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Protein

Sorting nexin-30

Gene

Snx30

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-30
Gene namesi
Name:Snx30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2443882. Snx30.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Sorting nexin-30PRO_0000284534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381PhosphothreonineCombined sources
Modified residuei40 – 401PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CE50.
MaxQBiQ8CE50.
PaxDbiQ8CE50.
PRIDEiQ8CE50.

PTM databases

iPTMnetiQ8CE50.
PhosphoSiteiQ8CE50.

Expressioni

Gene expression databases

BgeeiQ8CE50.
CleanExiMM_SNX30.
GenevisibleiQ8CE50. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8CE50. 1 interaction.
MINTiMINT-4115390.
STRINGi10090.ENSMUSP00000030080.

Structurei

3D structure databases

ProteinModelPortaliQ8CE50.
SMRiQ8CE50. Positions 87-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 210122PXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00840000129805.
HOGENOMiHOG000010283.
HOVERGENiHBG009723.
InParanoidiQ8CE50.
KOiK17921.
OMAiKQEDRTP.
OrthoDBiEOG7Z0JWD.
PhylomeDBiQ8CE50.
TreeFamiTF328543.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR004148. BAR_dom.
IPR001683. Phox.
IPR028649. SNX30.
[Graphical view]
PANTHERiPTHR10555:SF123. PTHR10555:SF123. 1 hit.
PfamiPF03114. BAR. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CE50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGPPKALP STGPQSLRDM PHPLAGSSSE EAVGGDSTPS PDLLMARSFG
60 70 80 90 100
DKDLILPNGG TPAGTASPAS SSSLLNRLQL DDDIDGEARD LFVTVDDPKK
110 120 130 140 150
HVCTMETYIT YRITTKSTRV EFDLPEYSVR RRYQDFDWLR NKLEESQPTH
160 170 180 190 200
LIPPLPEKFV VKGVVDRFSE EFVETRRKAL DKFLKRITDH PVLSFNEHFN
210 220 230 240 250
VFLTAKDLNA YKKQGIALLS RVGESVKHVT GGYKLRSRPL EFAAISDYLD
260 270 280 290 300
TFALKLGTID RIAQRIIKEE IEYLVELREY GPVYSTWSAL EGELAEPLEG
310 320 330 340 350
VSACIGNCST ALEELTDDIT EEFLPVLREY VLYSDSMKGV LKKRDQVQAE
360 370 380 390 400
YEAKLEAVAL RKEERPKVPA DVEKCQDRME CFNADLKADM ERWQSNKRHD
410 420 430
FRQLLVGLAD KNIQYYEKCL MAWESIIPLL QEKQETK
Length:437
Mass (Da):49,520
Last modified:March 1, 2003 - v1
Checksum:i52805380D0E0D158
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191D → G in BAE27911 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029012 mRNA. Translation: BAC26242.1.
AK147437 mRNA. Translation: BAE27911.1.
AK165619 mRNA. Translation: BAE38299.1.
AK170774 mRNA. Translation: BAE42020.1.
AK170999 mRNA. Translation: BAE42170.1.
AL831738 Genomic DNA. Translation: CAM24713.1.
BC099674 mRNA. Translation: AAH99674.1.
CCDSiCCDS18226.1.
RefSeqiNP_766056.1. NM_172468.2.
UniGeneiMm.259705.
Mm.490979.

Genome annotation databases

EnsembliENSMUST00000030080; ENSMUSP00000030080; ENSMUSG00000028385.
GeneIDi209131.
KEGGimmu:209131.
UCSCiuc008tae.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029012 mRNA. Translation: BAC26242.1.
AK147437 mRNA. Translation: BAE27911.1.
AK165619 mRNA. Translation: BAE38299.1.
AK170774 mRNA. Translation: BAE42020.1.
AK170999 mRNA. Translation: BAE42170.1.
AL831738 Genomic DNA. Translation: CAM24713.1.
BC099674 mRNA. Translation: AAH99674.1.
CCDSiCCDS18226.1.
RefSeqiNP_766056.1. NM_172468.2.
UniGeneiMm.259705.
Mm.490979.

3D structure databases

ProteinModelPortaliQ8CE50.
SMRiQ8CE50. Positions 87-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CE50. 1 interaction.
MINTiMINT-4115390.
STRINGi10090.ENSMUSP00000030080.

PTM databases

iPTMnetiQ8CE50.
PhosphoSiteiQ8CE50.

Proteomic databases

EPDiQ8CE50.
MaxQBiQ8CE50.
PaxDbiQ8CE50.
PRIDEiQ8CE50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030080; ENSMUSP00000030080; ENSMUSG00000028385.
GeneIDi209131.
KEGGimmu:209131.
UCSCiuc008tae.1. mouse.

Organism-specific databases

CTDi401548.
MGIiMGI:2443882. Snx30.

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00840000129805.
HOGENOMiHOG000010283.
HOVERGENiHBG009723.
InParanoidiQ8CE50.
KOiK17921.
OMAiKQEDRTP.
OrthoDBiEOG7Z0JWD.
PhylomeDBiQ8CE50.
TreeFamiTF328543.

Miscellaneous databases

ChiTaRSiSnx30. mouse.
NextBioi372561.
PROiQ8CE50.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CE50.
CleanExiMM_SNX30.
GenevisibleiQ8CE50. MM.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR004148. BAR_dom.
IPR001683. Phox.
IPR028649. SNX30.
[Graphical view]
PANTHERiPTHR10555:SF123. PTHR10555:SF123. 1 hit.
PfamiPF03114. BAR. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Brain, Dendritic cell, Skin and Submandibular gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-38 AND SER-40, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSNX30_MOUSE
AccessioniPrimary (citable) accession number: Q8CE50
Secondary accession number(s): Q3UHE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.