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Protein

BTB/POZ domain-containing protein KCTD20

Gene

Kctd20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes the phosphorylation of AKT family members.1 Publication

GO - Biological processi

  • positive regulation of phosphorylation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD20
Alternative name(s):
Potassium channel tetramerization domain containing 20
Gene namesi
Name:Kctd20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914239. Kctd20.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Colocalizes with BTBD10 in filamentous structures.1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419BTB/POZ domain-containing protein KCTD20PRO_0000255249Add
BLAST

Proteomic databases

MaxQBiQ8CDD8.
PaxDbiQ8CDD8.
PRIDEiQ8CDD8.

PTM databases

iPTMnetiQ8CDD8.
PhosphoSiteiQ8CDD8.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000005936.
ExpressionAtlasiQ8CDD8. baseline and differential.
GenevisibleiQ8CDD8. MM.

Interactioni

Subunit structurei

Interacts with AKT1; AKT2 and AKT3 (PubMed:24156551). Interacts with PPP2CA and PPP1CA (PubMed:24156551). Part of a complex containing MARK4 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi211857. 5 interactions.
IntActiQ8CDD8. 1 interaction.
MINTiMINT-217556.
STRINGi10090.ENSMUSP00000062282.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FO0X-ray2.50P207-214[»]
1NANX-ray2.30M/Q207-214[»]
2CLZX-ray1.90C/M207-214[»]
ProteinModelPortaliQ8CDD8.
SMRiQ8CDD8. Positions 116-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 19175BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiENOG410ISJ3. Eukaryota.
ENOG410YA9I. LUCA.
GeneTreeiENSGT00390000007975.
HOGENOMiHOG000261659.
HOVERGENiHBG059410.
InParanoidiQ8CDD8.
OMAiDYASQPA.
OrthoDBiEOG091G05SP.
PhylomeDBiQ8CDD8.
TreeFamiTF314369.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CDD8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVHQGSDGD WSLQPELSCL GDEALAATQE KEGSSLVSSG LHSVTYPLAA
60 70 80 90 100
RSEDLALDYA SQPASLPHPH IMPLPEDNKG SCFQSGSKRS HEPFIVPERF
110 120 130 140 150
GNSGLGFGGG AHSQAPEKVT LLVDGTRFVV NPQIFTAHPD TMLGRMFGPG
160 170 180 190 200
REYNFTRPNE KGEYVIAEGI SATVFRTVLD YYKTGIINCP DGISIPDLRD
210 220 230 240 250
TCDYLCINFD FNTIRCQDLS ALLHELSNDG AHKQFDHYLE ELILPIMVGC
260 270 280 290 300
AKKGERECHI VVLTDEDSVD WDEDHPPPMG EEYSQILYSS KLYRFFKYIE
310 320 330 340 350
NRDVAKTVLK ERGLKNIRIG IEGYPTCKEK IKRRPGGRSE VIYNYVQRPF
360 370 380 390 400
IQMSWEKEEG KSRHVDFQCV RSKSLTNLVA AGEDVLEDQE IIMHHPPQVD
410
ELDRLNAPLS QMAPNDFQD
Length:419
Mass (Da):47,068
Last modified:March 1, 2003 - v1
Checksum:i4354C06990BE5A66
GO
Isoform 2 (identifier: Q8CDD8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Show »
Length:348
Mass (Da):39,599
Checksum:i4C60CF4471784A71
GO

Sequence cautioni

The sequence BAE39167 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7171Missing in isoform 2. 2 PublicationsVSP_021279Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010404 mRNA. Translation: BAB26913.1.
AK013254 mRNA. Translation: BAB28748.2.
AK030202 mRNA. Translation: BAC26839.1.
AK088807 mRNA. Translation: BAC40584.1.
AK166987 mRNA. Translation: BAE39167.1. Different initiation.
AK168440 mRNA. Translation: BAE40345.1.
BC036318 mRNA. Translation: AAH36318.1.
BC049250 mRNA. Translation: AAH49250.1.
CCDSiCCDS28588.1. [Q8CDD8-1]
RefSeqiNP_080164.2. NM_025888.5. [Q8CDD8-1]
XP_006524873.1. XM_006524810.1. [Q8CDD8-1]
XP_006524874.1. XM_006524811.1. [Q8CDD8-1]
XP_006536839.1. XM_006536776.1. [Q8CDD8-1]
XP_006536840.1. XM_006536777.1. [Q8CDD8-1]
UniGeneiMm.435.

