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Q8CF89

- TAB1_MOUSE

UniProt

Q8CF89 - TAB1_MOUSE

Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Gene

Tab1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. kinase activator activity Source: MGI
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of MAPKKK activity Source: MGI
    2. heart morphogenesis Source: MGI
    3. in utero embryonic development Source: MGI
    4. lung development Source: MGI
    5. positive regulation of MAP kinase activity Source: Ensembl
    6. transforming growth factor beta receptor signaling pathway Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198536. IRAK2 mediated activation of TAK1 complex.
    REACT_198539. TRAF6 mediated induction of TAK1 complex.
    REACT_198690. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
    REACT_204812. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
    REACT_205561. FCERI mediated NF-kB activation.
    REACT_211125. NOD1/2 Signaling Pathway.
    REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_224208. Interleukin-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
    Alternative name(s):
    Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
    TGF-beta-activated kinase 1-binding protein 1
    Short name:
    TAK1-binding protein 1
    Gene namesi
    Name:Tab1
    Synonyms:Map3k7ip1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1913763. Tab1.

    Subcellular locationi

    GO - Cellular componenti

    1. protein complex Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502TGF-beta-activated kinase 1 and MAP3K7-binding protein 1PRO_0000057798Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei7 – 71PhosphoserineBy similarity
    Modified residuei436 – 4361PhosphoserineBy similarity

    Post-translational modificationi

    Monoubiquitinated.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ8CF89.
    PaxDbiQ8CF89.
    PRIDEiQ8CF89.

    PTM databases

    PhosphoSiteiQ8CF89.

    Expressioni

    Gene expression databases

    BgeeiQ8CF89.
    GenevestigatoriQ8CF89.

    Interactioni

    Subunit structurei

    Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Map3k7Q620732EBI-1778503,EBI-1775345
    VRK2Q86Y07-12EBI-1778503,EBI-1207633From a different organism.

    Protein-protein interaction databases

    BioGridi211528. 2 interactions.
    IntActiQ8CF89. 9 interactions.
    STRINGi10090.ENSMUSP00000023050.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4LOOX-ray1.95B384-412[»]
    4LOPX-ray2.05K/L/M/N384-412[»]
    4LOQX-ray2.32K/L/M/N384-412[»]
    ProteinModelPortaliQ8CF89.
    SMRiQ8CF89. Positions 16-370, 466-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 368305PP2C-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi450 – 4556Poly-Ser

    Sequence similaritiesi

    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiNOG320352.
    GeneTreeiENSGT00510000048276.
    HOGENOMiHOG000044226.
    HOVERGENiHBG007302.
    InParanoidiQ8CF89.
    KOiK04403.
    OMAiSHPPEDN.
    OrthoDBiEOG7W41C0.
    PhylomeDBiQ8CF89.
    TreeFamiTF317785.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q8CF89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE    50
    DNWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNTEHTEA 100
    DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK 150
    ILERLKALER EISGGAMAVV AVLLNSKLYV ANVGTNRALL CKSTVDGLQV 200
    TQLNMDHTTE NEDELFRLSQ LGLDAGKIKQ MGVICGQEST RRIGDYKVKY 250
    GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 300
    GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAK 350
    FCPRHEDMTL LVRNFGYPLG EMSQPTPTPA PGGRVYPVSV PYSSAQSTSK 400
    TSVTLSLVMP SQGQMVNGSH SASTLDEATP TLTNQSPTLT LQSTNTHTQS 450
    SSSSSDGGLF RSRPAHSLPP GEDGRVEPYV DFAEFYRLWS VDHGEQSVMT 500
    AP 502
    Length:502
    Mass (Da):54,616
    Last modified:October 25, 2005 - v2
    Checksum:iF7529D2E3CF30696
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti199 – 1991Q → H in BAC43729. (PubMed:12464436)Curated
    Sequence conflicti210 – 2123ENE → DND in BAC43729. (PubMed:12464436)Curated
    Sequence conflicti323 – 3231L → P in BAC43729. (PubMed:12464436)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB088136 mRNA. Translation: BAC43729.1.
    BC027054 mRNA. Translation: AAH27054.1.
    BC041110 mRNA. Translation: AAH41110.1.
    BC054369 mRNA. Translation: AAH54369.1.
    CCDSiCCDS27659.1.
    RefSeqiNP_079885.2. NM_025609.2.
    UniGeneiMm.288245.

    Genome annotation databases

    EnsembliENSMUST00000023050; ENSMUSP00000023050; ENSMUSG00000022414.
    GeneIDi66513.
    KEGGimmu:66513.
    UCSCiuc007wve.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB088136 mRNA. Translation: BAC43729.1 .
    BC027054 mRNA. Translation: AAH27054.1 .
    BC041110 mRNA. Translation: AAH41110.1 .
    BC054369 mRNA. Translation: AAH54369.1 .
    CCDSi CCDS27659.1.
    RefSeqi NP_079885.2. NM_025609.2.
    UniGenei Mm.288245.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4LOO X-ray 1.95 B 384-412 [» ]
    4LOP X-ray 2.05 K/L/M/N 384-412 [» ]
    4LOQ X-ray 2.32 K/L/M/N 384-412 [» ]
    ProteinModelPortali Q8CF89.
    SMRi Q8CF89. Positions 16-370, 466-494.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211528. 2 interactions.
    IntActi Q8CF89. 9 interactions.
    STRINGi 10090.ENSMUSP00000023050.

    PTM databases

    PhosphoSitei Q8CF89.

    Proteomic databases

    MaxQBi Q8CF89.
    PaxDbi Q8CF89.
    PRIDEi Q8CF89.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023050 ; ENSMUSP00000023050 ; ENSMUSG00000022414 .
    GeneIDi 66513.
    KEGGi mmu:66513.
    UCSCi uc007wve.1. mouse.

    Organism-specific databases

    CTDi 10454.
    MGIi MGI:1913763. Tab1.

    Phylogenomic databases

    eggNOGi NOG320352.
    GeneTreei ENSGT00510000048276.
    HOGENOMi HOG000044226.
    HOVERGENi HBG007302.
    InParanoidi Q8CF89.
    KOi K04403.
    OMAi SHPPEDN.
    OrthoDBi EOG7W41C0.
    PhylomeDBi Q8CF89.
    TreeFami TF317785.

    Enzyme and pathway databases

    Reactomei REACT_198536. IRAK2 mediated activation of TAK1 complex.
    REACT_198539. TRAF6 mediated induction of TAK1 complex.
    REACT_198690. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
    REACT_204812. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
    REACT_205561. FCERI mediated NF-kB activation.
    REACT_211125. NOD1/2 Signaling Pathway.
    REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_224208. Interleukin-1 signaling.

    Miscellaneous databases

    NextBioi 321908.
    PROi Q8CF89.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CF89.
    Genevestigatori Q8CF89.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis."
      Komatsu Y., Shibuya H., Takeda N., Ninomiya-Tsuji J., Yasui T., Miyado K., Sekimoto T., Ueno N., Matsumoto K., Yamada G.
      Mech. Dev. 119:239-249(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Eye, Kidney and Mammary tumor.

    Entry informationi

    Entry nameiTAB1_MOUSE
    AccessioniPrimary (citable) accession number: Q8CF89
    Secondary accession number(s): Q7TQJ5, Q80V65, Q8R0D1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3