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Protein

Cyclin-dependent kinase-like 1

Gene

Cdkl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 1 (EC:2.7.11.22)
Gene namesi
Name:Cdkl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1918341. Cdkl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858111 – 352Cyclin-dependent kinase-like 1Add BLAST352

Proteomic databases

MaxQBiQ8CEQ0.
PaxDbiQ8CEQ0.
PRIDEiQ8CEQ0.

PTM databases

iPTMnetiQ8CEQ0.
PhosphoSitePlusiQ8CEQ0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020990.
ExpressionAtlasiQ8CEQ0. baseline and differential.
GenevisibleiQ8CEQ0. MM.

Interactioni

Protein-protein interaction databases

BioGridi214470. 2 interactors.
STRINGi10090.ENSMUSP00000021377.

Structurei

3D structure databases

ProteinModelPortaliQ8CEQ0.
SMRiQ8CEQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 287Protein kinasePROSITE-ProRule annotationAdd BLAST284

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ8CEQ0.
KOiK08824.
OMAiHHPYFEN.
OrthoDBiEOG091G0BZP.
PhylomeDBiQ8CEQ0.
TreeFamiTF101031.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CEQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYEKIGKI GEGSYGVVFK CRNRDTGQIV AIKRFLETED DPVIKKIALR
60 70 80 90 100
EIRMLKQLKH PNLVNLLEVF RRKRRLHLVF EYCDHTVLHE LDRYQRGVPE
110 120 130 140 150
PLVKNITWQT LQAVNFCHKH NCIHRDVKPE NILITKQSAI KLCDFGFARL
160 170 180 190 200
LTGPGDYYTD YVATRWYRSP ELLVGDTQYG PPVDVWAIGC VFAELLSGVP
210 220 230 240 250
LWPGKSDVDQ LYLIRKTLGD LIPRHQQVFS MNQYFSGVKI PDPEDMETLE
260 270 280 290 300
LKFPNISYSA LGFLKGCLHM DPAERLTCEQ LLQHPYFDSI REVGELTRQH
310 320 330 340 350
DKPARKTLRQ SRKHLTGLQY LPQLTSSRIL PALDNKKYHC STKRFNYHFP

NI
Length:352
Mass (Da):41,024
Last modified:March 1, 2003 - v1
Checksum:i6E9F56C8080F35E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016781 mRNA. Translation: BAC25497.1.
CCDSiCCDS25955.1.
RefSeqiNP_899117.1. NM_183294.2.
XP_017170691.1. XM_017315202.1.
XP_017170692.1. XM_017315203.1.
UniGeneiMm.132325.

Genome annotation databases

EnsembliENSMUST00000021377; ENSMUSP00000021377; ENSMUSG00000020990.
GeneIDi71091.
KEGGimmu:71091.
UCSCiuc007nst.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016781 mRNA. Translation: BAC25497.1.
CCDSiCCDS25955.1.
RefSeqiNP_899117.1. NM_183294.2.
XP_017170691.1. XM_017315202.1.
XP_017170692.1. XM_017315203.1.
UniGeneiMm.132325.

3D structure databases

ProteinModelPortaliQ8CEQ0.
SMRiQ8CEQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214470. 2 interactors.
STRINGi10090.ENSMUSP00000021377.

PTM databases

iPTMnetiQ8CEQ0.
PhosphoSitePlusiQ8CEQ0.

Proteomic databases

MaxQBiQ8CEQ0.
PaxDbiQ8CEQ0.
PRIDEiQ8CEQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021377; ENSMUSP00000021377; ENSMUSG00000020990.
GeneIDi71091.
KEGGimmu:71091.
UCSCiuc007nst.1. mouse.

Organism-specific databases

CTDi8814.
MGIiMGI:1918341. Cdkl1.

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ8CEQ0.
KOiK08824.
OMAiHHPYFEN.
OrthoDBiEOG091G0BZP.
PhylomeDBiQ8CEQ0.
TreeFamiTF101031.

Miscellaneous databases

PROiQ8CEQ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020990.
ExpressionAtlasiQ8CEQ0. baseline and differential.
GenevisibleiQ8CEQ0. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDKL1_MOUSE
AccessioniPrimary (citable) accession number: Q8CEQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.