ID   Q8CED7_MOUSE            Unreviewed;       354 AA.
AC   Q8CED7;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 139.
DE   RecName: Full=Macrophage scavenger receptor types I and II {ECO:0008006|Google:ProtNLM};
GN   Name=Msr1 {ECO:0000313|MGI:MGI:98257};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC25973.1};
RN   [1] {ECO:0000313|EMBL:BAC25973.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC25973.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29630.1}, and Skin
RC   {ECO:0000313|EMBL:BAC25973.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAC25973.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC25973.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29630.1}, and Skin
RC   {ECO:0000313|EMBL:BAC25973.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAC25973.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC25973.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29630.1}, and Skin
RC   {ECO:0000313|EMBL:BAC25973.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAC25973.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC25973.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29630.1}, and Skin
RC   {ECO:0000313|EMBL:BAC25973.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAC25973.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC25973.1};
RC   TISSUE=Skin {ECO:0000313|EMBL:BAC25973.1};
RA   Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA   Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA   Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA   Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA   Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA   Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA   Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA   Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA   Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA   Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA   Hayashizaki Y.;
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:BAC25973.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC25973.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29630.1}, and Skin
RC   {ECO:0000313|EMBL:BAC25973.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [7] {ECO:0000313|EMBL:BAE29630.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE29630.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29630.1};
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA   Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA   Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA   Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA   Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:BAC25973.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC25973.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29630.1}, and Skin
RC   {ECO:0000313|EMBL:BAC25973.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [9] {ECO:0000313|EMBL:BAC25973.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC25973.1};
RC   TISSUE=Bone marrow {ECO:0000313|EMBL:BAE29630.1}, and Skin
RC   {ECO:0000313|EMBL:BAC25973.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
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DR   EMBL; AK028480; BAC25973.1; -; mRNA.
DR   EMBL; AK150518; BAE29630.1; -; mRNA.
DR   EMBL; AK151403; BAE30370.1; -; mRNA.
DR   EMBL; AK151855; BAE30744.1; -; mRNA.
DR   EMBL; AK155589; BAE33337.1; -; mRNA.
DR   RefSeq; NP_001106797.1; NM_001113326.1.
DR   RefSeq; NP_112472.2; NM_031195.2.
DR   AlphaFoldDB; Q8CED7; -.
DR   SMR; Q8CED7; -.
DR   MaxQB; Q8CED7; -.
DR   Antibodypedia; 601; 1059 antibodies from 39 providers.
DR   DNASU; 20288; -.
DR   GeneID; 20288; -.
DR   KEGG; mmu:20288; -.
DR   UCSC; uc009lmk.1; mouse.
DR   AGR; MGI:98257; -.
DR   CTD; 4481; -.
DR   MGI; MGI:98257; Msr1.
DR   VEuPathDB; HostDB:ENSMUSG00000025044; -.
DR   OrthoDB; 5354783at2759; -.
DR   BioGRID-ORCS; 20288; 2 hits in 83 CRISPR screens.
DR   ChiTaRS; Msr1; mouse.
DR   ExpressionAtlas; Q8CED7; baseline and differential.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   GO; GO:0006898; P:receptor-mediated endocytosis; IEA:InterPro.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR003543; SR-AI/II.
DR   PANTHER; PTHR15427:SF33; EMI DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR   Pfam; PF01391; Collagen; 2.
DR   Pfam; PF03523; Macscav_rec; 1.
DR   PRINTS; PR01408; MACSCAVRCPTR.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        56..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          272..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   354 AA;  38773 MW;  348E084D2D8B644B CRC64;
     MTKEMTENQR LCPHEQEDAD CSSESVKFDA RSMTASLPHS TKNGPSLQEK LKSFKAALIA
     LYLLVFAVLI PVVGIVTAQL LNWEMKNCLV CSLNTSDTSQ GPMEKENTSK VEMRFTIIME
     HMKDMEERIE SISNSKADLI DTERFQNFSM ATDQRLNDIL LQLNSLISSV QEHGNSLDAI
     SKSLQSLNMT LLDVQLHTET LNVRVRESTA KQQEDISKLE ERVYKVSAEV QSVKEEQAHV
     EQEVKQEVRV LNNITNDLRL KDWEHSQTLK NITFIQGPPG PQGEKGDRGL TGQTGPPGAP
     GIRGIPGVKG DRGQIGFPGG RGNPGAPGKP GRSGSPGPKG QKGEKGSVGG SRSV
//