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Protein

Probable E3 ubiquitin-protein ligase HECTD2

Gene

Hectd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei742 – 7421Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase HECTD2 (EC:6.3.2.-)
Alternative name(s):
HECT domain-containing protein 2
Gene namesi
Name:Hectd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2442663. Hectd2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 774774Probable E3 ubiquitin-protein ligase HECTD2PRO_0000240852Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8CDU6.
PaxDbiQ8CDU6.
PRIDEiQ8CDU6.

PTM databases

iPTMnetiQ8CDU6.
PhosphoSiteiQ8CDU6.

Expressioni

Gene expression databases

BgeeiQ8CDU6.
CleanExiMM_HECTD2.
ExpressionAtlasiQ8CDU6. baseline and differential.
GenevisibleiQ8CDU6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128387.

Structurei

3D structure databases

ProteinModelPortaliQ8CDU6.
SMRiQ8CDU6. Positions 414-766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini435 – 774340HECTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0941. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00830000128260.
HOVERGENiHBG081596.
InParanoidiQ8CDU6.
KOiK12232.

Family and domain databases

InterProiIPR000569. HECT_dom.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CDU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEAARDLSP GAPPAVAAAA PEERKGKEPE REKLPPIVTA GAAAGLDRGS
60 70 80 90 100
KGQISTFSSF VSTVTQKKEA AENRSSPTHL ALPNIRNVRD LPPICLDVRQ
110 120 130 140 150
KQRMSVEALP SEVKVPPLPE PSLPSQPKTV KDFEEDLEKA EATGNWKTVH
160 170 180 190 200
AFYITAFDSF TELNTAFKKD ATASFNTIED SGLNANLVNA VFDALLNTPQ
210 220 230 240 250
DIQKSVLKGI INSLLQEWKG PRTKDDLRAY FILLQNPQFN ITSTYVIYAH
260 270 280 290 300
LLRQIATLVE ADHHFLVHWL KKLSQKKFKQ LVERLLQFVS LRLFPAKPEE
310 320 330 340 350
FPPLTKCTWW IPSAAKVLAL LNTANNLVHP PLVPYTDFYN STLDHIDLME
360 370 380 390 400
EYHTWQSFGN SHRFSFCQYP FVISIAAKKI IIQRDSEQQM ISIARQSLVD
410 420 430 440 450
KVSRRQRPDM NMLFLNMKVR RTHLVSDSLD ELTRKRADLK KKLKVTFVGE
460 470 480 490 500
AGLDMGGLTK EWFLLLIRQI FHPDYGMFTY HKDSHCHWFS SFKCDNYSEF
510 520 530 540 550
RLVGILMGLA VYNSITLDIR FPPCCYKKLL SPPVVPSDQS TPVGICSVTI
560 570 580 590 600
DDLCQVMPEL AHGLKELLSY EGNVEEDFYS TFQVFQEEFG VIKSYNLKPG
610 620 630 640 650
GDKIPVTNQN RREYVQLYTD FLLNKSIYKQ FAAFYCGFHS VCASNALMLL
660 670 680 690 700
RPEEVEILVC GSPELDMHAL QRSTQYDGYA KTDLTIRYFW DVVLGFPLEL
710 720 730 740 750
QKKLLHFTTG SDRVPVGGMA DLNFKISKNE TSTNWLPVAH TCFNQLCLPP
760 770
YKSKKDLKQK LIIGISNSEG FGLE
Length:774
Mass (Da):87,773
Last modified:July 27, 2011 - v2
Checksum:iC7427B2D1C3E1957
GO

Sequence cautioni

The sequence BAC29085.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti315 – 3151A → G in BAC26510 (PubMed:16141072).Curated
Sequence conflicti754 – 7541K → R in BAC26510 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029549 mRNA. Translation: BAC26510.1.
AK035511 mRNA. Translation: BAC29085.1. Different initiation.
AC113514 Genomic DNA. No translation available.
AC119947 Genomic DNA. No translation available.
CCDSiCCDS29773.1.
RefSeqiNP_001156943.1. NM_001163471.1.
NP_766225.2. NM_172637.3.
UniGeneiMm.61107.

Genome annotation databases

EnsembliENSMUST00000047247; ENSMUSP00000042646; ENSMUSG00000041180.
GeneIDi226098.
KEGGimmu:226098.
UCSCiuc008hho.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029549 mRNA. Translation: BAC26510.1.
AK035511 mRNA. Translation: BAC29085.1. Different initiation.
AC113514 Genomic DNA. No translation available.
AC119947 Genomic DNA. No translation available.
CCDSiCCDS29773.1.
RefSeqiNP_001156943.1. NM_001163471.1.
NP_766225.2. NM_172637.3.
UniGeneiMm.61107.

3D structure databases

ProteinModelPortaliQ8CDU6.
SMRiQ8CDU6. Positions 414-766.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128387.

PTM databases

iPTMnetiQ8CDU6.
PhosphoSiteiQ8CDU6.

Proteomic databases

MaxQBiQ8CDU6.
PaxDbiQ8CDU6.
PRIDEiQ8CDU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047247; ENSMUSP00000042646; ENSMUSG00000041180.
GeneIDi226098.
KEGGimmu:226098.
UCSCiuc008hho.2. mouse.

Organism-specific databases

CTDi143279.
MGIiMGI:2442663. Hectd2.

Phylogenomic databases

eggNOGiKOG0941. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00830000128260.
HOVERGENiHBG081596.
InParanoidiQ8CDU6.
KOiK12232.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ8CDU6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CDU6.
CleanExiMM_HECTD2.
ExpressionAtlasiQ8CDU6. baseline and differential.
GenevisibleiQ8CDU6. MM.

Family and domain databases

InterProiIPR000569. HECT_dom.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis and Urinary bladder.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiHECD2_MOUSE
AccessioniPrimary (citable) accession number: Q8CDU6
Secondary accession number(s): E9QK99, Q8CBQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.