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Protein

Blood group Rh(D) polypeptide

Gene

Rhd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.By similarity

GO - Molecular functioni

GO - Biological processi

  • ammonium transport Source: MGI
  • erythrocyte development Source: MGI
  • multicellular organismal iron ion homeostasis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Blood group Rh(D) polypeptide
Alternative name(s):
Erythrocyte membrane glycoprotein Rh30
CD_antigen: CD240D
Gene namesi
Name:Rhd
Synonyms:Rh30, Rhced
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1202882. Rhd.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei112 – 13120HelicalSequence AnalysisAdd
BLAST
Transmembranei133 – 15523HelicalSequence AnalysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence AnalysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence AnalysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: MGI
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 418417Blood group Rh(D) polypeptidePRO_0000383326Add
BLAST

Proteomic databases

MaxQBiQ8CF94.
PaxDbiQ8CF94.
PRIDEiQ8CF94.

Expressioni

Gene expression databases

BgeeiQ8CF94.
ExpressionAtlasiQ8CF94. baseline and differential.
GenevestigatoriQ8CF94.

Structurei

3D structure databases

ProteinModelPortaliQ8CF94.
SMRiQ8CF94. Positions 42-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG314742.
HOGENOMiHOG000007656.
InParanoidiQ8CF94.
KOiK06579.
OrthoDBiEOG73NG3C.
PhylomeDBiQ8CF94.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CF94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKYPRSLR CCLPLWALEL QTAFSLLFCF FIPHDTAQVD HRFMASYQVL
60 70 80 90 100
RNLTLMAALG FGFLSSSFRR HSWSSVAFNL FMLALGVQGT ILLDHFLGQV
110 120 130 140 150
LQWNKINNLS SIQIATMSTL PVLISAGAVL GKVNLVQLTV MVLMEAMAFG
160 170 180 190 200
AIRFADEKVF KMTEHIIMMH GHVFGAYFGL TVAWWLSRSL PRRVGENAQT
210 220 230 240 250
EKVQMATSSS LFAMLGTLFL WIFWPAINSA LLEGTKKRNA VFNTYYALAV
260 270 280 290 300
SAVTATSMSA LSHPQGKINM VHIHNAVLAG GVAVGAPGCL ISSPWISMVL
310 320 330 340 350
GLIAGLISIW GAKCPRACLN HMLQNSSGIH YTFGLPGLLG ALTYYCLQIV
360 370 380 390 400
TEPKSSDLWI ITQTVTHIGA LSFAVAMGMV TGLLTGCLLS VRVWRAPHAA
410
KYFDDQTFWE FPHLAVGF
Length:418
Mass (Da):45,877
Last modified:March 1, 2003 - v1
Checksum:i76AAC777FA5BF633
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31S → C in AAC25123 (PubMed:16227429).Curated
Sequence conflicti19 – 191E → V in BAA32438 (PubMed:9705835).Curated
Sequence conflicti20 – 201L → V in AAC25123 (PubMed:16227429).Curated
Sequence conflicti22 – 221T → I in BAA32439 (PubMed:9705835).Curated
Sequence conflicti25 – 251S → I in BAA32438 (PubMed:9705835).Curated
Sequence conflicti28 – 281F → S in BAA32438 (PubMed:9705835).Curated
Sequence conflicti42 – 421R → K in BAA32438 (PubMed:9705835).Curated
Sequence conflicti45 – 451A → E in BAA32438 (PubMed:9705835).Curated
Sequence conflicti140 – 1401V → M in BAA32438 (PubMed:9705835).Curated
Sequence conflicti282 – 2821V → M in AAC25123 (PubMed:16227429).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti398 – 3981H → R.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015189 mRNA. Translation: BAA32438.1.
AB015190 mRNA. Translation: BAA32439.1.
AF069311 mRNA. Translation: AAC64038.1.
AF047827 mRNA. Translation: AAD13391.1.
AB076248 Genomic DNA. Translation: BAC21151.1.
AF057524 mRNA. Translation: AAC25123.1.
AK079335 mRNA. Translation: BAC37610.1.
AK171641 mRNA. Translation: BAE42581.1.
AL611963 Genomic DNA. Translation: CAM26944.1.
CH466552 Genomic DNA. Translation: EDL29999.1.
BC145805 mRNA. Translation: AAI45806.1.
CCDSiCCDS18778.1.
RefSeqiNP_035400.3. NM_011270.3.
UniGeneiMm.195461.

Genome annotation databases

GeneIDi19746.
KEGGimmu:19746.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015189 mRNA. Translation: BAA32438.1.
AB015190 mRNA. Translation: BAA32439.1.
AF069311 mRNA. Translation: AAC64038.1.
AF047827 mRNA. Translation: AAD13391.1.
AB076248 Genomic DNA. Translation: BAC21151.1.
AF057524 mRNA. Translation: AAC25123.1.
AK079335 mRNA. Translation: BAC37610.1.
AK171641 mRNA. Translation: BAE42581.1.
AL611963 Genomic DNA. Translation: CAM26944.1.
CH466552 Genomic DNA. Translation: EDL29999.1.
BC145805 mRNA. Translation: AAI45806.1.
CCDSiCCDS18778.1.
RefSeqiNP_035400.3. NM_011270.3.
UniGeneiMm.195461.

3D structure databases

ProteinModelPortaliQ8CF94.
SMRiQ8CF94. Positions 42-311.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ8CF94.
PaxDbiQ8CF94.
PRIDEiQ8CF94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19746.
KEGGimmu:19746.

Organism-specific databases

CTDi6007.
MGIiMGI:1202882. Rhd.

Phylogenomic databases

eggNOGiNOG314742.
HOGENOMiHOG000007656.
InParanoidiQ8CF94.
KOiK06579.
OrthoDBiEOG73NG3C.
PhylomeDBiQ8CF94.
TreeFamiTF314450.

Miscellaneous databases

NextBioi297200.
PROiQ8CF94.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CF94.
ExpressionAtlasiQ8CF94. baseline and differential.
GenevestigatoriQ8CF94.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene."
    Kitano T., Sumiyama K., Shiroishi T., Saitou N.
    Biochem. Biophys. Res. Commun. 249:78-85(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BFM-2MsfB6C3FI and C57BL-10SnJ.
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Spleen.
  3. "The members of the RH gene family (RH50 and RH30) followed different evolutionary pathways."
    Matassi G., Cherif-Zahar B., Pesole G., Raynal V., Cartron J.-P.
    J. Mol. Evol. 48:151-159(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  4. "Entire sequence of a mouse chromosomal segment containing the gene Rhced and a comparative analysis of the homologous human sequence."
    Kumada M., Iwamoto S., Kamesaki T., Okuda H., Kajii E.
    Gene 299:165-172(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Evolutionary conservation and diversification of Rh family genes and proteins."
    Huang C.-H., Peng J.
    Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum and Spleen.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  8. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRHD_MOUSE
AccessioniPrimary (citable) accession number: Q8CF94
Secondary accession number(s): O88296
, O88297, Q9QUM6, Q9QX04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 1, 2003
Last modified: May 27, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.