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Protein

Cyclin-dependent kinase-like 1

Gene

Cdkl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 1Curated (EC:2.7.11.22)
Gene namesi
Name:Cdkl1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1918341 Cdkl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858111 – 352Cyclin-dependent kinase-like 1Add BLAST352

Proteomic databases

MaxQBiQ8CEQ0
PaxDbiQ8CEQ0
PRIDEiQ8CEQ0

PTM databases

iPTMnetiQ8CEQ0
PhosphoSitePlusiQ8CEQ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000020990
ExpressionAtlasiQ8CEQ0 baseline and differential
GenevisibleiQ8CEQ0 MM

Interactioni

Protein-protein interaction databases

BioGridi214470, 2 interactors
STRINGi10090.ENSMUSP00000021377

Structurei

3D structure databases

ProteinModelPortaliQ8CEQ0
SMRiQ8CEQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 287Protein kinasePROSITE-ProRule annotationAdd BLAST284

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0593 Eukaryota
ENOG410XNSW LUCA
GeneTreeiENSGT00830000128262
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ8CEQ0
KOiK08824
OMAiDNKKYYC
OrthoDBiEOG091G0BZP
PhylomeDBiQ8CEQ0
TreeFamiTF101031

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CEQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYEKIGKI GEGSYGVVFK CRNRDTGQIV AIKRFLETED DPVIKKIALR
60 70 80 90 100
EIRMLKQLKH PNLVNLLEVF RRKRRLHLVF EYCDHTVLHE LDRYQRGVPE
110 120 130 140 150
PLVKNITWQT LQAVNFCHKH NCIHRDVKPE NILITKQSAI KLCDFGFARL
160 170 180 190 200
LTGPGDYYTD YVATRWYRSP ELLVGDTQYG PPVDVWAIGC VFAELLSGVP
210 220 230 240 250
LWPGKSDVDQ LYLIRKTLGD LIPRHQQVFS MNQYFSGVKI PDPEDMETLE
260 270 280 290 300
LKFPNISYSA LGFLKGCLHM DPAERLTCEQ LLQHPYFDSI REVGELTRQH
310 320 330 340 350
DKPARKTLRQ SRKHLTGLQY LPQLTSSRIL PALDNKKYHC STKRFNYHFP

NI
Length:352
Mass (Da):41,024
Last modified:March 1, 2003 - v1
Checksum:i6E9F56C8080F35E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016781 mRNA Translation: BAC25497.1
CCDSiCCDS25955.1
RefSeqiNP_899117.1, NM_183294.2
XP_017170691.1, XM_017315202.1
XP_017170692.1, XM_017315203.1
UniGeneiMm.132325

Genome annotation databases

EnsembliENSMUST00000021377; ENSMUSP00000021377; ENSMUSG00000020990
GeneIDi71091
KEGGimmu:71091
UCSCiuc007nst.1 mouse

Entry informationi

Entry nameiCDKL1_MOUSE
AccessioniPrimary (citable) accession number: Q8CEQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

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