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Q8CF94 (RHD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Blood group Rh(D) polypeptide
Alternative name(s):
Erythrocyte membrane glycoprotein Rh30
CD_antigen=CD240D
Gene names
Name:Rhd
Synonyms:Rh30, Rhced
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 418417Blood group Rh(D) polypeptide
PRO_0000383326

Regions

Transmembrane12 – 3221Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane112 – 13120Helical; Potential
Transmembrane133 – 15523Helical; Potential
Transmembrane166 – 18621Helical; Potential
Transmembrane211 – 23121Helical; Potential
Transmembrane241 – 26121Helical; Potential
Transmembrane268 – 28821Helical; Potential
Transmembrane290 – 31021Helical; Potential
Transmembrane331 – 35121Helical; Potential
Transmembrane368 – 38821Helical; Potential

Natural variations

Natural variant3981H → R.

Experimental info

Sequence conflict31S → C in AAC25123. Ref.5
Sequence conflict191E → V in BAA32438. Ref.1
Sequence conflict201L → V in AAC25123. Ref.5
Sequence conflict221T → I in BAA32439. Ref.1
Sequence conflict251S → I in BAA32438. Ref.1
Sequence conflict281F → S in BAA32438. Ref.1
Sequence conflict421R → K in BAA32438. Ref.1
Sequence conflict451A → E in BAA32438. Ref.1
Sequence conflict1401V → M in BAA32438. Ref.1
Sequence conflict2821V → M in AAC25123. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q8CF94 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 76AAC777FA5BF633

FASTA41845,877
        10         20         30         40         50         60 
MGSKYPRSLR CCLPLWALEL QTAFSLLFCF FIPHDTAQVD HRFMASYQVL RNLTLMAALG 

        70         80         90        100        110        120 
FGFLSSSFRR HSWSSVAFNL FMLALGVQGT ILLDHFLGQV LQWNKINNLS SIQIATMSTL 

       130        140        150        160        170        180 
PVLISAGAVL GKVNLVQLTV MVLMEAMAFG AIRFADEKVF KMTEHIIMMH GHVFGAYFGL 

       190        200        210        220        230        240 
TVAWWLSRSL PRRVGENAQT EKVQMATSSS LFAMLGTLFL WIFWPAINSA LLEGTKKRNA 

       250        260        270        280        290        300 
VFNTYYALAV SAVTATSMSA LSHPQGKINM VHIHNAVLAG GVAVGAPGCL ISSPWISMVL 

       310        320        330        340        350        360 
GLIAGLISIW GAKCPRACLN HMLQNSSGIH YTFGLPGLLG ALTYYCLQIV TEPKSSDLWI 

       370        380        390        400        410 
ITQTVTHIGA LSFAVAMGMV TGLLTGCLLS VRVWRAPHAA KYFDDQTFWE FPHLAVGF 

« Hide

References

« Hide 'large scale' references
[1]"Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene."
Kitano T., Sumiyama K., Shiroishi T., Saitou N.
Biochem. Biophys. Res. Commun. 249:78-85(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BFM-2MsfB6C3FI and C57BL-10SnJ.
Tissue: Bone marrow.
[2]"Characterization of the mouse Rh blood group gene."
Westhoff C.M., Schultze A., From A., Wylie D.E., Silberstein L.E.
Genomics 57:451-454(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Spleen.
[3]"The members of the RH gene family (RH50 and RH30) followed different evolutionary pathways."
Matassi G., Cherif-Zahar B., Pesole G., Raynal V., Cartron J.-P.
J. Mol. Evol. 48:151-159(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[4]"Entire sequence of a mouse chromosomal segment containing the gene Rhced and a comparative analysis of the homologous human sequence."
Kumada M., Iwamoto S., Kamesaki T., Okuda H., Kajii E.
Gene 299:165-172(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Evolutionary conservation and diversification of Rh family genes and proteins."
Huang C.-H., Peng J.
Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Cerebellum and Spleen.
[7]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[8]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB015189 mRNA. Translation: BAA32438.1.
AB015190 mRNA. Translation: BAA32439.1.
AF069311 mRNA. Translation: AAC64038.1.
AF047827 mRNA. Translation: AAD13391.1.
AB076248 Genomic DNA. Translation: BAC21151.1.
AF057524 mRNA. Translation: AAC25123.1.
AK079335 mRNA. Translation: BAC37610.1.
AK171641 mRNA. Translation: BAE42581.1.
AL611963 Genomic DNA. Translation: CAM26944.1.
CH466552 Genomic DNA. Translation: EDL29999.1.
BC145805 mRNA. Translation: AAI45806.1.
CCDSCCDS18778.1.
RefSeqNP_035400.3. NM_011270.3.
UniGeneMm.195461.

3D structure databases

ProteinModelPortalQ8CF94.
SMRQ8CF94. Positions 42-311.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ8CF94.
PRIDEQ8CF94.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030627; ENSMUSP00000030627; ENSMUSG00000028825.
GeneID19746.
KEGGmmu:19746.

Organism-specific databases

CTD6007.
MGIMGI:1202882. Rhd.

Phylogenomic databases

eggNOGNOG314742.
GeneTreeENSGT00390000005787.
HOGENOMHOG000007656.
InParanoidO88296.
KOK06579.
OrthoDBEOG73NG3C.
PhylomeDBQ8CF94.
TreeFamTF314450.

Gene expression databases

ArrayExpressQ8CF94.
BgeeQ8CF94.
GenevestigatorQ8CF94.

Family and domain databases

Gene3D1.10.3430.10. 1 hit.
InterProIPR029020. Ammonium/urea_transptr.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PfamPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSPR00342. RHESUSRHD.
SUPFAMSSF111352. SSF111352. 1 hit.
ProtoNetSearch...

Other

NextBio297200.
PROQ8CF94.
SOURCESearch...

Entry information

Entry nameRHD_MOUSE
AccessionPrimary (citable) accession number: Q8CF94
Secondary accession number(s): O88296 expand/collapse secondary AC list , O88297, Q9QUM6, Q9QX04
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot