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Q8CF94

- RHD_MOUSE

UniProt

Q8CF94 - RHD_MOUSE

Protein

Blood group Rh(D) polypeptide

Gene

Rhd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.By similarity

    GO - Molecular functioni

    1. ammonium transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. ammonium transport Source: MGI
    2. erythrocyte development Source: MGI
    3. multicellular organismal iron ion homeostasis Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Blood group Rh(D) polypeptide
    Alternative name(s):
    Erythrocyte membrane glycoprotein Rh30
    CD_antigen: CD240D
    Gene namesi
    Name:Rhd
    Synonyms:Rh30, Rhced
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1202882. Rhd.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: MGI
    2. membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 418417Blood group Rh(D) polypeptidePRO_0000383326Add
    BLAST

    Proteomic databases

    PaxDbiQ8CF94.
    PRIDEiQ8CF94.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8CF94.
    BgeeiQ8CF94.
    GenevestigatoriQ8CF94.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CF94.
    SMRiQ8CF94. Positions 42-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei211 – 23121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei331 – 35121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei368 – 38821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG314742.
    GeneTreeiENSGT00390000005787.
    HOGENOMiHOG000007656.
    InParanoidiO88296.
    KOiK06579.
    OrthoDBiEOG73NG3C.
    PhylomeDBiQ8CF94.
    TreeFamiTF314450.

    Family and domain databases

    Gene3Di1.10.3430.10. 1 hit.
    InterProiIPR029020. Ammonium/urea_transptr.
    IPR024041. NH4_transpt_AmtB-like_dom.
    IPR002229. RhesusRHD.
    [Graphical view]
    PfamiPF00909. Ammonium_transp. 1 hit.
    [Graphical view]
    PRINTSiPR00342. RHESUSRHD.
    SUPFAMiSSF111352. SSF111352. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CF94-1 [UniParc]FASTAAdd to Basket

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    MGSKYPRSLR CCLPLWALEL QTAFSLLFCF FIPHDTAQVD HRFMASYQVL    50
    RNLTLMAALG FGFLSSSFRR HSWSSVAFNL FMLALGVQGT ILLDHFLGQV 100
    LQWNKINNLS SIQIATMSTL PVLISAGAVL GKVNLVQLTV MVLMEAMAFG 150
    AIRFADEKVF KMTEHIIMMH GHVFGAYFGL TVAWWLSRSL PRRVGENAQT 200
    EKVQMATSSS LFAMLGTLFL WIFWPAINSA LLEGTKKRNA VFNTYYALAV 250
    SAVTATSMSA LSHPQGKINM VHIHNAVLAG GVAVGAPGCL ISSPWISMVL 300
    GLIAGLISIW GAKCPRACLN HMLQNSSGIH YTFGLPGLLG ALTYYCLQIV 350
    TEPKSSDLWI ITQTVTHIGA LSFAVAMGMV TGLLTGCLLS VRVWRAPHAA 400
    KYFDDQTFWE FPHLAVGF 418
    Length:418
    Mass (Da):45,877
    Last modified:March 1, 2003 - v1
    Checksum:i76AAC777FA5BF633
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31S → C in AAC25123. (PubMed:16227429)Curated
    Sequence conflicti19 – 191E → V in BAA32438. (PubMed:9705835)Curated
    Sequence conflicti20 – 201L → V in AAC25123. (PubMed:16227429)Curated
    Sequence conflicti22 – 221T → I in BAA32439. (PubMed:9705835)Curated
    Sequence conflicti25 – 251S → I in BAA32438. (PubMed:9705835)Curated
    Sequence conflicti28 – 281F → S in BAA32438. (PubMed:9705835)Curated
    Sequence conflicti42 – 421R → K in BAA32438. (PubMed:9705835)Curated
    Sequence conflicti45 – 451A → E in BAA32438. (PubMed:9705835)Curated
    Sequence conflicti140 – 1401V → M in BAA32438. (PubMed:9705835)Curated
    Sequence conflicti282 – 2821V → M in AAC25123. (PubMed:16227429)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti398 – 3981H → R.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015189 mRNA. Translation: BAA32438.1.
    AB015190 mRNA. Translation: BAA32439.1.
    AF069311 mRNA. Translation: AAC64038.1.
    AF047827 mRNA. Translation: AAD13391.1.
    AB076248 Genomic DNA. Translation: BAC21151.1.
    AF057524 mRNA. Translation: AAC25123.1.
    AK079335 mRNA. Translation: BAC37610.1.
    AK171641 mRNA. Translation: BAE42581.1.
    AL611963 Genomic DNA. Translation: CAM26944.1.
    CH466552 Genomic DNA. Translation: EDL29999.1.
    BC145805 mRNA. Translation: AAI45806.1.
    CCDSiCCDS18778.1.
    RefSeqiNP_035400.3. NM_011270.3.
    UniGeneiMm.195461.

    Genome annotation databases

    EnsembliENSMUST00000030627; ENSMUSP00000030627; ENSMUSG00000028825.
    GeneIDi19746.
    KEGGimmu:19746.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015189 mRNA. Translation: BAA32438.1 .
    AB015190 mRNA. Translation: BAA32439.1 .
    AF069311 mRNA. Translation: AAC64038.1 .
    AF047827 mRNA. Translation: AAD13391.1 .
    AB076248 Genomic DNA. Translation: BAC21151.1 .
    AF057524 mRNA. Translation: AAC25123.1 .
    AK079335 mRNA. Translation: BAC37610.1 .
    AK171641 mRNA. Translation: BAE42581.1 .
    AL611963 Genomic DNA. Translation: CAM26944.1 .
    CH466552 Genomic DNA. Translation: EDL29999.1 .
    BC145805 mRNA. Translation: AAI45806.1 .
    CCDSi CCDS18778.1.
    RefSeqi NP_035400.3. NM_011270.3.
    UniGenei Mm.195461.

    3D structure databases

    ProteinModelPortali Q8CF94.
    SMRi Q8CF94. Positions 42-311.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q8CF94.
    PRIDEi Q8CF94.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030627 ; ENSMUSP00000030627 ; ENSMUSG00000028825 .
    GeneIDi 19746.
    KEGGi mmu:19746.

    Organism-specific databases

    CTDi 6007.
    MGIi MGI:1202882. Rhd.

    Phylogenomic databases

    eggNOGi NOG314742.
    GeneTreei ENSGT00390000005787.
    HOGENOMi HOG000007656.
    InParanoidi O88296.
    KOi K06579.
    OrthoDBi EOG73NG3C.
    PhylomeDBi Q8CF94.
    TreeFami TF314450.

    Miscellaneous databases

    NextBioi 297200.
    PROi Q8CF94.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CF94.
    Bgeei Q8CF94.
    Genevestigatori Q8CF94.

    Family and domain databases

    Gene3Di 1.10.3430.10. 1 hit.
    InterProi IPR029020. Ammonium/urea_transptr.
    IPR024041. NH4_transpt_AmtB-like_dom.
    IPR002229. RhesusRHD.
    [Graphical view ]
    Pfami PF00909. Ammonium_transp. 1 hit.
    [Graphical view ]
    PRINTSi PR00342. RHESUSRHD.
    SUPFAMi SSF111352. SSF111352. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene."
      Kitano T., Sumiyama K., Shiroishi T., Saitou N.
      Biochem. Biophys. Res. Commun. 249:78-85(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BFM-2MsfB6C3FI and C57BL-10SnJ.
      Tissue: Bone marrow.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Spleen.
    3. "The members of the RH gene family (RH50 and RH30) followed different evolutionary pathways."
      Matassi G., Cherif-Zahar B., Pesole G., Raynal V., Cartron J.-P.
      J. Mol. Evol. 48:151-159(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    4. "Entire sequence of a mouse chromosomal segment containing the gene Rhced and a comparative analysis of the homologous human sequence."
      Kumada M., Iwamoto S., Kamesaki T., Okuda H., Kajii E.
      Gene 299:165-172(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Evolutionary conservation and diversification of Rh family genes and proteins."
      Huang C.-H., Peng J.
      Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Cerebellum and Spleen.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    8. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRHD_MOUSE
    AccessioniPrimary (citable) accession number: Q8CF94
    Secondary accession number(s): O88296
    , O88297, Q9QUM6, Q9QX04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3