Q8CDM1 (ATAD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATPase family AAA domain-containing protein 2
EC=3.6.1.3

Gene names

Name:

Atad2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1040 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation By similarity.
Catalytic activity	ATP + H2O = ADP + phosphate.
Subunit structure	Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro) By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the AAA ATPase family. Contains 1 bromo domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Bromodomain Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Activator Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Hist1h4h	P62806	2	EBI-2944582,EBI-299632

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8CDM1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8CDM1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.
     202-203: IH → MF
     601-601: V → G
     602-1040: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1040	1040	ATPase family AAA domain-containing protein 2		PRO_0000084797
Regions
	Domain	650 – 720	71	Bromo
	Nucleotide binding	122 – 129	8	ATP Potential
	Coiled coil	619 – 643	25	Potential
	Coiled coil	735 – 761	27	Potential
	Compositional bias	13 – 22	10	Poly-Ser
	Compositional bias	891 – 894	4	Poly-Ser
Amino acid modifications
	Modified residue	401	1	Phosphoserine By similarity
	Modified residue	406	1	Phosphoserine By similarity
	Modified residue	801	1	Phosphothreonine Ref.2
	Modified residue	951	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 201	201	Missing in isoform 2.		VSP_035804
	Alternative sequence	202 – 203	2	IH → MF in isoform 2.		VSP_035805
	Alternative sequence	601	1	V → G in isoform 2.		VSP_035806
	Alternative sequence	602 – 1040	439	Missing in isoform 2.		VSP_035807

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 50DF23CA677ABC38	FASTA	1,040	117,943
	10 20 30 40 50 60 MSLLKMRRHA IHSSDSTSSS SSEDDCFERR TKRNRNRAIN RCLPLNFRKD EIRGIYKDRM 70 80 90 100 110 120 KIGASLADVD PMQLDTSVRF DSVGGLSSHI AALKEMVVFP LLYPEVFEKF KIQPPRGCLF 130 140 150 160 170 180 YGPPGTGKTL VARALANECS RGDKRVAFFM RKGADCLSKW VGESERQLRL LFDQAYQMRP 190 200 210 220 230 240 AIIFFDEIDG LAPVRSSRQD QIHSSIVSTL LALMDGLDSR GEIVVIGATN RLDSIDPALR 250 260 270 280 290 300 RPGRFDREFL FSLPDKNARK EILKIHTRDW NPKPVDMFLE ELAEHCVGYC GADIKSICAE 310 320 330 340 350 360 AALCALRRRY PQIYTTSEKL QLDLSSITIS AKDFEAALQK IRPASQRAVT SPGQALSAIV 370 380 390 400 410 420 KPLLQNTVHR ILDALQKVFP HVEVGTNKSL NSDVSCPFLE SDLAYSDDDT PSVYENGLSQ 430 440 450 460 470 480 KENLNFLHLN RNACYQPMSF RPRLLIVGEP GFGQSSHLAP AVIHALEKFT VYTLDIPVLF 490 500 510 520 530 540 GISTTSPEEA CSQMIREAKR TAPSIVYVPH IHLWWEIVGP TLKATFTTLL QTIPSFAPVL 550 560 570 580 590 600 LLATSEKPYS ALPEEVQELF THDYGEIFNV QLPDKEERTK FFEDLILKQA SKPPVSQKKA 610 620 630 640 650 660 VLQALEVLPV APPPEPRPLT AEEVKRLEEQ EEDTFRELRI FLRNVTHRLA IDKRFRVFTK 670 680 690 700 710 720 PVDPDEVPDY VTVIKQPMDL SSVISKIDLH KYLTVKDYLK DIDLICSNAL EYNPDRDPGD 730 740 750 760 770 780 RLIRHRACAL RDTAYAIIKE ELDEDFEQLC EEIQESRKKR GCSSSKYAPS YYHVMPKQNS 790 800 810 820 830 840 PPVGDKKPDQ EQNEKLKVPC TPVACSTPAQ LKRKFHKKSK WHVGTKIKRR KISQAKDNSL 850 860 870 880 890 900 NAMNSSSRSD TEDSQHTHAE HTEPGNTDES SVEESDKQNR LESNIDLKNN SSSSNIENEL 910 920 930 940 950 960 EEPKETTEGT ELRKDRIVCR GDASASQVTD IPEDSESKEM DFLRMTLARG SQVEQQELIS 970 980 990 1000 1010 1020 MEQALAILSQ PTPSLVLDHK QLTNILKTVV KKSQKYNIFQ LENLYAVISQ CIYEHRRDYD 1030 1040 KTALVQKMEQ AVENFNCSRS
	Isoform 2 [UniParc]. Checksum: D07990372977E11D	FASTA	400	44,652
	10 20 30 40 50 60 MFSSIVSTLL ALMDGLDSRG EIVVIGATNR LDSIDPALRR PGRFDREFLF SLPDKNARKE 70 80 90 100 110 120 ILKIHTRDWN PKPVDMFLEE LAEHCVGYCG ADIKSICAEA ALCALRRRYP QIYTTSEKLQ 130 140 150 160 170 180 LDLSSITISA KDFEAALQKI RPASQRAVTS PGQALSAIVK PLLQNTVHRI LDALQKVFPH 190 200 210 220 230 240 VEVGTNKSLN SDVSCPFLES DLAYSDDDTP SVYENGLSQK ENLNFLHLNR NACYQPMSFR 250 260 270 280 290 300 PRLLIVGEPG FGQSSHLAPA VIHALEKFTV YTLDIPVLFG ISTTSPEEAC SQMIREAKRT 310 320 330 340 350 360 APSIVYVPHI HLWWEIVGPT LKATFTTLLQ TIPSFAPVLL LATSEKPYSA LPEEVQELFT 370 380 390 400 HDYGEIFNVQ LPDKEERTKF FEDLILKQAS KPPVSQKKAG

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J. Tissue: Testis.
[2]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-801, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK029867 mRNA. Translation: BAC26651.1. AK134319 mRNA. Translation: BAE22095.1.
IPI	IPI00135252. IPI00228860.
RefSeq	NP_081711.2. NM_027435.2.
UniGene	Mm.221758.
3D structure databases
ProteinModelPortal	Q8CDM1.
SMR	Q8CDM1. Positions 44-340, 630-757.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8CDM1. 1 interaction.
MINT	MINT-4605695.
STRING	10090.ENSMUSP00000043691.
PTM databases
PhosphoSite	Q8CDM1.
Proteomic databases
PRIDE	Q8CDM1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	70472.
KEGG	mmu:70472.
UCSC	uc007vtg.1. mouse.
Organism-specific databases
CTD	29028.
MGI	MGI:1917722. Atad2.
Phylogenomic databases
eggNOG	COG0464.
HOGENOM	HOG000034119.
HOVERGEN	HBG080873.
InParanoid	Q3UYW6.
Gene expression databases
CleanEx	MM_ATAD2.
Genevestigator	Q8CDM1.
GermOnline	ENSMUSG00000022360. Mus musculus.
Family and domain databases
Gene3D	1.20.920.10. 1 hit.
InterPro	IPR003593. AAA+_ATPase. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR001487. Bromodomain. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF00439. Bromodomain. 1 hit. [Graphical view]
PRINTS	PR00503. BROMODOMAIN.
SMART	SM00382. AAA. 1 hit. SM00297. BROMO. 1 hit. [Graphical view]
SUPFAM	SSF47370. Bromodomain. 1 hit. SSF52540. SSF52540. 2 hits.
PROSITE	PS00674. AAA. 1 hit. PS00633. BROMODOMAIN_1. False negative. PS50014. BROMODOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ATAD2. mouse.
NextBio	331701.
SOURCE	Search...

Entry information

Entry name

ATAD2_MOUSE

Accession

Primary (citable) accession number: Q8CDM1
Secondary accession number(s): Q3UYW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program