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Q8CF94

- RHD_MOUSE

UniProt

Q8CF94 - RHD_MOUSE

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Protein

Blood group Rh(D) polypeptide

Gene

Rhd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.By similarity

GO - Molecular functioni

  1. ammonium transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. ammonium transport Source: MGI
  2. erythrocyte development Source: MGI
  3. multicellular organismal iron ion homeostasis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Blood group Rh(D) polypeptide
Alternative name(s):
Erythrocyte membrane glycoprotein Rh30
CD_antigen: CD240D
Gene namesi
Name:Rhd
Synonyms:Rh30, Rhced
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1202882. Rhd.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei112 – 13120HelicalSequence AnalysisAdd
BLAST
Transmembranei133 – 15523HelicalSequence AnalysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence AnalysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence AnalysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: MGI
  2. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 418417Blood group Rh(D) polypeptidePRO_0000383326Add
BLAST

Proteomic databases

PaxDbiQ8CF94.
PRIDEiQ8CF94.

Expressioni

Gene expression databases

BgeeiQ8CF94.
ExpressionAtlasiQ8CF94. baseline and differential.
GenevestigatoriQ8CF94.

Structurei

3D structure databases

ProteinModelPortaliQ8CF94.
SMRiQ8CF94. Positions 42-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG314742.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
InParanoidiQ8CF94.
KOiK06579.
OrthoDBiEOG73NG3C.
PhylomeDBiQ8CF94.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CF94-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSKYPRSLR CCLPLWALEL QTAFSLLFCF FIPHDTAQVD HRFMASYQVL
60 70 80 90 100
RNLTLMAALG FGFLSSSFRR HSWSSVAFNL FMLALGVQGT ILLDHFLGQV
110 120 130 140 150
LQWNKINNLS SIQIATMSTL PVLISAGAVL GKVNLVQLTV MVLMEAMAFG
160 170 180 190 200
AIRFADEKVF KMTEHIIMMH GHVFGAYFGL TVAWWLSRSL PRRVGENAQT
210 220 230 240 250
EKVQMATSSS LFAMLGTLFL WIFWPAINSA LLEGTKKRNA VFNTYYALAV
260 270 280 290 300
SAVTATSMSA LSHPQGKINM VHIHNAVLAG GVAVGAPGCL ISSPWISMVL
310 320 330 340 350
GLIAGLISIW GAKCPRACLN HMLQNSSGIH YTFGLPGLLG ALTYYCLQIV
360 370 380 390 400
TEPKSSDLWI ITQTVTHIGA LSFAVAMGMV TGLLTGCLLS VRVWRAPHAA
410
KYFDDQTFWE FPHLAVGF
Length:418
Mass (Da):45,877
Last modified:March 1, 2003 - v1
Checksum:i76AAC777FA5BF633
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31S → C in AAC25123. (PubMed:16227429)Curated
Sequence conflicti19 – 191E → V in BAA32438. (PubMed:9705835)Curated
Sequence conflicti20 – 201L → V in AAC25123. (PubMed:16227429)Curated
Sequence conflicti22 – 221T → I in BAA32439. (PubMed:9705835)Curated
Sequence conflicti25 – 251S → I in BAA32438. (PubMed:9705835)Curated
Sequence conflicti28 – 281F → S in BAA32438. (PubMed:9705835)Curated
Sequence conflicti42 – 421R → K in BAA32438. (PubMed:9705835)Curated
Sequence conflicti45 – 451A → E in BAA32438. (PubMed:9705835)Curated
Sequence conflicti140 – 1401V → M in BAA32438. (PubMed:9705835)Curated
Sequence conflicti282 – 2821V → M in AAC25123. (PubMed:16227429)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti398 – 3981H → R.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015189 mRNA. Translation: BAA32438.1.
AB015190 mRNA. Translation: BAA32439.1.
AF069311 mRNA. Translation: AAC64038.1.
AF047827 mRNA. Translation: AAD13391.1.
AB076248 Genomic DNA. Translation: BAC21151.1.
AF057524 mRNA. Translation: AAC25123.1.
AK079335 mRNA. Translation: BAC37610.1.
AK171641 mRNA. Translation: BAE42581.1.
AL611963 Genomic DNA. Translation: CAM26944.1.
CH466552 Genomic DNA. Translation: EDL29999.1.
BC145805 mRNA. Translation: AAI45806.1.
CCDSiCCDS18778.1.
RefSeqiNP_035400.3. NM_011270.3.
UniGeneiMm.195461.

Genome annotation databases

EnsembliENSMUST00000030627; ENSMUSP00000030627; ENSMUSG00000028825.
GeneIDi19746.
KEGGimmu:19746.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015189 mRNA. Translation: BAA32438.1 .
AB015190 mRNA. Translation: BAA32439.1 .
AF069311 mRNA. Translation: AAC64038.1 .
AF047827 mRNA. Translation: AAD13391.1 .
AB076248 Genomic DNA. Translation: BAC21151.1 .
AF057524 mRNA. Translation: AAC25123.1 .
AK079335 mRNA. Translation: BAC37610.1 .
AK171641 mRNA. Translation: BAE42581.1 .
AL611963 Genomic DNA. Translation: CAM26944.1 .
CH466552 Genomic DNA. Translation: EDL29999.1 .
BC145805 mRNA. Translation: AAI45806.1 .
CCDSi CCDS18778.1.
RefSeqi NP_035400.3. NM_011270.3.
UniGenei Mm.195461.

3D structure databases

ProteinModelPortali Q8CF94.
SMRi Q8CF94. Positions 42-311.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q8CF94.
PRIDEi Q8CF94.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030627 ; ENSMUSP00000030627 ; ENSMUSG00000028825 .
GeneIDi 19746.
KEGGi mmu:19746.

Organism-specific databases

CTDi 6007.
MGIi MGI:1202882. Rhd.

Phylogenomic databases

eggNOGi NOG314742.
GeneTreei ENSGT00390000005787.
HOGENOMi HOG000007656.
InParanoidi Q8CF94.
KOi K06579.
OrthoDBi EOG73NG3C.
PhylomeDBi Q8CF94.
TreeFami TF314450.

Miscellaneous databases

NextBioi 297200.
PROi Q8CF94.
SOURCEi Search...

Gene expression databases

Bgeei Q8CF94.
ExpressionAtlasi Q8CF94. baseline and differential.
Genevestigatori Q8CF94.

Family and domain databases

Gene3Di 1.10.3430.10. 1 hit.
InterProi IPR029020. Ammonium/urea_transptr.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view ]
Pfami PF00909. Ammonium_transp. 1 hit.
[Graphical view ]
PRINTSi PR00342. RHESUSRHD.
SUPFAMi SSF111352. SSF111352. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene."
    Kitano T., Sumiyama K., Shiroishi T., Saitou N.
    Biochem. Biophys. Res. Commun. 249:78-85(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BFM-2MsfB6C3FI and C57BL-10SnJ.
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Spleen.
  3. "The members of the RH gene family (RH50 and RH30) followed different evolutionary pathways."
    Matassi G., Cherif-Zahar B., Pesole G., Raynal V., Cartron J.-P.
    J. Mol. Evol. 48:151-159(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  4. "Entire sequence of a mouse chromosomal segment containing the gene Rhced and a comparative analysis of the homologous human sequence."
    Kumada M., Iwamoto S., Kamesaki T., Okuda H., Kajii E.
    Gene 299:165-172(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Evolutionary conservation and diversification of Rh family genes and proteins."
    Huang C.-H., Peng J.
    Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum and Spleen.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  8. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRHD_MOUSE
AccessioniPrimary (citable) accession number: Q8CF94
Secondary accession number(s): O88296
, O88297, Q9QUM6, Q9QX04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3