Genome annotation databases

EnsembliENSMUST00000057174; ENSMUSP00000062282; ENSMUSG00000005936. [Q8CDD8-1]
ENSMUST00000117672; ENSMUSP00000113740; ENSMUSG00000005936. [Q8CDD8-2]
ENSMUST00000118762; ENSMUSP00000112890; ENSMUSG00000005936. [Q8CDD8-2]
ENSMUST00000122163; ENSMUSP00000112957; ENSMUSG00000005936. [Q8CDD8-1]
ENSMUST00000168507; ENSMUSP00000131435; ENSMUSG00000005936. [Q8CDD8-1]
GeneIDi66989.
KEGGimmu:66989.
UCSCiuc008brw.1. mouse. [Q8CDD8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010404 mRNA. Translation: BAB26913.1.
AK013254 mRNA. Translation: BAB28748.2.
AK030202 mRNA. Translation: BAC26839.1.
AK088807 mRNA. Translation: BAC40584.1.
AK166987 mRNA. Translation: BAE39167.1. Different initiation.
AK168440 mRNA. Translation: BAE40345.1.
BC036318 mRNA. Translation: AAH36318.1.
BC049250 mRNA. Translation: AAH49250.1.
CCDSiCCDS28588.1. [Q8CDD8-1]
RefSeqiNP_080164.2. NM_025888.5. [Q8CDD8-1]
XP_006524873.1. XM_006524810.1. [Q8CDD8-1]
XP_006524874.1. XM_006524811.1. [Q8CDD8-1]
XP_006536839.1. XM_006536776.1. [Q8CDD8-1]
XP_006536840.1. XM_006536777.1. [Q8CDD8-1]
UniGeneiMm.435.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FO0X-ray2.50P207-214[»]
1NANX-ray2.30M/Q207-214[»]
2CLZX-ray1.90C/M207-214[»]
ProteinModelPortaliQ8CDD8.
SMRiQ8CDD8. Positions 116-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211857. 5 interactions.
IntActiQ8CDD8. 1 interaction.
MINTiMINT-217556.
STRINGi10090.ENSMUSP00000062282.

PTM databases

iPTMnetiQ8CDD8.
PhosphoSiteiQ8CDD8.

Proteomic databases

MaxQBiQ8CDD8.
PaxDbiQ8CDD8.
PRIDEiQ8CDD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057174; ENSMUSP00000062282; ENSMUSG00000005936. [Q8CDD8-1]
ENSMUST00000117672; ENSMUSP00000113740; ENSMUSG00000005936. [Q8CDD8-2]
ENSMUST00000118762; ENSMUSP00000112890; ENSMUSG00000005936. [Q8CDD8-2]
ENSMUST00000122163; ENSMUSP00000112957; ENSMUSG00000005936. [Q8CDD8-1]
ENSMUST00000168507; ENSMUSP00000131435; ENSMUSG00000005936. [Q8CDD8-1]
GeneIDi66989.
KEGGimmu:66989.
UCSCiuc008brw.1. mouse. [Q8CDD8-1]

Organism-specific databases

CTDi222658.
MGIiMGI:1914239. Kctd20.

Phylogenomic databases

eggNOGiENOG410ISJ3. Eukaryota.
ENOG410YA9I. LUCA.
GeneTreeiENSGT00390000007975.
HOGENOMiHOG000261659.
HOVERGENiHBG059410.
InParanoidiQ8CDD8.
OMAiDYASQPA.
OrthoDBiEOG091G05SP.
PhylomeDBiQ8CDD8.
TreeFamiTF314369.

Miscellaneous databases

ChiTaRSiKctd20. mouse.
PROiQ8CDD8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005936.
ExpressionAtlasiQ8CDD8. baseline and differential.
GenevisibleiQ8CDD8. MM.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCD20_MOUSE
AccessioniPrimary (citable) accession number: Q8CDD8
Secondary accession number(s): Q3TKH8
, Q5U5Z7, Q9CSC4, Q9CWT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.