Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8CF89 (TAB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
TGF-beta-activated kinase 1-binding protein 1
Short name=TAK1-binding protein 1
Gene names
Name:Tab1
Synonyms:Map3k7ip1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Subunit structure

Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 By similarity.

Post-translational modification

Monoubiquitinated By similarity.

Sequence similarities

Contains 1 PP2C-like domain.

Caution

Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Map3k7Q620732EBI-1778503,EBI-1775345
VRK2Q86Y07-12EBI-1778503,EBI-1207633From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
PRO_0000057798

Regions

Domain64 – 368305PP2C-like
Compositional bias450 – 4556Poly-Ser

Amino acid modifications

Modified residue71Phosphoserine By similarity
Modified residue4361Phosphoserine By similarity

Experimental info

Sequence conflict1991Q → H in BAC43729. Ref.1
Sequence conflict210 – 2123ENE → DND in BAC43729. Ref.1
Sequence conflict3231L → P in BAC43729. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8CF89 [UniParc].

Last modified October 25, 2005. Version 2.
Checksum: F7529D2E3CF30696

FASTA50254,616
        10         20         30         40         50         60 
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DNWLKFRSEN 

        70         80         90        100        110        120 
NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNTEHTEA DVRRVLLQAF DVVERSFLES 

       130        140        150        160        170        180 
IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKALER EISGGAMAVV AVLLNSKLYV 

       190        200        210        220        230        240 
ANVGTNRALL CKSTVDGLQV TQLNMDHTTE NEDELFRLSQ LGLDAGKIKQ MGVICGQEST 

       250        260        270        280        290        300 
RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 

       310        320        330        340        350        360 
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAK FCPRHEDMTL 

       370        380        390        400        410        420 
LVRNFGYPLG EMSQPTPTPA PGGRVYPVSV PYSSAQSTSK TSVTLSLVMP SQGQMVNGSH 

       430        440        450        460        470        480 
SASTLDEATP TLTNQSPTLT LQSTNTHTQS SSSSSDGGLF RSRPAHSLPP GEDGRVEPYV 

       490        500 
DFAEFYRLWS VDHGEQSVMT AP 

« Hide

References

« Hide 'large scale' references
[1]"Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis."
Komatsu Y., Shibuya H., Takeda N., Ninomiya-Tsuji J., Yasui T., Miyado K., Sekimoto T., Ueno N., Matsumoto K., Yamada G.
Mech. Dev. 119:239-249(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Eye, Kidney and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB088136 mRNA. Translation: BAC43729.1.
BC027054 mRNA. Translation: AAH27054.1.
BC041110 mRNA. Translation: AAH41110.1.
BC054369 mRNA. Translation: AAH54369.1.
CCDSCCDS27659.1.
RefSeqNP_079885.2. NM_025609.2.
UniGeneMm.288245.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4LOOX-ray1.95B384-412[»]
4LOPX-ray2.05K/L/M/N384-412[»]
4LOQX-ray2.32K/L/M/N384-412[»]
ProteinModelPortalQ8CF89.
SMRQ8CF89. Positions 16-370, 466-494.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid211528. 2 interactions.
IntActQ8CF89. 9 interactions.
STRING10090.ENSMUSP00000023050.

PTM databases

PhosphoSiteQ8CF89.

Proteomic databases

MaxQBQ8CF89.
PaxDbQ8CF89.
PRIDEQ8CF89.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023050; ENSMUSP00000023050; ENSMUSG00000022414.
GeneID66513.
KEGGmmu:66513.
UCSCuc007wve.1. mouse.

Organism-specific databases

CTD10454.
MGIMGI:1913763. Tab1.

Phylogenomic databases

eggNOGNOG320352.
GeneTreeENSGT00510000048276.
HOGENOMHOG000044226.
HOVERGENHBG007302.
InParanoidQ8CF89.
KOK04403.
OMASHPPEDN.
OrthoDBEOG7W41C0.
PhylomeDBQ8CF89.
TreeFamTF317785.

Gene expression databases

BgeeQ8CF89.
GenevestigatorQ8CF89.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 2 hits.
ProtoNetSearch...

Other

NextBio321908.
PROQ8CF89.
SOURCESearch...

Entry information

Entry nameTAB1_MOUSE
AccessionPrimary (citable) accession number: Q8CF89
Secondary accession number(s): Q7TQJ5, Q80V65, Q8R0D1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: July 9, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot