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Protein

Stonin-1

Gene

Ston1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the endocytic machinery.By similarity

GO - Biological processi

  • endocytosis Source: UniProtKB-KW
  • regulation of endocytosis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Stonin-1
Alternative name(s):
Stoned B-like factor
Gene namesi
Name:Ston1
Synonyms:Salf, Sblf, Stn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1924307. Ston1.

Subcellular locationi

  • Cytoplasm By similarity
  • Membrane By similarity

  • Note: Some fraction is membrane-associated.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 730730Stonin-1PRO_0000185737Add
BLAST

Proteomic databases

MaxQBiQ8CDJ8.
PaxDbiQ8CDJ8.
PRIDEiQ8CDJ8.

PTM databases

PhosphoSiteiQ8CDJ8.

Expressioni

Gene expression databases

BgeeiQ8CDJ8.
CleanExiMM_STON1.
ExpressionAtlasiQ8CDJ8. baseline and differential.
GenevisibleiQ8CDJ8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8CDJ8. 1 interaction.
STRINGi10090.ENSMUSP00000067027.

Structurei

3D structure databases

ProteinModelPortaliQ8CDJ8.
SMRiQ8CDJ8. Positions 366-639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini269 – 402134SHDPROSITE-ProRule annotationAdd
BLAST
Domaini407 – 710304MHDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Stoned B family.Curated
Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation
Contains 1 SHD (stonin homology) domain.Curated

Phylogenomic databases

eggNOGiKOG2677. Eukaryota.
ENOG410XQHF. LUCA.
GeneTreeiENSGT00830000128302.
HOGENOMiHOG000133061.
HOVERGENiHBG037269.
InParanoidiQ8CDJ8.
OMAiYNIQVEI.
OrthoDBiEOG7R2BHW.
TreeFamiTF318623.

Family and domain databases

InterProiIPR028565. MHD.
IPR012320. SHD.
IPR031232. Ston1.
[Graphical view]
PANTHERiPTHR10529:SF238. PTHR10529:SF238. 2 hits.
PfamiPF00928. Adap_comp_sub. 1 hit.
[Graphical view]
SUPFAMiSSF49447. SSF49447. 2 hits.
PROSITEiPS51072. MHD. 1 hit.
PS51070. SHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CDJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSTNPGSWV TFDDDPAFQS SQKRKDFSLE TQGVCRPNGL KLTLPTLRDP
60 70 80 90 100
PSTPSSASST PLSSPMVDFY FSPGPPSNSP LSTPTKDFPG FPGIPKAGTH
110 120 130 140 150
VLYPIPECSS SSAPTTAGGV GPPLLLTKPD CSPHVSLPSS HSHTQPTPTL
160 170 180 190 200
GFTEDAGPQR VQSEARQFEY FQDHCAFSNP FWKDEGSASP FPLDSLASRK
210 220 230 240 250
PFSPKDKEVP IGHKSLTQCS LDYICEKLEH LHSAETQDPL GDLSMQDPYA
260 270 280 290 300
GDTVSFVPHS LFRSQPRAGW SFMLRIPEKK NMMSSRQWGP IFLKVLPGGI
310 320 330 340 350
LQMYYEKGLE KPFKEFQLDP HCRLSEPKLE NFSMAGKIHT VKVEHVSYSE
360 370 380 390 400
KRKYHAKTEV VHEPEVEQML KLGSTEHRDF LEFLTTVEEE LIKLPATAKP
410 420 430 440 450
KNKSYEEQEI CLDIQDSLWG KVTKEGQLVE SAVVTQICCL CFLNGPAECF
460 470 480 490 500
LALNDRELQK RDECYFEKEP EKKGIAILDY HFHTCVKAEE FEQSRIIKFV
510 520 530 540 550
PLDACRFELM RFKTSYEAGE LPFAVKSVVT VQGAYVELQA FVNMTPAAQG
560 570 580 590 600
SPHAGALRSC NNIMIHFPVP AQWIKALWTR NLQRQKSLKA KMNRRACLGS
610 620 630 640 650
LQEPESEPVI QVTVGSAKYE SAYRAVVWKI DRLPDKNSSP DQPHCLSYKL
660 670 680 690 700
ELGSDQEVPS DWYPFATVQF SMLEACASRT EVRSLGVESD AQPQKHVCQR
710 720 730
ACYNIQVEIE KKWIQVDGED ADKTGGCVTQ
Length:730
Mass (Da):81,793
Last modified:August 15, 2003 - v2
Checksum:iFC55399706280B81
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti278 – 2781E → V in BAC26699 (PubMed:16141072).Curated
Sequence conflicti322 – 3221C → F in BAC26699 (PubMed:16141072).Curated
Sequence conflicti603 – 6031E → D in BAB29639 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014958 mRNA. Translation: BAB29639.1.
AK029878 mRNA. Translation: BAC26656.1.
AK029959 mRNA. Translation: BAC26699.1.
CCDSiCCDS50207.1.
RefSeqiNP_084134.2. NM_029858.2.
XP_006525174.1. XM_006525111.2.
XP_006525175.1. XM_006525112.2.
UniGeneiMm.482203.

