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Protein

Pannexin-3

Gene

Panx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Structural component of the gap junctions and the hemichannels.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Pannexin-3
Gene namesi
Name:Panx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1918881. Panx3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939CytoplasmicSequence analysisAdd
BLAST
Transmembranei40 – 6021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini61 – 11353ExtracellularSequence analysisAdd
BLAST
Transmembranei114 – 13421HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini135 – 21581CytoplasmicSequence analysisAdd
BLAST
Transmembranei216 – 23621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini237 – 26731ExtracellularSequence analysisAdd
BLAST
Transmembranei268 – 28821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini289 – 392104CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endomembrane system Source: GO_Central
  • gap junction Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi71 – 711N → Q: Impairs glycosylation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Pannexin-3PRO_0000208492Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)1 Publication

Post-translational modificationi

N-glycosylation may play a role in cell surface targeting.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8CEG0.
PaxDbiQ8CEG0.
PRIDEiQ8CEG0.

PTM databases

iPTMnetiQ8CEG0.
PhosphoSiteiQ8CEG0.

Expressioni

Tissue specificityi

Expressed in skin, cartilage, heart, lung, liver, spleen, thymus and kidney. Not expressed in brain.

Gene expression databases

BgeeiQ8CEG0.
CleanExiMM_PANX3.
ExpressionAtlasiQ8CEG0. baseline and differential.
GenevisibleiQ8CEG0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011262.

Structurei

3D structure databases

ProteinModelPortaliQ8CEG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE65. Eukaryota.
ENOG410ZSQN. LUCA.
GeneTreeiENSGT00390000009703.
HOGENOMiHOG000063721.
HOVERGENiHBG053497.
InParanoidiQ8CEG0.
KOiK03443.
OMAiKMFPYSL.
OrthoDBiEOG74N5G9.
PhylomeDBiQ8CEG0.
TreeFamiTF333142.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CEG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAHTAAEY MLSDALLPDR RGSRLKGLRL ELPLDKMVKF ITVGFPLLLM
60 70 80 90 100
SLAFAQEFSS GSPISCFSPS NFSVRQAAYV DSSCWDSLAH HTQDKAGQYK
110 120 130 140 150
VKSLWPHKAL PYSLLALAVA MYLPVLLWQY VAVPSLSSDL LFIISELDKS
160 170 180 190 200
YNRSIRLVQH MLQIRQSSSD PHVFWDELEK ARKERYFEFP LLERYLECKQ
210 220 230 240 250
RSHWLVATYL LRNALLLLFT SATYLYLGQF HLDVFFQDEF NCFIKTGLLH
260 270 280 290 300
DETHVPELIT CRLTSLSVFQ IVSVSSAAIY TILVPVIIYN LTRLCRWDKG
310 320 330 340 350
LLSIYEMLPA FDLLSRKMLG CPINDLNVIL LFLRANISEL ISFSWLSVLS
360 370 380 390
VLKDTTTQKH NIDTVVDFMT FVAGLEPSKP KHLTQHTYDE HA
Length:392
Mass (Da):44,928
Last modified:March 1, 2003 - v1
Checksum:iF78A6C1CD7B4C8A1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921L → V in BAC29644 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028288 mRNA. Translation: BAC25860.1.
AK036933 mRNA. Translation: BAC29644.1.
BC052822 mRNA. Translation: AAH52822.1.
CCDSiCCDS22984.1.
RefSeqiNP_766042.2. NM_172454.2.
UniGeneiMm.217159.

Genome annotation databases

EnsembliENSMUST00000011262; ENSMUSP00000011262; ENSMUSG00000011118.
GeneIDi208098.
KEGGimmu:208098.
UCSCiuc009ovi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028288 mRNA. Translation: BAC25860.1.
AK036933 mRNA. Translation: BAC29644.1.
BC052822 mRNA. Translation: AAH52822.1.
CCDSiCCDS22984.1.
RefSeqiNP_766042.2. NM_172454.2.
UniGeneiMm.217159.

3D structure databases

ProteinModelPortaliQ8CEG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011262.

PTM databases

iPTMnetiQ8CEG0.
PhosphoSiteiQ8CEG0.

Proteomic databases

EPDiQ8CEG0.
PaxDbiQ8CEG0.
PRIDEiQ8CEG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000011262; ENSMUSP00000011262; ENSMUSG00000011118.
GeneIDi208098.
KEGGimmu:208098.
UCSCiuc009ovi.1. mouse.

Organism-specific databases

CTDi116337.
MGIiMGI:1918881. Panx3.

Phylogenomic databases

eggNOGiENOG410IE65. Eukaryota.
ENOG410ZSQN. LUCA.
GeneTreeiENSGT00390000009703.
HOGENOMiHOG000063721.
HOVERGENiHBG053497.
InParanoidiQ8CEG0.
KOiK03443.
OMAiKMFPYSL.
OrthoDBiEOG74N5G9.
PhylomeDBiQ8CEG0.
TreeFamiTF333142.

Miscellaneous databases

PROiQ8CEG0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CEG0.
CleanExiMM_PANX3.
ExpressionAtlasiQ8CEG0. baseline and differential.
GenevisibleiQ8CEG0. MM.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/He.
    Tissue: Osteoblast.
  3. "Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins."
    Penuela S., Bhalla R., Gong X.Q., Cowan K.N., Celetti S.J., Cowan B.J., Bai D., Shao Q., Laird D.W.
    J. Cell Sci. 120:3772-3783(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-71, MUTAGENESIS OF ASN-71.

Entry informationi

Entry nameiPANX3_MOUSE
AccessioniPrimary (citable) accession number: Q8CEG0
Secondary accession number(s): Q8CB28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.