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Protein

CREB3 regulatory factor

Gene

Crebrf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Stress response, Transcription, Transcription regulation, Transport, Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
CREB3 regulatory factor
Alternative name(s):
Luman recruitment factor
Short name:
LRF
Gene namesi
Name:Crebrf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1924378. Crebrf.

Subcellular locationi

  • Nucleus By similarity

  • Note: Colocalizes with CREB3 in nuclear foci.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640CREB3 regulatory factorPRO_0000299307Add
BLAST

Post-translational modificationi

Probably degraded by the proteasome.By similarity

Proteomic databases

EPDiQ8CDG5.
MaxQBiQ8CDG5.
PaxDbiQ8CDG5.
PeptideAtlasiQ8CDG5.
PRIDEiQ8CDG5.

PTM databases

iPTMnetiQ8CDG5.
PhosphoSiteiQ8CDG5.

Expressioni

Tissue specificityi

Highly expressed in intestin, testis, heart and kidney, weakly in brain adipose, colon, liver, lung and skeletal.1 Publication

Gene expression databases

BgeeiQ8CDG5.
CleanExiMM_A930001N09RIK.
ExpressionAtlasiQ8CDG5. baseline and differential.
GenevisibleiQ8CDG5. MM.

Interactioni

Subunit structurei

Interacts (via leucine-zipper domain) with CREB3 (via leucine-zipper domain); the interaction promotes CREB3 degradation.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059102.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini522 – 58564bZIPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni524 – 53310Basic motifBy similarity
Regioni534 – 5418Leucine-zipperBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi356 – 39439Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. CREBRF subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IHZR. Eukaryota.
ENOG410Y9V2. LUCA.
GeneTreeiENSGT00390000007125.
HOGENOMiHOG000088620.
HOVERGENiHBG106858.
InParanoidiQ8CDG5.
OrthoDBiEOG7R2BJ4.
PhylomeDBiQ8CDG5.
TreeFamiTF330810.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PROSITEiPS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CDG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQPSVSGMD PPFGDAFRSH TFSEQTLMST DLLANSSDPD FMYELDREMN
60 70 80 90 100
YQQNPRDNFL SLEDCKDIEN LETFTDVLDN EDALTSNWEQ WDTYCEDLTK
110 120 130 140 150
YTKLTSCDIW GTKEVDYLGL DDFSSPYQDE EVISKTPTLA QLNSEDSQSV
160 170 180 190 200
SDSLYYPDSL FSVKQNPLPP SSFPSKKITN RAAAPVCSSK TLQAEVPSSD
210 220 230 240 250
CVQKASKPTS STQIMVKTNM YHNEKVNFHV ECKDYVKKAK VKINPVQQGR
260 270 280 290 300
PLLSQVHIDA AKENTCYCGA VAKRQERRGV EPHQGRGTPA LPFKETQELL
310 320 330 340 350
LSPLTQDSPG LVATAESGSL SASTSVSDSS QKKEEHNYSL FVSDNMREQP
360 370 380 390 400
TKYSPEDDED DEDEFDDEDH DEGFGSEHEL SENEEEEEEE EDYEDDRDDD
410 420 430 440 450
ISDTFSEPGY ENDSVEDLKE MTSISSRKRG KRRYFWEYSE QLTPSQQERI
460 470 480 490 500
LRPSEWNRDT LPSNMYQKNG LHHGKYAVKK SRRTDVEDLT PNPKKLLQIG
510 520 530 540 550
NELRKLNKVI SDLTPVSELP LTARPRSRKE KNKLASRACR LKKKAQYEAN
560 570 580 590 600
KVKLWGLNTE YDNLLFVINS IKQDIVNRVQ NPREEREPSM GQKLEILIKD
610 620 630 640
TLGLPVAGQT SEFVNQVLGK TAEGNPTGGL VGLRIPASKV
Length:640
Mass (Da):72,598
Last modified:March 1, 2003 - v1
Checksum:iFE02C532FA34E1DE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171F → V in AAI13192 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020796 mRNA. Translation: BAB32214.1.
AK030092 mRNA. Translation: BAC26779.1.
AK044760 mRNA. Translation: BAC32070.1.
CT025550 Genomic DNA. Translation: CAX15295.1.
BC113191 mRNA. Translation: AAI13192.1.
BC113192 mRNA. Translation: AAI13193.1.
CCDSiCCDS37516.1.
RefSeqiNP_084146.1. NM_029870.2.
XP_006525177.1. XM_006525114.2.
UniGeneiMm.275414.

Genome annotation databases

EnsembliENSMUST00000062519; ENSMUSP00000059102; ENSMUSG00000048249.
GeneIDi77128.
KEGGimmu:77128.
UCSCiuc008bej.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020796 mRNA. Translation: BAB32214.1.
AK030092 mRNA. Translation: BAC26779.1.
AK044760 mRNA. Translation: BAC32070.1.
CT025550 Genomic DNA. Translation: CAX15295.1.
BC113191 mRNA. Translation: AAI13192.1.
BC113192 mRNA. Translation: AAI13193.1.
CCDSiCCDS37516.1.
RefSeqiNP_084146.1. NM_029870.2.
XP_006525177.1. XM_006525114.2.
UniGeneiMm.275414.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059102.

PTM databases

iPTMnetiQ8CDG5.
PhosphoSiteiQ8CDG5.

Proteomic databases

EPDiQ8CDG5.
MaxQBiQ8CDG5.
PaxDbiQ8CDG5.
PeptideAtlasiQ8CDG5.
PRIDEiQ8CDG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062519; ENSMUSP00000059102; ENSMUSG00000048249.
GeneIDi77128.
KEGGimmu:77128.
UCSCiuc008bej.1. mouse.

Organism-specific databases

CTDi153222.
MGIiMGI:1924378. Crebrf.

Phylogenomic databases

eggNOGiENOG410IHZR. Eukaryota.
ENOG410Y9V2. LUCA.
GeneTreeiENSGT00390000007125.
HOGENOMiHOG000088620.
HOVERGENiHBG106858.
InParanoidiQ8CDG5.
OrthoDBiEOG7R2BJ4.
PhylomeDBiQ8CDG5.
TreeFamiTF330810.

Miscellaneous databases

PROiQ8CDG5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CDG5.
CleanExiMM_A930001N09RIK.
ExpressionAtlasiQ8CDG5. baseline and differential.
GenevisibleiQ8CDG5. MM.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PROSITEiPS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response."
    Audas T.E., Li Y., Liang G., Lu R.
    Mol. Cell. Biol. 28:3952-3966(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCRERF_MOUSE
AccessioniPrimary (citable) accession number: Q8CDG5
Secondary accession number(s): B8JJI1
, Q14DI2, Q8C8N7, Q9CTQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.