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Protein

Monocarboxylate transporter 13

Gene

Slc16a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 13
Short name:
MCT 13
Alternative name(s):
Solute carrier family 16 member 13
Gene namesi
Name:Slc16a13
Synonyms:Mct13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1916559 Slc16a13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 428CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871881 – 428Monocarboxylate transporter 13Add BLAST428

Proteomic databases

PaxDbiQ8CE94
PeptideAtlasiQ8CE94
PRIDEiQ8CE94

PTM databases

PhosphoSitePlusiQ8CE94

Expressioni

Gene expression databases

BgeeiENSMUSG00000044367
ExpressionAtlasiQ8CE94 baseline and differential
GenevisibleiQ8CE94 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053218

Structurei

3D structure databases

ProteinModelPortaliQ8CE94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG106552
InParanoidiQ8CE94
KOiK08189
OMAiYGMTEVQ
OrthoDBiEOG091G05SW
PhylomeDBiQ8CE94
TreeFamiTF313792

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CE94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRRAEPPDG GWGWMVVLSA FFQSALVFGV LRSFGVFFVE FVAAFEEQAA
60 70 80 90 100
RVSWIASIGI AVQQFGSPIG SALSTKLGPR PVVMTGGILA ALGMLLASFA
110 120 130 140 150
TSLTHLYLSI GLLSGSGWAL TFTPTMACLS RYFSQRRSLA MGLALTGVGI
160 170 180 190 200
SSFAFAPLFQ WLINNYAWRG ALLLVSALSL HLMACGALLR PLSLTEDAAV
210 220 230 240 250
GGPGAQITSL LRHGPFLRYT AALTLINTGF FIPYVHLVAH LQDLGWDPLP
260 270 280 290 300
AAFLLSVAAV SDLVGRVASG WLGDAVPGPV ARLLMLWTTL TGVSLALFPV
310 320 330 340 350
AQASSTLVVL AVAYGFTSGA LTPVAFSVLP ELVGTGRIYC GMGLVQMIES
360 370 380 390 400
IGGLLGAPLS GYLRDVTGNY TASFVVAGAF LLAGSGVLLT LPHFFSCISV
410 420
STSRPQDLVI EASDTKIPLP KEEGLGEN
Length:428
Mass (Da):44,862
Last modified:March 1, 2003 - v1
Checksum:iC0EE724184856D45
GO

Sequence cautioni

The sequence BAC25120 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54W → C in BAC25771 (PubMed:16141072).Curated1
Sequence conflicti57S → Y in BAC25771 (PubMed:16141072).Curated1
Sequence conflicti63Q → H in BAC25771 (PubMed:16141072).Curated1
Sequence conflicti67S → T in BAC25771 (PubMed:16141072).Curated1
Sequence conflicti109S → N in BAC25120 (PubMed:16141072).Curated1
Sequence conflicti137R → Q in BAC25120 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005699 mRNA Translation: BAC25120.1 Different initiation.
AK028143 mRNA Translation: BAC25771.1
AK028759 mRNA Translation: BAC26104.1
AL669869 Genomic DNA No translation available.
CR933731 Genomic DNA No translation available.
BC039949 mRNA Translation: AAH39949.1
CCDSiCCDS24938.1
RefSeqiNP_758959.1, NM_172371.3
UniGeneiMm.93266

Genome annotation databases

EnsembliENSMUST00000060010; ENSMUSP00000053218; ENSMUSG00000044367
GeneIDi69309
KEGGimmu:69309
UCSCiuc007jub.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMOT13_MOUSE
AccessioniPrimary (citable) accession number: Q8CE94
Secondary accession number(s): Q8CEH6, Q8CF46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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