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Q8CDM1

- ATAD2_MOUSE

UniProt

Q8CDM1 - ATAD2_MOUSE

Protein

ATPase family AAA domain-containing protein 2

Gene

Atad2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi122 – 1298ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Hydrolase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATPase family AAA domain-containing protein 2 (EC:3.6.1.3)
    Gene namesi
    Name:Atad2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1917722. Atad2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10401040ATPase family AAA domain-containing protein 2PRO_0000084797Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei401 – 4011PhosphoserineBy similarity
    Modified residuei406 – 4061PhosphoserineBy similarity
    Modified residuei801 – 8011PhosphothreonineBy similarity
    Modified residuei951 – 9511PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8CDM1.
    PRIDEiQ8CDM1.

    PTM databases

    PhosphoSiteiQ8CDM1.

    Expressioni

    Gene expression databases

    CleanExiMM_ATAD2.
    GenevestigatoriQ8CDM1.

    Interactioni

    Subunit structurei

    Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro) By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Hist4h4P628062EBI-2944582,EBI-299632

    Protein-protein interaction databases

    BioGridi214078. 1 interaction.
    IntActiQ8CDM1. 2 interactions.
    MINTiMINT-4605695.
    STRINGi10090.ENSMUSP00000043691.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CDM1.
    SMRiQ8CDM1. Positions 630-757.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini650 – 72071BromoPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili619 – 64325Sequence AnalysisAdd
    BLAST
    Coiled coili735 – 76127Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi13 – 2210Poly-Ser
    Compositional biasi891 – 8944Poly-Ser

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated
    Contains 1 bromo domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Bromodomain, Coiled coil

    Phylogenomic databases

    eggNOGiCOG0464.
    HOGENOMiHOG000034119.
    HOVERGENiHBG080873.
    InParanoidiQ3UYW6.
    PhylomeDBiQ8CDM1.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR001487. Bromodomain.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00382. AAA. 1 hit.
    SM00297. BROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF52540. SSF52540. 3 hits.
    PROSITEiPS00674. AAA. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8CDM1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLLKMRRHA IHSSDSTSSS SSEDDCFERR TKRNRNRAIN RCLPLNFRKD     50
    EIRGIYKDRM KIGASLADVD PMQLDTSVRF DSVGGLSSHI AALKEMVVFP 100
    LLYPEVFEKF KIQPPRGCLF YGPPGTGKTL VARALANECS RGDKRVAFFM 150
    RKGADCLSKW VGESERQLRL LFDQAYQMRP AIIFFDEIDG LAPVRSSRQD 200
    QIHSSIVSTL LALMDGLDSR GEIVVIGATN RLDSIDPALR RPGRFDREFL 250
    FSLPDKNARK EILKIHTRDW NPKPVDMFLE ELAEHCVGYC GADIKSICAE 300
    AALCALRRRY PQIYTTSEKL QLDLSSITIS AKDFEAALQK IRPASQRAVT 350
    SPGQALSAIV KPLLQNTVHR ILDALQKVFP HVEVGTNKSL NSDVSCPFLE 400
    SDLAYSDDDT PSVYENGLSQ KENLNFLHLN RNACYQPMSF RPRLLIVGEP 450
    GFGQSSHLAP AVIHALEKFT VYTLDIPVLF GISTTSPEEA CSQMIREAKR 500
    TAPSIVYVPH IHLWWEIVGP TLKATFTTLL QTIPSFAPVL LLATSEKPYS 550
    ALPEEVQELF THDYGEIFNV QLPDKEERTK FFEDLILKQA SKPPVSQKKA 600
    VLQALEVLPV APPPEPRPLT AEEVKRLEEQ EEDTFRELRI FLRNVTHRLA 650
    IDKRFRVFTK PVDPDEVPDY VTVIKQPMDL SSVISKIDLH KYLTVKDYLK 700
    DIDLICSNAL EYNPDRDPGD RLIRHRACAL RDTAYAIIKE ELDEDFEQLC 750
    EEIQESRKKR GCSSSKYAPS YYHVMPKQNS PPVGDKKPDQ EQNEKLKVPC 800
    TPVACSTPAQ LKRKFHKKSK WHVGTKIKRR KISQAKDNSL NAMNSSSRSD 850
    TEDSQHTHAE HTEPGNTDES SVEESDKQNR LESNIDLKNN SSSSNIENEL 900
    EEPKETTEGT ELRKDRIVCR GDASASQVTD IPEDSESKEM DFLRMTLARG 950
    SQVEQQELIS MEQALAILSQ PTPSLVLDHK QLTNILKTVV KKSQKYNIFQ 1000
    LENLYAVISQ CIYEHRRDYD KTALVQKMEQ AVENFNCSRS 1040
    Length:1,040
    Mass (Da):117,943
    Last modified:March 1, 2003 - v1
    Checksum:i50DF23CA677ABC38
    GO
    Isoform 2 (identifier: Q8CDM1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-201: Missing.
         202-203: IH → MF
         601-601: V → G
         602-1040: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:400
    Mass (Da):44,652
    Checksum:iD07990372977E11D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 201201Missing in isoform 2. 1 PublicationVSP_035804Add
    BLAST
    Alternative sequencei202 – 2032IH → MF in isoform 2. 1 PublicationVSP_035805
    Alternative sequencei601 – 6011V → G in isoform 2. 1 PublicationVSP_035806
    Alternative sequencei602 – 1040439Missing in isoform 2. 1 PublicationVSP_035807Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK029867 mRNA. Translation: BAC26651.1.
    AK134319 mRNA. Translation: BAE22095.1.
    RefSeqiNP_081711.2. NM_027435.2.
    UniGeneiMm.221758.

    Genome annotation databases

    GeneIDi70472.
    KEGGimmu:70472.
    UCSCiuc007vtg.1. mouse. [Q8CDM1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK029867 mRNA. Translation: BAC26651.1 .
    AK134319 mRNA. Translation: BAE22095.1 .
    RefSeqi NP_081711.2. NM_027435.2.
    UniGenei Mm.221758.

    3D structure databases

    ProteinModelPortali Q8CDM1.
    SMRi Q8CDM1. Positions 630-757.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 214078. 1 interaction.
    IntActi Q8CDM1. 2 interactions.
    MINTi MINT-4605695.
    STRINGi 10090.ENSMUSP00000043691.

    PTM databases

    PhosphoSitei Q8CDM1.

    Proteomic databases

    MaxQBi Q8CDM1.
    PRIDEi Q8CDM1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 70472.
    KEGGi mmu:70472.
    UCSCi uc007vtg.1. mouse. [Q8CDM1-2 ]

    Organism-specific databases

    CTDi 29028.
    MGIi MGI:1917722. Atad2.

    Phylogenomic databases

    eggNOGi COG0464.
    HOGENOMi HOG000034119.
    HOVERGENi HBG080873.
    InParanoidi Q3UYW6.
    PhylomeDBi Q8CDM1.

    Miscellaneous databases

    ChiTaRSi ATAD2. mouse.
    NextBioi 331701.
    PROi Q8CDM1.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_ATAD2.
    Genevestigatori Q8CDM1.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR001487. Bromodomain.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00382. AAA. 1 hit.
    SM00297. BROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF52540. SSF52540. 3 hits.
    PROSITEi PS00674. AAA. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Testis.

    Entry informationi

    Entry nameiATAD2_MOUSE
    AccessioniPrimary (citable) accession number: Q8CDM1
    Secondary accession number(s): Q3UYW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3