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Protein

ATP-binding cassette sub-family A member 5

Gene

Abca5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the processing of autolysosomes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi514 – 5218ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1333 – 13408ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • sterol transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 5
Gene namesi
Name:Abca5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi628661. Abca5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221HelicalSequence analysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence analysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence analysisAdd
BLAST
Transmembranei866 – 88621HelicalSequence analysisAdd
BLAST
Transmembranei967 – 98721HelicalSequence analysisAdd
BLAST
Transmembranei1021 – 104121HelicalSequence analysisAdd
BLAST
Transmembranei1071 – 109121HelicalSequence analysisAdd
BLAST
Transmembranei1102 – 112221HelicalSequence analysisAdd
BLAST
Transmembranei1139 – 115921HelicalSequence analysisAdd
BLAST
Transmembranei1164 – 118421HelicalSequence analysisAdd
BLAST
Transmembranei1207 – 122721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16421642ATP-binding cassette sub-family A member 5PRO_0000250671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence analysis
Glycosylationi919 – 9191N-linked (GlcNAc...)Sequence analysis
Glycosylationi996 – 9961N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CF82.
PRIDEiQ8CF82.

PTM databases

iPTMnetiQ8CF82.

Expressioni

Tissue specificityi

Expressed in testis, epididymis, lung and brain.2 Publications

Gene expression databases

ExpressionAtlasiQ8CF82. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005848.

Structurei

3D structure databases

ProteinModelPortaliQ8CF82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini478 – 713236ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini1290 – 1533244ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOGENOMiHOG000231057.
HOVERGENiHBG079884.
InParanoidiQ8CF82.
KOiK05648.
OMAiYIDRYCA.
OrthoDBiEOG73Z2SB.
PhylomeDBiQ8CF82.
TreeFamiTF105192.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030367. ABCA5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PTHR19229:SF100. PTHR19229:SF100. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CF82-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAIRDVGV WRQTRTLLLK NYLVKCRTKK SSVQEILFPL FFLFWLILIS
60 70 80 90 100
MMHPNKKYEE VSDIELSPMD KSILSNLILG YTPVTNTTSS VMQRVSTDHL
110 120 130 140 150
PDVLVTEEYA SEKELLASSL SKPSNFVGVV FKDVMSYELR FFPDMVPVSS
160 170 180 190 200
VYMDSRAGCS KSCDAAQYWS SGFTALQASI DAAIIQLKTN VSLWRELEST
210 220 230 240 250
KAVIMGEAAV VEIDTFPRGV ILIYLVIAFS PFGYFLAIHI VAEKEKRLKE
260 270 280 290 300
FLKIMGLHDT AFWLSWVLLY TSLIFLMSLL MAVIATASSL FPQSSSIVIF
310 320 330 340 350
LLFFLYGLSS VFFALMLTPL FKKSKHVGVV EFFVTVVFGF VGLLIVLVES
360 370 380 390 400
FPRSLVWLFS PLCQCAFLIG IAQVMHLEDF NEGALFSSLT EGPYPLIITL
410 420 430 440 450
TMLALDSVFY ALLAVYLDQV IPGEFGLRRS SLYFLKPSYW SKNKRNYKEL
460 470 480 490 500
SEGNINGNIS LNEIVEPVSS EFIGKEAIRI SGIQKAYRKK NETVEALRNL
510 520 530 540 550
SFDIYEGQIT ALLGHSGTGK STLMNILCGL CPPSDGFASI YGHRVSEIDE
560 570 580 590 600
MFEARKMIGI CPQSDMNFDV LTVEENLSIL ASVKGIPANN IIQEVQKVLL
610 620 630 640 650
DLDMQAIKDN QAKKLSGGQK RKLSLGIAVL GNPKILLLDE PTAGMDPCSR
660 670 680 690 700
HIVWNLLKYR KANRVTVFST HFMDEADILA DRKAVISQGM LKCVGSSIFL
710 720 730 740 750
KSKWGIGYRL SMYIDRYCAT ESLSSLVRQH IPAAALLQQN DQQIVYSLPF
760 770 780 790 800
KDMDKFSGLF SALDIHSNLG VISYGVSMTT LEDVFLKLEV EAEIDQADYS
810 820 830 840 850
VFTQQPREEE TDSKSFDEME QSLLILSETK ASLVSTMSLW KQQVSTIAKF
860 870 880 890 900
HFLSLKRESK SVRSVLLLLL IFFAVQIFMF LVHHSFKNAV VPIKLVPDLY
910 920 930 940 950
FLKPGDKPHK YKTSLLLQNS TDSDINDLID FFTQQNIIVA MFNDSDYVSA
960 970 980 990 1000
APHSAALNVV QSEKDYVFTA VFNSTMVYSL PVMMNIISNY YLYHLNVTDT
1010 1020 1030 1040 1050
IQIWSTPFIQ EITDIVFKVE LYFQAALLGI IVTAMPPYFA MENAENHKIK
1060 1070 1080 1090 1100
AYTQLKLSGL LPSAYWIGQA VVDIPLFFVV LTLMLGSLFA FHHGLYFYPV
1110 1120 1130 1140 1150
KFLAVVFCLI AYVPSVILFT YIASFTFKKI LNTKEFWSFI YSVTALACVA
1160 1170 1180 1190 1200
VTEITFFLGY GVTAVFHYTF CIAIPIYPLL GCLISFIKGS WKNIPKTENA
1210 1220 1230 1240 1250
YNPWDRLLVA VIMPYLQCVL WIFLLQHYEK KHGGRSIRKD PLFRALSQKA
1260 1270 1280 1290 1300
KHKKFPEPPI NEDEDEDVKA ERLKVKELMG CQCCEEKPAI MVYNLHKEYD
1310 1320 1330 1340 1350
DKKDFLHSRK TTKVATKYVS FCVKKGEILG LLGPNGAGKS TIINILVGDV
1360 1370 1380 1390 1400
EPTSGKIFLG DYGSHSNEDD ESTKCMGYCP QTNPLWPDIT LQEHFEIYGA
1410 1420 1430 1440 1450
VKGMSSGDMK EVISRITKAL DLKEHLQKTV KKLPAGIKRK LCFALSMLGN
1460 1470 1480 1490 1500
PQVTLLDEPS TGMDPRAKQH MWRAIRTAFK NKKRAALLTT HYMEEAEAVC
1510 1520 1530 1540 1550
DRVAIMVSGQ LRCIGTVQHL KSKFGKGYFL EIKLKDWIEN LEIDRLQREI
1560 1570 1580 1590 1600
QYIFPNASRQ ESFSSILAYK IPKEDVQSLS QSFAKLEEAK HTFAIEEYSF
1610 1620 1630 1640
SQATLEQVFV ELTKEQEEED NSCGTLNSTL WWERRQEDRV VF
Length:1,642
Mass (Da):185,811
Last modified:March 1, 2003 - v1
Checksum:i3592F1D90ABCB81F
GO
Isoform 2 (identifier: Q8CF82-2) [UniParc]FASTAAdd to basket

