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Protein

Kelch-like protein 11

Gene

Klhl11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 11
Gene namesi
Name:Klhl11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2388648. Klhl11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000024391916 – 709Kelch-like protein 11Add BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei466PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CE33.
PaxDbiQ8CE33.
PRIDEiQ8CE33.

PTM databases

iPTMnetiQ8CE33.
PhosphoSitePlusiQ8CE33.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048732.
CleanExiMM_KLHL11.
ExpressionAtlasiQ8CE33. baseline and differential.
GenevisibleiQ8CE33. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with CUL3. Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054963.

Structurei

3D structure databases

ProteinModelPortaliQ8CE33.
SMRiQ8CE33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 171BTBPROSITE-ProRule annotationAdd BLAST77
Domaini206 – 308BACKAdd BLAST103
Repeati361 – 408Kelch 1Add BLAST48
Repeati409 – 454Kelch 2Add BLAST46
Repeati456 – 502Kelch 3Add BLAST47
Repeati504 – 557Kelch 4Add BLAST54
Repeati611 – 662Kelch 5Add BLAST52

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00800000124141.
HOGENOMiHOG000113235.
HOVERGENiHBG066980.
InParanoidiQ8CE33.
KOiK10449.
OMAiERYNPNR.
OrthoDBiEOG091G02UE.
PhylomeDBiQ8CE33.
TreeFamiTF331981.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CE33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVAAAAA AAAAAASFQV LEMESMETAV AGSASLAAEV RGSGTVDFVT
60 70 80 90 100
GAGISTLVDT GGSDPGPEAE DFECSTHCSE LSWRQNEQRR QGLFCDITLC
110 120 130 140 150
FGGAGGREFR AHRSVLAAAT EYFTPLLSGQ FSESRSGRVE MRKWSSEPGP
160 170 180 190 200
EPDTVEAVIE YMYTGRIRVS TGSVHEVLEL ADRFLLIRLK EFCGEFLKKK
210 220 230 240 250
LHLSNCVAIH SLAHMYTLSQ LALKAADMIR RNFYKVIQDE EFYTLPFHLI
260 270 280 290 300
RDWLSDLEIT VDSEEVLFET VLKWVQRNAE ERERYFEELF KLLRLSQMKP
310 320 330 340 350
TYLTRHVKPE RLVANNEVCV KLVAEAVERH ALRAENIQSG TLQQPTSQVS
360 370 380 390 400
LLPRYGQNMD VIMVIGGVSE GGDYLSECVG YFVDEDRWVN LPHIHNHLDG
410 420 430 440 450
HAVAITESYV YVAGSMEPGF AKTVERYNPN LNTWEHVCSL MTRKHSFGLT
460 470 480 490 500
EVKGKLYSIG GHGNFSPGFK DVTVYNPELD KWHNLESAPK ILRDVKALAI
510 520 530 540 550
EDRFVYIAAR TPVDRDTEDG LKAVITCYDT ETRQWQDVES LPLIDNYCFF
560 570 580 590 600
QMSVVNSNFY QTASCCPKSY SLENEEAVRK IAGQVSDEIL ESLPPEVLSI
610 620 630 640 650
EGAAICYYRD DVFIIGGWKN SDDIDKQYRK EAYRYCAERK RWMLLPPMPQ
660 670 680 690 700
PRCRATACHV RIPYRYLHGT QRYPMPQNLM WQKDRIRQMQ EIHRHALNMR

RVPSSQIEC
Length:709
Mass (Da):80,429
Last modified:March 1, 2003 - v1
Checksum:iBA3DB8D4CA6FEB7A
GO
Isoform 2 (identifier: Q8CE33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.

Note: No experimental confirmation available.
Show »
Length:569
Mass (Da):66,060
Checksum:i1D62418ECE28F988
GO

Sequence cautioni

The sequence BAE41452 differs from that shown. Reason: Frameshift at position 189.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0194961 – 140Missing in isoform 2. 1 PublicationAdd BLAST140

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029101 mRNA. Translation: BAC26297.1.
AK169910 mRNA. Translation: BAE41452.1. Frameshift.
BC011167 mRNA. Translation: AAH11167.1.
CCDSiCCDS25424.1. [Q8CE33-1]
RefSeqiNP_766153.1. NM_172565.2. [Q8CE33-1]
UniGeneiMm.183320.

Genome annotation databases

EnsembliENSMUST00000056665; ENSMUSP00000054963; ENSMUSG00000048732. [Q8CE33-1]
GeneIDi217194.
KEGGimmu:217194.
UCSCiuc007llj.1. mouse. [Q8CE33-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029101 mRNA. Translation: BAC26297.1.
AK169910 mRNA. Translation: BAE41452.1. Frameshift.
BC011167 mRNA. Translation: AAH11167.1.
CCDSiCCDS25424.1. [Q8CE33-1]
RefSeqiNP_766153.1. NM_172565.2. [Q8CE33-1]
UniGeneiMm.183320.

3D structure databases

ProteinModelPortaliQ8CE33.
SMRiQ8CE33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054963.

PTM databases

iPTMnetiQ8CE33.
PhosphoSitePlusiQ8CE33.

Proteomic databases

EPDiQ8CE33.
PaxDbiQ8CE33.
PRIDEiQ8CE33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056665; ENSMUSP00000054963; ENSMUSG00000048732. [Q8CE33-1]
GeneIDi217194.
KEGGimmu:217194.
UCSCiuc007llj.1. mouse. [Q8CE33-1]

Organism-specific databases

CTDi55175.
MGIiMGI:2388648. Klhl11.

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00800000124141.
HOGENOMiHOG000113235.
HOVERGENiHBG066980.
InParanoidiQ8CE33.
KOiK10449.
OMAiERYNPNR.
OrthoDBiEOG091G02UE.
PhylomeDBiQ8CE33.
TreeFamiTF331981.

Miscellaneous databases

PROiQ8CE33.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048732.
CleanExiMM_KLHL11.
ExpressionAtlasiQ8CE33. baseline and differential.
GenevisibleiQ8CE33. MM.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH11_MOUSE
AccessioniPrimary (citable) accession number: Q8CE33
Secondary accession number(s): Q3TDZ6, Q91VP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.