Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear pore complex protein Nup88

Gene

Nup88

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of nuclear pore complex.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-191859. snRNP Assembly.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup88
Alternative name(s):
88 kDa nucleoporin
Nucleoporin Nup88
Gene namesi
Name:Nup88
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104900. Nup88.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002048882 – 753Nuclear pore complex protein Nup88Add BLAST752

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei35PhosphoserineCombined sources1
Modified residuei380PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei518PhosphoserineBy similarity1
Modified residuei526PhosphothreonineCombined sources1
Modified residuei541PhosphoserineBy similarity1
Modified residuei710PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8CEC0.
PRIDEiQ8CEC0.

PTM databases

iPTMnetiQ8CEC0.
PhosphoSitePlusiQ8CEC0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040667.
CleanExiMM_NUP88.
ExpressionAtlasiQ8CEC0. baseline and differential.
GenevisibleiQ8CEC0. MM.

Interactioni

Subunit structurei

Interacts with NUP214/CAN.By similarity

Protein-protein interaction databases

BioGridi202355. 8 interactors.
IntActiQ8CEC0. 6 interactors.
MINTiMINT-4104352.
STRINGi10090.ENSMUSP00000048101.

Structurei

3D structure databases

ProteinModelPortaliQ8CEC0.
SMRiQ8CEC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili623 – 663Sequence analysisAdd BLAST41

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4460. Eukaryota.
ENOG410YC30. LUCA.
GeneTreeiENSGT00390000015063.
HOGENOMiHOG000234330.
HOVERGENiHBG052700.
InParanoidiQ8CEC0.
KOiK14318.
OMAiAWYPSEI.
OrthoDBiEOG091G0O97.
PhylomeDBiQ8CEC0.
TreeFamiTF105307.

Family and domain databases

InterProiIPR019321. Nucleoporin_Nup88.
[Graphical view]
PfamiPF10168. Nup88. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CEC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVGPLGD GELWQSWLPN HVVFLRLREG VRNQSPAEAE KPAASTSPSC
60 70 80 90 100
PSLPPHLPTR NLVFGLGGEL FLWDAEGSAF LVVRLRGPSG GGVEPPLSQY
110 120 130 140 150
QRLLCINPPL FEIHQVLLSP TQHHVALIGS KGLMALELPQ RWGKDSEFEG
160 170 180 190 200
GKATVNCSTI PIAERFFTSS TSLTLKHAAW YPSEMLDPHI VLLTSDNVIR
210 220 230 240 250
IYSLREPQTP TKVIVLSEAE EESLILNKGR AYTASLGETA VAFDFGPLVT
260 270 280 290 300
VSKNIFEQKD RDVVAYPLYI LYENGETFLT YVSLLHSPGN IGKLLGPLPM
310 320 330 340 350
HPAAEDNYGY DACAILCLPC VPNILVIATE SGMLYHCVVL EGEEEDDQTL
360 370 380 390 400
EKSWDPRADF IPSLYVFECV ELELALKLAS GEDDPFASDF SCPIKLHRDP
410 420 430 440 450
KCPSRYHCSH EAGVHSVGLT WIHKLHKFLG SDEEDKDSLQ ELTAEQKCFV
460 470 480 490 500
EHILCTKPLP CRQPAPIRGF WIVPDILGPT MICITSTYEC LIRPLLSTVH
510 520 530 540 550
PASPPLLCTQ EDAEVAESPL RILAETPDSF EKHIKRILQR SAANPAFLKN
560 570 580 590 600
CSARSSEKDL APPPEECLQL ISRATQVFRE QYILKQDLAK EEIQRRVKLL
610 620 630 640 650
CDQKRKQLED LNYCREERVS HLFRKSLREM AERLADKYEE AKEKQEDIMN
660 670 680 690 700
RMKKVLHSFH AQLPVLSDSE RDMKKELQLI PDQLRHLGNA IKQVTMKKDY
710 720 730 740 750
QQRKMEKVLS PQKPTITLSA YQRKCIQSIL KEEGEHIREM VKQINDIRNH

VTF
Length:753
Mass (Da):84,938
Last modified:March 1, 2003 - v1
Checksum:iF537DCC5D50D140C
GO
Isoform 2 (identifier: Q8CEC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-623: Missing.

Show »
Length:747
Mass (Da):84,198
Checksum:i5D556289CDECAE7E
GO
Isoform 3 (identifier: Q8CEC0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-554: Missing.
     618-623: Missing.