Genome annotation databases

EnsembliENSMUST00000064035; ENSMUSP00000067027; ENSMUSG00000033855.
ENSMUST00000150023; ENSMUSP00000122928; ENSMUSG00000033855.
ENSMUST00000163588; ENSMUSP00000131703; ENSMUSG00000033855.
GeneIDi77057.
KEGGimmu:77057.
UCSCiuc012ayo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014958 mRNA. Translation: BAB29639.1.
AK029878 mRNA. Translation: BAC26656.1.
AK029959 mRNA. Translation: BAC26699.1.
CCDSiCCDS50207.1.
RefSeqiNP_084134.2. NM_029858.2.
XP_006525174.1. XM_006525111.2.
XP_006525175.1. XM_006525112.2.
UniGeneiMm.482203.

3D structure databases

ProteinModelPortaliQ8CDJ8.
SMRiQ8CDJ8. Positions 366-639.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CDJ8. 1 interaction.
STRINGi10090.ENSMUSP00000067027.

PTM databases

PhosphoSiteiQ8CDJ8.

Proteomic databases

MaxQBiQ8CDJ8.
PaxDbiQ8CDJ8.
PRIDEiQ8CDJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064035; ENSMUSP00000067027; ENSMUSG00000033855.
ENSMUST00000150023; ENSMUSP00000122928; ENSMUSG00000033855.
ENSMUST00000163588; ENSMUSP00000131703; ENSMUSG00000033855.
GeneIDi77057.
KEGGimmu:77057.
UCSCiuc012ayo.1. mouse.

Organism-specific databases

CTDi11037.
MGIiMGI:1924307. Ston1.

Phylogenomic databases

eggNOGiKOG2677. Eukaryota.
ENOG410XQHF. LUCA.
GeneTreeiENSGT00830000128302.
HOGENOMiHOG000133061.
HOVERGENiHBG037269.
InParanoidiQ8CDJ8.
OMAiYNIQVEI.
OrthoDBiEOG7R2BHW.
TreeFamiTF318623.

Miscellaneous databases

NextBioi346400.
PROiQ8CDJ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CDJ8.
CleanExiMM_STON1.
ExpressionAtlasiQ8CDJ8. baseline and differential.
GenevisibleiQ8CDJ8. MM.

Family and domain databases

InterProiIPR028565. MHD.
IPR012320. SHD.
IPR031232. Ston1.
[Graphical view]
PANTHERiPTHR10529:SF238. PTHR10529:SF238. 2 hits.
PfamiPF00928. Adap_comp_sub. 1 hit.
[Graphical view]
SUPFAMiSSF49447. SSF49447. 2 hits.
PROSITEiPS51072. MHD. 1 hit.
PS51070. SHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiSTON1_MOUSE
AccessioniPrimary (citable) accession number: Q8CDJ8
Secondary accession number(s): Q8CDL8, Q9D5T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: February 17, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In contrast to other members of the family, it does not contain NPF (Asn-Pro-Phe) sites and thereby does not interact with EPS15, EPS15R and ITSN1.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.