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Protein

Thioredoxin-like protein 1

Gene

Txnl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Active thioredoxin with a redox potential of about -250 mV.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 1
Alternative name(s):
32 kDa thioredoxin-related protein
Gene namesi
Name:Txnl1
Synonyms:Trp32, Txnl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1860078. Txnl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001200171 – 289Thioredoxin-like protein 1Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 37Redox-activeBy similarity
Modified residuei113PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ8CDN6.
MaxQBiQ8CDN6.
PaxDbiQ8CDN6.
PRIDEiQ8CDN6.

2D gel databases

REPRODUCTION-2DPAGEiQ8CDN6.

PTM databases

iPTMnetiQ8CDN6.
PhosphoSitePlusiQ8CDN6.
SwissPalmiQ8CDN6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024583.
CleanExiMM_TXNL1.
GenevisibleiQ8CDN6. MM.

Interactioni

Subunit structurei

Component of the 19S regulatory cap of the 26S proteasome. Interacts with PSMD14/RPN11. Interacts with, and reduces EEF1A1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi207304. 2 interactors.
IntActiQ8CDN6. 2 interactors.
MINTiMINT-4138869.
STRINGi10090.ENSMUSP00000025476.

Structurei

3D structure databases

ProteinModelPortaliQ8CDN6.
SMRiQ8CDN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 109ThioredoxinAdd BLAST108
Domaini115 – 285PITHPROSITE-ProRule annotationAdd BLAST171

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0908. Eukaryota.
ENOG410YQ2G. LUCA.
GeneTreeiENSGT00530000063008.
HOVERGENiHBG055982.
InParanoidiQ8CDN6.
OMAiPIFEMFP.
OrthoDBiEOG091G0G71.
PhylomeDBiQ8CDN6.
TreeFamiTF314399.

Family and domain databases

Gene3Di2.60.120.470. 1 hit.
InterProiView protein in InterPro
IPR008979. Galactose-bd-like.
IPR010400. PITH_dom.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
PfamiView protein in Pfam
PF06201. PITH. 1 hit.
PF00085. Thioredoxin. 1 hit.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51532. PITH. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CDN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGVKPVGSD PDFQPELSGA GSRLAVVKFT MRGCGPCLRI APAFSSMSNK
60 70 80 90 100
YPQAVFLEVD VHQCQGTAAT NNISATPTFL FFRNKVRIDQ YQGADAVGLE
110 120 130 140 150
EKIKQHLEND PGSNEDADIP KGYMDLMPFI NKAGCECLNE SDEHGFDNCL
160 170 180 190 200
RKDMSFLESD CDEQLLITVA FNQPVKLYSM KFQGPDNGQG PKYVKIFINL
210 220 230 240 250
PRSMDFEEAE RSEPTQALEL TEDDIKEDGI VPLRYVKFQN VNSVTLFVQS
260 270 280
NQGEEETTRI SYFTFIGTPV QATNMNDFKR VVGKKGESH
Length:289
Mass (Da):32,237
Last modified:January 23, 2007 - v3
Checksum:i4BE29C6C1D1DFA0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251N → K in AAC40183 (PubMed:9668102).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052660 mRNA. Translation: AAC40183.1.
AK029807 mRNA. Translation: BAC26626.1.
AK150326 mRNA. Translation: BAE29469.1.
AK167954 mRNA. Translation: BAE39954.1.
AK168712 mRNA. Translation: BAE40554.1.
BC061123 mRNA. Translation: AAH61123.1.
CCDSiCCDS29297.1.
RefSeqiNP_058072.2. NM_016792.4.
UniGeneiMm.19169.

Genome annotation databases

EnsembliENSMUST00000025476; ENSMUSP00000025476; ENSMUSG00000024583.
GeneIDi53382.
KEGGimmu:53382.
UCSCiuc008fdx.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiTXNL1_MOUSE
AccessioniPrimary (citable) accession number: Q8CDN6
Secondary accession number(s): O70379, Q3TI92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot