ID   RHD_MOUSE               Reviewed;         418 AA.
AC   Q8CF94; O88296; O88297; Q9QUM6; Q9QX04;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 109.
DE   RecName: Full=Blood group Rh(D) polypeptide;
DE   AltName: Full=Erythrocyte membrane glycoprotein Rh30;
DE   AltName: CD_antigen=CD240D;
GN   Name=Rhd; Synonyms=Rh30, Rhced;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BFM-2MsfB6C3FI, and C57BL-10SnJ; TISSUE=Bone marrow;
RX   PubMed=9705835; DOI=10.1006/bbrc.1998.9074;
RA   Kitano T., Sumiyama K., Shiroishi T., Saitou N.;
RT   "Conserved evolution of the Rh50 gene compared to its homologous Rh blood
RT   group gene.";
RL   Biochem. Biophys. Res. Commun. 249:78-85(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/cJ; TISSUE=Spleen;
RX   PubMed=10329015; DOI=10.1006/geno.1999.5783;
RA   Westhoff C.M., Schultze A., From A., Wylie D.E., Silberstein L.E.;
RT   "Characterization of the mouse Rh blood group gene.";
RL   Genomics 57:451-454(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=9929383; DOI=10.1007/pl00006453;
RA   Matassi G., Cherif-Zahar B., Pesole G., Raynal V., Cartron J.-P.;
RT   "The members of the RH gene family (RH50 and RH30) followed different
RT   evolutionary pathways.";
RL   J. Mol. Evol. 48:151-159(1999).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12459264; DOI=10.1016/s0378-1119(02)01054-5;
RA   Kumada M., Iwamoto S., Kamesaki T., Okuda H., Kajii E.;
RT   "Entire sequence of a mouse chromosomal segment containing the gene Rhced
RT   and a comparative analysis of the homologous human sequence.";
RL   Gene 299:165-172(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16227429; DOI=10.1073/pnas.0507886102;
RA   Huang C.-H., Peng J.;
RT   "Evolutionary conservation and diversification of Rh family genes and
RT   proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Cerebellum, and Spleen;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [10]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May be part of an oligomeric complex which is likely to have
CC       a transport or channel function in the erythrocyte membrane.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q02161};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- PTM: Palmitoylated. {ECO:0000250|UniProtKB:Q02161}.
CC   -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AB015189; BAA32438.1; -; mRNA.
DR   EMBL; AB015190; BAA32439.1; -; mRNA.
DR   EMBL; AF069311; AAC64038.1; -; mRNA.
DR   EMBL; AF047827; AAD13391.1; -; mRNA.
DR   EMBL; AB076248; BAC21151.1; -; Genomic_DNA.
DR   EMBL; AF057524; AAC25123.1; -; mRNA.
DR   EMBL; AK079335; BAC37610.1; -; mRNA.
DR   EMBL; AK171641; BAE42581.1; -; mRNA.
DR   EMBL; AL611963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466552; EDL29999.1; -; Genomic_DNA.
DR   EMBL; BC145805; AAI45806.1; -; mRNA.
DR   CCDS; CCDS18778.1; -.
DR   RefSeq; NP_035400.3; NM_011270.3.
DR   AlphaFoldDB; Q8CF94; -.
DR   SMR; Q8CF94; -.
DR   STRING; 10090.ENSMUSP00000030627; -.
DR   GlyGen; Q8CF94; 1 site, 1 O-linked glycan (1 site).
DR   MaxQB; Q8CF94; -.
DR   PaxDb; 10090-ENSMUSP00000030627; -.
DR   ProteomicsDB; 255199; -.
DR   DNASU; 19746; -.
DR   GeneID; 19746; -.
DR   KEGG; mmu:19746; -.
DR   AGR; MGI:1202882; -.
DR   CTD; 6007; -.
DR   MGI; MGI:1202882; Rhd.
DR   eggNOG; KOG3796; Eukaryota.
DR   InParanoid; Q8CF94; -.
DR   OrthoDB; 5483564at2759; -.
DR   PhylomeDB; Q8CF94; -.
DR   TreeFam; TF314450; -.
DR   BioGRID-ORCS; 19746; 1 hit in 78 CRISPR screens.
DR   ChiTaRS; Rhd; mouse.
DR   PRO; PR:Q8CF94; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q8CF94; Protein.
DR   GO; GO:0170014; C:ankyrin-1 complex; ISO:MGI.
DR   GO; GO:0016020; C:membrane; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR   GO; GO:0072488; P:ammonium transmembrane transport; IMP:MGI.
DR   GO; GO:0048821; P:erythrocyte development; IMP:MGI.
DR   GO; GO:0060586; P:multicellular organismal-level iron ion homeostasis; IMP:MGI.
DR   Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   InterPro; IPR002229; RhesusRHD.
DR   PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1.
DR   PANTHER; PTHR11730:SF43; BLOOD GROUP RH(CE) POLYPEPTIDE-RELATED; 1.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   PRINTS; PR00342; RHESUSRHD.
DR   SUPFAM; SSF111352; Ammonium transporter; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..418
FT                   /note="Blood group Rh(D) polypeptide"
FT                   /id="PRO_0000383326"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         398
FT                   /note="H -> R"
FT   CONFLICT        3
FT                   /note="S -> C (in Ref. 5; AAC25123)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        19
FT                   /note="E -> V (in Ref. 1; BAA32438)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        20
FT                   /note="L -> V (in Ref. 5; AAC25123)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        22
FT                   /note="T -> I (in Ref. 1; BAA32439)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        25
FT                   /note="S -> I (in Ref. 1; BAA32438)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        28
FT                   /note="F -> S (in Ref. 1; BAA32438)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        42
FT                   /note="R -> K (in Ref. 1; BAA32438)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        45
FT                   /note="A -> E (in Ref. 1; BAA32438)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        140
FT                   /note="V -> M (in Ref. 1; BAA32438)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        282
FT                   /note="V -> M (in Ref. 5; AAC25123)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   418 AA;  45877 MW;  76AAC777FA5BF633 CRC64;
     MGSKYPRSLR CCLPLWALEL QTAFSLLFCF FIPHDTAQVD HRFMASYQVL RNLTLMAALG
     FGFLSSSFRR HSWSSVAFNL FMLALGVQGT ILLDHFLGQV LQWNKINNLS SIQIATMSTL
     PVLISAGAVL GKVNLVQLTV MVLMEAMAFG AIRFADEKVF KMTEHIIMMH GHVFGAYFGL
     TVAWWLSRSL PRRVGENAQT EKVQMATSSS LFAMLGTLFL WIFWPAINSA LLEGTKKRNA
     VFNTYYALAV SAVTATSMSA LSHPQGKINM VHIHNAVLAG GVAVGAPGCL ISSPWISMVL
     GLIAGLISIW GAKCPRACLN HMLQNSSGIH YTFGLPGLLG ALTYYCLQIV TEPKSSDLWI
     ITQTVTHIGA LSFAVAMGMV TGLLTGCLLS VRVWRAPHAA KYFDDQTFWE FPHLAVGF
//