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Protein

Blood group Rh(D) polypeptide

Gene

Rhd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.By similarity

GO - Molecular functioni

GO - Biological processi

  • ammonium transmembrane transport Source: GO_Central
  • ammonium transport Source: MGI
  • erythrocyte development Source: MGI
  • multicellular organismal iron ion homeostasis Source: MGI
  • nitrogen utilization Source: GO_Central
  • organic cation transport Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Blood group Rh(D) polypeptide
Alternative name(s):
Erythrocyte membrane glycoprotein Rh30
CD_antigen: CD240D
Gene namesi
Name:Rhd
Synonyms:Rh30, Rhced
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1202882. Rhd.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei112 – 131HelicalSequence analysisAdd BLAST20
Transmembranei133 – 155HelicalSequence analysisAdd BLAST23
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003833262 – 418Blood group Rh(D) polypeptideAdd BLAST417

Proteomic databases

MaxQBiQ8CF94.
PaxDbiQ8CF94.
PRIDEiQ8CF94.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028825.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030627.

Structurei

3D structure databases

ProteinModelPortaliQ8CF94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
HOGENOMiHOG000007656.
InParanoidiQ8CF94.
KOiK06579.
PhylomeDBiQ8CF94.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CF94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKYPRSLR CCLPLWALEL QTAFSLLFCF FIPHDTAQVD HRFMASYQVL
60 70 80 90 100
RNLTLMAALG FGFLSSSFRR HSWSSVAFNL FMLALGVQGT ILLDHFLGQV
110 120 130 140 150
LQWNKINNLS SIQIATMSTL PVLISAGAVL GKVNLVQLTV MVLMEAMAFG
160 170 180 190 200
AIRFADEKVF KMTEHIIMMH GHVFGAYFGL TVAWWLSRSL PRRVGENAQT
210 220 230 240 250
EKVQMATSSS LFAMLGTLFL WIFWPAINSA LLEGTKKRNA VFNTYYALAV
260 270 280 290 300
SAVTATSMSA LSHPQGKINM VHIHNAVLAG GVAVGAPGCL ISSPWISMVL
310 320 330 340 350
GLIAGLISIW GAKCPRACLN HMLQNSSGIH YTFGLPGLLG ALTYYCLQIV
360 370 380 390 400
TEPKSSDLWI ITQTVTHIGA LSFAVAMGMV TGLLTGCLLS VRVWRAPHAA
410
KYFDDQTFWE FPHLAVGF
Length:418
Mass (Da):45,877
Last modified:March 1, 2003 - v1
Checksum:i76AAC777FA5BF633
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → C in AAC25123 (PubMed:16227429).Curated1
Sequence conflicti19E → V in BAA32438 (PubMed:9705835).Curated1
Sequence conflicti20L → V in AAC25123 (PubMed:16227429).Curated1
Sequence conflicti22T → I in BAA32439 (PubMed:9705835).Curated1
Sequence conflicti25S → I in BAA32438 (PubMed:9705835).Curated1
Sequence conflicti28F → S in BAA32438 (PubMed:9705835).Curated1
Sequence conflicti42R → K in BAA32438 (PubMed:9705835).Curated1
Sequence conflicti45A → E in BAA32438 (PubMed:9705835).Curated1
Sequence conflicti140V → M in BAA32438 (PubMed:9705835).Curated1
Sequence conflicti282V → M in AAC25123 (PubMed:16227429).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti398H → R.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015189 mRNA. Translation: BAA32438.1.
AB015190 mRNA. Translation: BAA32439.1.
AF069311 mRNA. Translation: AAC64038.1.
AF047827 mRNA. Translation: AAD13391.1.
AB076248 Genomic DNA. Translation: BAC21151.1.
AF057524 mRNA. Translation: AAC25123.1.
AK079335 mRNA. Translation: BAC37610.1.
AK171641 mRNA. Translation: BAE42581.1.
AL611963 Genomic DNA. Translation: CAM26944.1.
CH466552 Genomic DNA. Translation: EDL29999.1.
BC145805 mRNA. Translation: AAI45806.1.
CCDSiCCDS18778.1.
RefSeqiNP_035400.3. NM_011270.3.
UniGeneiMm.195461.

Genome annotation databases

GeneIDi19746.
KEGGimmu:19746.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015189 mRNA. Translation: BAA32438.1.
AB015190 mRNA. Translation: BAA32439.1.
AF069311 mRNA. Translation: AAC64038.1.
AF047827 mRNA. Translation: AAD13391.1.
AB076248 Genomic DNA. Translation: BAC21151.1.
AF057524 mRNA. Translation: AAC25123.1.
AK079335 mRNA. Translation: BAC37610.1.
AK171641 mRNA. Translation: BAE42581.1.
AL611963 Genomic DNA. Translation: CAM26944.1.
CH466552 Genomic DNA. Translation: EDL29999.1.
BC145805 mRNA. Translation: AAI45806.1.
CCDSiCCDS18778.1.
RefSeqiNP_035400.3. NM_011270.3.
UniGeneiMm.195461.

3D structure databases

ProteinModelPortaliQ8CF94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030627.

Proteomic databases

MaxQBiQ8CF94.
PaxDbiQ8CF94.
PRIDEiQ8CF94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19746.
KEGGimmu:19746.

Organism-specific databases

CTDi6007.
MGIiMGI:1202882. Rhd.

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
HOGENOMiHOG000007656.
InParanoidiQ8CF94.
KOiK06579.
PhylomeDBiQ8CF94.
TreeFamiTF314450.

Miscellaneous databases

PROiQ8CF94.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028825.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHD_MOUSE
AccessioniPrimary (citable) accession number: Q8CF94
Secondary accession number(s): O88296
, O88297, Q9QUM6, Q9QX04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.