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Protein

BTB/POZ domain-containing protein KCTD20

Gene

Kctd20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the phosphorylation of AKT family members.1 Publication

GO - Biological processi

  • positive regulation of phosphorylation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD20
Alternative name(s):
Potassium channel tetramerization domain containing 20
Gene namesi
Name:Kctd20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1914239 Kctd20

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002552491 – 419BTB/POZ domain-containing protein KCTD20Add BLAST419

Proteomic databases

PaxDbiQ8CDD8
PRIDEiQ8CDD8

PTM databases

iPTMnetiQ8CDD8
PhosphoSitePlusiQ8CDD8

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000005936
ExpressionAtlasiQ8CDD8 baseline and differential
GenevisibleiQ8CDD8 MM

Interactioni

Subunit structurei

Interacts with AKT1; AKT2 and AKT3 (PubMed:24156551). Interacts with PPP2CA and PPP1CA (PubMed:24156551). Part of a complex containing MARK4 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi211857, 5 interactors
IntActiQ8CDD8, 1 interactor
MINTiQ8CDD8
STRINGi10090.ENSMUSP00000062282

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FO0X-ray2.50P207-214[»]
1NANX-ray2.30M/Q207-214[»]
2CLZX-ray1.90C/M207-214[»]
ProteinModelPortaliQ8CDD8
SMRiQ8CDD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 191BTBAdd BLAST75

Phylogenomic databases

eggNOGiENOG410ISJ3 Eukaryota
ENOG410YA9I LUCA
GeneTreeiENSGT00390000007975
HOGENOMiHOG000261659
HOVERGENiHBG059410
InParanoidiQ8CDD8
OMAiYASQPAN
OrthoDBiEOG091G05SP
PhylomeDBiQ8CDD8
TreeFamiTF314369

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CDD8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVHQGSDGD WSLQPELSCL GDEALAATQE KEGSSLVSSG LHSVTYPLAA
60 70 80 90 100
RSEDLALDYA SQPASLPHPH IMPLPEDNKG SCFQSGSKRS HEPFIVPERF
110 120 130 140 150
GNSGLGFGGG AHSQAPEKVT LLVDGTRFVV NPQIFTAHPD TMLGRMFGPG
160 170 180 190 200
REYNFTRPNE KGEYVIAEGI SATVFRTVLD YYKTGIINCP DGISIPDLRD
210 220 230 240 250
TCDYLCINFD FNTIRCQDLS ALLHELSNDG AHKQFDHYLE ELILPIMVGC
260 270 280 290 300
AKKGERECHI VVLTDEDSVD WDEDHPPPMG EEYSQILYSS KLYRFFKYIE
310 320 330 340 350
NRDVAKTVLK ERGLKNIRIG IEGYPTCKEK IKRRPGGRSE VIYNYVQRPF
360 370 380 390 400
IQMSWEKEEG KSRHVDFQCV RSKSLTNLVA AGEDVLEDQE IIMHHPPQVD
410
ELDRLNAPLS QMAPNDFQD
Length:419
Mass (Da):47,068
Last modified:March 1, 2003 - v1
Checksum:i4354C06990BE5A66
GO
Isoform 2 (identifier: Q8CDD8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Show »
Length:348
Mass (Da):39,599
Checksum:i4C60CF4471784A71
GO

Sequence cautioni

The sequence BAE39167 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0212791 – 71Missing in isoform 2. 2 PublicationsAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010404 mRNA Translation: BAB26913.1
AK013254 mRNA Translation: BAB28748.2
AK030202 mRNA Translation: BAC26839.1
AK088807 mRNA Translation: BAC40584.1
AK166987 mRNA Translation: BAE39167.1 Different initiation.
AK168440 mRNA Translation: BAE40345.1
BC036318 mRNA Translation: AAH36318.1
BC049250 mRNA Translation: AAH49250.1
CCDSiCCDS28588.1 [Q8CDD8-1]
RefSeqiNP_080164.2, NM_025888.5 [Q8CDD8-1]
XP_006524873.1, XM_006524810.1
XP_006524874.1, XM_006524811.1 [Q8CDD8-1]
UniGeneiMm.435

Genome annotation databases

EnsembliENSMUST00000057174; ENSMUSP00000062282; ENSMUSG00000005936 [Q8CDD8-1]
ENSMUST00000117672; ENSMUSP00000113740; ENSMUSG00000005936 [Q8CDD8-2]
ENSMUST00000118762; ENSMUSP00000112890; ENSMUSG00000005936 [Q8CDD8-2]
ENSMUST00000122163; ENSMUSP00000112957; ENSMUSG00000005936 [Q8CDD8-1]
ENSMUST00000168507; ENSMUSP00000131435; ENSMUSG00000005936 [Q8CDD8-1]
GeneIDi66989
KEGGimmu:66989
UCSCiuc008brw.1 mouse [Q8CDD8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiKCD20_MOUSE
AccessioniPrimary (citable) accession number: Q8CDD8
Secondary accession number(s): Q3TKH8
, Q5U5Z7, Q9CSC4, Q9CWT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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