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Protein

ATPase family AAA domain-containing protein 2

Gene

Atad2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi122 – 129ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 2 (EC:3.6.1.3)
Gene namesi
Name:Atad2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917722. Atad2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847971 – 1040ATPase family AAA domain-containing protein 2Add BLAST1040

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65PhosphoserineBy similarity1
Modified residuei401PhosphoserineBy similarity1
Modified residuei406PhosphoserineBy similarity1
Cross-linki777Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki797Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei801PhosphothreonineCombined sources1
Modified residuei825PhosphothreonineBy similarity1
Modified residuei849PhosphoserineBy similarity1
Modified residuei883PhosphoserineCombined sources1
Modified residuei891PhosphoserineBy similarity1
Modified residuei951PhosphoserineBy similarity1
Modified residuei972PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8CDM1.
PaxDbiQ8CDM1.
PeptideAtlasiQ8CDM1.
PRIDEiQ8CDM1.

PTM databases

iPTMnetiQ8CDM1.
PhosphoSitePlusiQ8CDM1.

Expressioni

Gene expression databases

CleanExiMM_ATAD2.

Interactioni

Subunit structurei

Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro) (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Hist4h4P628062EBI-2944582,EBI-299632

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214078. 1 interactor.
IntActiQ8CDM1. 2 interactors.
MINTiMINT-4605695.
STRINGi10090.ENSMUSP00000043691.

Structurei

3D structure databases

ProteinModelPortaliQ8CDM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini650 – 720BromoAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili619 – 643Sequence analysisAdd BLAST25
Coiled coili735 – 761Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 22Poly-Ser10
Compositional biasi891 – 894Poly-Ser4

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Bromodomain, Coiled coil

Phylogenomic databases

eggNOGiKOG0732. Eukaryota.
COG0464. LUCA.
HOGENOMiHOG000034119.
HOVERGENiHBG080873.
InParanoidiQ8CDM1.
PhylomeDBiQ8CDM1.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR031252. ANCCA.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR036427. Bromodomain-like_sf.
IPR027417. P-loop_NTPase.
PANTHERiPTHR23069:SF4. PTHR23069:SF4. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CDM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLKMRRHA IHSSDSTSSS SSEDDCFERR TKRNRNRAIN RCLPLNFRKD
60 70 80 90 100
EIRGIYKDRM KIGASLADVD PMQLDTSVRF DSVGGLSSHI AALKEMVVFP
110 120 130 140 150
LLYPEVFEKF KIQPPRGCLF YGPPGTGKTL VARALANECS RGDKRVAFFM
160 170 180 190 200
RKGADCLSKW VGESERQLRL LFDQAYQMRP AIIFFDEIDG LAPVRSSRQD
210 220 230 240 250
QIHSSIVSTL LALMDGLDSR GEIVVIGATN RLDSIDPALR RPGRFDREFL
260 270 280 290 300
FSLPDKNARK EILKIHTRDW NPKPVDMFLE ELAEHCVGYC GADIKSICAE
310 320 330 340 350
AALCALRRRY PQIYTTSEKL QLDLSSITIS AKDFEAALQK IRPASQRAVT
360 370 380 390 400
SPGQALSAIV KPLLQNTVHR ILDALQKVFP HVEVGTNKSL NSDVSCPFLE
410 420 430 440 450
SDLAYSDDDT PSVYENGLSQ KENLNFLHLN RNACYQPMSF RPRLLIVGEP
460 470 480 490 500
GFGQSSHLAP AVIHALEKFT VYTLDIPVLF GISTTSPEEA CSQMIREAKR
510 520 530 540 550
TAPSIVYVPH IHLWWEIVGP TLKATFTTLL QTIPSFAPVL LLATSEKPYS
560 570 580 590 600
ALPEEVQELF THDYGEIFNV QLPDKEERTK FFEDLILKQA SKPPVSQKKA
610 620 630 640 650
VLQALEVLPV APPPEPRPLT AEEVKRLEEQ EEDTFRELRI FLRNVTHRLA
660 670 680 690 700
IDKRFRVFTK PVDPDEVPDY VTVIKQPMDL SSVISKIDLH KYLTVKDYLK
710 720 730 740 750
DIDLICSNAL EYNPDRDPGD RLIRHRACAL RDTAYAIIKE ELDEDFEQLC
760 770 780 790 800
EEIQESRKKR GCSSSKYAPS YYHVMPKQNS PPVGDKKPDQ EQNEKLKVPC
810 820 830 840 850
TPVACSTPAQ LKRKFHKKSK WHVGTKIKRR KISQAKDNSL NAMNSSSRSD
860 870 880 890 900
TEDSQHTHAE HTEPGNTDES SVEESDKQNR LESNIDLKNN SSSSNIENEL
910 920 930 940 950
EEPKETTEGT ELRKDRIVCR GDASASQVTD IPEDSESKEM DFLRMTLARG
960 970 980 990 1000
SQVEQQELIS MEQALAILSQ PTPSLVLDHK QLTNILKTVV KKSQKYNIFQ
1010 1020 1030 1040
LENLYAVISQ CIYEHRRDYD KTALVQKMEQ AVENFNCSRS
Length:1,040
Mass (Da):117,943
Last modified:March 1, 2003 - v1
Checksum:i50DF23CA677ABC38
GO
Isoform 2 (identifier: Q8CDM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.
     202-203: IH → MF
     601-601: V → G
     602-1040: Missing.

Note: No experimental confirmation available.
Show »
Length:400
Mass (Da):44,652
Checksum:iD07990372977E11D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0358041 – 201Missing in isoform 2. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_035805202 – 203IH → MF in isoform 2. 1 Publication2
Alternative sequenceiVSP_035806601V → G in isoform 2. 1 Publication1
Alternative sequenceiVSP_035807602 – 1040Missing in isoform 2. 1 PublicationAdd BLAST439

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029867 mRNA. Translation: BAC26651.1.
AK134319 mRNA. Translation: BAE22095.1.
RefSeqiNP_081711.2. NM_027435.2.
UniGeneiMm.221758.

Genome annotation databases

GeneIDi70472.
KEGGimmu:70472.
UCSCiuc007vtg.1. mouse. [Q8CDM1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiATAD2_MOUSE
AccessioniPrimary (citable) accession number: Q8CDM1
Secondary accession number(s): Q3UYW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families