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Protein

Protein fem-1 homolog C

Gene

Fem1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fem-1 homolog C
Short name:
FEM1c
Alternative name(s):
FEM1-gamma
Gene namesi
Name:Fem1c
Synonyms:Kiaa1785
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2444737. Fem1c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Protein fem-1 homolog CPRO_0000324537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8CEF1.
PaxDbiQ8CEF1.
PRIDEiQ8CEF1.

PTM databases

PhosphoSiteiQ8CEF1.

Expressioni

Tissue specificityi

Widely expressed. Expressed at higher level in testis.1 Publication

Gene expression databases

BgeeiQ8CEF1.
CleanExiMM_FEM1C.
ExpressionAtlasiQ8CEF1. baseline and differential.
GenevisibleiQ8CEF1. MM.

Interactioni

Subunit structurei

Component of some E3 ubiquitin-protein ligase complex.By similarity

Protein-protein interaction databases

BioGridi232187. 1 interaction.
STRINGi10090.ENSMUSP00000038816.

Structurei

3D structure databases

ProteinModelPortaliQ8CEF1.
SMRiQ8CEF1. Positions 1-567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3130ANK 1Add
BLAST
Repeati40 – 7031ANK 2Add
BLAST
Repeati82 – 11130ANK 3Add
BLAST
Repeati115 – 14430ANK 4Add
BLAST
Repeati148 – 17730ANK 5Add
BLAST
Repeati181 – 21030ANK 6Add
BLAST
Repeati213 – 24230ANK 7Add
BLAST
Repeati245 – 27935TPR 1Add
BLAST
Repeati338 – 37134TPR 2Add
BLAST
Repeati481 – 52343ANK 8Add
BLAST
Repeati527 – 55630ANK 9Add
BLAST

Sequence similaritiesi

Belongs to the fem-1 family.Curated
Contains 9 ANK repeats.PROSITE-ProRule annotation
Contains 2 TPR repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129781.
HOGENOMiHOG000008180.
HOVERGENiHBG057774.
InParanoidiQ8CEF1.
OMAiDRNTTCV.
OrthoDBiEOG7T4MJT.
PhylomeDBiQ8CEF1.
TreeFamiTF351376.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF13606. Ank_3. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CEF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKTAVFNA ARDGKLRLLT KLLASKSKAE VSSLISEKTN GATPLLMAAR
60 70 80 90 100
YGHLDMVEFL LEQCSASIEV GGSVNFDGET IEGAPPLWAA SAAGHLKVVQ
110 120 130 140 150
SLLNHGASVN NTTLTNSTPL RAACFDGHLE IVKYLVEHKA DLEVSNRHGH
160 170 180 190 200
TCLMISCYKG HKEIAQYLLE KGADVNRKSV KGNTALHDCA ESGSLDIMKM
210 220 230 240 250
LLMYCAKMEK DGYGMTPLLS ASVTGHTNIV DFLTHHAQTS KTERINALEL
260 270 280 290 300
LGATFVDKKR DLLGALKYWK KAMNMRYSDR TNIISKPVPQ TLIMAYDYAK
310 320 330 340 350
EVNSAEELEG LIADPDEMRM QALLIRERIL GPSHPDTSYY IRYRGAVYAD
360 370 380 390 400
SGNFKRCINL WKYALDMQQS NLDPLSPMTA SSLLSFAELF SFMLQDRAKG
410 420 430 440 450
LLGTTVTFDD LMGILCKSVL EIERAIKQTQ CPADPLQLNK ALSIILHLIC
460 470 480 490 500
LLEKVPCTVE QDHFKKQTIY RFLKLHPRGK NNFSPLHLAV DKNTTCVGRY
510 520 530 540 550
PVCKFPSLQV TAILIECGAD VNVRDSDDNS PLHIAALNNH PDIMNLLIKS
560 570 580 590 600
GAHFDATNLH KQTASDLLDE KEIAKNLIQP INHTTLQCLA ARVIVNHRIY
610
YKGNIPEKLE TFVSLHR
Length:617
Mass (Da):68,578
Last modified:March 1, 2003 - v1
Checksum:iE9DBE053E96197BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351I → V in BAC33691 (PubMed:14621295).Curated
Sequence conflicti64 – 641C → Y in BAE28099 (PubMed:14621295).Curated
Sequence conflicti528 – 5281D → G in BAC33691 (PubMed:14621295).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY249189 mRNA. Translation: AAO64430.1.
AK049336 mRNA. Translation: BAC33691.1.
AK129440 mRNA. Translation: BAC98250.1.
AK147729 mRNA. Translation: BAE28099.1.
AK028330 mRNA. Translation: BAC25884.1.
CCDSiCCDS29231.1.
RefSeqiNP_775599.1. NM_173423.4.
UniGeneiMm.38249.
Mm.393068.

Genome annotation databases

EnsembliENSMUST00000036226; ENSMUSP00000038816; ENSMUSG00000033319.
GeneIDi240263.
KEGGimmu:240263.
UCSCiuc008evo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY249189 mRNA. Translation: AAO64430.1.
AK049336 mRNA. Translation: BAC33691.1.
AK129440 mRNA. Translation: BAC98250.1.
AK147729 mRNA. Translation: BAE28099.1.
AK028330 mRNA. Translation: BAC25884.1.
CCDSiCCDS29231.1.
RefSeqiNP_775599.1. NM_173423.4.
UniGeneiMm.38249.
Mm.393068.

3D structure databases

ProteinModelPortaliQ8CEF1.
SMRiQ8CEF1. Positions 1-567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232187. 1 interaction.
STRINGi10090.ENSMUSP00000038816.

PTM databases

PhosphoSiteiQ8CEF1.

Proteomic databases

MaxQBiQ8CEF1.
PaxDbiQ8CEF1.
PRIDEiQ8CEF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036226; ENSMUSP00000038816; ENSMUSG00000033319.
GeneIDi240263.
KEGGimmu:240263.
UCSCiuc008evo.1. mouse.

Organism-specific databases

CTDi56929.
MGIiMGI:2444737. Fem1c.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129781.
HOGENOMiHOG000008180.
HOVERGENiHBG057774.
InParanoidiQ8CEF1.
OMAiDRNTTCV.
OrthoDBiEOG7T4MJT.
PhylomeDBiQ8CEF1.
TreeFamiTF351376.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi384534.
PROiQ8CEF1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CEF1.
CleanExiMM_FEM1C.
ExpressionAtlasiQ8CEF1. baseline and differential.
GenevisibleiQ8CEF1. MM.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF13606. Ank_3. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Fem1c genes: conserved members of the Fem1 gene family in vertebrates."
    Ventura-Holman T., Lu D., Si X., Izevbigie E.B., Maher J.F.
    Gene 314:133-139(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: CD-1.
    Tissue: Testis.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: ROSA3 MICE.

Entry informationi

Entry nameiFEM1C_MOUSE
AccessioniPrimary (citable) accession number: Q8CEF1
Secondary accession number(s): Q3UGV8, Q8C7S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Insertion of the beta Geo promoter trap into the Fem1c gene is the cause of ROSA3 mice. Adult ROSA3 mice exhibit widespread expression of the trap gene in epithelial cells found in most organs. Although normal processing of the Fem1c transcript is disrupted in homozygous ROSA3 mice, some tissues show low levels of a partially processed transcript containing exons 2 and 3, which contain the entire coding region of Fem1c. ROSA3 mice show no adverse effects in their sexual development or fertility or in the attenuation of neuronal cell death.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.