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Q8CDM1 (ATAD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATPase family AAA domain-containing protein 2

EC=3.6.1.3
Gene names
Name:Atad2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1040 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subunit structure

Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro) By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the AAA ATPase family.

Contains 1 bromo domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainBromodomain
Coiled coil
   LigandATP-binding
Nucleotide-binding
   Molecular functionActivator
Hydrolase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Hist4h4P628062EBI-2944582,EBI-299632

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8CDM1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8CDM1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.
     202-203: IH → MF
     601-601: V → G
     602-1040: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10401040ATPase family AAA domain-containing protein 2
PRO_0000084797

Regions

Domain650 – 72071Bromo
Nucleotide binding122 – 1298ATP Potential
Coiled coil619 – 64325 Potential
Coiled coil735 – 76127 Potential
Compositional bias13 – 2210Poly-Ser
Compositional bias891 – 8944Poly-Ser

Amino acid modifications

Modified residue4011Phosphoserine By similarity
Modified residue4061Phosphoserine By similarity
Modified residue8011Phosphothreonine By similarity
Modified residue9511Phosphoserine By similarity

Natural variations

Alternative sequence1 – 201201Missing in isoform 2.
VSP_035804
Alternative sequence202 – 2032IH → MF in isoform 2.
VSP_035805
Alternative sequence6011V → G in isoform 2.
VSP_035806
Alternative sequence602 – 1040439Missing in isoform 2.
VSP_035807

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 50DF23CA677ABC38

FASTA1,040117,943
        10         20         30         40         50         60 
MSLLKMRRHA IHSSDSTSSS SSEDDCFERR TKRNRNRAIN RCLPLNFRKD EIRGIYKDRM 

        70         80         90        100        110        120 
KIGASLADVD PMQLDTSVRF DSVGGLSSHI AALKEMVVFP LLYPEVFEKF KIQPPRGCLF 

       130        140        150        160        170        180 
YGPPGTGKTL VARALANECS RGDKRVAFFM RKGADCLSKW VGESERQLRL LFDQAYQMRP 

       190        200        210        220        230        240 
AIIFFDEIDG LAPVRSSRQD QIHSSIVSTL LALMDGLDSR GEIVVIGATN RLDSIDPALR 

       250        260        270        280        290        300 
RPGRFDREFL FSLPDKNARK EILKIHTRDW NPKPVDMFLE ELAEHCVGYC GADIKSICAE 

       310        320        330        340        350        360 
AALCALRRRY PQIYTTSEKL QLDLSSITIS AKDFEAALQK IRPASQRAVT SPGQALSAIV 

       370        380        390        400        410        420 
KPLLQNTVHR ILDALQKVFP HVEVGTNKSL NSDVSCPFLE SDLAYSDDDT PSVYENGLSQ 

       430        440        450        460        470        480 
KENLNFLHLN RNACYQPMSF RPRLLIVGEP GFGQSSHLAP AVIHALEKFT VYTLDIPVLF 

       490        500        510        520        530        540 
GISTTSPEEA CSQMIREAKR TAPSIVYVPH IHLWWEIVGP TLKATFTTLL QTIPSFAPVL 

       550        560        570        580        590        600 
LLATSEKPYS ALPEEVQELF THDYGEIFNV QLPDKEERTK FFEDLILKQA SKPPVSQKKA 

       610        620        630        640        650        660 
VLQALEVLPV APPPEPRPLT AEEVKRLEEQ EEDTFRELRI FLRNVTHRLA IDKRFRVFTK 

       670        680        690        700        710        720 
PVDPDEVPDY VTVIKQPMDL SSVISKIDLH KYLTVKDYLK DIDLICSNAL EYNPDRDPGD 

       730        740        750        760        770        780 
RLIRHRACAL RDTAYAIIKE ELDEDFEQLC EEIQESRKKR GCSSSKYAPS YYHVMPKQNS 

       790        800        810        820        830        840 
PPVGDKKPDQ EQNEKLKVPC TPVACSTPAQ LKRKFHKKSK WHVGTKIKRR KISQAKDNSL 

       850        860        870        880        890        900 
NAMNSSSRSD TEDSQHTHAE HTEPGNTDES SVEESDKQNR LESNIDLKNN SSSSNIENEL 

       910        920        930        940        950        960 
EEPKETTEGT ELRKDRIVCR GDASASQVTD IPEDSESKEM DFLRMTLARG SQVEQQELIS 

       970        980        990       1000       1010       1020 
MEQALAILSQ PTPSLVLDHK QLTNILKTVV KKSQKYNIFQ LENLYAVISQ CIYEHRRDYD 

      1030       1040 
KTALVQKMEQ AVENFNCSRS 

« Hide

Isoform 2 [UniParc].

Checksum: D07990372977E11D
Show »

FASTA40044,652

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK029867 mRNA. Translation: BAC26651.1.
AK134319 mRNA. Translation: BAE22095.1.
RefSeqNP_081711.2. NM_027435.2.
UniGeneMm.221758.

3D structure databases

ProteinModelPortalQ8CDM1.
SMRQ8CDM1. Positions 630-757.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8CDM1. 2 interactions.
MINTMINT-4605695.
STRING10090.ENSMUSP00000043691.

PTM databases

PhosphoSiteQ8CDM1.

Proteomic databases

PRIDEQ8CDM1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID70472.
KEGGmmu:70472.
UCSCuc007vtg.1. mouse. [Q8CDM1-2]

Organism-specific databases

CTD29028.
MGIMGI:1917722. Atad2.

Phylogenomic databases

eggNOGCOG0464.
HOGENOMHOG000034119.
HOVERGENHBG080873.
InParanoidQ3UYW6.
PhylomeDBQ8CDM1.

Gene expression databases

CleanExMM_ATAD2.
GenevestigatorQ8CDM1.

Family and domain databases

Gene3D1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSPR00503. BROMODOMAIN.
SMARTSM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEPS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATAD2. mouse.
NextBio331701.
PROQ8CDM1.
SOURCESearch...

Entry information

Entry nameATAD2_MOUSE
AccessionPrimary (citable) accession number: Q8CDM1
Secondary accession number(s): Q3UYW6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot