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Q8CDM1

- ATAD2_MOUSE

UniProt

Q8CDM1 - ATAD2_MOUSE

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Protein

ATPase family AAA domain-containing protein 2

Gene

Atad2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi122 – 1298ATPSequence Analysis

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 2 (EC:3.6.1.3)
Gene namesi
Name:Atad2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1917722. Atad2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10401040ATPase family AAA domain-containing protein 2PRO_0000084797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei401 – 4011PhosphoserineBy similarity
Modified residuei406 – 4061PhosphoserineBy similarity
Modified residuei801 – 8011PhosphothreonineBy similarity
Modified residuei951 – 9511PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8CDM1.
PRIDEiQ8CDM1.

PTM databases

PhosphoSiteiQ8CDM1.

Expressioni

Gene expression databases

CleanExiMM_ATAD2.
GenevestigatoriQ8CDM1.

Interactioni

Subunit structurei

Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro) (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Hist4h4P628062EBI-2944582,EBI-299632

Protein-protein interaction databases

BioGridi214078. 1 interaction.
IntActiQ8CDM1. 2 interactions.
MINTiMINT-4605695.
STRINGi10090.ENSMUSP00000043691.

Structurei

3D structure databases

ProteinModelPortaliQ8CDM1.
SMRiQ8CDM1. Positions 630-757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini650 – 72071BromoPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili619 – 64325Sequence AnalysisAdd
BLAST
Coiled coili735 – 76127Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 2210Poly-Ser
Compositional biasi891 – 8944Poly-Ser

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated
Contains 1 bromo domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Coiled coil

Phylogenomic databases

eggNOGiCOG0464.
HOGENOMiHOG000034119.
HOVERGENiHBG080873.
InParanoidiQ8CDM1.
PhylomeDBiQ8CDM1.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CDM1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLKMRRHA IHSSDSTSSS SSEDDCFERR TKRNRNRAIN RCLPLNFRKD
60 70 80 90 100
EIRGIYKDRM KIGASLADVD PMQLDTSVRF DSVGGLSSHI AALKEMVVFP
110 120 130 140 150
LLYPEVFEKF KIQPPRGCLF YGPPGTGKTL VARALANECS RGDKRVAFFM
160 170 180 190 200
RKGADCLSKW VGESERQLRL LFDQAYQMRP AIIFFDEIDG LAPVRSSRQD
210 220 230 240 250
QIHSSIVSTL LALMDGLDSR GEIVVIGATN RLDSIDPALR RPGRFDREFL
260 270 280 290 300
FSLPDKNARK EILKIHTRDW NPKPVDMFLE ELAEHCVGYC GADIKSICAE
310 320 330 340 350
AALCALRRRY PQIYTTSEKL QLDLSSITIS AKDFEAALQK IRPASQRAVT
360 370 380 390 400
SPGQALSAIV KPLLQNTVHR ILDALQKVFP HVEVGTNKSL NSDVSCPFLE
410 420 430 440 450
SDLAYSDDDT PSVYENGLSQ KENLNFLHLN RNACYQPMSF RPRLLIVGEP
460 470 480 490 500
GFGQSSHLAP AVIHALEKFT VYTLDIPVLF GISTTSPEEA CSQMIREAKR
510 520 530 540 550
TAPSIVYVPH IHLWWEIVGP TLKATFTTLL QTIPSFAPVL LLATSEKPYS
560 570 580 590 600
ALPEEVQELF THDYGEIFNV QLPDKEERTK FFEDLILKQA SKPPVSQKKA
610 620 630 640 650
VLQALEVLPV APPPEPRPLT AEEVKRLEEQ EEDTFRELRI FLRNVTHRLA
660 670 680 690 700
IDKRFRVFTK PVDPDEVPDY VTVIKQPMDL SSVISKIDLH KYLTVKDYLK
710 720 730 740 750
DIDLICSNAL EYNPDRDPGD RLIRHRACAL RDTAYAIIKE ELDEDFEQLC
760 770 780 790 800
EEIQESRKKR GCSSSKYAPS YYHVMPKQNS PPVGDKKPDQ EQNEKLKVPC
810 820 830 840 850
TPVACSTPAQ LKRKFHKKSK WHVGTKIKRR KISQAKDNSL NAMNSSSRSD
860 870 880 890 900
TEDSQHTHAE HTEPGNTDES SVEESDKQNR LESNIDLKNN SSSSNIENEL
910 920 930 940 950
EEPKETTEGT ELRKDRIVCR GDASASQVTD IPEDSESKEM DFLRMTLARG
960 970 980 990 1000
SQVEQQELIS MEQALAILSQ PTPSLVLDHK QLTNILKTVV KKSQKYNIFQ
1010 1020 1030 1040
LENLYAVISQ CIYEHRRDYD KTALVQKMEQ AVENFNCSRS
Length:1,040
Mass (Da):117,943
Last modified:March 1, 2003 - v1
Checksum:i50DF23CA677ABC38
GO
Isoform 2 (identifier: Q8CDM1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.
     202-203: IH → MF
     601-601: V → G
     602-1040: Missing.

Note: No experimental confirmation available.

Show »
Length:400
Mass (Da):44,652
Checksum:iD07990372977E11D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 201201Missing in isoform 2. 1 PublicationVSP_035804Add
BLAST
Alternative sequencei202 – 2032IH → MF in isoform 2. 1 PublicationVSP_035805
Alternative sequencei601 – 6011V → G in isoform 2. 1 PublicationVSP_035806
Alternative sequencei602 – 1040439Missing in isoform 2. 1 PublicationVSP_035807Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK029867 mRNA. Translation: BAC26651.1.
AK134319 mRNA. Translation: BAE22095.1.
RefSeqiNP_081711.2. NM_027435.2.
UniGeneiMm.221758.

Genome annotation databases

GeneIDi70472.
KEGGimmu:70472.
UCSCiuc007vtg.1. mouse. [Q8CDM1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK029867 mRNA. Translation: BAC26651.1 .
AK134319 mRNA. Translation: BAE22095.1 .
RefSeqi NP_081711.2. NM_027435.2.
UniGenei Mm.221758.

3D structure databases

ProteinModelPortali Q8CDM1.
SMRi Q8CDM1. Positions 630-757.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 214078. 1 interaction.
IntActi Q8CDM1. 2 interactions.
MINTi MINT-4605695.
STRINGi 10090.ENSMUSP00000043691.

PTM databases

PhosphoSitei Q8CDM1.

Proteomic databases

MaxQBi Q8CDM1.
PRIDEi Q8CDM1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 70472.
KEGGi mmu:70472.
UCSCi uc007vtg.1. mouse. [Q8CDM1-2 ]

Organism-specific databases

CTDi 29028.
MGIi MGI:1917722. Atad2.

Phylogenomic databases

eggNOGi COG0464.
HOGENOMi HOG000034119.
HOVERGENi HBG080873.
InParanoidi Q8CDM1.
PhylomeDBi Q8CDM1.

Miscellaneous databases

ChiTaRSi ATAD2. mouse.
NextBioi 331701.
PROi Q8CDM1.
SOURCEi Search...

Gene expression databases

CleanExi MM_ATAD2.
Genevestigatori Q8CDM1.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEi PS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiATAD2_MOUSE
AccessioniPrimary (citable) accession number: Q8CDM1
Secondary accession number(s): Q3UYW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3