Q8CF89 (TAB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
TGF-beta-activated kinase 1-binding protein 1
Short name=TAK1-binding protein 1

Gene names

Name:	Tab1
Synonyms:	Map3k7ip1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Subunit structure	Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 By similarity.
Post-translational modification	Monoubiquitinated By similarity.
Sequence similarities	Contains 1 PP2C-like domain.
Caution	Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.

Ontologies

Keywords
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPKKK activity Inferred from mutant phenotype Ref.1. Source: MGI heart morphogenesis Inferred from mutant phenotype Ref.1. Source: MGI in utero embryonic development Inferred from mutant phenotype Ref.1. Source: MGI lung development Inferred from mutant phenotype Ref.1. Source: MGI metabolic process Inferred from electronic annotation. Source: GOC transforming growth factor beta receptor signaling pathway Inferred from mutant phenotype Ref.1. Source: MGI
Molecular_function	catalytic activity Inferred from electronic annotation. Source: InterPro kinase activator activity Inferred from mutant phenotype Ref.1. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
VRK2	Q86Y07-1	2	EBI-1778503,EBI-1207633	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 502	502	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1		PRO_0000057798
Regions
	Domain	64 – 368	305	PP2C-like
	Compositional bias	450 – 455	6	Poly-Ser
Amino acid modifications
	Modified residue	7	1	Phosphoserine By similarity
	Modified residue	436	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	199	1	Q → H in BAC43729. Ref.1
	Sequence conflict	210 – 212	3	ENE → DND in BAC43729. Ref.1
	Sequence conflict	323	1	L → P in BAC43729. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8CF89 [UniParc]. Last modified October 25, 2005. Version 2. Checksum: F7529D2E3CF30696	FASTA	502	54,616
	10 20 30 40 50 60 MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DNWLKFRSEN 70 80 90 100 110 120 NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNTEHTEA DVRRVLLQAF DVVERSFLES 130 140 150 160 170 180 IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKALER EISGGAMAVV AVLLNSKLYV 190 200 210 220 230 240 ANVGTNRALL CKSTVDGLQV TQLNMDHTTE NEDELFRLSQ LGLDAGKIKQ MGVICGQEST 250 260 270 280 290 300 RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 310 320 330 340 350 360 GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAK FCPRHEDMTL 370 380 390 400 410 420 LVRNFGYPLG EMSQPTPTPA PGGRVYPVSV PYSSAQSTSK TSVTLSLVMP SQGQMVNGSH 430 440 450 460 470 480 SASTLDEATP TLTNQSPTLT LQSTNTHTQS SSSSSDGGLF RSRPAHSLPP GEDGRVEPYV 490 500 DFAEFYRLWS VDHGEQSVMT AP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis." Komatsu Y., Shibuya H., Takeda N., Ninomiya-Tsuji J., Yasui T., Miyado K., Sekimoto T., Ueno N., Matsumoto K., Yamada G. Mech. Dev. 119:239-249(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Eye, Kidney and Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB088136 mRNA. Translation: BAC43729.1. BC027054 mRNA. Translation: AAH27054.1. BC041110 mRNA. Translation: AAH41110.1. BC054369 mRNA. Translation: AAH54369.1.
IPI	IPI00380503.
RefSeq	NP_079885.2. NM_025609.2.
UniGene	Mm.288245.
3D structure databases
ProteinModelPortal	Q8CF89.
SMR	Q8CF89. Positions 16-370, 466-494.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8CF89. 9 interactions.
STRING	10090.ENSMUSP00000023050.
PTM databases
PhosphoSite	Q8CF89.
Proteomic databases
PaxDb	Q8CF89.
PRIDE	Q8CF89.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023050; ENSMUSP00000023050; ENSMUSG00000022414.
GeneID	66513.
KEGG	mmu:66513.
UCSC	uc007wve.1. mouse.
Organism-specific databases
CTD	10454.
MGI	MGI:1913763. Tab1.
Phylogenomic databases
eggNOG	NOG320352.
GeneTree	ENSGT00510000048276.
HOGENOM	HOG000044226.
HOVERGEN	HBG007302.
InParanoid	Q8CF89.
KO	K04403.
OMA	AEHTEAD.
OrthoDB	EOG4R7V9G.
Gene expression databases
ArrayExpress	Q8CF89.
Bgee	Q8CF89.
Genevestigator	Q8CF89.
GermOnline	ENSMUSG00000022414. Mus musculus.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001932. PP2C-like. IPR015655. Protein_Pase_2C. [Graphical view]
PANTHER	PTHR13832. PTHR13832. 1 hit.
Pfam	PF00481. PP2C. 1 hit. [Graphical view]
SMART	SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
ProtoNet	Search...
Other
NextBio	321908.
SOURCE	Search...

Entry information

Entry name

TAB1_MOUSE

Accession

Primary (citable) accession number: Q8CF89
Secondary accession number(s): Q7TQJ5, Q80V65, Q8R0D1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	October 25, 2005
Last modified:	April 3, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program