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Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Gene

Tab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. kinase activator activity Source: MGI

GO - Biological processi

  1. activation of MAPKKK activity Source: MGI
  2. heart morphogenesis Source: MGI
  3. in utero embryonic development Source: MGI
  4. lung development Source: MGI
  5. positive regulation of MAP kinase activity Source: Ensembl
  6. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_288310. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_301153. NOD1/2 Signaling Pathway.
REACT_305279. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_308717. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
REACT_315145. FCERI mediated NF-kB activation.
REACT_324009. activated TAK1 mediates p38 MAPK activation.
REACT_331416. IRAK2 mediated activation of TAK1 complex.
REACT_336073. TRAF6 mediated induction of TAK1 complex.
REACT_337033. Interleukin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
TGF-beta-activated kinase 1-binding protein 1
Short name:
TAK1-binding protein 1
Gene namesi
Name:Tab1
Synonyms:Map3k7ip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913763. Tab1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleoplasm Source: MGI
  3. protein complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502TGF-beta-activated kinase 1 and MAP3K7-binding protein 1PRO_0000057798Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei436 – 4361PhosphoserineBy similarity
Modified residuei440 – 4401PhosphothreonineBy similarity

Post-translational modificationi

Monoubiquitinated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8CF89.
PaxDbiQ8CF89.
PRIDEiQ8CF89.

PTM databases

PhosphoSiteiQ8CF89.

Expressioni

Gene expression databases

BgeeiQ8CF89.
ExpressionAtlasiQ8CF89. baseline.
GenevestigatoriQ8CF89.

Interactioni

Subunit structurei

Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Map3k1P533494EBI-1778503,EBI-447913
Map3k7Q620732EBI-1778503,EBI-1775345
VRK2Q86Y07-12EBI-1778503,EBI-1207633From a different organism.

Protein-protein interaction databases

BioGridi211528. 5 interactions.
IntActiQ8CF89. 11 interactions.
STRINGi10090.ENSMUSP00000023050.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LOOX-ray1.95B384-412[»]
4LOPX-ray2.05K/L/M/N384-412[»]
4LOQX-ray2.32K/L/M/N384-412[»]
ProteinModelPortaliQ8CF89.
SMRiQ8CF89. Positions 16-370, 466-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 365338PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi450 – 4556Poly-Ser

Sequence similaritiesi

Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG320352.
GeneTreeiENSGT00510000048276.
HOGENOMiHOG000044226.
HOVERGENiHBG007302.
InParanoidiQ8CF89.
KOiK04403.
OMAiSHPPEDN.
OrthoDBiEOG7W41C0.
PhylomeDBiQ8CF89.
TreeFamiTF317785.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CF89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE
60 70 80 90 100
DNWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNTEHTEA
110 120 130 140 150
DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK
160 170 180 190 200
ILERLKALER EISGGAMAVV AVLLNSKLYV ANVGTNRALL CKSTVDGLQV
210 220 230 240 250
TQLNMDHTTE NEDELFRLSQ LGLDAGKIKQ MGVICGQEST RRIGDYKVKY
260 270 280 290 300
GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH
310 320 330 340 350
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAK
360 370 380 390 400
FCPRHEDMTL LVRNFGYPLG EMSQPTPTPA PGGRVYPVSV PYSSAQSTSK
410 420 430 440 450
TSVTLSLVMP SQGQMVNGSH SASTLDEATP TLTNQSPTLT LQSTNTHTQS
460 470 480 490 500
SSSSSDGGLF RSRPAHSLPP GEDGRVEPYV DFAEFYRLWS VDHGEQSVMT

AP
Length:502
Mass (Da):54,616
Last modified:October 24, 2005 - v2
Checksum:iF7529D2E3CF30696
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti199 – 1991Q → H in BAC43729 (PubMed:12464436).Curated
Sequence conflicti210 – 2123ENE → DND in BAC43729 (PubMed:12464436).Curated
Sequence conflicti323 – 3231L → P in BAC43729 (PubMed:12464436).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088136 mRNA. Translation: BAC43729.1.
BC027054 mRNA. Translation: AAH27054.1.
BC041110 mRNA. Translation: AAH41110.1.
BC054369 mRNA. Translation: AAH54369.1.
CCDSiCCDS27659.1.
RefSeqiNP_079885.2. NM_025609.2.
UniGeneiMm.288245.

Genome annotation databases

EnsembliENSMUST00000023050; ENSMUSP00000023050; ENSMUSG00000022414.
GeneIDi66513.
KEGGimmu:66513.
UCSCiuc007wve.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088136 mRNA. Translation: BAC43729.1.
BC027054 mRNA. Translation: AAH27054.1.
BC041110 mRNA. Translation: AAH41110.1.
BC054369 mRNA. Translation: AAH54369.1.
CCDSiCCDS27659.1.
RefSeqiNP_079885.2. NM_025609.2.
UniGeneiMm.288245.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LOOX-ray1.95B384-412[»]
4LOPX-ray2.05K/L/M/N384-412[»]
4LOQX-ray2.32K/L/M/N384-412[»]
ProteinModelPortaliQ8CF89.
SMRiQ8CF89. Positions 16-370, 466-494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211528. 5 interactions.
IntActiQ8CF89. 11 interactions.
STRINGi10090.ENSMUSP00000023050.

PTM databases

PhosphoSiteiQ8CF89.

Proteomic databases

MaxQBiQ8CF89.
PaxDbiQ8CF89.
PRIDEiQ8CF89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023050; ENSMUSP00000023050; ENSMUSG00000022414.
GeneIDi66513.
KEGGimmu:66513.
UCSCiuc007wve.1. mouse.

Organism-specific databases

CTDi10454.
MGIiMGI:1913763. Tab1.

Phylogenomic databases

eggNOGiNOG320352.
GeneTreeiENSGT00510000048276.
HOGENOMiHOG000044226.
HOVERGENiHBG007302.
InParanoidiQ8CF89.
KOiK04403.
OMAiSHPPEDN.
OrthoDBiEOG7W41C0.
PhylomeDBiQ8CF89.
TreeFamiTF317785.

Enzyme and pathway databases

ReactomeiREACT_288310. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_301153. NOD1/2 Signaling Pathway.
REACT_305279. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_308717. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
REACT_315145. FCERI mediated NF-kB activation.
REACT_324009. activated TAK1 mediates p38 MAPK activation.
REACT_331416. IRAK2 mediated activation of TAK1 complex.
REACT_336073. TRAF6 mediated induction of TAK1 complex.
REACT_337033. Interleukin-1 signaling.

Miscellaneous databases

NextBioi321908.
PROiQ8CF89.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CF89.
ExpressionAtlasiQ8CF89. baseline.
GenevestigatoriQ8CF89.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis."
    Komatsu Y., Shibuya H., Takeda N., Ninomiya-Tsuji J., Yasui T., Miyado K., Sekimoto T., Ueno N., Matsumoto K., Yamada G.
    Mech. Dev. 119:239-249(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Eye, Kidney and Mammary tumor.

Entry informationi

Entry nameiTAB1_MOUSE
AccessioniPrimary (citable) accession number: Q8CF89
Secondary accession number(s): Q7TQJ5, Q80V65, Q8R0D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2005
Last sequence update: October 24, 2005
Last modified: March 31, 2015
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.