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Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Gene

Tab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Caution

Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei482Required for interaction with MAP3K7By similarity1

GO - Molecular functioni

  • kinase activator activity Source: MGI
  • protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  • activation of MAPKKK activity Source: MGI
  • aorta development Source: MGI
  • cardiac septum development Source: MGI
  • coronary vasculature development Source: MGI
  • heart morphogenesis Source: MGI
  • in utero embryonic development Source: MGI
  • lung development Source: MGI
  • transforming growth factor beta receptor signaling pathway Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-168638 NOD1/2 Signaling Pathway
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-450302 activated TAK1 mediates p38 MAPK activation
R-MMU-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-MMU-5357956 TNFR1-induced NFkappaB signaling pathway
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-5689880 Ub-specific processing proteases
R-MMU-9020702 Interleukin-1 signaling
R-MMU-937042 IRAK2 mediated activation of TAK1 complex
R-MMU-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-MMU-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
TGF-beta-activated kinase 1-binding protein 1
Short name:
TAK1-binding protein 1
Gene namesi
Name:Tab1
Synonyms:Map3k7ip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913763 Tab1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577981 – 502TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1
Modified residuei436PhosphoserineBy similarity1
Modified residuei440PhosphothreonineBy similarity1

Post-translational modificationi

Monoubiquitinated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8CF89
MaxQBiQ8CF89
PaxDbiQ8CF89
PeptideAtlasiQ8CF89
PRIDEiQ8CF89

PTM databases

iPTMnetiQ8CF89
PhosphoSitePlusiQ8CF89

Expressioni

Gene expression databases

BgeeiENSMUSG00000022414
GenevisibleiQ8CF89 MM

Interactioni

Subunit structurei

Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi211528, 9 interactors
ELMiQ8CF89
IntActiQ8CF89, 11 interactors
MINTiQ8CF89
STRINGi10090.ENSMUSP00000023050

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LOOX-ray1.95B384-412[»]
4LOPX-ray2.05K/L/M/N384-412[»]
4LOQX-ray2.32K/L/M/N384-412[»]
ProteinModelPortaliQ8CF89
SMRiQ8CF89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 365PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST338

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi450 – 455Poly-Ser6

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00510000048276
HOGENOMiHOG000044226
HOVERGENiHBG007302
InParanoidiQ8CF89
KOiK04403
OMAiSTNQIYR
OrthoDBiEOG091G0B0E
PhylomeDBiQ8CF89
TreeFamiTF317785

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 2 hits
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CF89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE
60 70 80 90 100
DNWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNTEHTEA
110 120 130 140 150
DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK
160 170 180 190 200
ILERLKALER EISGGAMAVV AVLLNSKLYV ANVGTNRALL CKSTVDGLQV
210 220 230 240 250
TQLNMDHTTE NEDELFRLSQ LGLDAGKIKQ MGVICGQEST RRIGDYKVKY
260 270 280 290 300
GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH
310 320 330 340 350
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAK
360 370 380 390 400
FCPRHEDMTL LVRNFGYPLG EMSQPTPTPA PGGRVYPVSV PYSSAQSTSK
410 420 430 440 450
TSVTLSLVMP SQGQMVNGSH SASTLDEATP TLTNQSPTLT LQSTNTHTQS
460 470 480 490 500
SSSSSDGGLF RSRPAHSLPP GEDGRVEPYV DFAEFYRLWS VDHGEQSVMT

AP
Length:502
Mass (Da):54,616
Last modified:October 25, 2005 - v2
Checksum:iF7529D2E3CF30696
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199Q → H in BAC43729 (PubMed:12464436).Curated1
Sequence conflicti210 – 212ENE → DND in BAC43729 (PubMed:12464436).Curated3
Sequence conflicti323L → P in BAC43729 (PubMed:12464436).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088136 mRNA Translation: BAC43729.1
BC027054 mRNA Translation: AAH27054.1
BC041110 mRNA Translation: AAH41110.1
BC054369 mRNA Translation: AAH54369.1
CCDSiCCDS27659.1
RefSeqiNP_079885.2, NM_025609.2
UniGeneiMm.288245

Genome annotation databases

EnsembliENSMUST00000023050; ENSMUSP00000023050; ENSMUSG00000022414
GeneIDi66513
KEGGimmu:66513
UCSCiuc007wve.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTAB1_MOUSE
AccessioniPrimary (citable) accession number: Q8CF89
Secondary accession number(s): Q7TQJ5, Q80V65, Q8R0D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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