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Protein

Pseudouridylate synthase 7 homolog-like protein

Gene

Pus7l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

tRNA uridine = tRNA pseudouridine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei339 – 3391NucleophileBy similarity

GO - Molecular functioni

  1. pseudouridine synthase activity Source: InterPro
  2. RNA binding Source: InterPro

GO - Biological processi

  1. pseudouridine synthesis Source: InterPro
  2. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Pseudouridylate synthase 7 homolog-like protein (EC:5.4.99.-)
Gene namesi
Name:Pus7l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1926145. Pus7l.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 702702Pseudouridylate synthase 7 homolog-like proteinPRO_0000316786Add
BLAST

Proteomic databases

MaxQBiQ8CE46.
PaxDbiQ8CE46.
PRIDEiQ8CE46.

PTM databases

PhosphoSiteiQ8CE46.

Expressioni

Gene expression databases

BgeeiQ8CE46.
ExpressionAtlasiQ8CE46. baseline and differential.
GenevestigatoriQ8CE46.

Structurei

3D structure databases

ProteinModelPortaliQ8CE46.
SMRiQ8CE46. Positions 293-699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini424 – 646223TRUDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.Curated
Contains 1 TRUD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0585.
GeneTreeiENSGT00530000063554.
HOGENOMiHOG000115802.
HOVERGENiHBG060973.
InParanoidiQ8CE46.
KOiK06176.
OMAiENLEMFE.
OrthoDBiEOG7XWPN5.
PhylomeDBiQ8CE46.
TreeFamiTF314278.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR017091. PsdUridine_synth_TruD_euk.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 1 hit.
[Graphical view]
PIRSFiPIRSF037016. Pseudouridin_synth_euk_prd. 1 hit.
SUPFAMiSSF55120. SSF55120. 3 hits.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CE46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEDTDGGIR FNSLCFINDH VGFQGSIKTS PSDFIVIEID EQGQLVSKAT
60 70 80 90 100
DGSLYEISKI QSEPSNSVKK PKLNIQNVSL EHKNSEGAAD LPGCSDGDRS
110 120 130 140 150
HQSDSEKENS VNSVTSKCEE ESVDLLRSLL DEKTHTSLGQ FACDIKRMWN
160 170 180 190 200
SQTELTEPSP ELSLGKILDK NRRAVLHSAV RQAFPFLITV GNQGEVVVKP
210 220 230 240 250
NRECKELCRL VSEEEALGFF KYLDAKKENS KFTFKPDPNK DHRKAVHHFL
260 270 280 290 300
NKKFGNLVET KSFPGQHHSA GNPDSAITVR FREKARGKRS HPEGCERGKA
310 320 330 340 350
VYTAFTLQKE NLETFEAIGL LAVKLGVIPS DFSYAGLKDK RAITYQSMVV
360 370 380 390 400
KKVTPERLKS IKEEIEKKRM NVFNIRSVGD CLRLGQLKGN HFEIIIRHLR
410 420 430 440 450
NQLNDSANLT ERILEAIENV KNKGFVNYYG PQRFGKGQKI QTDQIGLALL
460 470 480 490 500
KNEMVKAIKL FLTPEDVDDP VNKAKQYFLR TEDAKGTLSL MPEFRVRERA
510 520 530 540 550
LLESLHRFGV TEEGCVRAWF SFPHSMRIFY IHAYSSRIWN EAASYRLAAY
560 570 580 590 600
GPKVVEGDLI CSDEDADKHF PSSKVHLVTK EEESAHTYAL HQVVLPVLGY
610 620 630 640 650
NVQYPENQVG RWYQEALSRD GLQACRFRVP ALKLNVPGCY RHIVKHPRNV
660 670 680 690 700
SHRLVHPDPA TEEARVEGPH SDDTASSLSL SFDLDASCYA TVCLREMMKG

DI
Length:702
Mass (Da):79,197
Last modified:March 1, 2003 - v1
Checksum:i77D12455B78BCAEE
GO

Sequence cautioni

The sequence BAC30554.1 differs from that shown.Probable cloning artifact. May result from internal priming due to genomic poly-A tracts.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511S → P in AAH66798. (PubMed:15489334)Curated
Sequence conflicti558 – 5581D → N in AAH66798. (PubMed:15489334)Curated
Sequence conflicti667 – 6671E → G in AAH66798. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029027 mRNA. Translation: BAC26251.1.
AK040257 mRNA. Translation: BAC30554.1. Sequence problems.
BC066798 mRNA. Translation: AAH66798.1.
CCDSiCCDS27771.1.
RefSeqiNP_766025.1. NM_172437.3.
UniGeneiMm.34344.

Genome annotation databases

EnsembliENSMUST00000049151; ENSMUSP00000044075; ENSMUSG00000033356.
GeneIDi78895.
KEGGimmu:78895.
UCSCiuc007xjh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029027 mRNA. Translation: BAC26251.1.
AK040257 mRNA. Translation: BAC30554.1. Sequence problems.
BC066798 mRNA. Translation: AAH66798.1.
CCDSiCCDS27771.1.
RefSeqiNP_766025.1. NM_172437.3.
UniGeneiMm.34344.

3D structure databases

ProteinModelPortaliQ8CE46.
SMRiQ8CE46. Positions 293-699.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8CE46.

Proteomic databases

MaxQBiQ8CE46.
PaxDbiQ8CE46.
PRIDEiQ8CE46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049151; ENSMUSP00000044075; ENSMUSG00000033356.
GeneIDi78895.
KEGGimmu:78895.
UCSCiuc007xjh.2. mouse.

Organism-specific databases

CTDi83448.
MGIiMGI:1926145. Pus7l.

Phylogenomic databases

eggNOGiCOG0585.
GeneTreeiENSGT00530000063554.
HOGENOMiHOG000115802.
HOVERGENiHBG060973.
InParanoidiQ8CE46.
KOiK06176.
OMAiENLEMFE.
OrthoDBiEOG7XWPN5.
PhylomeDBiQ8CE46.
TreeFamiTF314278.

Miscellaneous databases

NextBioi349698.
PROiQ8CE46.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CE46.
ExpressionAtlasiQ8CE46. baseline and differential.
GenevestigatoriQ8CE46.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR017091. PsdUridine_synth_TruD_euk.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 1 hit.
[Graphical view]
PIRSFiPIRSF037016. Pseudouridin_synth_euk_prd. 1 hit.
SUPFAMiSSF55120. SSF55120. 3 hits.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.

Entry informationi

Entry nameiPUS7L_MOUSE
AccessioniPrimary (citable) accession number: Q8CE46
Secondary accession number(s): Q6NY03, Q8C9X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.