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Protein

Monocarboxylate transporter 13

Gene

Slc16a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 13
Short name:
MCT 13
Alternative name(s):
Solute carrier family 16 member 13
Gene namesi
Name:Slc16a13
Synonyms:Mct13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1916559. Slc16a13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence analysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence analysisAdd
BLAST
Transmembranei338 – 35821HelicalSequence analysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence analysisAdd
BLAST
Topological domaini395 – 42834CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Monocarboxylate transporter 13PRO_0000287188Add
BLAST

Proteomic databases

PaxDbiQ8CE94.
PeptideAtlasiQ8CE94.
PRIDEiQ8CE94.

PTM databases

PhosphoSiteiQ8CE94.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044367.
ExpressionAtlasiQ8CE94. baseline and differential.
GenevisibleiQ8CE94. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053218.

Structurei

3D structure databases

ProteinModelPortaliQ8CE94.
SMRiQ8CE94. Positions 54-80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG106552.
InParanoidiQ8CE94.
KOiK08189.
OMAiDWDPLSA.
OrthoDBiEOG091G05SW.
PhylomeDBiQ8CE94.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CE94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRRAEPPDG GWGWMVVLSA FFQSALVFGV LRSFGVFFVE FVAAFEEQAA
60 70 80 90 100
RVSWIASIGI AVQQFGSPIG SALSTKLGPR PVVMTGGILA ALGMLLASFA
110 120 130 140 150
TSLTHLYLSI GLLSGSGWAL TFTPTMACLS RYFSQRRSLA MGLALTGVGI
160 170 180 190 200
SSFAFAPLFQ WLINNYAWRG ALLLVSALSL HLMACGALLR PLSLTEDAAV
210 220 230 240 250
GGPGAQITSL LRHGPFLRYT AALTLINTGF FIPYVHLVAH LQDLGWDPLP
260 270 280 290 300
AAFLLSVAAV SDLVGRVASG WLGDAVPGPV ARLLMLWTTL TGVSLALFPV
310 320 330 340 350
AQASSTLVVL AVAYGFTSGA LTPVAFSVLP ELVGTGRIYC GMGLVQMIES
360 370 380 390 400
IGGLLGAPLS GYLRDVTGNY TASFVVAGAF LLAGSGVLLT LPHFFSCISV
410 420
STSRPQDLVI EASDTKIPLP KEEGLGEN
Length:428
Mass (Da):44,862
Last modified:March 1, 2003 - v1
Checksum:iC0EE724184856D45
GO

Sequence cautioni

The sequence BAC25120 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541W → C in BAC25771 (PubMed:16141072).Curated
Sequence conflicti57 – 571S → Y in BAC25771 (PubMed:16141072).Curated
Sequence conflicti63 – 631Q → H in BAC25771 (PubMed:16141072).Curated
Sequence conflicti67 – 671S → T in BAC25771 (PubMed:16141072).Curated
Sequence conflicti109 – 1091S → N in BAC25120 (PubMed:16141072).Curated
Sequence conflicti137 – 1371R → Q in BAC25120 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005699 mRNA. Translation: BAC25120.1. Different initiation.
AK028143 mRNA. Translation: BAC25771.1.
AK028759 mRNA. Translation: BAC26104.1.
CR933731 Genomic DNA. Translation: CAM28089.1.
AL669869 Genomic DNA. Translation: CAI35222.1.
BC039949 mRNA. Translation: AAH39949.1.
CCDSiCCDS24938.1.
RefSeqiNP_758959.1. NM_172371.3.
UniGeneiMm.93266.

Genome annotation databases

EnsembliENSMUST00000060010; ENSMUSP00000053218; ENSMUSG00000044367.
GeneIDi69309.
KEGGimmu:69309.
UCSCiuc007jub.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005699 mRNA. Translation: BAC25120.1. Different initiation.
AK028143 mRNA. Translation: BAC25771.1.
AK028759 mRNA. Translation: BAC26104.1.
CR933731 Genomic DNA. Translation: CAM28089.1.
AL669869 Genomic DNA. Translation: CAI35222.1.
BC039949 mRNA. Translation: AAH39949.1.
CCDSiCCDS24938.1.
RefSeqiNP_758959.1. NM_172371.3.
UniGeneiMm.93266.

3D structure databases

ProteinModelPortaliQ8CE94.
SMRiQ8CE94. Positions 54-80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053218.

PTM databases

PhosphoSiteiQ8CE94.

Proteomic databases

PaxDbiQ8CE94.
PeptideAtlasiQ8CE94.
PRIDEiQ8CE94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060010; ENSMUSP00000053218; ENSMUSG00000044367.
GeneIDi69309.
KEGGimmu:69309.
UCSCiuc007jub.1. mouse.

Organism-specific databases

CTDi201232.
MGIiMGI:1916559. Slc16a13.

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG106552.
InParanoidiQ8CE94.
KOiK08189.
OMAiDWDPLSA.
OrthoDBiEOG091G05SW.
PhylomeDBiQ8CE94.
TreeFamiTF313792.

Miscellaneous databases

PROiQ8CE94.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044367.
ExpressionAtlasiQ8CE94. baseline and differential.
GenevisibleiQ8CE94. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT13_MOUSE
AccessioniPrimary (citable) accession number: Q8CE94
Secondary accession number(s): Q8CEH6, Q8CF46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.