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Protein

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

Gene

Ppwd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC:5.2.1.8)
Gene namesi
Name:Ppwd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2443069. Ppwd1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Associated with spliceosomal complexes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002403072 – 646Peptidylprolyl isomerase domain and WD repeat-containing protein 1Add BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8CEC6.
MaxQBiQ8CEC6.
PaxDbiQ8CEC6.
PeptideAtlasiQ8CEC6.
PRIDEiQ8CEC6.

PTM databases

iPTMnetiQ8CEC6.
PhosphoSitePlusiQ8CEC6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021713.
GenevisibleiQ8CEC6. MM.

Interactioni

Subunit structurei

Identified in the spliceosome C complex.By similarity

Protein-protein interaction databases

IntActiQ8CEC6. 1 interactor.
MINTiMINT-4115466.
STRINGi10090.ENSMUSP00000022226.

Structurei

3D structure databases

ProteinModelPortaliQ8CEC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati88 – 126WD 1Add BLAST39
Repeati131 – 170WD 2Add BLAST40
Repeati221 – 260WD 3Add BLAST40
Repeati278 – 319WD 4Add BLAST42
Domaini490 – 645PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 17Poly-Arg6

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation
Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0882. Eukaryota.
ENOG410XQB4. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000213214.
HOVERGENiHBG079869.
InParanoidiQ8CEC6.
KOiK12736.
OMAiPMPSEQS.
OrthoDBiEOG091G03B9.
TreeFamiTF105686.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF50978. SSF50978. 3 hits.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CEC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATESGSDSQ LRRRRRRDPE GSEKTELSER EPALAVAGSE ENDDENEERW
60 70 80 90 100
VGPLPVEATL AKKRKVLEFE RVYLDNLPSA SMYERSYMHR DVITHVVCTK
110 120 130 140 150
TDFIITASHD GHVKFWKKIE EGIEFVKHFR SHLGVIESIA VSSEGALFCS
160 170 180 190 200
VGDDKAMKVF DVVNFDMINM LKLGYFPGQC EWIYCPGDAI SSVAASEKST
210 220 230 240 250
GKIFIYDGRG DNQPLHIFDK LHVSPLTQIR LNPVYKAVVS SDKSGMIEYW
260 270 280 290 300
TGPPHEYKFP KNVNWEYKTD TDLYEFAKCK AYPTSICFSP DGKKIATIGS
310 320 330 340 350
DRKVRIFRFL TGKLMRVFDE SLSMFTELQQ MRQQLPDMEF GRRMAVEREL
360 370 380 390 400
EKVDAVRLVN IVFDETGHFV LYGTMLGIKV INVETNRCVR ILGKQENIRV
410 420 430 440 450
MQLALFQGIA KKHRAAATIE MKASENPVLQ NIQADPTIVC TSFKKNRFYM
460 470 480 490 500
FTKREPEDTK TADSDRDVFN EKPSKEEVMA ATQAEGPKRV SDSAIVHTSM
510 520 530 540 550
GDIHIKLFPV ECPKTVENFC VHSRNGYYNG HTFHRIIKGF MIQTGDPTGT
560 570 580 590 600
GMGGESIWGG EFEDEFHSTL RHDRPYTLSM ANAGSNTNGS QFFITVVPTP
610 620 630 640
WLDNKHTVFG RVTKGMEVVQ RISNVKVNPK TDKPYEDVSI INITVK
Length:646
Mass (Da):73,385
Last modified:July 27, 2011 - v2
Checksum:iFEF78325D862560A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti385T → P in BAC25996 (PubMed:16141072).Curated1
Sequence conflicti456P → T in BAC25996 (PubMed:16141072).Curated1
Sequence conflicti613T → S in BAC25996 (PubMed:16141072).Curated1
Sequence conflicti623S → F in BAC25996 (PubMed:16141072).Curated1
Sequence conflicti630K → Q in BAC25996 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028532 mRNA. Translation: BAC25996.1.
BC119282 mRNA. Translation: AAI19283.1.
BC119310 mRNA. Translation: AAI19311.1.
CCDSiCCDS26748.1.
RefSeqiNP_766395.2. NM_172807.4.
UniGeneiMm.98910.

Genome annotation databases

EnsembliENSMUST00000022226; ENSMUSP00000022226; ENSMUSG00000021713.
GeneIDi238831.
KEGGimmu:238831.
UCSCiuc007rsz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028532 mRNA. Translation: BAC25996.1.
BC119282 mRNA. Translation: AAI19283.1.
BC119310 mRNA. Translation: AAI19311.1.
CCDSiCCDS26748.1.
RefSeqiNP_766395.2. NM_172807.4.
UniGeneiMm.98910.

3D structure databases

ProteinModelPortaliQ8CEC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CEC6. 1 interactor.
MINTiMINT-4115466.
STRINGi10090.ENSMUSP00000022226.

PTM databases

iPTMnetiQ8CEC6.
PhosphoSitePlusiQ8CEC6.

Proteomic databases

EPDiQ8CEC6.
MaxQBiQ8CEC6.
PaxDbiQ8CEC6.
PeptideAtlasiQ8CEC6.
PRIDEiQ8CEC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022226; ENSMUSP00000022226; ENSMUSG00000021713.
GeneIDi238831.
KEGGimmu:238831.
UCSCiuc007rsz.2. mouse.

Organism-specific databases

CTDi23398.
MGIiMGI:2443069. Ppwd1.

Phylogenomic databases

eggNOGiKOG0882. Eukaryota.
ENOG410XQB4. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000213214.
HOVERGENiHBG079869.
InParanoidiQ8CEC6.
KOiK12736.
OMAiPMPSEQS.
OrthoDBiEOG091G03B9.
TreeFamiTF105686.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ8CEC6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021713.
GenevisibleiQ8CEC6. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF50978. SSF50978. 3 hits.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPWD1_MOUSE
AccessioniPrimary (citable) accession number: Q8CEC6
Secondary accession number(s): Q0VEA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.