Show »
Length:742
Mass (Da):83,666
Checksum:i9EFA900AE4001F23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34Q → H in CAD58713 (Ref. 1) Curated1
Sequence conflicti40E → D in CAD58713 (Ref. 1) Curated1
Sequence conflicti86R → P in CAD58713 (Ref. 1) Curated1
Sequence conflicti397H → D in CAD58713 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011195550 – 554Missing in isoform 3. 1 Publication5
Alternative sequenceiVSP_011196618 – 623Missing in isoform 2 and isoform 3. 2 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ532593 mRNA. Translation: CAD58713.1.
AK028563 mRNA. Translation: BAC26010.1.
BC032929 mRNA. Translation: AAH32929.1.
CCDSiCCDS36206.1. [Q8CEC0-1]
CCDS36207.1. [Q8CEC0-3]
CCDS70233.1. [Q8CEC0-2]
RefSeqiNP_001076800.1. NM_001083331.2. [Q8CEC0-1]
NP_001263335.1. NM_001276406.1. [Q8CEC0-2]
NP_765982.2. NM_172394.3. [Q8CEC0-3]
UniGeneiMm.288962.

Genome annotation databases

EnsembliENSMUST00000035283; ENSMUSP00000048101; ENSMUSG00000040667. [Q8CEC0-1]
ENSMUST00000108530; ENSMUSP00000104170; ENSMUSG00000040667. [Q8CEC0-3]
ENSMUST00000108531; ENSMUSP00000104171; ENSMUSG00000040667. [Q8CEC0-2]
GeneIDi19069.
KEGGimmu:19069.
UCSCiuc007jww.2. mouse. [Q8CEC0-1]
uc007jwy.2. mouse. [Q8CEC0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ532593 mRNA. Translation: CAD58713.1.
AK028563 mRNA. Translation: BAC26010.1.
BC032929 mRNA. Translation: AAH32929.1.
CCDSiCCDS36206.1. [Q8CEC0-1]
CCDS36207.1. [Q8CEC0-3]
CCDS70233.1. [Q8CEC0-2]
RefSeqiNP_001076800.1. NM_001083331.2. [Q8CEC0-1]
NP_001263335.1. NM_001276406.1. [Q8CEC0-2]
NP_765982.2. NM_172394.3. [Q8CEC0-3]
UniGeneiMm.288962.

3D structure databases

ProteinModelPortaliQ8CEC0.
SMRiQ8CEC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202355. 8 interactors.
IntActiQ8CEC0. 6 interactors.
MINTiMINT-4104352.
STRINGi10090.ENSMUSP00000048101.

PTM databases

iPTMnetiQ8CEC0.
PhosphoSitePlusiQ8CEC0.

Proteomic databases

PaxDbiQ8CEC0.
PRIDEiQ8CEC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035283; ENSMUSP00000048101; ENSMUSG00000040667. [Q8CEC0-1]
ENSMUST00000108530; ENSMUSP00000104170; ENSMUSG00000040667. [Q8CEC0-3]
ENSMUST00000108531; ENSMUSP00000104171; ENSMUSG00000040667. [Q8CEC0-2]
GeneIDi19069.
KEGGimmu:19069.
UCSCiuc007jww.2. mouse. [Q8CEC0-1]
uc007jwy.2. mouse. [Q8CEC0-2]

Organism-specific databases

CTDi4927.
MGIiMGI:104900. Nup88.

Phylogenomic databases

eggNOGiKOG4460. Eukaryota.
ENOG410YC30. LUCA.
GeneTreeiENSGT00390000015063.
HOGENOMiHOG000234330.
HOVERGENiHBG052700.
InParanoidiQ8CEC0.
KOiK14318.
OMAiAWYPSEI.
OrthoDBiEOG091G0O97.
PhylomeDBiQ8CEC0.
TreeFamiTF105307.

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-191859. snRNP Assembly.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

ChiTaRSiNup88. mouse.
PROiQ8CEC0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040667.
CleanExiMM_NUP88.
ExpressionAtlasiQ8CEC0. baseline and differential.
GenevisibleiQ8CEC0. MM.

Family and domain databases

InterProiIPR019321. Nucleoporin_Nup88.
[Graphical view]
PfamiPF10168. Nup88. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUP88_MOUSE
AccessioniPrimary (citable) accession number: Q8CEC0
Secondary accession number(s): Q80Z13, Q8K090
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.