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Q8CE39

- Q8CE39_MOUSE

UniProt

Q8CE39 - Q8CE39_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene

Sorl1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. beta-amyloid binding Source: Ensembl
  2. low-density lipoprotein particle binding Source: Ensembl

GO - Biological processi

  1. cell migration Source: Ensembl
  2. cell proliferation Source: Ensembl
  3. negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: Ensembl
  4. negative regulation of beta-amyloid formation Source: Ensembl
  5. negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Source: Ensembl
  6. negative regulation of protein binding Source: Ensembl
  7. negative regulation of protein oligomerization Source: Ensembl
  8. positive regulation of early endosome to recycling endosome transport Source: Ensembl
  9. positive regulation of endocytic recycling Source: Ensembl
  10. positive regulation of ER to Golgi vesicle-mediated transport Source: Ensembl
  11. positive regulation of protein catabolic process Source: Ensembl
  12. positive regulation of protein exit from endoplasmic reticulum Source: Ensembl
  13. positive regulation of protein localization to early endosome Source: Ensembl
  14. post-Golgi vesicle-mediated transport Source: Ensembl
  15. protein maturation Source: Ensembl
  16. protein retention in Golgi apparatus Source: Ensembl
  17. protein targeting to Golgi Source: Ensembl
  18. protein targeting to lysosome Source: Ensembl
  19. regulation of smooth muscle cell migration Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Sorl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1202296. Sorl1.

Subcellular locationi

GO - Cellular componenti

  1. early endosome Source: Ensembl
  2. endoplasmic reticulum Source: Ensembl
  3. extracellular space Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. Golgi cisterna Source: Ensembl
  6. membrane Source: Ensembl
  7. multivesicular body Source: Ensembl
  8. neuronal cell body Source: Ensembl
  9. nuclear envelope lumen Source: Ensembl
  10. perinuclear region of cytoplasm Source: MGI
  11. recycling endosome Source: Ensembl
  12. trans-Golgi network Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8CE39.
ExpressionAtlasiQ8CE39. baseline and differential.
GenevestigatoriQ8CE39.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058613.

Structurei

3D structure databases

ProteinModelPortaliQ8CE39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8CE39-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
KLEPGGKYHI IVQLGNMSKD SSIKITTVSL SAPDALKIIT ENDHVLLFWK
60 70 80 90 100
SLALKEKQFN ETRGYEIHMS DSAVNLTAYL GNTTDNFFKV SNLKMGHNYT
110 120 130 140 150
FTVQARCLFG SQICGEPAVL LYDELSSGAD AAVIQAARST DVAAVVVPIL
160 170 180 190 200
FLILLSLGVG FAILYTKHRR LQSSFSAFAN SHYSSRLGSA IFSSGDDLGE
210 220
DDEDAPMITG FSDDVPMVIA
Length:220
Mass (Da):23,892
Last modified:March 1, 2003 - v1
Checksum:iA501D6A65D3D0516
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK029071 mRNA. Translation: BAC26276.1.
UniGeneiMm.121920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK029071 mRNA. Translation: BAC26276.1 .
UniGenei Mm.121920.

3D structure databases

ProteinModelPortali Q8CE39.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000058613.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1202296. Sorl1.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Bgeei Q8CE39.
ExpressionAtlasi Q8CE39. baseline and differential.
Genevestigatori Q8CE39.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.

Entry informationi

Entry nameiQ8CE39_MOUSE
AccessioniPrimary (citable) accession number: Q8CE39
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)