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Protein

ATPase family AAA domain-containing protein 2

Gene

Atad2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi122 – 129ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 2 (EC:3.6.1.3)
Gene namesi
Name:Atad2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1917722 Atad2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847971 – 1040ATPase family AAA domain-containing protein 2Add BLAST1040

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65PhosphoserineBy similarity1
Modified residuei401PhosphoserineBy similarity1
Modified residuei406PhosphoserineBy similarity1
Cross-linki777Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki797Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei801PhosphothreonineCombined sources1
Modified residuei825PhosphothreonineBy similarity1
Modified residuei849PhosphoserineBy similarity1
Modified residuei883PhosphoserineCombined sources1
Modified residuei891PhosphoserineBy similarity1
Modified residuei951PhosphoserineBy similarity1
Modified residuei972PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8CDM1
PaxDbiQ8CDM1
PeptideAtlasiQ8CDM1
PRIDEiQ8CDM1

PTM databases

iPTMnetiQ8CDM1
PhosphoSitePlusiQ8CDM1

Expressioni

Gene expression databases

CleanExiMM_ATAD2
ExpressionAtlasiQ8CDM1 baseline and differential

Interactioni

Subunit structurei

Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro) (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Hist4h4P628062EBI-2944582,EBI-299632

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214078, 1 interactor
IntActiQ8CDM1, 2 interactors
MINTiQ8CDM1
STRINGi10090.ENSMUSP00000043691

Structurei

3D structure databases

ProteinModelPortaliQ8CDM1
SMRiQ8CDM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini650 – 720BromoPROSITE-ProRule annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili619 – 643Sequence analysisAdd BLAST25
Coiled coili735 – 761Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 22Poly-Ser10
Compositional biasi891 – 894Poly-Ser4

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Bromodomain, Coiled coil

Phylogenomic databases

eggNOGiKOG0732 Eukaryota
COG0464 LUCA
GeneTreeiENSGT00550000074694
HOGENOMiHOG000034119
HOVERGENiHBG080873
InParanoidiQ8CDM1
KOiK22531
PhylomeDBiQ8CDM1

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR031252 ANCCA
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR23069:SF4 PTHR23069:SF4, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF00439 Bromodomain, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit
PS50014 BROMODOMAIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CDM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLKMRRHA IHSSDSTSSS SSEDDCFERR TKRNRNRAIN RCLPLNFRKD
60 70 80 90 100
EIRGIYKDRM KIGASLADVD PMQLDTSVRF DSVGGLSSHI AALKEMVVFP
110 120 130 140 150
LLYPEVFEKF KIQPPRGCLF YGPPGTGKTL VARALANECS RGDKRVAFFM
160 170 180 190 200
RKGADCLSKW VGESERQLRL LFDQAYQMRP AIIFFDEIDG LAPVRSSRQD
210 220 230 240 250
QIHSSIVSTL LALMDGLDSR GEIVVIGATN RLDSIDPALR RPGRFDREFL
260 270 280 290 300
FSLPDKNARK EILKIHTRDW NPKPVDMFLE ELAEHCVGYC GADIKSICAE
310 320 330 340 350
AALCALRRRY PQIYTTSEKL QLDLSSITIS AKDFEAALQK IRPASQRAVT
360 370 380 390 400
SPGQALSAIV KPLLQNTVHR ILDALQKVFP HVEVGTNKSL NSDVSCPFLE
410 420 430 440 450
SDLAYSDDDT PSVYENGLSQ KENLNFLHLN RNACYQPMSF RPRLLIVGEP
460 470 480 490 500
GFGQSSHLAP AVIHALEKFT VYTLDIPVLF GISTTSPEEA CSQMIREAKR
510 520 530 540 550
TAPSIVYVPH IHLWWEIVGP TLKATFTTLL QTIPSFAPVL LLATSEKPYS
560 570 580 590 600
ALPEEVQELF THDYGEIFNV QLPDKEERTK FFEDLILKQA SKPPVSQKKA
610 620 630 640 650
VLQALEVLPV APPPEPRPLT AEEVKRLEEQ EEDTFRELRI FLRNVTHRLA
660 670 680 690 700
IDKRFRVFTK PVDPDEVPDY VTVIKQPMDL SSVISKIDLH KYLTVKDYLK
710 720 730 740 750
DIDLICSNAL EYNPDRDPGD RLIRHRACAL RDTAYAIIKE ELDEDFEQLC
760 770 780 790 800
EEIQESRKKR GCSSSKYAPS YYHVMPKQNS PPVGDKKPDQ EQNEKLKVPC
810 820 830 840 850
TPVACSTPAQ LKRKFHKKSK WHVGTKIKRR KISQAKDNSL NAMNSSSRSD
860 870 880 890 900
TEDSQHTHAE HTEPGNTDES SVEESDKQNR LESNIDLKNN SSSSNIENEL
910 920 930 940 950
EEPKETTEGT ELRKDRIVCR GDASASQVTD IPEDSESKEM DFLRMTLARG
960 970 980 990 1000
SQVEQQELIS MEQALAILSQ PTPSLVLDHK QLTNILKTVV KKSQKYNIFQ
1010 1020 1030 1040
LENLYAVISQ CIYEHRRDYD KTALVQKMEQ AVENFNCSRS
Length:1,040
Mass (Da):117,943
Last modified:March 1, 2003 - v1
Checksum:i50DF23CA677ABC38
GO
Isoform 2 (identifier: Q8CDM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.
     202-203: IH → MF
     601-601: V → G
     602-1040: Missing.

Note: No experimental confirmation available.
Show »
Length:400
Mass (Da):44,652
Checksum:iD07990372977E11D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0358041 – 201Missing in isoform 2. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_035805202 – 203IH → MF in isoform 2. 1 Publication2
Alternative sequenceiVSP_035806601V → G in isoform 2. 1 Publication1
Alternative sequenceiVSP_035807602 – 1040Missing in isoform 2. 1 PublicationAdd BLAST439

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029867 mRNA Translation: BAC26651.1
AK134319 mRNA Translation: BAE22095.1
RefSeqiNP_081711.2, NM_027435.2
UniGeneiMm.221758

Genome annotation databases

EnsembliENSMUST00000228783; ENSMUSP00000153936; ENSMUSG00000022360 [Q8CDM1-1]
GeneIDi70472
KEGGimmu:70472
UCSCiuc007vtg.1 mouse [Q8CDM1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiATAD2_MOUSE
AccessioniPrimary (citable) accession number: Q8CDM1
Secondary accession number(s): Q3UYW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health