni

Gene expression databases

BgeeiENSMUSG00000032607
CleanExiMM_AMT
ExpressionAtlasiQ8CFA2 baseline and differential

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Protein-protein interaction databases

IntActiQ8CFA2, 2 interactors
MINTiQ8CFA2
STRINGi10090.ENSMUSP00000035230

Structurei

3D structure databases

ProteinModelPortaliQ8CFA2
SMRiQ8CFA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2770 Eukaryota
COG0404 LUCA
GeneTreeiENSGT00530000063120
HOGENOMiHOG000239380
HOVERGENiHBG005822
InParanoidiQ8CFA2
KOiK00605
OMAiMPVQYPA
OrthoDBiEOG091G07Z1
PhylomeDBiQ8CFA2
TreeFamiTF313026

Family and domain databases

Gene3Di3.30.1360.120, 2 hits
InterProiView protein in InterPro
IPR006223 GCS_T
IPR028896 GCST/YgfZ/DmdA
IPR013977 GCV_T_C
IPR006222 GCV_T_N
IPR029043 GcvT/YgfZ_C
IPR027266 TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01571 GCV_T, 1 hit
PF08669 GCV_T_C, 1 hit
PIRSFiPIRSF006487 GcvT, 1 hit
SUPFAMiSSF101790 SSF101790, 1 hit
TIGRFAMsiTIGR00528 gcvT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CFA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRIVSVVAP LGFRLQAQPL VQSRPLSSVQ DVLRRTPLYD FHLAHGGKMV
60 70 80 90 100
AFAGWSLPVQ YRDSHVDSHL HTRRHCSLFD VSHMLQTKIF GCDRVKLLES
110 120 130 140 150
VVVGDIAELR PNQGTLSLFT NEAGGILDDL IVSNTSEGHL YVVSNAGCRD
160 170 180 190 200
KDLALMQDKV KEFQNRGLDV GLEVVENALL ALQGPTATQV LQAGVTDDMK
210 220 230 240 250
KLPFMTSAVM EVFGVSGCRV TRCGYTGEDG VEISVPATGA VHLATTLLKN
260 270 280 290 300
PEVKLAGLAA RDSLRLEAGL CLYGNDIDEH TTPVEGSLSW TLGKRRRIAM
310 320 330 340 350
DFPGAKIIVP QLKGEVQRRR VGLICEGAPV RAHSPILNTE GTVIGTVTSG
360 370 380 390 400
CPSPSLKKNV AMGYVPFKYS RPGTQLLVEV RRKQQMTVVS KMPFVPTNYY

TLK
Length:403
Mass (Da):44,009
Last modified:March 1, 2003 - v1
Checksum:i4FDEC0DC81492167
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ437692 Genomic DNA Translation: CAD26917.1
CCDSiCCDS23519.1
RefSeqiNP_001013836.1, NM_001013814.1
UniGeneiMm.390225

Genome annotation databases

EnsembliENSMUST00000035230; ENSMUSP00000035230; ENSMUSG00000032607
GeneIDi434437
KEGGimmu:434437
UCSCiuc009rpc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGCST_MOUSE
AccessioniPrimary (citable) accession number: Q8CFA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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