Also known as: V20+16

The sequence of this isoform differs from the canonical sequence as follows:
     922-925: DSDI → GESV
     926-1642: Missing.

Show »
Length:925
Mass (Da):103,850
Checksum:iCC9EAA7D0F81D478
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei922 – 9254DSDI → GESV in isoform 2. 1 PublicationVSP_020693
Alternative sequencei926 – 1642717Missing in isoform 2. 1 PublicationVSP_020694Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ426052 mRNA. Translation: CAD19800.2.
AJ550165 mRNA. Translation: CAD80052.1.
RefSeqiNP_775429.1. NM_173307.1. [Q8CF82-1]
UniGeneiRn.35782.

Genome annotation databases

EnsembliENSRNOT00000005848; ENSRNOP00000005848; ENSRNOG00000004378. [Q8CF82-1]
GeneIDi286970.
KEGGirno:286970.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ426052 mRNA. Translation: CAD19800.2.
AJ550165 mRNA. Translation: CAD80052.1.
RefSeqiNP_775429.1. NM_173307.1. [Q8CF82-1]
UniGeneiRn.35782.

3D structure databases

ProteinModelPortaliQ8CF82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005848.

PTM databases

iPTMnetiQ8CF82.

Proteomic databases

PaxDbiQ8CF82.
PRIDEiQ8CF82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005848; ENSRNOP00000005848; ENSRNOG00000004378. [Q8CF82-1]
GeneIDi286970.
KEGGirno:286970.

Organism-specific databases

CTDi23461.
RGDi628661. Abca5.

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOGENOMiHOG000231057.
HOVERGENiHBG079884.
InParanoidiQ8CF82.
KOiK05648.
OMAiYIDRYCA.
OrthoDBiEOG73Z2SB.
PhylomeDBiQ8CF82.
TreeFamiTF105192.

Miscellaneous databases

PROiQ8CF82.

Gene expression databases

ExpressionAtlasiQ8CF82. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030367. ABCA5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PTHR19229:SF100. PTHR19229:SF100. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of human and rat ABCA5/Abca5 and detection of a human splice variant."
    Petry F., Kotthaus A., Hirsch-Ernst K.I.
    Biochem. Biophys. Res. Commun. 300:343-350(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: Wistar.
  2. "Subcellular localization of rat Abca5, a rat ATP-binding-cassette transporter expressed in Leydig cells, and characterization of its splice variant apparently encoding a half-transporter."
    Petry F., Ritz V., Meineke C., Middel P., Kietzmann T., Schmitz-Salue C., Hirsch-Ernst K.I.
    Biochem. J. 393:79-87(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: Wistar.
    Tissue: Testis.

Entry informationi

Entry nameiABCA5_RAT
AccessioniPrimary (citable) accession number: Q8CF82
Secondary accession number(s): Q80Z07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.