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Q8CE46 (PUS7L_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pseudouridylate synthase 7 homolog-like protein

EC=5.4.99.-
Gene names
Name:Pus7l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length702 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

tRNA uridine = tRNA pseudouridine.

Sequence similarities

Belongs to the pseudouridine synthase TruD family.

Contains 1 TRUD domain.

Sequence caution

The sequence BAC30554.1 differs from that shown. Reason: Probable cloning artifact. May result from internal priming due to genomic poly-A tracts.

Ontologies

Keywords
   Biological processtRNA processing
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpseudouridine synthesis

Inferred from electronic annotation. Source: InterPro

tRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

pseudouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 702702Pseudouridylate synthase 7 homolog-like protein
PRO_0000316786

Regions

Domain424 – 646223TRUD

Sites

Active site3391Nucleophile By similarity

Experimental info

Sequence conflict1511S → P in AAH66798. Ref.2
Sequence conflict5581D → N in AAH66798. Ref.2
Sequence conflict6671E → G in AAH66798. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8CE46 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 77D12455B78BCAEE

FASTA70279,197
        10         20         30         40         50         60 
MAEDTDGGIR FNSLCFINDH VGFQGSIKTS PSDFIVIEID EQGQLVSKAT DGSLYEISKI 

        70         80         90        100        110        120 
QSEPSNSVKK PKLNIQNVSL EHKNSEGAAD LPGCSDGDRS HQSDSEKENS VNSVTSKCEE 

       130        140        150        160        170        180 
ESVDLLRSLL DEKTHTSLGQ FACDIKRMWN SQTELTEPSP ELSLGKILDK NRRAVLHSAV 

       190        200        210        220        230        240 
RQAFPFLITV GNQGEVVVKP NRECKELCRL VSEEEALGFF KYLDAKKENS KFTFKPDPNK 

       250        260        270        280        290        300 
DHRKAVHHFL NKKFGNLVET KSFPGQHHSA GNPDSAITVR FREKARGKRS HPEGCERGKA 

       310        320        330        340        350        360 
VYTAFTLQKE NLETFEAIGL LAVKLGVIPS DFSYAGLKDK RAITYQSMVV KKVTPERLKS 

       370        380        390        400        410        420 
IKEEIEKKRM NVFNIRSVGD CLRLGQLKGN HFEIIIRHLR NQLNDSANLT ERILEAIENV 

       430        440        450        460        470        480 
KNKGFVNYYG PQRFGKGQKI QTDQIGLALL KNEMVKAIKL FLTPEDVDDP VNKAKQYFLR 

       490        500        510        520        530        540 
TEDAKGTLSL MPEFRVRERA LLESLHRFGV TEEGCVRAWF SFPHSMRIFY IHAYSSRIWN 

       550        560        570        580        590        600 
EAASYRLAAY GPKVVEGDLI CSDEDADKHF PSSKVHLVTK EEESAHTYAL HQVVLPVLGY 

       610        620        630        640        650        660 
NVQYPENQVG RWYQEALSRD GLQACRFRVP ALKLNVPGCY RHIVKHPRNV SHRLVHPDPA 

       670        680        690        700 
TEEARVEGPH SDDTASSLSL SFDLDASCYA TVCLREMMKG DI 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Skin and Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK029027 mRNA. Translation: BAC26251.1.
AK040257 mRNA. Translation: BAC30554.1. Sequence problems.
BC066798 mRNA. Translation: AAH66798.1.
CCDSCCDS27771.1.
RefSeqNP_766025.1. NM_172437.3.
UniGeneMm.34344.

3D structure databases

ProteinModelPortalQ8CE46.
SMRQ8CE46. Positions 293-699.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8CE46.

Proteomic databases

MaxQBQ8CE46.
PaxDbQ8CE46.
PRIDEQ8CE46.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049151; ENSMUSP00000044075; ENSMUSG00000033356.
GeneID78895.
KEGGmmu:78895.
UCSCuc007xjh.2. mouse.

Organism-specific databases

CTD83448.
MGIMGI:1926145. Pus7l.

Phylogenomic databases

eggNOGCOG0585.
GeneTreeENSGT00530000063554.
HOGENOMHOG000115802.
HOVERGENHBG060973.
InParanoidQ8CE46.
KOK06176.
OMAENLEMFE.
OrthoDBEOG7XWPN5.
PhylomeDBQ8CE46.
TreeFamTF314278.

Gene expression databases

ArrayExpressQ8CE46.
BgeeQ8CE46.
GenevestigatorQ8CE46.

Family and domain databases

InterProIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR017091. PsdUridine_synth_TruD_euk.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERPTHR13326. PTHR13326. 1 hit.
PfamPF01142. TruD. 1 hit.
[Graphical view]
PIRSFPIRSF037016. Pseudouridin_synth_euk_prd. 1 hit.
SUPFAMSSF55120. SSF55120. 3 hits.
TIGRFAMsTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEPS50984. TRUD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio349698.
PROQ8CE46.
SOURCESearch...

Entry information

Entry namePUS7L_MOUSE
AccessionPrimary (citable) accession number: Q8CE46
Secondary accession number(s): Q6NY03, Q8C9X5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot