Reviewed,
UniProtKB/Swiss-Prot Q8CDM1 (ATAD2_MOUSE)
Last modified
June 16, 2009.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: ATPase family AAA domain-containing protein 2 EC=3.6.1.3 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 1040 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation By similarity. |
| Catalytic activity | ATP + H2O = ADP + phosphate. |
| Subunit structure | Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol By similarity. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the AAA ATPase family. Contains 1 bromo domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing |
| Domain | Bromodomain Coiled coil |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Activator Hydrolase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, uncoupledInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8CDM1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8CDM1-2) The sequence of this isoform differs from the canonical sequence as follows: 1-201: Missing. 202-203: IH → MF 601-601: V → G 602-1040: Missing. | ||||||
| Note: No experimental evidence available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1040 | 1040 | ATPase family AAA domain-containing protein 2 | PRO_0000084797 | |||||
Regions | |||||||||
| Domain | 650 – 720 | 71 | Bromo | ||||||
| Nucleotide binding | 122 – 129 | 8 | ATP Potential | ||||||
| Coiled coil | 619 – 643 | 25 | Potential | ||||||
| Coiled coil | 735 – 761 | 27 | Potential | ||||||
| Compositional bias | 13 – 22 | 10 | Poly-Ser | ||||||
| Compositional bias | 891 – 894 | 4 | Poly-Ser | ||||||
Amino acid modifications | |||||||||
| Modified residue | 401 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 406 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 801 | 1 | Phosphothreonine Ref.2 | ||||||
| Modified residue | 807 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 891 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 951 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 201 | 201 | Missing in isoform 2. | VSP_035804 | |||||
| Alternative sequence | 202 – 203 | 2 | IH → MF in isoform 2. | VSP_035805 | |||||
| Alternative sequence | 601 | 1 | V → G in isoform 2. | VSP_035806 | |||||
| Alternative sequence | 602 – 1040 | 439 | Missing in isoform 2. | VSP_035807 | |||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J. Tissue: Testis. |
| [2] | "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-801, MASS SPECTROMETRY. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AK029867 mRNA. Translation: BAC26651.1. AK134319 mRNA. Translation: BAE22095.1. | |
| IPI | IPI00135252. IPI00228860. |
| RefSeq | NP_081711.2. |
| UniGene | Mm.221758 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1R7R based on UniProtKB Q01853. |
| SMR | Q8CDM1. Positions 633-761. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q8CDM1. |
Proteomic databases | |
| PRIDE | Q8CDM1. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000022360. Mus musculus. [Contig view] |
| GeneID | 70472. |
| KEGG | mmu:70472. |
Organism-specific databases | |
| MGI | MGI:1917722. Atad2. |
Phylogenomic databases | |
| HOGENOM | Q8CDM1. |
| HOVERGEN | Q8CDM1. |
Gene expression databases | |
| ArrayExpress | Q8CDM1. |
| Bgee | Q8CDM1. |
| CleanEx | MM_ATAD2. |
| GermOnline | ENSMUSG00000022360. Mus musculus. |
Family and domain databases | |
| InterPro | IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR001487. Bromodomain. IPR018359. Bromodomain_CS. [Graphical view] |
| Gene3D | G3DSA:1.20.920.10. Bromodomain. 1 hit. |
| Pfam | PF00004. AAA. 1 hit. PF00439. Bromodomain. 1 hit. [Graphical view] |
| PRINTS | PR00503. BROMODOMAIN. |
| SMART | SM00382. AAA. 1 hit. SM00297. BROMO. 1 hit. [Graphical view] |
| PROSITE | PS00674. AAA. 1 hit. PS00633. BROMODOMAIN_1. False negative. PS50014. BROMODOMAIN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 331701. |
| SOURCE | Search... |
Entry information
| Entry name | ATAD2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8CDM1 Secondary accession number(s): Q3UYW6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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