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Protein

Nuclear pore complex protein Nup88

Gene

Nup88

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of nuclear pore complex.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-MMU-191859 snRNP Assembly
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup88
Alternative name(s):
88 kDa nucleoporin
Nucleoporin Nup88
Gene namesi
Name:Nup88
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104900 Nup88

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002048882 – 753Nuclear pore complex protein Nup88Add BLAST752

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei35PhosphoserineCombined sources1
Modified residuei380PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei518PhosphoserineBy similarity1
Modified residuei526PhosphothreonineCombined sources1
Modified residuei541PhosphoserineBy similarity1
Modified residuei710PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8CEC0
PRIDEiQ8CEC0

PTM databases

iPTMnetiQ8CEC0
PhosphoSitePlusiQ8CEC0

Expressioni

Gene expression databases

BgeeiENSMUSG00000040667
CleanExiMM_NUP88
ExpressionAtlasiQ8CEC0 baseline and differential
GenevisibleiQ8CEC0 MM

Interactioni

Subunit structurei

Interacts with NUP214/CAN.By similarity

Protein-protein interaction databases

BioGridi202355, 8 interactors
IntActiQ8CEC0, 6 interactors
MINTiQ8CEC0
STRINGi10090.ENSMUSP00000048101

Structurei

3D structure databases

ProteinModelPortaliQ8CEC0
SMRiQ8CEC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili623 – 663Sequence analysisAdd BLAST41

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4460 Eukaryota
ENOG410YC30 LUCA
GeneTreeiENSGT00390000015063
HOGENOMiHOG000234330
HOVERGENiHBG052700
InParanoidiQ8CEC0
KOiK14318
OMAiLYENGET
OrthoDBiEOG091G0O97
PhylomeDBiQ8CEC0
TreeFamiTF105307

Family and domain databases

InterProiView protein in InterPro
IPR019321 Nucleoporin_Nup88
IPR037700 NUP84
PANTHERiPTHR13257 PTHR13257, 1 hit
PfamiView protein in Pfam
PF10168 Nup88, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CEC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVGPLGD GELWQSWLPN HVVFLRLREG VRNQSPAEAE KPAASTSPSC
60 70 80 90 100
PSLPPHLPTR NLVFGLGGEL FLWDAEGSAF LVVRLRGPSG GGVEPPLSQY
110 120 130 140 150
QRLLCINPPL FEIHQVLLSP TQHHVALIGS KGLMALELPQ RWGKDSEFEG
160 170 180 190 200
GKATVNCSTI PIAERFFTSS TSLTLKHAAW YPSEMLDPHI VLLTSDNVIR
210 220 230 240 250
IYSLREPQTP TKVIVLSEAE EESLILNKGR AYTASLGETA VAFDFGPLVT
260 270 280 290 300
VSKNIFEQKD RDVVAYPLYI LYENGETFLT YVSLLHSPGN IGKLLGPLPM
310 320 330 340 350
HPAAEDNYGY DACAILCLPC VPNILVIATE SGMLYHCVVL EGEEEDDQTL
360 370 380 390 400
EKSWDPRADF IPSLYVFECV ELELALKLAS GEDDPFASDF SCPIKLHRDP
410 420 430 440 450
KCPSRYHCSH EAGVHSVGLT WIHKLHKFLG SDEEDKDSLQ ELTAEQKCFV
460 470 480 490 500
EHILCTKPLP CRQPAPIRGF WIVPDILGPT MICITSTYEC LIRPLLSTVH
510 520 530 540 550
PASPPLLCTQ EDAEVAESPL RILAETPDSF EKHIKRILQR SAANPAFLKN
560 570 580 590 600
CSARSSEKDL APPPEECLQL ISRATQVFRE QYILKQDLAK EEIQRRVKLL
610 620 630 640 650
CDQKRKQLED LNYCREERVS HLFRKSLREM AERLADKYEE AKEKQEDIMN
660 670 680 690 700
RMKKVLHSFH AQLPVLSDSE RDMKKELQLI PDQLRHLGNA IKQVTMKKDY
710 720 730 740 750
QQRKMEKVLS PQKPTITLSA YQRKCIQSIL KEEGEHIREM VKQINDIRNH

VTF
Length:753
Mass (Da):84,938
Last modified:March 1, 2003 - v1
Checksum:iF537DCC5D50D140C
GO
Isoform 2 (identifier: Q8CEC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-623: Missing.

Show »
Length:747
Mass (Da):84,198
Checksum:i5D556289CDECAE7E
GO
Isoform 3 (identifier: Q8CEC0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-554: Missing.
     618-623: Missing.

Show »
Length:742
Mass (Da):83,666
Checksum:i9EFA900AE4001F23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34Q → H in CAD58713 (Ref. 1) Curated1
Sequence conflicti40E → D in CAD58713 (Ref. 1) Curated1
Sequence conflicti86R → P in CAD58713 (Ref. 1) Curated1
Sequence conflicti397H → D in CAD58713 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011195550 – 554Missing in isoform 3. 1 Publication5
Alternative sequenceiVSP_011196618 – 623Missing in isoform 2 and isoform 3. 2 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ532593 mRNA Translation: CAD58713.1
AK028563 mRNA Translation: BAC26010.1
BC032929 mRNA Translation: AAH32929.1
CCDSiCCDS36206.1 [Q8CEC0-1]
CCDS36207.1 [Q8CEC0-3]
CCDS70233.1 [Q8CEC0-2]
RefSeqiNP_001076800.1, NM_001083331.2 [Q8CEC0-1]
NP_001263335.1, NM_001276406.1 [Q8CEC0-2]
NP_765982.2, NM_172394.3 [Q8CEC0-3]
UniGeneiMm.288962

Genome annotation databases

EnsembliENSMUST00000035283; ENSMUSP00000048101; ENSMUSG00000040667 [Q8CEC0-1]
ENSMUST00000108530; ENSMUSP00000104170; ENSMUSG00000040667 [Q8CEC0-3]
ENSMUST00000108531; ENSMUSP00000104171; ENSMUSG00000040667 [Q8CEC0-2]
GeneIDi19069
KEGGimmu:19069
UCSCiuc007jww.2 mouse [Q8CEC0-1]
uc007jwy.2 mouse [Q8CEC0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNUP88_MOUSE
AccessioniPrimary (citable) accession number: Q8CEC0
Secondary accession number(s): Q80Z13, Q8K090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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