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Protein

Zinc finger protein 276

Gene

Znf276

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri434 – 458C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri465 – 490C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri496 – 518C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 577C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 276
Short name:
Zfp-276
Gene namesi
Name:Znf276
Synonyms:Zfp276
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1888495. Zfp276.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473241 – 614Zinc finger protein 276Add BLAST614

Proteomic databases

PaxDbiQ8CE64.
PeptideAtlasiQ8CE64.
PRIDEiQ8CE64.

PTM databases

iPTMnetiQ8CE64.
PhosphoSitePlusiQ8CE64.

Expressioni

Tissue specificityi

Found in all the examined tissues, with highest levels in kidney, liver, lung, and spleen.1 Publication

Developmental stagei

Expressed at low levels in all stages of embryonic development examined.1 Publication

Gene expression databases

BgeeiENSMUSG00000001065.
CleanExiMM_ZFP276.
ExpressionAtlasiQ8CE64. baseline and differential.
GenevisibleiQ8CE64. MM.

Interactioni

Protein-protein interaction databases

BioGridi208217. 1 interactor.
STRINGi10090.ENSMUSP00000001092.

Structurei

3D structure databases

ProteinModelPortaliQ8CE64.
SMRiQ8CE64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 153ZADAdd BLAST75

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri434 – 458C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri465 – 490C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri496 – 518C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 577C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063153.
HOGENOMiHOG000155790.
HOVERGENiHBG061026.
InParanoidiQ8CE64.
OMAiGCDQGHD.
OrthoDBiEOG091G04WK.
PhylomeDBiQ8CE64.
TreeFamiTF332664.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR012934. Znf_AD.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF07776. zf-AD. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CE64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRDRLGRFL SPGIARQRGG SGGGCGSGRT RGRPSRSGGT SADGAAAQLS
60 70 80 90 100
WGSMTRSCGD TGDDGTDEAG AGRTLAMGHC RLCHGKFSSR SLRSISDRVP
110 120 130 140 150
GETSERLSPG ERVFIRDFQR LLGVAVHQDP ALPQSVCKNC YTQFYQCHSL
160 170 180 190 200
LRTFLQRVNV SPAGQRKPCT KVGVQPTTVA EEGACVADLI ASSPRCLHGL
210 220 230 240 250
VGWVHEHAVS CGSLPSLQRT LSSEYCGIIQ AVWGCDQGHD FTMDTASSCR
260 270 280 290 300
ALFLDSALAV KWAWGKDLSP RLAQNSESNP TGAASRLCQA RETQVGSETK
310 320 330 340 350
TLPSVDVALL HSHGDSVGPG LGPCTQPHLA PSEAPGQLGE TQVPSSTSDD
360 370 380 390 400
RVKDEFSDLS EGDFLSEDES DKKQTPQSSD ESFEPYPEKK VSGKKSEGRE
410 420 430 440 450
AKRPEEPKIR KKPGPKPGWK KKLRCEREEL PTIYKCPYQG CTAVYRGADG
460 470 480 490 500
MKKHIKEHHE EVRERPCPHP GCNKVFMIDR YLQRHVKLIH TEVRNYICDE
510 520 530 540 550
CGQTFKQRKH LLVHQMRHSG AKPLQCEVCG FQCRQRASLK YHMTKHKAET
560 570 580 590 600
ELDFACDQCG RRFEKAHNLN VHMSMVHPLT QAQDRALPLE AEPPPGPLSP
610
SGTMEGQAVK PEPT
Length:614
Mass (Da):67,339
Last modified:June 12, 2007 - v3
Checksum:i1F5716CFADE16533
GO
Isoform 2 (identifier: Q8CE64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-350: QLGETQVPSSTSDD → KQHLWLMLEQDSVF
     351-614: Missing.

Show »
Length:350
Mass (Da):37,228
Checksum:i01CDDE5D404D230D
GO

Sequence cautioni

The sequence AAG01634 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC31505 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353K → R in BAC26204 (PubMed:16141072).Curated1
Sequence conflicti509 – 510KH → ND in AAG01634 (PubMed:10936049).Curated2
Sequence conflicti521A → G in AAG01634 (PubMed:10936049).Curated1
Sequence conflicti579L → W in AAG01634 (PubMed:10936049).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026106337 – 350QLGET…STSDD → KQHLWLMLEQDSVF in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_026107351 – 614Missing in isoform 2. 1 PublicationAdd BLAST264

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028939 mRNA. Translation: BAC26204.1.
AK043258 mRNA. Translation: BAC31505.1. Different initiation.
AK133363 mRNA. Translation: BAE21616.1.
AK163486 mRNA. Translation: BAE37365.1.
AF178935 mRNA. Translation: AAG01634.1. Different initiation.
CCDSiCCDS52699.1. [Q8CE64-1]
RefSeqiNP_065243.2. NM_020497.2. [Q8CE64-1]
UniGeneiMm.379084.

Genome annotation databases

EnsembliENSMUST00000001092; ENSMUSP00000001092; ENSMUSG00000001065. [Q8CE64-1]
GeneIDi57247.
KEGGimmu:57247.
UCSCiuc009nva.2. mouse. [Q8CE64-2]
uc009nvb.2. mouse. [Q8CE64-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028939 mRNA. Translation: BAC26204.1.
AK043258 mRNA. Translation: BAC31505.1. Different initiation.
AK133363 mRNA. Translation: BAE21616.1.
AK163486 mRNA. Translation: BAE37365.1.
AF178935 mRNA. Translation: AAG01634.1. Different initiation.
CCDSiCCDS52699.1. [Q8CE64-1]
RefSeqiNP_065243.2. NM_020497.2. [Q8CE64-1]
UniGeneiMm.379084.

3D structure databases

ProteinModelPortaliQ8CE64.
SMRiQ8CE64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208217. 1 interactor.
STRINGi10090.ENSMUSP00000001092.

PTM databases

iPTMnetiQ8CE64.
PhosphoSitePlusiQ8CE64.

Proteomic databases

PaxDbiQ8CE64.
PeptideAtlasiQ8CE64.
PRIDEiQ8CE64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001092; ENSMUSP00000001092; ENSMUSG00000001065. [Q8CE64-1]
GeneIDi57247.
KEGGimmu:57247.
UCSCiuc009nva.2. mouse. [Q8CE64-2]
uc009nvb.2. mouse. [Q8CE64-1]

Organism-specific databases

CTDi57247.
MGIiMGI:1888495. Zfp276.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063153.
HOGENOMiHOG000155790.
HOVERGENiHBG061026.
InParanoidiQ8CE64.
OMAiGCDQGHD.
OrthoDBiEOG091G04WK.
PhylomeDBiQ8CE64.
TreeFamiTF332664.

Miscellaneous databases

PROiQ8CE64.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001065.
CleanExiMM_ZFP276.
ExpressionAtlasiQ8CE64. baseline and differential.
GenevisibleiQ8CE64. MM.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR012934. Znf_AD.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF07776. zf-AD. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN276_MOUSE
AccessioniPrimary (citable) accession number: Q8CE64
Secondary accession number(s): Q3TQL7
, Q3V088, Q80ZN3, Q8C912, Q9ESV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 12, 2007
Last modified: November 30, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.